LOCUS       NM_009327               3203 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus HNF1 homeobox A (Hnf1a), mRNA.
ACCESSION   NM_009327
VERSION     NM_009327.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3203)
  AUTHORS   Mathisen,A.F., Legoy,T.A., Larsen,U., Unger,L., Abadpour,S.,
            Paulo,J.A., Scholz,H., Ghila,L. and Chera,S.
  TITLE     The age-dependent regulation of pancreatic islet landscape is
            fueled by a HNF1a-immune signaling loop
  JOURNAL   Mech Ageing Dev 220, 111951 (2024)
   PUBMED   38825059
  REMARK    GeneRIF: The age-dependent regulation of pancreatic islet landscape
            is fueled by a HNF1a-immune signaling loop.
REFERENCE   2  (bases 1 to 3203)
  AUTHORS   Tooley,K., Jerby,L., Escobar,G., Krovi,S.H., Mangani,D.,
            Dandekar,G., Cheng,H., Madi,A., Goldschmidt,E., Lambden,C.,
            Krishnan,R.K., Rozenblatt-Rosen,O., Regev,A. and Anderson,A.C.
  TITLE     Pan-cancer mapping of single CD8+ T cell profiles reveals a
            TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor
            immunity
  JOURNAL   Cell Rep Med 5 (7), 101640 (2024)
   PUBMED   38959885
  REMARK    GeneRIF: Pan-cancer mapping of single CD8[+] T cell profiles
            reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and
            anti-tumor immunity.
REFERENCE   3  (bases 1 to 3203)
  AUTHORS   Lucchesi,D., Randazzo,E., Del Prato,S. and Bianchi,C.
  TITLE     An Italian MODY family with proband and son carrying variants in
            GCK and HFN1A: is it a true case of digenic MODY?
  JOURNAL   Acta Diabetol 61 (1), 131-134 (2024)
   PUBMED   37730861
  REMARK    GeneRIF: An Italian MODY family with proband and son carrying
            variants in GCK and HFN1A: is it a true case of digenic MODY?
REFERENCE   4  (bases 1 to 3203)
  AUTHORS   Chu,Y., Zhao,L., Liu,X., Chen,H., Zhao,C., Chen,S., Xiang,S.,
            Lu,J., Wang,X., Wan,Y., Dong,D., Yao,S., Li,C., Yin,R., Ren,G.,
            Yang,X. and Yu,M.
  TITLE     Lysine 117 Residue Is Essential for the Function of the Hepatocyte
            Nuclear Factor 1alpha
  JOURNAL   Diabetes 72 (10), 1502-1516 (2023)
   PUBMED   37440709
  REMARK    GeneRIF: Lysine 117 Residue Is Essential for the Function of the
            Hepatocyte Nuclear Factor 1alpha.
REFERENCE   5  (bases 1 to 3203)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3203)
  AUTHORS   Cereghini,S., Ott,M.O., Power,S. and Maury,M.
  TITLE     Expression patterns of vHNF1 and HNF1 homeoproteins in early
            postimplantation embryos suggest distinct and sequential
            developmental roles
  JOURNAL   Development 116 (3), 783-797 (1992)
   PUBMED   1363228
REFERENCE   7  (bases 1 to 3203)
  AUTHORS   Bach,I., Pontoglio,M. and Yaniv,M.
  TITLE     Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1)
  JOURNAL   Nucleic Acids Res 20 (16), 4199-4204 (1992)
   PUBMED   1354855
REFERENCE   8  (bases 1 to 3203)
  AUTHORS   Szpirer,C., Riviere,M., Cortese,R., Nakamura,T., Islam,M.Q.,
            Levan,G. and Szpirer,J.
  TITLE     Chromosomal localization in man and rat of the genes encoding the
            liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1
            (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of
            the hepatocyte growth factor/scatter factor gene (HGF)
  JOURNAL   Genomics 13 (2), 293-300 (1992)
   PUBMED   1535333
REFERENCE   9  (bases 1 to 3203)
  AUTHORS   Ott,M.O., Rey-Campos,J., Cereghini,S. and Yaniv,M.
  TITLE     vHNF1 is expressed in epithelial cells of distinct embryonic origin
            during development and precedes HNF1 expression
  JOURNAL   Mech Dev 36 (1-2), 47-58 (1991)
   PUBMED   1685890
REFERENCE   10 (bases 1 to 3203)
  AUTHORS   Blumenfeld,M., Maury,M., Chouard,T., Yaniv,M. and Condamine,H.
  TITLE     Hepatic nuclear factor 1 (HNF1) shows a wider distribution than
            products of its known target genes in developing mouse
  JOURNAL   Development 113 (2), 589-599 (1991)
   PUBMED   1685988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144051.1, BC080698.1 and AK141225.1.
            
            On Jan 31, 2008 this sequence version replaced NM_009327.2.
            
            Summary: This gene encodes a hepatic transcription factor. The
            encoded protein is not a member of the T-cell factor family, and is
            distinct from T-cell specific transcription factor 7 which has also
            been referred to by the symbol Tcf1. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080698.1, AK144051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-912               AK144051.1         8-919
            913-1267            BC080698.1         915-1269
            1268-1774           AK141225.1         1074-1580
            1775-3203           BC080698.1         1777-3205
FEATURES             Location/Qualifiers
     source          1..3203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..3203
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /note="HNF1 homeobox A"
                     /db_xref="GeneID:21405"
                     /db_xref="MGI:MGI:98504"
     exon            1..544
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2105
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /note="liver-specific transcription factor LF-B1;
                     transcription factor 1"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 1-alpha"
                     /protein_id="NP_033353.2"
                     /db_xref="CCDS:CCDS19577.1"
                     /db_xref="GeneID:21405"
                     /db_xref="MGI:MGI:98504"
                     /translation="MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPL
                     DKGESCGGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKA
                     VVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRA
                     ALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAY
                     ERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEA
                     FRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVP
                     SSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTS
                     PGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINS
                     MGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEV
                     AQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPPSPATTIHIP
                     SQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHSVIETFISTQMA
                     SSSQ"
     exon            545..744
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..931
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1173
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1322
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1524
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1716
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1835
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1980
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..3186
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /note="hexamer: AGTAAA"
     polyA_site      3186
                     /gene="Hnf1a"
                     /gene_synonym="Hnf-1; HNF1; HNF1-alpha; Hnf1alpha;
                     HNF1[a]; LFB1; Tcf-1; Tcf1"
                     /note="major polyA site"
ORIGIN      
        1 aaacagagca ggcaggggcc ctgattcact ggccgctggg gccagggttg ggggctgggg
       61 gtgcccacag agcttgacta gtgggatttg ggggggcagt gggtgcagcg agcccggtcc
      121 gttgactgcc agcctgccgg caggtagaca ccggccgtgg gtgggggagg cggctagctc
      181 agtggccttg ggccgcgtgg cctggtggca gcggagccat ggtttctaag ctgagccagc
      241 tgcagacgga gctcctggct gccctgctcg agtctggcct gagcaaagag gccctgatcc
      301 aggccttggg ggagccaggg ccctacctga tggttggaga gggtcccctg gacaaggggg
      361 agtcctgcgg tgggagtcga ggggacctga ccgagttgcc taatggcctt ggagaaacgc
      421 gtggctctga agatgacacg gatgacgatg gggaagactt cgcgccaccc attctgaaag
      481 agctggagaa cctcagccca gaggaggcag cccaccagaa agccgtggtg gagtcacttc
      541 ttcaggagga cccatggcgc gtggcgaaga tggtcaagtc gtacttgcag cagcacaaca
      601 tcccccagcg ggaggtggtg gacaccacgg gtctcaacca gtcccacctg tcacagcacc
      661 tcaacaaggg cacacccatg aagacacaga agcgggccgc tctgtacacc tggtacgtcc
      721 gcaagcagcg agaggtggct cagcaattca cccacgcagg gcagggcgga ctgattgaag
      781 agcccacagg cgatgagctg ccaactaaga aggggcgtag gaaccggttc aagtggggcc
      841 ccgcatccca gcagatcctg ttccaggcct acgagaggca aaaaaacccc agcaaggaag
      901 agcgagagac cttggtggag gagtgtaata gggcggagtg catccagagg ggggtgtcac
      961 catcgcaggc ccaggggcta ggctccaacc ttgtcacgga ggtgcgtgtc tacaactggt
     1021 ttgccaaccg gcgcaaggag gaagccttcc ggcacaagtt ggccatggac acctataacg
     1081 gacctccacc ggggccaggc ccgggccctg cgctgcctgc tcacagttcc cccggcctgc
     1141 ccacaaccac cctctctccc agtaaggtcc acggtgtacg gtacggacag tctgcaacca
     1201 gtgaggcagc cgaggtgccc tccagcagcg gaggtccctt agtcacagtg tctgcggcct
     1261 tacaccaagt atcccccaca ggcctggagc ccagcagcct gctgagcaca gaggccaagc
     1321 tggtctcagc cacggggggt cccctgcctc ccgtcagcac cctgacagca ctgcacagct
     1381 tggagcagac atctccgggt ctcaaccagc agccgcagaa ccttatcatg gcctcgctac
     1441 ctggggtcat gaccatcggg cccggggagc ctgcctccct gggacccacg ttcacgaaca
     1501 cgggcgcctc caccctggtt atcggtctgg cctccactca ggcacagagc gtgcctgtca
     1561 tcaacagcat ggggagtagc ctgaccacgc tgcagccggt ccagttttcc caaccactgc
     1621 atccctccta tcagcagcct ctcatgcccc ccgtacagag ccacgtggcc cagagcccct
     1681 tcatggcaac catggcccag ctgcagagcc cccacgcctt atacagccac aagcctgagg
     1741 tggcccagta cacgcacacc agcctgctcc cgcagaccat gttgatcaca gacaccaacc
     1801 tcagcaccct tgccagcctc acacccacca agcaggtctt cacctcagac acagaggcct
     1861 ccagtgagcc cgggcttcac gagccaccct ctccagccac caccatccac atccccagcc
     1921 aggacccgtc gaacatccag cacctgcagc ctgctcaccg gctcagcacc agtcccacag
     1981 tgtcctccag cagcctggtg ttgtatcaga gttccgactc caacgggcac agccacctgc
     2041 tgccatccaa ccatagtgtc atcgagactt ttatctccac ccagatggcc tcctcttccc
     2101 agtaaccgtg gtgactgcct cccaggagct gggtccccag ggcctgcact gcctgcatag
     2161 ggggtgagga gggccgcagc cacactgcct ggaggatatc tgagcctgcc atgccacctg
     2221 acacaggctg ctggccttcc cagaagtcta cgcattcatt gacactgctg ctcctccatc
     2281 atcaggaagg gatggctctg aggtgtctca gcctgacaag cgagcctcga ggagctggag
     2341 gacggcccaa tctgggcagt attgtggacc accatccctg ctgtttagaa taggaaattt
     2401 aatgcttggg acaggagtgg ggaagctcgt ggtgcccgca cccccccagt cagagcctgc
     2461 aggccttcaa ggatctgtgc tgagctctga ggccctagat caacacagct gcctgctgcc
     2521 tcctgcacct ccccaggcca ttccaccctg caccagagac ccacgtgcct gtttgaggat
     2581 taccctcccc accacgggga tttcctaccc agctgttctg ctaggctcgg gagctgaggg
     2641 gaagccactc ggggctctcc taggctttcc cctaccaagc catcccttct cccagcccca
     2701 ggactgcact tgcaggccat ctgttccctt ggatgtgtct tctgatgcca gcctggcaac
     2761 ttgcatccac tagaaaggcc atttcagggc tcgggttgtc atccctgttc cttaggacct
     2821 gcaactcatg ccaagaccac accatggaca atccactcct ctgcctgtag gcccctgaca
     2881 acttccttcc tgctatgagg gagacctgca gaactcagaa gtcaaggcct gggcagtgtc
     2941 tagtggagag ggtaccaaga ccagcagaga gaagccacct aagtggcctg ggggctagca
     3001 gccattctga gaaatcctgg gtcccgagca gcccagggaa acacagcaca catgactgtc
     3061 tcctcgggcc tactgcaggg aacctggcct tcagccagct cctttgtcat cctggactgt
     3121 agcctacggc caaccataag tgagcctgta tgtttattta acttttagta aagtcagtaa
     3181 aaagcaaaaa aaaaaaaaaa aaa
//
