LOCUS       NM_009330               2843 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus HNF1 homeobox B (Hnf1b), transcript variant 1, mRNA.
ACCESSION   NM_009330 XM_001002217
VERSION     NM_009330.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Jankowski,J., Lee,H.K., Liu,C., Wilflingseder,J. and
            Hennighausen,L.
  TITLE     Sexually dimorphic renal expression of mouse Klotho is directed by
            a kidney-specific distal enhancer responsive to HNF1b
  JOURNAL   Commun Biol 7 (1), 1142 (2024)
   PUBMED   39277686
  REMARK    GeneRIF: Sexually dimorphic renal expression of mouse Klotho is
            directed by a kidney-specific distal enhancer responsive to HNF1b.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Sun,J., Wang,Y., Fu,H., Kang,F., Song,J., Xu,M., Ning,G., Wang,J.,
            Wang,W. and Wang,Q.
  TITLE     Mettl3-Mediated m6A Methylation Controls Pancreatic Bipotent
            Progenitor Fate and Islet Formation
  JOURNAL   Diabetes 73 (2), 237-249 (2024)
   PUBMED   37963393
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Weisser,I., Eckberg,K., D'Amico,S., Buttram,D. and Aboudehen,K.
  TITLE     Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in
            Mouse Polycystic Kidney Disease
  JOURNAL   J Am Soc Nephrol 35 (1), 41-55 (2024)
   PUBMED   37953472
REFERENCE   6  (bases 1 to 2843)
  AUTHORS   Cereghini,S., Ott,M.O., Power,S. and Maury,M.
  TITLE     Expression patterns of vHNF1 and HNF1 homeoproteins in early
            postimplantation embryos suggest distinct and sequential
            developmental roles
  JOURNAL   Development 116 (3), 783-797 (1992)
   PUBMED   1363228
REFERENCE   7  (bases 1 to 2843)
  AUTHORS   Karolyi,I.J., Guenet,J.L., Rey-Campos,J. and Camper,S.A.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   8  (bases 1 to 2843)
  AUTHORS   Ott,M.O., Rey-Campos,J., Cereghini,S. and Yaniv,M.
  TITLE     vHNF1 is expressed in epithelial cells of distinct embryonic origin
            during development and precedes HNF1 expression
  JOURNAL   Mech Dev 36 (1-2), 47-58 (1991)
   PUBMED   1685890
REFERENCE   9  (bases 1 to 2843)
  AUTHORS   Blumenfeld,M., Maury,M., Chouard,T., Yaniv,M. and Condamine,H.
  TITLE     Hepatic nuclear factor 1 (HNF1) shows a wider distribution than
            products of its known target genes in developing mouse
  JOURNAL   Development 113 (2), 589-599 (1991)
   PUBMED   1685988
REFERENCE   10 (bases 1 to 2843)
  AUTHORS   De Simone,V., De Magistris,L., Lazzaro,D., Gerstner,J., Monaci,P.,
            Nicosia,A. and Cortese,R.
  TITLE     LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is
            expressed in specialized epithelia
  JOURNAL   EMBO J 10 (6), 1435-1443 (1991)
   PUBMED   1673925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004837.2, AV140806.1 and AK019258.1.
            
            On Mar 30, 2014 this sequence version replaced NM_009330.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004837.2, X55842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2741              AK004837.2         2-2742
            2742-2753           AV140806.1         175-186
            2754-2843           AK019258.1         2308-2397
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.23 cM"
     gene            1..2843
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="HNF1 homeobox B"
                     /db_xref="GeneID:21410"
                     /db_xref="MGI:MGI:98505"
     exon            1..524
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1857
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatocyte nuclear factor 1-beta; homeoprotein LFB3;
                     transcription factor 2"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 1-beta isoform 1"
                     /protein_id="NP_033356.2"
                     /db_xref="CCDS:CCDS25179.1"
                     /db_xref="GeneID:21410"
                     /db_xref="MGI:MGI:98505"
                     /translation="MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLE
                     TLPLSPGSGADLDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEE
                     AAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPM
                     KTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQ
                     SEDTCSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQR
                     GVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGS
                     PHHQPSSSPPNKMSGVRYNQPGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPG
                     HSLLSPDSKMQITVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLN
                     TSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQL
                     QNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSINTLTSMSSSKQCPLQAW"
     exon            525..724
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..989
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1225
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1386
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1522
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1717
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1836
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2843
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="hexamer: AGTAAA"
     regulatory      2348..2353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="hexamer: TATAAA"
     polyA_site      2353
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="major polyA site"
     polyA_site      2372
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="hexamer: ATTAAA"
     polyA_site      2746
                     /gene="Hnf1b"
                     /gene_synonym="HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta;
                     LFB3; Tcf-2; Tcf2; vHNF1"
                     /note="major polyA site"
ORIGIN      
        1 aagttagaag ttttctgact cctctcggag gagtctccgg gaccccagag agtaacaggt
       61 gtctgaaagc taaagggtgg aggggttcca ggacttggag ttctcttgta aaactcccct
      121 ccaccctcct ctctcacacc cacccatccc ctcaacccct tctttttccg tccttggaaa
      181 atggtgtcca agctcacgtc gctccagcaa gaactcctga gtgccctgct gagctccgga
      241 gtcaccaagg aagtgctgat ccaggccttg gaggagttac tgccgtcccc gaatttcggg
      301 gtgaagctgg agacactgcc cctgtccccc gggagcgggg cggatctcga caccaagccg
      361 gttttccata ctctcaccaa tggccacgcc aagggccgct tgtctgggga cgagggctca
      421 gaggacggcg acgactatga cactcctccc atcctcaaag agctccaggc gctcaacacc
      481 gaggaggccg cggagcagcg ggccgaggtg gaccggatgc tcagcgagga cccgtggagg
      541 gctgccaaaa tgatcaaggg atacatgcaa cagcacaata tcccccagag ggaggtggtc
      601 gatgtcacag gcctgaacca atcccacctc tctcaacacc tcaacaaggg cacccccatg
      661 aagacccaga agagagctgc cctgtacact tggtacgtca gaaagcaacg ggagatcctc
      721 cgacagttca accagacagt ccagagctct ggaaacatga cagacaaaag cagtcaggat
      781 cagctgctgt ttctctttcc agagttcagt caacagaacc aggggcctgg gcagtcggag
      841 gacacctgct ccgagcccac caacaagaag atgcgccgca accggtttaa atgggggccc
      901 gcatcccagc aaattttgta ccaggcctac gaccggcaaa agaatcccag caaggaagag
      961 agggaggcct tagtggagga gtgtaacagg gcagaatgtt tgcaacgagg ggtctcccct
     1021 tccaaagccc acggcctagg ctccaacttg gtcacggagg tccgtgtcta caactggttc
     1081 gcaaaccgcc ggaaggaaga ggcgttcagg cagaagctgg ccatggatgc ctatagctcc
     1141 aaccagacgc acaacctgaa ccccctgctc acccatggct cccctcacca tcagccaagc
     1201 tcctctccac ccaacaagat gtcaggagtg cgctacaacc agccgggaaa caatgaggtc
     1261 acttcctctt cgacaatcag tcaccatggt aacagtgcca tggtgaccag ccagtcggtt
     1321 ttacagcaag tctccccagc cagcctggac ccaggccaca gtctcctctc acctgacagt
     1381 aaaatgcaga tcacagtgtc gggaggagga ctgcctcccg tcagcacctt gacgaatatc
     1441 cacagcctct cccaccacaa tccccagcaa tctcagaacc tcatcatgac ccccctgtct
     1501 ggagtcatgg ccattgcaca gagcctcaac acctcccaag cccagggtgt cccggtcatt
     1561 aacagtgtgg ctagcagcct ggcagcccta cagcccgtcc agttctctca acagctgcac
     1621 agccctcacc agcagcccct catgcagcag agcccaggca gtcacatggc ccagcagccc
     1681 ttcatggccg cggtgactca gctacagaac tcccacatgt atgcacataa gcaggaaccc
     1741 ccccagtatt cccacacctc ccggttccca tctgcaatgg tggtcacaga taccagtagc
     1801 atcaacactc tcaccagcat gtcttccagt aaacagtgtc cactgcaagc ctggtgatac
     1861 tcacataacc actcactctg tgcacagcaa caaggacccc attttccaca ccatcagtct
     1921 ctggggaagt ccagcaacca gacaggcacc tgggagccca ggagagggcc ctgctcacct
     1981 gacatcctgc caggcacctc agataagccg ttcccgagag ctgcagcccg aagcccagct
     2041 tcccttcttt gcagtattgt catgatggct ctcccaagat gccaagtgct cttgtgtccc
     2101 ccagaggcgg gcctgctgcg gaatggtgca acgagaaggg agaaacccgt ggagtctccc
     2161 ctgcaaccca tcatcgaaca aactgatgca aaaacttgaa tctgttactg aaataagatg
     2221 aggaccaagg agggtgtgtg ctaatgaact gagccagaca ctgtaaatac tgacagaccc
     2281 ccctctccca tcccagatga tctcaagatt tcttctaaag aagtaaattt gtccaatggg
     2341 tgtaaactat aaactactgt aattaagtgc aattttcctt ccacgttatc tacccctgcc
     2401 ctgtatataa tactaaagtg tctatcactt ttctttgtaa aggtcagagt tgaaattcca
     2461 agagtgactt gctccctctc cctccctctc ccccacccga aaccaccgca agtgggaaat
     2521 gaatctcttc accagcatcc ctctggccat agggatggca tactttggac agactgccag
     2581 ataacactcc ccacccccat gttaagacac atctctggat tcctagaggg atggggcata
     2641 atggcagcaa gatgccccta gctccctgtg ggcctgggcg gggacactga ctggctgacg
     2701 gccatctcag gaagcctccc attaaagcaa tttattttgt cactgcttcg agtctcatat
     2761 atcttccctg gctatggctt caccaagaat ccccaggcct ggtctcggtg agattttcca
     2821 gtgaatacac atgttatcct ctc
//
