LOCUS       NM_013552               3914 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hyaluronan mediated motility receptor (RHAMM) (Hmmr),
            mRNA.
ACCESSION   NM_013552
VERSION     NM_013552.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3914)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3914)
  AUTHORS   He,L., Li,H., Li,C., Liu,Z.K., Lu,M., Zhang,R.Y., Wu,D., Wei,D.,
            Shao,J., Liu,M., Wei,H.L., Zhang,C., Wang,Z., Kong,L.M., Chen,Z.N.
            and Bian,H.
  TITLE     HMMR alleviates endoplasmic reticulum stress by promoting
            autophagolysosomal activity during endoplasmic reticulum
            stress-driven hepatocellular carcinoma progression
  JOURNAL   Cancer Commun (Lond) 43 (9), 981-1002 (2023)
   PUBMED   37405956
  REMARK    GeneRIF: HMMR alleviates endoplasmic reticulum stress by promoting
            autophagolysosomal activity during endoplasmic reticulum
            stress-driven hepatocellular carcinoma progression.
REFERENCE   3  (bases 1 to 3914)
  AUTHORS   Hao,R.C., Li,Z.L., Wang,F.Y., Tang,J., Li,P.L., Yin,B.F., Li,X.T.,
            Han,M.Y., Mao,N., Liu,B., Ding,L. and Zhu,H.
  TITLE     Single-cell transcriptomic analysis identifies a highly replicating
            Cd168+ skeletal stem/progenitor cell population in mouse long bones
  JOURNAL   J Genet Genomics 50 (9), 702-712 (2023)
   PUBMED   37075860
  REMARK    GeneRIF: Single-cell transcriptomic analysis identifies a highly
            replicating Cd168[+] skeletal stem/progenitor cell population in
            mouse long bones.
REFERENCE   4  (bases 1 to 3914)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3914)
  AUTHORS   Lin,A., Feng,J., Chen,X., Wang,D., Wong,M., Zhang,G., Na,J.,
            Zhang,T., Chen,Z., Chen,Y.T. and Nancy Du,Y.C.
  TITLE     High levels of truncated RHAMM cooperate with dysfunctional p53 to
            accelerate the progression of pancreatic cancer
  JOURNAL   Cancer Lett 514, 79-89 (2021)
   PUBMED   34044069
  REMARK    GeneRIF: High levels of truncated RHAMM cooperate with
            dysfunctional p53 to accelerate the progression of pancreatic
            cancer.
REFERENCE   6  (bases 1 to 3914)
  AUTHORS   Entwistle,J., Zhang,S., Yang,B., Wong,C., Li,Q., Hall,C.L., A,J.,
            Mowat,M., Greenberg,A.H. and Turley,E.A.
  TITLE     Characterization of the murine gene encoding the hyaluronan
            receptor RHAMM
  JOURNAL   Gene 163 (2), 233-238 (1995)
   PUBMED   7590272
REFERENCE   7  (bases 1 to 3914)
  AUTHORS   Sherman,L., Sleeman,J., Herrlich,P. and Ponta,H.
  TITLE     Hyaluronate receptors: key players in growth, differentiation,
            migration and tumor progression
  JOURNAL   Curr Opin Cell Biol 6 (5), 726-733 (1994)
   PUBMED   7530464
  REMARK    Review article
REFERENCE   8  (bases 1 to 3914)
  AUTHORS   Hall,C.L., Wang,C., Lange,L.A. and Turley,E.A.
  TITLE     Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion
            turnover and transient tyrosine kinase activity
  JOURNAL   J Cell Biol 126 (2), 575-588 (1994)
   PUBMED   7518470
REFERENCE   9  (bases 1 to 3914)
  AUTHORS   .
  TITLE     Correction. Molecular cloning of a novel hyaluronan receptor that
            mediates tumor cell motility
  JOURNAL   J Cell Biol 118 (3), 753 (1992)
   PUBMED   1639856
  REMARK    Correction to:[J Cell Biol. 1992 Jun;117(6):1343-50. PMID: 1376732]
REFERENCE   10 (bases 1 to 3914)
  AUTHORS   Hardwick,C., Hoare,K., Owens,R., Hohn,H.P., Hook,M., Moore,D.,
            Cripps,V., Austen,L., Nance,D.M. and Turley,E.A.
  TITLE     Molecular cloning of a novel hyaluronan receptor that mediates
            tumor cell motility
  JOURNAL   J Cell Biol 117 (6), 1343-1350 (1992)
   PUBMED   1376732
  REMARK    Erratum:[J Cell Biol. 1992 Aug;118(3):753. PMID: 1639856]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN455388.1, AK143123.1, AF031932.1 and AL646055.10.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_013552.3.
            
            On Apr 14, 2009 this sequence version replaced NM_013552.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031932.1, AF079222.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CN455388.1         4-11
            9-2018              AK143123.1         9-2018
            2019-2976           AF031932.1         2004-2961
            2977-3914           AL646055.10        74429-75366         c
FEATURES             Location/Qualifiers
     source          1..3914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 24.4 cM"
     gene            1..3914
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /note="hyaluronan mediated motility receptor (RHAMM)"
                     /db_xref="GeneID:15366"
                     /db_xref="MGI:MGI:104667"
     exon            1..124
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2463
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /note="receptor for hyaluronan-mediated motility;
                     intracellular hyaluronic acid-binding protein"
                     /codon_start=1
                     /product="hyaluronan mediated motility receptor"
                     /protein_id="NP_038580.2"
                     /db_xref="CCDS:CCDS24548.1"
                     /db_xref="GeneID:15366"
                     /db_xref="MGI:MGI:104667"
                     /translation="MSFPKAPLKRFNDPSGCAPSPGAYDVKTSEATKGPVSFQKSQRF
                     KNQRESQQNLNIDKDTTLLASAKKAKKSVSKKDSQKNDKDVKRLEKEIRALLQERGTQ
                     DKRIQDMESELEKTEAKLNAAVREKTSLSASNASLEKRLTELTRANELLKAKFSEDGH
                     QKNMRALSLELMKLRNKRETKMRSMMVKQEGMELKLQATQKDLTESKGKIVQLEGKLV
                     SIEKEKIDEKCETEKLLEYIQEISCASDQVEKCKVDIAQLEEDLKEKDREILSLKQSL
                     EENITFSKQIEDLTVKCQLLETERDNLVSKDRERAETLSAEMQILTERLALERQEYEK
                     LQQKELQSQSLLQQEKELSARLQQQLCSFQEEMTSEKNVFKEELKLALAELDAVQQKE
                     EQSERLVKQLEEETKSTAEQLTRLDNLLREKEVELEKHIAAHAQAILIAQEKYNDTAQ
                     SLRDVTAQLESVQEKYNDTAQSLRDVTAQLESEQEKYNDTAQSLRDVTAQLESEQEKY
                     NDTAQSLRDVTAQLESVQEKYNDTAQSLRDVTAQLESYKSSTLKEIEDLKLENLTLQE
                     KVAMAEKSVEDVQQQILTAESTNQEYARMVQDLQNRSTLKEEEIKEITSSFLEKITDL
                     KNQLRQQDEDFRKQLEEKGKRTAEKENVMTELTMEINKWRLLYEELYEKTKPFQQQLD
                     AFEAEKQALLNEHGATQEQLNKIRDSYAQLLGHQNLKQKIKHVVKLKDENSQLKSEVS
                     KLRSQLVKRKQNELRLQGELDKALGIRHFDPSKAFCHASKENFTPLKEGNPNCC"
     exon            125..223
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            224..303
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            304..351
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            352..540
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            541..627
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            628..728
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            729..803
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            804..979
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1128
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1343
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1712
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1859
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2012
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2112
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2289
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2443
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..3914
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3886..3891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /note="hexamer: AATAAA"
     polyA_site      3907
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /note="major polyA site"
ORIGIN      
        1 gaggtaaatt tgaattcagg cgagctgaca gtttgctggg gcgtttgatt gctgtctcat
       61 ctggacccag gcgtcagaat gtcctttcct aaggcgcccc tgaagagatt caatgaccct
      121 tcgggttgtg ctccatctcc gggtgcttat gatgttaaaa cttcagaagc aactaaagga
      181 ccagtgtctt ttcagaaatc acaaagattt aaaaaccaaa gagagtctca acaaaatctt
      241 aacattgaca aagatacaac cttgcttgct tcggctaaaa aagcaaagaa gtctgtgtca
      301 aagaaggact ctcagaagaa tgataaagat gtgaagagat tagaaaaaga gattcgcgct
      361 cttttgcaag agcgagggac tcaggacaaa cggatccagg acatggaatc tgaattggag
      421 aagacagaag caaagctcaa tgcagcagtc agagagaaaa catctctctc tgcgagtaat
      481 gcttcactgg aaaaacggct tactgaatta accagagcca acgagctact aaaggctaag
      541 ttttctgaag atggtcacca aaagaatatg agagctctaa gcctggaatt gatgaaactc
      601 agaaataaga gagagacaaa gatgaggagt atgatggtca aacaggaagg catggagctg
      661 aagctgcagg ccactcagaa ggacctcacg gagtctaagg gaaaaatagt ccagctggag
      721 ggaaagcttg tttcaataga gaaagaaaag atcgatgaaa aatgtgaaac agaaaaactc
      781 ttagaataca tccaagaaat tagctgtgca tctgatcaag tggaaaaatg caaagtagat
      841 attgcccagt tagaagaaga tttgaaagag aaggatcgtg agattttaag tcttaagcag
      901 tctcttgagg aaaacattac attttctaag caaatagaag acctgactgt taaatgccag
      961 ctacttgaaa cagaaagaga caaccttgtc agcaaggata gagaaagggc tgaaactctc
     1021 agtgctgaga tgcagatcct gacagagagg ctggctctgg aaaggcaaga atatgaaaag
     1081 ctgcaacaaa aagaattgca aagccagtca cttctgcagc aagagaagga actgtctgct
     1141 cgtctgcagc agcagctctg ctctttccaa gaggaaatga cttctgagaa gaacgtcttt
     1201 aaagaagagc taaagctcgc cctggctgag ttggatgcgg tccagcagaa ggaggagcag
     1261 agtgaaaggc tggttaaaca gctggaagag gaaacgaagt caactgcaga acaactgacg
     1321 cggctggaca acctgctgag agagaaagaa gttgaactgg agaaacatat tgctgctcac
     1381 gcccaagcca tcttgattgc acaagagaag tataatgaca cagcacagag tctgagggac
     1441 gtcactgctc agttggaaag tgtgcaagag aagtataatg acacagcaca gagtctgagg
     1501 gacgtcactg ctcagttgga aagtgagcaa gagaagtaca atgacacagc acagagtctg
     1561 agggacgtca ctgctcagtt ggaaagtgag caagagaagt acaatgacac agcacagagt
     1621 ctgagggacg tcactgctca gttggaaagt gtgcaagaga agtacaatga cacagcacag
     1681 agtctgaggg acgtcactgc tcagttggaa agctataagt catcaacact taaagaaata
     1741 gaagatctta aactggagaa tttgactcta caagaaaaag tagctatggc tgaaaaaagt
     1801 gtagaagatg ttcaacagca gatattgaca gctgagagca caaatcaaga atatgcaagg
     1861 atggttcaag atttgcagaa cagatcaacc ttaaaagaag aagaaattaa agaaatcaca
     1921 tcttcatttc ttgagaaaat aactgatttg aaaaatcaac tcagacaaca agatgaagac
     1981 tttaggaagc agctggaaga gaaaggaaaa agaacagcag agaaagaaaa tgtaatgaca
     2041 gaattaacca tggaaattaa taaatggcgt ctcctatatg aagaactata tgaaaaaact
     2101 aaaccttttc agcaacaact ggatgccttt gaagccgaga aacaggcatt gttgaatgaa
     2161 catggtgcaa ctcaggagca gctaaataaa atcagagact cctatgcaca gctacttggt
     2221 caccagaacc taaagcaaaa aatcaaacat gttgtgaaat tgaaagatga aaatagccaa
     2281 ctcaaatcgg aggtgtcaaa actccgatct cagcttgtta aaaggaaaca aaatgagctc
     2341 agacttcagg gagaattaga taaagctctg ggcatcagac actttgaccc ttccaaggct
     2401 ttttgtcatg catctaagga gaattttact ccattaaaag aaggcaaccc aaactgctgc
     2461 tgagttcaga tgcaacttca agaatcatgg aagtatacgt ctgaaatact tgttgaagat
     2521 tattttcttc attgttcttg atattatgtt tatagtatat attatataat gtatttaatt
     2581 tctactgcct agtcttaggt atatgaaacg gtaattcagc atttgttctc tgtcttagtc
     2641 agggtttctg ttcctgcata aacatcagac caagaaacaa gctggggagg aaagggttta
     2701 ttcagcttac acttccatac tgctgttcat caccaaagga agtcaggact ggaactcaag
     2761 caggtcagga agtaggagct gatgcagagg ccatggaggg acattcctta ctggcttgct
     2821 tcccctggct tgctcagctt gctttcttac agaacccaag tctaccagcc tagagacagc
     2881 accaaccaca aggggccctc ccacccttga tcaataattg agaaaaatgc cttacagttg
     2941 gatctcatga aggcattttc tcacctgaag ctcctttctc tgtgataact ccaggtggtg
     3001 tcaagttgac acacaaacac attactatta agcctcaacc cttactttct tattaatccc
     3061 catgatcaaa ataactttaa aagtcccaca gtctttgaaa attcttaaaa tttcaatccc
     3121 tttaaaatat ccaatctctt ttaaaattca aagtcttttt acaattaaaa agtctcttaa
     3181 ctgtggtctc cactaaaata ctttcttcct tcaagaggga aaaatatcag ggcacagtca
     3241 caaacaatta aaagcaaaat caaactacaa cctcaaacgt ctgggaccct ccaagggctt
     3301 gggtcacttc tctagctctg ccctttgtag cacacaactt gtcttctagg ctccagatgc
     3361 ctgtactcca ctgctgctgc tgttcttggt agtcatttat ggtactggca tctccaaaac
     3421 actgttgtct ttgctgtaac taggcttcac caatagcctc tcataggctc tcttcatggt
     3481 gccaagcctc aaatcctttg catgacccct tcagtcctgg gccatcaact gctactgagg
     3541 ctgcaccttt accagtggcc ttccatggcc tctcacatgc caagcctcag ctgctcttta
     3601 tgtcttcaaa accagtatga ctcttaaaca taaccaagtc cagctgcagc taaggtagaa
     3661 ccttgtctat ctctggaaca cagcctcttt gtgctctcag aaaacacttc cctcctatga
     3721 ctaggcaggc cttttactca gatctccttg cttatgtctc ccaattacta ggatttaagg
     3781 caagcatcac atggccaggc tctcaagcaa atctgaaaaa ctttacatgt atgattttta
     3841 gagaatttat catctgcata tcctctgaat gtgtgtgtaa tataaaataa agtaatataa
     3901 aaactcatac accc
//
