LOCUS       NM_010445               1782 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus H6 homeobox 1 (Hmx1), transcript variant 1, mRNA.
ACCESSION   NM_010445 XM_993543
VERSION     NM_010445.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Sivori,M., Dempsey,B., Chettouh,Z., Boismoreau,F., Ayerdi,M.,
            Eymael,A., Baulande,S., Lameiras,S., Coulpier,F., Delattre,O.,
            Rohrer,H., Mirabeau,O. and Brunet,J.F.
  TITLE     The pelvic organs receive no parasympathetic innervation
  JOURNAL   Elife 12, 91576 (2024)
   PUBMED   38488657
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Zhang,Q., Huang,R., Ye,Y., Guo,X., Lu,J., Zhu,F., Gong,X.,
            Zhang,Q., Yan,J., Luo,L., Zhuang,S., Chen,Y., Zhao,X., Evans,S.M.,
            Jiang,C., Liang,X. and Sun,Y.
  TITLE     Temporal requirements for ISL1 in sympathetic neuron proliferation,
            differentiation, and diversification
  JOURNAL   Cell Death Dis 9 (2), 247 (2018)
   PUBMED   29445148
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Rosin,J.M., Li,W., Cox,L.L., Rolfe,S.M., Latorre,V., Akiyama,J.A.,
            Visel,A., Kuramoto,T., Bobola,N., Turner,E.E. and Cox,T.C.
  TITLE     A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral
            facial morphogenesis and is regulated by the Hox-Pbx-Meis complex
  JOURNAL   Development 143 (14), 2582-2592 (2016)
   PUBMED   27287804
  REMARK    GeneRIF: Hoxa2, Meis and Pbx proteins act cooperatively on the ECR,
            via a core 32 bp sequence, to regulate Hmx1 expression.
REFERENCE   5  (bases 1 to 1782)
  AUTHORS   Funato,N., Kokubo,H., Nakamura,M., Yanagisawa,H. and Saga,Y.
  TITLE     Specification of jaw identity by the Hand2 transcription factor
  JOURNAL   Sci Rep 6, 28405 (2016)
   PUBMED   27329940
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1782)
  AUTHORS   Yoshiura,K., Leysens,N.J., Reiter,R.S. and Murray,J.C.
  TITLE     Cloning, characterization, and mapping of the mouse homeobox gene
            Hmx1
  JOURNAL   Genomics 50 (1), 61-68 (1998)
   PUBMED   9628823
REFERENCE   7  (bases 1 to 1782)
  AUTHORS   Wang,W., Van De Water,T. and Lufkin,T.
  TITLE     Inner ear and maternal reproductive defects in mice lacking the
            Hmx3 homeobox gene
  JOURNAL   Development 125 (4), 621-634 (1998)
   PUBMED   9435283
REFERENCE   8  (bases 1 to 1782)
  AUTHORS   Wang,W., Yoshiura,K., Murray,J. and Lufkin,T.
  TITLE     Assignment of the murine Hmx1 homeobox gene to the proximal region
            of mouse chromosome 5
  JOURNAL   Mamm Genome 8 (11), 869-870 (1997)
   PUBMED   9337406
REFERENCE   9  (bases 1 to 1782)
  AUTHORS   Stadler,H.S., Murray,J.C., Leysens,N.J., Goodfellow,P.J. and
            Solursh,M.
  TITLE     Phylogenetic conservation and physical mapping of members of the H6
            homeobox gene family
  JOURNAL   Mamm Genome 6 (6), 383-388 (1995)
   PUBMED   7647458
REFERENCE   10 (bases 1 to 1782)
  AUTHORS   Mentzer,R.M., Alegre,C.A. and Nolan,S.P.
  TITLE     The effects of dopamine and isoproterenol on the pulmonary
            circulation
  JOURNAL   J Thorac Cardiovasc Surg 71 (6), 807-814 (1976)
   PUBMED   5634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152824.4.
            
            On Jun 18, 2019 this sequence version replaced NM_010445.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF009367.1, FO716119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AC152824.4         61907-62535         c
            630-1782            AC152824.4         58506-59658         c
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.14 cM"
     gene            1..1782
                     /gene="Hmx1"
                     /gene_synonym="Nkx5-3"
                     /note="H6 homeobox 1"
                     /db_xref="GeneID:15371"
                     /db_xref="MGI:MGI:107178"
     exon            1..629
                     /gene="Hmx1"
                     /gene_synonym="Nkx5-3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1782
                     /gene="Hmx1"
                     /gene_synonym="Nkx5-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1760..1765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmx1"
                     /gene_synonym="Nkx5-3"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="Hmx1"
                     /gene_synonym="Nkx5-3"
                     /note="major polyA site"
ORIGIN      
        1 gaaacgcgag ggaggctgct gcgggaacgg ccgtccgcgc gcacccgctc ccgcccagcc
       61 cagcccggca cagaagccga cgcccgcctc gtggagcccg acgccctcac tccgggcagc
      121 ggctctccag ggccaggccg cgcgtgcgcc aggcggccgt tcgccactat ccaaacgggg
      181 ccgggaagag cagctgcgcc ccaggcaacc agggaccccc aggatcccag ccttgcccga
      241 cgggcccgcg gccgcgatgc cggatgagct gaccgagccc gggcgcgcca caccagctcg
      301 cgcctcctcc ttcctcatcg agaacctgct agcagccgag gccaagggcg cggggcgctc
      361 aacccagggc gatggcgtcc gcgaggaaga ggaagaggac gacgacgacc ccgaggacga
      421 ggatccggag caggcgcgac gacgactaca gcggcggcga cagcagcgcg cgggcagcgg
      481 gccgggcggg gaggcgaggg cccgggcact gggcctaggg ccccggccgc ctcctgggcc
      541 cggcccgccc ttcgcgctcg gctgcggagg tacaacgcgg tggtacccac gggtgcacgg
      601 cggctacgga ggtggtctaa gtcctgacac aagcgaccgg gactctccgg agaccggcga
      661 ggagatgggc cgcgcagaga gcgcctggcc gcggtgcccc gggccgggaa ccgttccgcg
      721 ggaggtgacg acgcagggcc cggcgaccgg cggggaggag gcggcggagt tggccgaggc
      781 tccagcggtg gcggcggcgg cgacagggga ggcgcgcggt ggccgcagga agaagacgcg
      841 cacggtcttc tcgcgcagcc aggtcttcca gctcgagtcc actttcgatc tgaagcgcta
      901 cctgagcagc gcagagcgcg cgggcctcgc cgcctcgctg cagctcacgg agacgcaggt
      961 caagatctgg tttcagaacc gccgcaacaa gtggaagcgg cagctggcag cggagctgga
     1021 ggcggccagc ctgtccccgc cgggtgcgca gcgcctggtc cgcgtgccgg tgctctacca
     1081 cgagagtccc ccggccgccg cggggcccgc gctgcctttc ccgctggcgc cgcccgcacc
     1141 cgcaccgccg ccgccgctgc ttggtttctc gggcgcgctt gcttacccgc ttgccgcctt
     1201 ccctgccgcc gcctcggtgc ccttccttcg cgcgcagatg ccggggctag tgtgagccgg
     1261 cgccctccat gtaggaggcg gttgggggaa ggcgccgcgc acctcgcagt ccctcgagcg
     1321 gccgtctccg tgggcagctg ctctacagtg taccggacag cggcggcagc cgggactcgc
     1381 agccagctgc aggactggag acccgttccg atggaaagcc gcggcgatgc gctagctctc
     1441 gccggcacgg agtgctgagc agatgccggc tccgagtcag caaacggaca cttggaatgg
     1501 gctggccgag gaaccgtatg gcgactgtcc cgaggcatcc tggccctaat tcacattgtc
     1561 cttttctcgg gagggatctt gcaggaaccc agacatcagg ggccccttcc aagggacagt
     1621 acagagtgct gcgggccttg ggacaactca tcttgggcct cttttccgaa gagggcttct
     1681 ctcttggcgg ccttggttct cttggcttga caagactttt tttttttttt ctgtgataaa
     1741 tctacttctt tgcatatgga ataaaaaggg acgttttctt ga
//
