LOCUS       NM_145998               2870 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus H6 homeobox 2 (Hmx2), transcript variant 1, mRNA.
ACCESSION   NM_145998
VERSION     NM_145998.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Qin,T., So,K.K.H., Hui,C.C. and Sham,M.H.
  TITLE     Ptch1 is essential for cochlear marginal cell differentiation and
            stria vascularis formation
  JOURNAL   Cell Rep 43 (4), 114083 (2024)
   PUBMED   38602877
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Sivori,M., Dempsey,B., Chettouh,Z., Boismoreau,F., Ayerdi,M.,
            Eymael,A., Baulande,S., Lameiras,S., Coulpier,F., Delattre,O.,
            Rohrer,H., Mirabeau,O. and Brunet,J.F.
  TITLE     The pelvic organs receive no parasympathetic innervation
  JOURNAL   Elife 12, 91576 (2024)
   PUBMED   38488657
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Kim,D.W., Washington,P.W., Wang,Z.Q., Lin,S.H., Sun,C.,
            Ismail,B.T., Wang,H., Jiang,L. and Blackshaw,S.
  TITLE     The cellular and molecular landscape of hypothalamic patterning and
            differentiation from embryonic to late postnatal development
  JOURNAL   Nat Commun 11 (1), 4360 (2020)
   PUBMED   32868762
  REMARK    Erratum:[Nat Commun. 2022 Jan 11;13(1):332. doi:
            10.1038/s41467-021-27676-9.. PMID: 35017490]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Lee,B., Kim,J., An,T., Kim,S., Patel,E.M., Raber,J., Lee,S.K.,
            Lee,S. and Lee,J.W.
  TITLE     Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and
            AgRP-neurons
  JOURNAL   Nat Commun 9 (1), 2026 (2018)
   PUBMED   29795232
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Hadrys,T., Braun,T., Rinkwitz-Brandt,S., Arnold,H.H. and Bober,E.
  TITLE     Nkx5-1 controls semicircular canal formation in the mouse inner ear
  JOURNAL   Development 125 (1), 33-39 (1998)
   PUBMED   9389661
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Rinkwitz-Brandt,S., Arnold,H.H. and Bober,E.
  TITLE     Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes
            during mouse inner ear development
  JOURNAL   Hear Res 99 (1-2), 129-138 (1996)
   PUBMED   8970821
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   Rinkwitz-Brandt,S., Justus,M., Oldenettel,I., Arnold,H.H. and
            Bober,E.
  TITLE     Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox
            genes during brain and ear development
  JOURNAL   Mech Dev 52 (2-3), 371-381 (1995)
   PUBMED   8541222
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Stadler,H.S., Murray,J.C., Leysens,N.J., Goodfellow,P.J. and
            Solursh,M.
  TITLE     Phylogenetic conservation and physical mapping of members of the H6
            homeobox gene family
  JOURNAL   Mamm Genome 6 (6), 383-388 (1995)
   PUBMED   7647458
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   Bober,E., Baum,C., Braun,T. and Arnold,H.H.
  TITLE     A novel NK-related mouse homeobox gene: expression in central and
            peripheral nervous structures during embryonic development
  JOURNAL   Dev Biol 162 (1), 288-303 (1994)
   PUBMED   7510254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138228.1 and AC159994.7.
            
            On Feb 8, 2019 this sequence version replaced NM_145998.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053014.1, AK138228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1438              AK138228.1         233-1670
            1439-2870           AC159994.7         106180-107611
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 74.34 cM"
     gene            1..2870
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="H6 homeobox 2"
                     /db_xref="GeneID:15372"
                     /db_xref="MGI:MGI:107159"
     exon            1..282
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..836
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="NK-related homeobox; homeobox protein Nkx-5.2; H6
                     homeo box 2"
                     /codon_start=1
                     /product="homeobox protein HMX2"
                     /protein_id="NP_666110.1"
                     /db_xref="CCDS:CCDS21918.1"
                     /db_xref="GeneID:15372"
                     /db_xref="MGI:MGI:107159"
                     /translation="MGSKEDVGKGCPAAGGVSSFTIQSILGGGPSEAPREPAGWPARK
                     RSLSVSSEEEEPEEGWKAPACFCPDPHGPKEPSPKHHTPIPFPCLGTPKGSGGAGPAA
                     SERTPFLSPSHPDFKEEKERLLPAGSPSPGPERPRDGGAERQTGAAKKKTRTVFSRSQ
                     VYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMA
                     HASAQTLVGMPLVFRDSSLLRVPVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY"
     exon            283..2870
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      959..964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="hexamer: AATACA"
     polyA_site      987
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="major polyA site"
     regulatory      1418..1423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="hexamer: AATAAA"
     polyA_site      1445
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
ORIGIN      
        1 cttatgaacc caggatgggc agcaaggaag atgtggggaa gggatgtccg gcggccggtg
       61 gcgtctccag cttcaccatc cagtccatcc tgggcggggg cccctccgag gcaccgcggg
      121 agcccgccgg gtggccagcc aggaaacgca gcctgtctgt gtcctcggag gaggaggagc
      181 cggaggaagg ttggaaggct ccggcttgct tctgcccaga tccgcacggc cccaaggagc
      241 caagccctaa gcaccatacc cccatccctt tcccttgcct gggtaccccc aagggcagcg
      301 gaggcgcagg gcctgcggcc tcggagcgca cgccattcct ttctccttct cacccggact
      361 ttaaggaaga gaaggagagg cttttgccgg cgggctcgcc ttctccgggc ccggagcggc
      421 cacgggacgg cggtgcggag cgccaaaccg gagcggccaa gaagaagacg cgcaccgtct
      481 tctcccgcag ccaagtgtac cagctcgagt ctaccttcga catgaaacgc tacctgagca
      541 gctcggagcg cgcttgcctc gcctccagcc tgcagctcac cgagacccag gttaagactt
      601 ggttccagaa tcgccgcaac aagtggaagc ggcagctctc agccgagctt gaggcagcca
      661 acatggcaca cgcgtcggcg cagactctcg tgggcatgcc gctcgtgttt cgggacagtt
      721 cgctgctgcg agtgccggtg ccgcgctctc tggccttccc ggctccgctt tattacccga
      781 gcagcaatct ctcggcctta ccgctctaca acctgtacaa caagcttgac tactgacatg
      841 ctcgcccgcc ggctcccggg acgcccctgg tcgcctgcag ctgcctgcat agcccggcgc
      901 ggtcgggatc cttcgcagag ctccggagca gagcggcgcg tgtccagaaa tattaagaaa
      961 tacaccatgt gtattcgtta tgtcttattt atggcctctt tcctaccttt tgttttgttt
     1021 tgttttattt tgttttgttt tgttttgagt atttatctgc attcctcacg ccagagcacc
     1081 tgctttctac acaaaaccaa acaactcgcg tttgaaacta ttttggaagg ggaggctctc
     1141 gggtggtggt gggaagtggg gttttgatta ggtcggtttt gaccagtagc aagaaaaaaa
     1201 aaaaaacatc agaaaaacca ccaacagaac caggcagtct ttctcccata tatacacctg
     1261 tatatagaaa atgtggtagg acacaagctc agccgagccg aaccaactag ggctttggtc
     1321 gttgaactaa tcacttctct ttattccctt catcttgagg atgggtaggg gcaaaacgag
     1381 gagagtacag atctgtaaat atttttaaag agaaaaaaat aaaacgtttt aaacatggtt
     1441 gctaactttg gagggatgga ttgtcccagg agacagcggc agaggagttt ctggattttt
     1501 tttttttttt ttgccagagc atgcaggatt ctgtctcctc cctcagcccc caaggttctg
     1561 ctctcaccac gtgtgggtgg ggctgggctc agaggttaaa ggtcgggata ttggggctgc
     1621 ccaggcagca cgtgactggg gctgcttaca ggaacagcac agttcccacg acccaggtgt
     1681 gcgggttggg gtgcactcga gatggaatcc agatccacag ccccgcgcag cgaaagacaa
     1741 agccaggagc ctggctgctg acccggtcgc ctctgggaat gagccaagca aggaggtgaa
     1801 catctccccg atactgggct gttttgggct agacgaaagc tgggcacgcc gcgaaaggcc
     1861 ggagctcttg gcgttcttgg cgtcctcctg cgcggagtaa aacgtggggt gagagaaagc
     1921 gtccgcttgg gttccagagc cacaggcgac tggcttgcag ccctcgcagg ggtctcccgc
     1981 tggtgacaca gttgcgagag ttctgcgcag agcgggaagt gatgcctaag ggtcagattt
     2041 cgttggaggg attcgtggag cagatgacac gggcgcttcc ctagtttctt tttgtagttg
     2101 ttaaatttgc ccgtgaatga caaaaaggtc ggatcactgg ctaacttgca gcagctgttt
     2161 ctgaattgag cactgaggat tgcagtgccc ggctgcctgc ctccatgcag ggttagggag
     2221 gctctgcacc cggagaactg cttcgtcagg atcatgcaaa tcacagcact gtattttctc
     2281 tacgttttca tagcatccac ctgttccttg ttaaatgtca gaaatgggcc tggagcttgg
     2341 aggaggcctc aggtagagtt attaggtcca gcccgcctcc cctcagtggt tgatcagggt
     2401 gcaaagagct aggagtctgc agcgccaagg ccctatctat ttctttcttc agaagaaaac
     2461 ctggtgcctg agggaccggt ctctttgagc caagggggca tcgaaatgac ttgcattttg
     2521 tagaaattca cagaatgtaa acgtttacat ggcccatatc attccgtgaa atatgcctgg
     2581 cagaagagat ttgctctgat attgcctatt tttttcttaa cacattatat tttataaaac
     2641 ctgcaactcc tcctaggtga cattagatgg atgctacaca agaatgcacc gggcaatact
     2701 aggttggttt gcttacattt gttttatttt agctgtgttc acctcaataa gtatttgttg
     2761 aggtctcaac atgtgctaag aacctacact aaatttgggg tggtccaaag gagaacacaa
     2821 agaggcctat cagttctctt cttacttatt aaatatgtgt tttcaattgc
//
