LOCUS       NM_001039129            1944 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1),
            transcript variant 2, mRNA.
ACCESSION   NM_001039129
VERSION     NM_001039129.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Yao,L., Peng,P., Ding,T., Yi,J. and Liang,J.
  TITLE     m6A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion
            Injury Via Modulating Oxidative Stress and Mitochondrial
            Dysfunction by hnRNPA1/Sirt2 Axis
  JOURNAL   Mol Neurobiol 61 (9), 6893-6908 (2024)
   PUBMED   38358439
  REMARK    GeneRIF: m[6]A-Induced lncRNA MEG3 Promotes Cerebral
            Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and
            Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis.
            Erratum:[Mol Neurobiol. 2024 Sep;61(9):6909. doi:
            10.1007/s12035-024-04162-z.. PMID: 38652353]
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Li,X., Su,Y., Xu,Y., Hu,T., Lu,X., Sun,J., Li,W., Zhou,J., Ma,X.,
            Yang,Y. and Bao,Y.
  TITLE     Adipocyte-Specific Hnrnpa1 Knockout Aggravates Obesity-Induced
            Metabolic Dysfunction via Upregulation of CCL2
  JOURNAL   Diabetes 73 (5), 713-727 (2024)
   PUBMED   38320300
  REMARK    GeneRIF: Adipocyte-Specific Hnrnpa1 Knockout Aggravates
            Obesity-Induced Metabolic Dysfunction via Upregulation of CCL2.
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   White,T.L.A., Jin,Y., Roberts,S.D.A., Gable,M.J. and Morel,P.A.
  TITLE     Phosphorylation of hnRNP A1-Serine 199 Is Not Required for T Cell
            Differentiation and Function
  JOURNAL   Immunohorizons 8 (2), 136-146 (2024)
   PUBMED   38334757
  REMARK    GeneRIF: Phosphorylation of hnRNP A1-Serine 199 Is Not Required for
            T Cell Differentiation and Function.
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Wang,M., Wang,X., Cui,Y. and Wen,X.
  TITLE     Impact of heterogeneous nuclear ribonucleoprotein A/B subtype
            overexpression on the expression of cancer stem cell markers CD133
            and CD44 and cellular proliferation capacity
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 101-108 (2023)
   PUBMED   38279469
  REMARK    GeneRIF: Impact of heterogeneous nuclear ribonucleoprotein A/B
            subtype overexpression on the expression of cancer stem cell
            markers CD133 and CD44 and cellular proliferation capacity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Zhang,Q., Weng,W., Gu,X., Xiang,J., Yang,Y., Zhu,M.X., Gu,W., He,Z.
            and Li,Y.
  TITLE     hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic
            inflammatory pain by stabilizing TRPA1 mRNA
  JOURNAL   Cell Rep 42 (11), 113401 (2023)
   PUBMED   37943660
  REMARK    GeneRIF: hnRNPA1 SUMOylation promotes cold hypersensitivity in
            chronic inflammatory pain by stabilizing TRPA1 mRNA.
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Frankfort,B.J. and Gelman,I.H.
  TITLE     Identification of novel cellular genes transcriptionally suppressed
            by v-src
  JOURNAL   Biochem Biophys Res Commun 206 (3), 916-926 (1995)
   PUBMED   7832805
REFERENCE   8  (bases 1 to 1944)
  AUTHORS   Yang,X., Bani,M.R., Lu,S.J., Rowan,S., Ben-David,Y. and Chabot,B.
  TITLE     The A1 and A1B proteins of heterogeneous nuclear
            ribonucleoparticles modulate 5' splice site selection in vivo
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 6924-6928 (1994)
   PUBMED   8041722
REFERENCE   9  (bases 1 to 1944)
  AUTHORS   Ben-David,Y., Bani,M.R., Chabot,B., De Koven,A. and Bernstein,A.
  TITLE     Retroviral insertions downstream of the heterogeneous nuclear
            ribonucleoprotein A1 gene in erythroleukemia cells: evidence that
            A1 is not essential for cell growth
  JOURNAL   Mol Cell Biol 12 (10), 4449-4455 (1992)
   PUBMED   1406633
REFERENCE   10 (bases 1 to 1944)
  AUTHORS   Varmuza,S. and Tate,P.
  TITLE     Isolation of epiblast-specific cDNA clones by differential
            hybridization with polymerase chain reaction-amplified probes
            derived from single embryos
  JOURNAL   Mol Reprod Dev 32 (4), 339-348 (1992)
   PUBMED   1497882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164069.9.
            
            On Aug 24, 2022 this sequence version replaced NM_001039129.4.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longer isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168733.1, AK166989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC164069.9         102970-103085       c
            117-233             AC164069.9         102302-102418       c
            234-380             AC164069.9         101906-102052       c
            381-591             AC164069.9         101385-101595       c
            592-684             AC164069.9         101200-101292       c
            685-777             AC164069.9         101026-101118       c
            778-852             AC164069.9         100780-100854       c
            853-1011            AC164069.9         100418-100576       c
            1012-1167           AC164069.9         99718-99873         c
            1168-1237           AC164069.9         99470-99539         c
            1238-1944           AC164069.9         98536-99242         c
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.58 cM"
     gene            1..1944
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /note="heterogeneous nuclear ribonucleoprotein A1"
                     /db_xref="GeneID:15382"
                     /db_xref="MGI:MGI:104820"
     exon            1..116
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1223
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /note="isoform b is encoded by transcript variant 2; hnRNP
                     core protein A1; helix-destabilizing protein;
                     single-strand-binding protein; topoisomerase-inhibitor
                     suppressed"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A1
                     isoform b"
                     /protein_id="NP_001034218.1"
                     /db_xref="CCDS:CCDS37232.1"
                     /db_xref="GeneID:15382"
                     /db_xref="MGI:MGI:104820"
                     /translation="MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCV
                     VMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHL
                     TVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVD
                     KIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGR
                     GGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGSPGYSGGSRGYGSGGQGYGN
                     QGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNF
                     GGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF"
     exon            117..233
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..380
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..591
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..684
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..777
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..852
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1011
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1167
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1237
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1944
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /note="hexamer: AATAAA"
     polyA_site      1944
                     /gene="Hnrnpa1"
                     /gene_synonym="Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1"
                     /note="major polyA site"
ORIGIN      
        1 gagcagaagg taggctggcg ggcacgttcg ttatcgtatt cctttctgct ctttgacgct
       61 gccgaggaag catcgctgaa ggctctcgta actctaccgt catgtctaag tccgagtctc
      121 ccaaggagcc agaacagctg cggaagctct tcatcggagg gctgagcttc gaaacaaccg
      181 acgagagtct gaggagccat tttgagcaat ggggaacact aacagactgt gtggtaatga
      241 gagatccaaa caccaagaga tccaggggct ttgggtttgt cacatatgcc actgtggaag
      301 aagtggatgc tgccatgaat gcaagaccac acaaggtgga tggaagagtt gtggaaccta
      361 agagagctgt ctcaagagaa gattctcagc gaccaggtgc ccacttaact gtgaaaaaga
      421 tctttgttgg tggtattaaa gaagacactg aagaacatca cctacgagat tattttgagc
      481 agtatgggaa gattgaagtg atagaaatta tgactgacag aggcagtggg aaaaagaggg
      541 gctttgcttt tgttaccttt gatgaccatg actctgtgga taagattgtt attcagaaat
      601 accatactgt gaatggccac aactgtgaag taagaaaggc tctgtcgaag caagagatgg
      661 ctagtgcttc atccagtcag agaggtcgca gtggttctgg aaactttggt ggtggtcgtg
      721 gaggcggttt tggtggcaat gacaattttg gtcgaggagg gaacttcagt ggtcgtggtg
      781 gctttggtgg cagccgtggt ggtggtggat atggtggcag tggggatggc tataatggat
      841 ttggcaatga tggtggttat ggaggaggca gccctggtta ctctggagga agcagaggct
      901 atggaagtgg tggacagggt tatggaaacc agggcagtgg ctatggcggg agtggcagct
      961 atgacagcta taacaacgga ggaggcggag gcggctttgg cggtggtagt ggaagcaatt
     1021 ttggaggtgg tggaagctac aatgattttg gcaattacaa caatcagtct tccaattttg
     1081 ggccgatgaa gggaggaaac tttggaggca ggagctctgg cccttatggt ggtggaggcc
     1141 agtactttgc taaaccacgg aaccaaggtg gctatggcgg ttccagcagc agcagtagct
     1201 atggcagtgg caggaggttc taattacata cagccaggaa acaaagctta gcaggagagg
     1261 agagccagag aagtgacagg gaagctacag gttacaacag atttgtgaac tcagccaagc
     1321 acagtggtgg cagggcctag ctgctacaaa gaagacatgt tttagacaat actcatgtgt
     1381 gtgggcaaaa actccaggac tgtatttgtg actaattgta taacaggtta ttttagtttc
     1441 tgttctgtgg aaagtgtaaa gcattccaac aaaaggtttt actgtagacc tttttcaccc
     1501 atgctgttga ttgctaaatg taatagtctg atcatgacgc tgaataaatg tgtctttttt
     1561 tttttttttt taaatgtgct gtgtaaagtt agtctattct gaagccatct tggtaaactt
     1621 ccccaacagt gtgaagttag aattccttca gggtggtgcc aagttccatt tggaatttat
     1681 ttatggttgc ttgggtggag aagccattgt cttcaaaaac cttgatgtcg ttaaactgcc
     1741 agttactatt gtaactttta atgagtttca ccattgaaag ggtcatccaa gcaaggtcac
     1801 aatttggtta taaaatggtt gttggcacac cctatgcaat atcaaaattg aataacggta
     1861 tcagataaaa taacagatgg gaatgaagct tatgtatcca ttatcatgtg tactcaataa
     1921 acgatttaat tctcttgaat ggaa
//
