LOCUS       NM_001395870            3935 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus hepatocyte nuclear factor 4, gamma (Hnf4g), transcript
            variant 1, mRNA.
ACCESSION   NM_001395870 XM_006530072
VERSION     NM_001395870.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3935)
  AUTHORS   Michelson,D.A., Zuo,C., Verzi,M., Benoist,C. and Mathis,D.
  TITLE     Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver
            development within the thymus
  JOURNAL   J Exp Med 220 (10) (2023)
   PUBMED   37399024
REFERENCE   3  (bases 1 to 3935)
  AUTHORS   Song,X., Zhang,H., Zhang,Y., Goh,B., Bao,B., Mello,S.S., Sun,X.,
            Zheng,W., Gazzaniga,F.S., Wu,M., Qu,F., Yin,Q., Gilmore,M.S.,
            Oh,S.F. and Kasper,D.L.
  TITLE     Gut microbial fatty acid isomerization modulates intraepithelial T
            cells
  JOURNAL   Nature 619 (7971), 837-843 (2023)
   PUBMED   37380774
REFERENCE   4  (bases 1 to 3935)
  AUTHORS   Zhan,J., Zhang,Q., Tong,X., Liu,X. and Zhao,C.
  TITLE     HNF4G stimulates the development of pancreatic cancer by promoting
            IGF2BP2 transcription
  JOURNAL   Clin Transl Oncol 25 (5), 1472-1481 (2023)
   PUBMED   36607591
  REMARK    GeneRIF: HNF4G stimulates the development of pancreatic cancer by
            promoting IGF2BP2 transcription.
REFERENCE   5  (bases 1 to 3935)
  AUTHORS   Datta,R., Gholampour,M.A., Yang,C.D., Volk,R., Lin,S.,
            Podolsky,M.J., Arnold,T., Rieder,F., Zaro,B.W., Verzi,M.,
            Lehner,R., Abumrad,N., Lizama,C.O. and Atabai,K.
  TITLE     MFGE8 links absorption of dietary fatty acids with catabolism of
            enterocyte lipid stores through HNF4gamma-dependent transcription
            of CES enzymes
  JOURNAL   Cell Rep 42 (3), 112249 (2023)
   PUBMED   36924494
REFERENCE   6  (bases 1 to 3935)
  AUTHORS   Li,X., Madison,B.B., Zacharias,W., Kolterud,A., States,D. and
            Gumucio,D.L.
  TITLE     Deconvoluting the intestine: molecular evidence for a major role of
            the mesenchyme in the modulation of signaling cross talk
  JOURNAL   Physiol Genomics 29 (3), 290-301 (2007)
   PUBMED   17299133
REFERENCE   7  (bases 1 to 3935)
  AUTHORS   Lein,E.S., Hawrylycz,M.J., Ao,N., Ayres,M., Bensinger,A.,
            Bernard,A., Boe,A.F., Boguski,M.S., Brockway,K.S., Byrnes,E.J.,
            Chen,L., Chen,L., Chen,T.M., Chin,M.C., Chong,J., Crook,B.E.,
            Czaplinska,A., Dang,C.N., Datta,S., Dee,N.R., Desaki,A.L.,
            Desta,T., Diep,E., Dolbeare,T.A., Donelan,M.J., Dong,H.W.,
            Dougherty,J.G., Duncan,B.J., Ebbert,A.J., Eichele,G., Estin,L.K.,
            Faber,C., Facer,B.A., Fields,R., Fischer,S.R., Fliss,T.P.,
            Frensley,C., Gates,S.N., Glattfelder,K.J., Halverson,K.R.,
            Hart,M.R., Hohmann,J.G., Howell,M.P., Jeung,D.P., Johnson,R.A.,
            Karr,P.T., Kawal,R., Kidney,J.M., Knapik,R.H., Kuan,C.L.,
            Lake,J.H., Laramee,A.R., Larsen,K.D., Lau,C., Lemon,T.A.,
            Liang,A.J., Liu,Y., Luong,L.T., Michaels,J., Morgan,J.J.,
            Morgan,R.J., Mortrud,M.T., Mosqueda,N.F., Ng,L.L., Ng,R.,
            Orta,G.J., Overly,C.C., Pak,T.H., Parry,S.E., Pathak,S.D.,
            Pearson,O.C., Puchalski,R.B., Riley,Z.L., Rockett,H.R.,
            Rowland,S.A., Royall,J.J., Ruiz,M.J., Sarno,N.R., Schaffnit,K.,
            Shapovalova,N.V., Sivisay,T., Slaughterbeck,C.R., Smith,S.C.,
            Smith,K.A., Smith,B.I., Sodt,A.J., Stewart,N.N., Stumpf,K.R.,
            Sunkin,S.M., Sutram,M., Tam,A., Teemer,C.D., Thaller,C.,
            Thompson,C.L., Varnam,L.R., Visel,A., Whitlock,R.M.,
            Wohnoutka,P.E., Wolkey,C.K., Wong,V.Y., Wood,M., Yaylaoglu,M.B.,
            Young,R.C., Youngstrom,B.L., Yuan,X.F., Zhang,B., Zwingman,T.A. and
            Jones,A.R.
  TITLE     Genome-wide atlas of gene expression in the adult mouse brain
  JOURNAL   Nature 445 (7124), 168-176 (2007)
   PUBMED   17151600
REFERENCE   8  (bases 1 to 3935)
  AUTHORS   Gerdin,A.K., Surve,V.V., Jonsson,M., Bjursell,M., Bjorkman,M.,
            Edenro,A., Schuelke,M., Saad,A., Bjurstrom,S., Lundgren,E.J.,
            Snaith,M., Fransson-Steen,R., Tornell,J., Berg,A.L. and
            Bohlooly-Y,M.
  TITLE     Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma
            receptor knockout mice
  JOURNAL   Biochem Biophys Res Commun 349 (2), 825-832 (2006)
   PUBMED   16945327
  REMARK    GeneRIF: HNF4g has a role in energy expenditure, locomotor activity
            during night time, and higher body weight
REFERENCE   9  (bases 1 to 3935)
  AUTHORS   Choi,M.Y., Romer,A.I., Hu,M., Lepourcelet,M., Mechoor,A.,
            Yesilaltay,A., Krieger,M., Gray,P.A. and Shivdasani,R.A.
  TITLE     A dynamic expression survey identifies transcription factors
            relevant in mouse digestive tract development
  JOURNAL   Development 133 (20), 4119-4129 (2006)
   PUBMED   16971476
REFERENCE   10 (bases 1 to 3935)
  AUTHORS   Taraviras,S., Mantamadiotis,T., Dong-Si,T., Mincheva,A.,
            Lichter,P., Drewes,T., Ryffel,G.U., Monaghan,A.P. and Schutz,G.
  TITLE     Primary structure, chromosomal mapping, expression and
            transcriptional activity of murine hepatocyte nuclear factor 4gamma
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 21-32 (2000)
   PUBMED   10786614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170259.2 and AC157926.4.
            
            On Aug 20, 2021 this sequence version replaced XM_006530072.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.121596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC170259.2         17166-17360         c
            196-367             AC170259.2         13283-13454         c
            368-462             AC170259.2         10196-10290         c
            463-569             AC170259.2         8443-8549           c
            570-725             AC170259.2         6822-6977           c
            726-813             AC170259.2         3392-3479           c
            814-966             AC170259.2         89-241              c
            967-1203            AC157926.4         230725-230961       c
            1204-1326           AC157926.4         229550-229672       c
            1327-3935           AC157926.4         222846-225454       c
FEATURES             Location/Qualifiers
     source          1..3935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 1.82 cM"
     gene            1..3935
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /note="hepatocyte nuclear factor 4, gamma"
                     /db_xref="GeneID:30942"
                     /db_xref="MGI:MGI:1353604"
     exon            1..195
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1448
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HNF-4-gamma; nuclear receptor subfamily 2 group A member
                     2"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 4-gamma isoform 1"
                     /protein_id="NP_001382799.1"
                     /db_xref="GeneID:30942"
                     /db_xref="MGI:MGI:1353604"
                     /translation="MCVSQSMMRVSEPILDMDMGNYSEVLDPTYSTLEFDTMQILYNP
                     NDSSAPETTSMNTTDSGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSC
                     RFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTYEGSNIPSINT
                     LAQAEVRSCQISVPSPSSSTDINIKKIASISDVCESMKQQLLVLVEWAKYIPAFCELP
                     LDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNHYVIHRNSCEVEVSRVANRVLDE
                     LVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQISLEDYINDRQYD
                     SRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGAANDGSHLHH
                     PMHPHLSQDPLTGQTILLGPMSTLVHTDQIATPETPLPSPPQGSGQEPYKITANQASV
                     ISHQSLSKQKQL"
     exon            196..367
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..462
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..569
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..725
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..813
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..966
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1203
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1326
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..3935
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /note="hexamer: AATAAA"
     polyA_site      3935
                     /gene="Hnf4g"
                     /gene_synonym="NR2A2"
                     /note="major polyA site"
ORIGIN      
        1 agtactcaca acgtgaaagc ataacagcta gcatactctg ggtgtgtgga gccatttgta
       61 tgtgtgtctc tcaatcgatg atgagggttt cagagccgat actggacatg gacatgggaa
      121 actacagtga agttttggac ccaacttact cgaccttgga gtttgacact atgcagattc
      181 tgtataatcc caatgacagt tctgccccag agaccacaag tatgaatacc acagacagtg
      241 gtgtcaactg tttatgtgcc atctgtggtg acagagcaac aggaaagcac tatggggcat
      301 ccagttgtga tggctgcaaa ggctttttca ggcgcagcat tcggaagagt catgtttatt
      361 cctgcaggtt cagtcggcag tgtgttgttg acaaggacaa aaggaatcaa tgcagatact
      421 gtcgattaag aaagtgtttt agagcaggaa tgaaaaaaga agcggtgcaa aatgaacgcg
      481 acagaatcag tacaagaaga agtacctacg agggcagcaa catcccctcc ataaacactc
      541 tggcacaagc ggaagtgagg tcttgccaga tttcagtccc aagccccagt tccagcactg
      601 acataaatat taagaaaatc gcaagcatca gtgacgtttg tgagtccatg aaacaacagc
      661 tcttagtctt ggtggaatgg gccaaataca tccctgcctt ctgtgaactg cccttggatg
      721 accaggtggc cctcttgaga gcccatgctg gagaacatct gctgcttgga gctacaaaga
      781 gatccatgat gtataaagat attttgcttt tgggaaacca ctatgttatt caccgcaaca
      841 gctgtgaagt tgaagtcagt cgtgtagcca acagagttct cgatgagctg gttagaccct
      901 tccaagagat ccagatagat gacaacgagt acgcgtgctt gaaggccatt gtgttttttg
      961 acccagatgc aaagggattg agtgaccctg tgaagattaa gaacatgcgg ttccaggtgc
     1021 agatcagctt ggaggactac atcaatgacc ggcagtatga ctctcgtggc aggtttggag
     1081 agctgctgtt gctgctgcca acactgcaga gcattacctg gcagatgatt gaacaaattc
     1141 agttcgtcaa actgttcggc atggtcaaaa ttgacaacct ccttcaggaa atgctgctgg
     1201 gtggtgctgc caatgatggt agtcatctcc atcatccaat gcacccacat ttatctcaag
     1261 atccactaac tgggcaaact atacttttag gtcccatgtc cacactggtt catacagacc
     1321 agattgcaac tccagagacc ccactccctt ccccaccaca aggctctgga caagaaccgt
     1381 acaaaattac tgcaaatcaa gcttcagtca tttcacatca atccctctct aagcaaaagc
     1441 agctgtgaga tggggcttcc ttctgaatag cactgcataa atgtgaaaca catttgtctt
     1501 caaatatctc aagatgatac ttttgtctac ttcaggcaag gcttcttcat ggtgctgtta
     1561 taagattcta tcctgttttc ttgtttgtaa acacattttg tttattgttg ctgtgaagta
     1621 aagctttcat atgctttatt ttcctatgta tatttgggtt tgaagtgtat tgtttccaac
     1681 tgttcctgca ctgtgcctga accacttata tatgacttcc atgttttcat aatattaact
     1741 taaatctgta aatatttgct ttgttatgat ctgatacaga actaagtatt ctttttgtta
     1801 gataagaaat gctagttaat ataaaaatca accaagtttt tttgtttctt tttgtttgtt
     1861 tttgtttttg ttttttttta ataaaaaaca aattgtaaac ttgaagatta caaaaggata
     1921 agcagtggct gtagaataga atatttctgt gatggagaat acatcaggga ctgctgaggc
     1981 cagcagtaaa tgtgcctatg ttaaattcag agaaacagca ccattgtaaa gatgacagga
     2041 tattttttgc aatatgactg cacttcaaga gatctgctaa agaaaagtat gctgcttctt
     2101 ttagttagca tagaagacaa aggaaaacaa agaaatatga aactgtattt caaccaaaaa
     2161 tgacattcat tttttactgt tgagaaatct ggaaaatcac ccattcattg gaacttagtg
     2221 tgtccccata cccagttcct tgggaagaca aaggagtctt tctagagtaa cctgtgttag
     2281 ttcaagatat gcaaatatgg cagaaaggat gctgggaatc aagtcactga ttacatttgt
     2341 tcaacccagt tctggttggt gaatgtgtca ccaaagaata cattaaatta ttgtagtatg
     2401 cttttgaaaa tatacaatga ctgatgatgg aatgttatct gtcatactac tcttaaatgt
     2461 aaataacaag ttgttggcag tactttcagt gaggaagaga gcagttttgt accttttata
     2521 atcctcatat cttcccctaa aatactaaag aagataaaat atacactaga tatattttta
     2581 tgacttagga attttcacaa catagaaatt tgctgaaaat ttaattctag attgataagt
     2641 agccccaact atttgagata atccatggtt gggatttatt ttaaaagcac taaaaatcaa
     2701 caataacaat gtgtatcagt gttctctctc tctctctctt tctctctctc tctctctctc
     2761 tctctctctc tctctttttc tctctctctc tgcctgtctc tctgtttctt tttctctctt
     2821 catgactttg ttggtttatt ccctctctta tatttactaa agtggtaaag tatggttgaa
     2881 tatacagctg taaaatttct ataacatata tcaagagaaa aaagtaactg aacctgtagg
     2941 attttggatt aaaagacttc atggatcttc acatttctca gattatatgt cataccctct
     3001 acctacctaa aactacagac atcattttag tattaactat cttggctata aaatagaaat
     3061 aatgggacag ttatctgtaa tttgacagca tcaattgtat ttactcaaat gctattatcc
     3121 tcatgaaact aaaatataac attgatggag gacggggaaa gagagaaaga gattcttaat
     3181 tctgaatatt ttgaaactgt attcttgttt catgaaataa gcaagttaat tactaaattt
     3241 catgaacaga aatatcatct gtaggttttt gtttacttgt ttattgtaaa ttcttcaaaa
     3301 agacataaat ggtctatttg ggattatata ttttatatat ggtatataat accatgacaa
     3361 gatactttaa actggataga gtaaacaaca ggaatttgtt tctcatagct gttcatgttg
     3421 ggaagctgaa ggtaaagaat tatctgatgc tctgatttat agatagtgat ttgtgagaca
     3481 gctctcaggg acctctttta tgaaaacagg attgccacac atgttggctc caccctcaga
     3541 ccctcctcac ctgctagttt tttcaccttt gtagatcact atatgtatga ctacatttca
     3601 acataaatga ggaggcatgt gcacattcaa accatagcaa ataattttaa aacacaaaat
     3661 ttatttttga taaataatac atccataatg atatactaaa catatgtttt agaaactact
     3721 actaataatt ctctttgaaa aaccacggtc agggattttg taatatacca tttttgtata
     3781 ctgaacttct agaaatggtt gacaatgaag agctgatgtt tttagcatgt tatcaaaata
     3841 ttgttaaaga aagttattgc ttttatataa tacatttcag gtgatagata taagtaattt
     3901 attgtaaaat aaaaatttgt tttataaatg caaaa
//
