LOCUS       NM_010442               1634 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus heme oxygenase 1 (Hmox1), mRNA.
ACCESSION   NM_010442
VERSION     NM_010442.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Shi,J., Piao,M., Liu,C., Yang,J., Guan,X., Liu,H., Li,Q., Zhang,Y.
            and Yu,J.
  TITLE     Electroacupuncture pretreatment maintains mitochondrial quality
            control via HO-1/MIC60 signaling pathway to alleviate
            endotoxin-induced acute lung injury
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167480 (2024)
   PUBMED   39209235
  REMARK    Erratum:[Biochim Biophys Acta Mol Basis Dis. 2025 Jan 30:167697.
            doi: 10.1016/j.bbadis.2025.167697.. PMID: 39890478]
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Ye,Y., Liang,J., Xu,C., Liu,Y., Chen,J. and Zhu,Y.
  TITLE     Inhibition of HMOX1 by MAFG potentiates the development of
            depression-like behavior in mice associated with astrocyte-mediated
            neuroinflammation
  JOURNAL   Brain Res 1843, 149115 (2024)
   PUBMED   38977234
  REMARK    GeneRIF: Inhibition of HMOX1 by MAFG potentiates the development of
            depression-like behavior in mice associated with astrocyte-mediated
            neuroinflammation.
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Chudy,P., Kochan,J., Wawro,M., Nguyen,P., Gorczyca,M., Varanko,A.,
            Retka,A., Ghadei,S.S., Napieralska,E., Grochot-Przeczek,A.,
            Szade,K., Berendes,L.S., Park,J., Sokolowski,G., Yu,Q.,
            Jozkowicz,A., Nowak,W.N. and Krzeptowski,W.
  TITLE     Heme oxygenase-1 protects cells from replication stress
  JOURNAL   Redox Biol 75, 103247 (2024)
   PUBMED   39047636
  REMARK    GeneRIF: Heme oxygenase-1 protects cells from replication stress.
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Li,M. and Zheng,N.
  TITLE     The Role of Heme Oxygenase 1 in Rheumatoid Arthritis and IL-1
            Induced Inflammatory Cell Model
  JOURNAL   Ann Clin Lab Sci 54 (4), 446-451 (2024)
   PUBMED   39293832
  REMARK    GeneRIF: The Role of Heme Oxygenase 1 in Rheumatoid Arthritis and
            IL-1 Induced Inflammatory Cell Model.
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Alam,J., Camhi,S. and Choi,A.M.
  TITLE     Identification of a second region upstream of the mouse heme
            oxygenase-1 gene that functions as a basal level and
            inducer-dependent transcription enhancer
  JOURNAL   J Biol Chem 270 (20), 11977-11984 (1995)
   PUBMED   7538129
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Alam,J.
  TITLE     Multiple elements within the 5' distal enhancer of the mouse heme
            oxygenase-1 gene mediate induction by heavy metals
  JOURNAL   J Biol Chem 269 (40), 25049-25056 (1994)
   PUBMED   7929191
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Alam,J., Cai,J. and Smith,A.
  TITLE     Isolation and characterization of the mouse heme oxygenase-1 gene.
            Distal 5' sequences are required for induction by heme or heavy
            metals
  JOURNAL   J Biol Chem 269 (2), 1001-1009 (1994)
   PUBMED   8288554
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Alam,J. and Den,Z.
  TITLE     Distal AP-1 binding sites mediate basal level enhancement and TPA
            induction of the mouse heme oxygenase-1 gene
  JOURNAL   J Biol Chem 267 (30), 21894-21900 (1992)
   PUBMED   1400499
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Kageyama,H., Hiwasa,T., Tokunaga,K. and Sakiyama,S.
  TITLE     Isolation and characterization of a complementary DNA clone for a
            Mr 32,000 protein which is induced with tumor promoters in BALB/c
            3T3 cells
  JOURNAL   Cancer Res 48 (17), 4795-4798 (1988)
   PUBMED   3409220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY319630.1, AK150934.1 and AA186175.1.
            
            On Aug 7, 2008 this sequence version replaced NM_010442.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153420.1, AK153516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY319630.1         3-6
            5-1565              AK150934.1         2-1562
            1566-1634           AA186175.1         211-279
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.59 cM"
     gene            1..1634
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /note="heme oxygenase 1"
                     /db_xref="GeneID:15368"
                     /db_xref="MGI:MGI:96163"
     exon            1..155
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1002
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /EC_number="1.14.14.18"
                     /note="P32 protein; hemoxygenase; heme oxygenase
                     (decycling) 1"
                     /codon_start=1
                     /product="heme oxygenase 1"
                     /protein_id="NP_034572.1"
                     /db_xref="CCDS:CCDS22423.1"
                     /db_xref="GeneID:15368"
                     /db_xref="MGI:MGI:96163"
                     /translation="MERPQPDSMPQDLSEALKEATKEVHIQAENAEFMKNFQKGQVSR
                     EGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQ
                     EIIPCTPATQHYVKRLHEVGRTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSS
                     GEGLAFFTFPNIDSPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQ
                     VMLTEEHKDQSPSQMASLRQRPASLVQDTAPAETPRGKPQISTSSSQTPLLQWVLTLS
                     FLLATVAVGIYAM"
     exon            156..276
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /inference="alignment:Splign:2.1.0"
     exon            277..768
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /inference="alignment:Splign:2.1.0"
     exon            769..868
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1576
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="Hmox1"
                     /gene_synonym="D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32"
                     /note="major polyA site"
ORIGIN      
        1 gctcacggtc tccagtcgcc tccagagttt ccgcatacaa ccagtgagtg gagcctgccc
       61 gcgcagagcc gtctcgagca tagcccggag cctgaatcga gcagaaccag cctgaactag
      121 cccagtccgg tgatggagcg tccacagccc gacagcatgc cccaggattt gtctgaggcc
      181 ttgaaggagg ccaccaagga ggtacacatc caagccgaga atgctgagtt catgaagaac
      241 tttcagaagg gtcaggtgtc cagagaaggc tttaagctgg tgatggcttc cttgtaccat
      301 atctacacgg ccctggaaga ggagatagag cgcaacaagc agaacccagt ctatgcccca
      361 ctctacttcc ctgaggagct gcaccgaagg gctgccctgg agcaggacat ggccttctgg
      421 tatgggcctc actggcagga aatcatccct tgcacgccag ccacacagca ctatgtaaag
      481 cgtctccacg aggtggggcg cactcaccct gagctgctgg tggcccacgc atatacccgc
      541 tacctgggtg acctctcagg gggtcaggtc ctgaagaaga ttgcacagaa ggccatggcc
      601 ttgcccagct ctggggaggg cctggctttt tttaccttcc cgaacatcga cagccccacc
      661 aagttcaaac agctctatcg tgctcgaatg aacactctgg agatgacacc tgaggtcaag
      721 cacagggtga cagaagaggc taagaccgcc ttcctgctca acattgagct gtttgaggag
      781 ctgcaggtga tgctgacaga ggaacacaaa gaccagagtc cctcacagat ggcgtcactt
      841 cgtcagaggc ctgctagcct ggtgcaagat actgcccctg cagagacacc ccgagggaaa
      901 ccccagatca gcactagctc atcccagaca ccgctcctcc agtgggtcct cactctcagc
      961 ttcctgttgg caacagtggc agtgggaatt tatgccatgt aaatgcaata ctggccccca
     1021 ggggctgtga actctgtcca atgtggcctt ctctctgtaa gggagaatct tgcctggctc
     1081 tcttctcttg ggcctctaag aaagcttttg gggtccctag cccactccct gtgtttcctt
     1141 tctctctgga atggagggag atacctgaca cagttccctc accaaaagca catccagcca
     1201 gtggcctgaa ctttgaaacc agcagcccca aatcctgcag cagagcccca aaactggcct
     1261 gtaaaagcag ctgttctgag cccagtgccc atggttgtaa gcatccatgt tgactgacca
     1321 cgactgctgt cccccagtgc catggccact ttgatatccg tttccagaca tttctgtctc
     1381 gtatttctgt cttgtttttt attatttccc cagttctacc agagtaatgg tattttgttg
     1441 ttttgttttg tcttgttttt cctaacaaag tggggctatc ttttgagggg tgggtgggaa
     1501 agaattattt aatagttgta accttggtct ctaacttctg tgtgaaataa taaatggcat
     1561 tatctaacag tcactaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aaaa
//
