LOCUS       NM_080462               1653 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus histamine N-methyltransferase (Hnmt), mRNA.
ACCESSION   NM_080462 XM_489815
VERSION     NM_080462.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   McClain,J.L., Morales-Soto,W., Gonzales,J., Parmar,V.,
            Demireva,E.Y. and Gulbransen,B.D.
  TITLE     Sexually Dimorphic Effects of Histamine Degradation by Enteric
            Glial Histamine N-Methyltransferase (HNMT) on Visceral
            Hypersensitivity
  JOURNAL   Biomolecules 13 (11), 1651 (2023)
   PUBMED   38002333
  REMARK    GeneRIF: Sexually Dimorphic Effects of Histamine Degradation by
            Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral
            Hypersensitivity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Otsuka,R., Naganuma,F., Nakamura,T., Miwa,H., Nakayama-Naono,R.,
            Matsuzawa,T., Komatsu,Y., Sato,Y., Takahashi,Y.,
            Tatsuoka-Kitano,H., Yanai,K. and Yoshikawa,T.
  TITLE     Contribution of astrocytic histamine N-methyltransferase to
            histamine clearance and brain function in mice
  JOURNAL   Neuropharmacology 212, 109065 (2022)
   PUBMED   35487272
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Naganuma,F., Nakamura,T., Yoshikawa,T., Iida,T., Miura,Y.,
            Karpati,A., Matsuzawa,T., Yanai,A., Mogi,A., Mochizuki,T.,
            Okamura,N. and Yanai,K.
  TITLE     Histamine N-methyltransferase regulates aggression and the
            sleep-wake cycle
  JOURNAL   Sci Rep 7 (1), 15899 (2017)
   PUBMED   29162912
  REMARK    GeneRIF: KO mice exhibited high aggressive behaviours and exhibited
            prolonged bouts of awakening during the light (inactive) period and
            compensatory sleep during the dark (active) period.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Furukawa,F., Yoshimasu,T., Yamamoto,Y., Kanazawa,N. and
            Tachibana,T.
  TITLE     Mast cells and histamine metabolism in skin lesions from
            MRL/MP-lpr/lpr mice
  JOURNAL   Autoimmun Rev 8 (6), 495-499 (2009)
   PUBMED   19162242
  REMARK    GeneRIF: decreasing expression over the time course of the skin
            pathological changes in MRL/lpr mice
            Review article
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Kitanaka,N., Kitanaka,J., Oue,T., Tada,Y., Tanaka,T. and
            Takemura,M.
  TITLE     Genomic structure of the rat and mouse histamine
            N-methyltransferase gene
  JOURNAL   Jpn J Pharmacol 88 (1), 85-92 (2002)
   PUBMED   11855681
  REMARK    GeneRIF: Genomic structure of the rat and mouse histamine
            N-methyltransferase gene
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Wang,L., Yan,L., McGuire,C., Kozak,C.A., Wang,M., Kim,U.J.,
            Siciliano,M. and Weinshilboum,R.M.
  TITLE     Mouse histamine N-methyltransferase: cDNA cloning, expression, gene
            cloning and chromosomal localization
  JOURNAL   Inflamm Res 50 (6), 300-308 (2001)
   PUBMED   11475331
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Preuss,C.V., Wood,T.C., Szumlanski,C.L., Raftogianis,R.B.,
            Otterness,D.M., Girard,B., Scott,M.C. and Weinshilboum,R.M.
  TITLE     Human histamine N-methyltransferase pharmacogenetics: common
            genetic polymorphisms that alter activity
  JOURNAL   Mol Pharmacol 53 (4), 708-717 (1998)
   PUBMED   9547362
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Aksoy,S., Raftogianis,R. and Weinshilboum,R.
  TITLE     Human histamine N-methyltransferase gene: structural
            characterization and chromosomal location
  JOURNAL   Biochem Biophys Res Commun 219 (2), 548-554 (1996)
   PUBMED   8605025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF297037.1, AK160131.1 and AW456742.1.
            
            On Apr 11, 2007 this sequence version replaced NM_080462.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF297037.1, AB070524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AF297037.1         1-60
            61-1636             AK160131.1         5-1580
            1637-1653           AW456742.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 16.06 cM"
     gene            1..1653
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="histamine N-methyltransferase"
                     /db_xref="GeneID:140483"
                     /db_xref="MGI:MGI:2153181"
     exon            1..60
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            61..207
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..958
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /EC_number="2.1.1.8"
                     /note="HMT"
                     /codon_start=1
                     /product="histamine N-methyltransferase"
                     /protein_id="NP_536710.1"
                     /db_xref="CCDS:CCDS15731.1"
                     /db_xref="GeneID:140483"
                     /db_xref="MGI:MGI:2153181"
                     /translation="MASCMRSLFSDQGRYVESFRRFLNNSTEHQCMQEFMDKKLPGII
                     ARIGEAKAEIKILSVGGGAGEVDLQILSKVQAQYPGICINNEVVEPSAEQIVKYKELV
                     AKTSNMENIKFSWHKETSSEYQKRMLEEEEEPPKWDFIHMIQMLYYVKDIPATLKFFH
                     GLLAASAKILIILVSGTSGWEKLWKKYGSRLPRDDLCQYVTSSDLAQILDDLGIKYEC
                     YDLVSTMDITDCFIDGNENGDLLWDFLTETCNFSKTAPLDLKAEIMKDLQEPEFSVKK
                     EGKVLFNNNLSFIVVEANV"
     exon            208..260
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            261..368
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..502
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            503..596
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1640
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1294
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="major polyA site"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="hexamer: ATTAAA"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1619
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="major polyA site"
     polyA_site      1640
                     /gene="Hnmt"
                     /gene_synonym="1500031F01Rik"
                     /note="major polyA site"
ORIGIN      
        1 caaaaactaa gatactaagg cagcgaactc tctgcaacaa acacacgtag ccagctgctg
       61 agaacccaat atggcatctt gcatgaggag cttattttct gaccaaggca gatacgtaga
      121 atcttttcgg aggtttctaa ataattccac ggaacaccag tgcatgcagg aattcatgga
      181 taagaagctt ccgggcataa tagcaaggat tggagaagca aaagcagaaa ttaagattct
      241 gagtgtaggc ggaggtgcag gtgaagttga ccttcaaatt ctttccaaag tccaggctca
      301 atacccagga atctgtatta acaatgaagt tgttgagcca agtgctgaac aaattgtcaa
      361 gtacaaagag cttgtagcca agacatcaaa catggagaac ataaaatttt cttggcacaa
      421 ggagacatca tctgaatatc aaaaacgtat gctggaagaa gaagaagagc caccgaagtg
      481 ggactttatt catatgattc agatgctgta ttatgtaaag gatattccag ccaccctgaa
      541 atttttccat ggtctcttag ctgccagtgc taaaattctc attattcttg tgtcaggaac
      601 tagtggctgg gaaaagctat ggaaaaagta tggatcccgc ctaccgaggg atgacctctg
      661 ccagtatgtc acatcttctg atcttgcgca gatactggat gacctgggta ttaagtatga
      721 atgctacgac cttgtgtcca ccatggacat aacagactgt tttattgatg gtaatgaaaa
      781 tggagacctg ctttgggatt ttttgacaga aacctgtaac tttagcaaaa cagcaccact
      841 ggatctcaaa gcagaaatta tgaaagatct tcaagagcct gaatttagtg ttaagaaaga
      901 ggggaaggta ctttttaata ataatctgag tttcatagtg gttgaggcaa atgtataagt
      961 cataagagta tccagagctc atattttgat caaatgctga tttatttaaa tatcaaatac
     1021 ttattattta aatattgaag ttaaaattaa tctcataata ggatgcaata ttatccctta
     1081 taatgaaatc tacaaatttc caagacaact taggctttct taagaaccat gtgggccact
     1141 tttggctgtg atcttgaaag aaaatactct gtctaaacac tgcctaactg aaaacatgtg
     1201 acttgagttt cattggctta ctgataataa agttctttcc attttcttag tgtactggga
     1261 attcttagaa taggaataaa gtatgtgtca ttcattcttt gagtaaggtg atatttgttg
     1321 attctctaat gacaaaatgt aagtatttct ctacctgtac tgaagtgttt atcttcccat
     1381 tttcttcaat agtagtttct atcatatgct ttattaacag catcataaag tcaggggctg
     1441 gtgggatggc tcttcccaag gacctgccga tgttcagtgt ggaatatgca tatgttacac
     1501 ctcggaacca tttgtgactt cagctctagg gaatcctatg tcatacactg gcctctctgg
     1561 gaattaacac ttaacatgta tatgcactac cccacacata taattaaaac taaaataaat
     1621 atttaaaagg attattaaaa aaaaaaaaaa aaa
//
