LOCUS       NP_038580                794 aa            linear   ROD 05-MAY-2025
DEFINITION  hyaluronan mediated motility receptor [Mus musculus].
ACCESSION   NP_038580
VERSION     NP_038580.2
DBSOURCE    REFSEQ: accession NM_013552.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 794)
  AUTHORS   Chen,Y.J., Tseng,S.C., Chen,P.T. and Hwang,E.
  TITLE     The non-mitotic role of HMMR in regulating the localization of TPX2
            and the dynamics of microtubules in neurons
  JOURNAL   Elife 13, 94547 (2024)
   PUBMED   38904660
  REMARK    GeneRIF: The non-mitotic role of HMMR in regulating the
            localization of TPX2 and the dynamics of microtubules in neurons.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 794)
  AUTHORS   Wu,H., Liu,Y., Liu,Q., Li,Z., Wan,Y., Cao,C., Wu,B., Liu,M.,
            Liang,R., Hu,L., Zhang,W., Lan,M., Yao,Q., Zhou,H., Lan,H.,
            Chen,L., Zhang,Y., Zhang,X., Bian,X.W. and Xu,C.
  TITLE     HMMR triggers immune evasion of hepatocellular carcinoma by
            inactivation of phagocyte killing
  JOURNAL   Sci Adv 10 (23), eadl6083 (2024)
   PUBMED   38838151
  REMARK    GeneRIF: HMMR triggers immune evasion of hepatocellular carcinoma
            by inactivation of phagocyte killing.
REFERENCE   3  (residues 1 to 794)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 794)
  AUTHORS   He,L., Li,H., Li,C., Liu,Z.K., Lu,M., Zhang,R.Y., Wu,D., Wei,D.,
            Shao,J., Liu,M., Wei,H.L., Zhang,C., Wang,Z., Kong,L.M., Chen,Z.N.
            and Bian,H.
  TITLE     HMMR alleviates endoplasmic reticulum stress by promoting
            autophagolysosomal activity during endoplasmic reticulum
            stress-driven hepatocellular carcinoma progression
  JOURNAL   Cancer Commun (Lond) 43 (9), 981-1002 (2023)
   PUBMED   37405956
  REMARK    GeneRIF: HMMR alleviates endoplasmic reticulum stress by promoting
            autophagolysosomal activity during endoplasmic reticulum
            stress-driven hepatocellular carcinoma progression.
REFERENCE   5  (residues 1 to 794)
  AUTHORS   Hao,R.C., Li,Z.L., Wang,F.Y., Tang,J., Li,P.L., Yin,B.F., Li,X.T.,
            Han,M.Y., Mao,N., Liu,B., Ding,L. and Zhu,H.
  TITLE     Single-cell transcriptomic analysis identifies a highly replicating
            Cd168+ skeletal stem/progenitor cell population in mouse long bones
  JOURNAL   J Genet Genomics 50 (9), 702-712 (2023)
   PUBMED   37075860
  REMARK    GeneRIF: Single-cell transcriptomic analysis identifies a highly
            replicating Cd168[+] skeletal stem/progenitor cell population in
            mouse long bones.
REFERENCE   6  (residues 1 to 794)
  AUTHORS   Entwistle,J., Zhang,S., Yang,B., Wong,C., Li,Q., Hall,C.L., A,J.,
            Mowat,M., Greenberg,A.H. and Turley,E.A.
  TITLE     Characterization of the murine gene encoding the hyaluronan
            receptor RHAMM
  JOURNAL   Gene 163 (2), 233-238 (1995)
   PUBMED   7590272
REFERENCE   7  (residues 1 to 794)
  AUTHORS   Sherman,L., Sleeman,J., Herrlich,P. and Ponta,H.
  TITLE     Hyaluronate receptors: key players in growth, differentiation,
            migration and tumor progression
  JOURNAL   Curr Opin Cell Biol 6 (5), 726-733 (1994)
   PUBMED   7530464
  REMARK    Review article
REFERENCE   8  (residues 1 to 794)
  AUTHORS   Hall,C.L., Wang,C., Lange,L.A. and Turley,E.A.
  TITLE     Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion
            turnover and transient tyrosine kinase activity
  JOURNAL   J Cell Biol 126 (2), 575-588 (1994)
   PUBMED   7518470
REFERENCE   9  (residues 1 to 794)
  AUTHORS   .
  TITLE     Correction. Molecular cloning of a novel hyaluronan receptor that
            mediates tumor cell motility
  JOURNAL   J Cell Biol 118 (3), 753 (1992)
   PUBMED   1639856
  REMARK    Correction to:[J Cell Biol. 1992 Jun;117(6):1343-50. doi:
            10.1083/jcb.117.6.1343. PMID: 1376732]
REFERENCE   10 (residues 1 to 794)
  AUTHORS   Hardwick,C., Hoare,K., Owens,R., Hohn,H.P., Hook,M., Moore,D.,
            Cripps,V., Austen,L., Nance,D.M. and Turley,E.A.
  TITLE     Molecular cloning of a novel hyaluronan receptor that mediates
            tumor cell motility
  JOURNAL   J Cell Biol 117 (6), 1343-1350 (1992)
   PUBMED   1376732
  REMARK    Erratum:[J Cell Biol. 1992 Aug;118(3):753. doi:
            10.1083/jcb.118.3.753. PMID: 1639856]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL646055.10.
            
            On Apr 14, 2009 this sequence version replaced NP_038580.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031932.1, AF079222.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..794
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 24.4 cM"
     Protein         1..794
                     /product="hyaluronan mediated motility receptor"
                     /note="receptor for hyaluronan-mediated motility;
                     intracellular hyaluronic acid-binding protein"
                     /calculated_mol_wt=91655
     Region          1..87
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00547.4)"
     Region          16..338
                     /region_name="HMMR_N"
                     /note="Hyaluronan mediated motility receptor N-terminal;
                     pfam15905"
                     /db_xref="CDD:464932"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75330; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Region          <105..>576
                     /region_name="PRK02224"
                     /note="DNA double-strand break repair Rad50 ATPase"
                     /db_xref="CDD:179385"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            279
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Region          365..630
                     /region_name="Required for interaction with FAM83D.
                     /evidence=ECO:0000250|UniProtKB:O75330"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00547.4)"
     Region          442..546
                     /region_name="5 X 21 AA tandem repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00547.4)"
     Site            446
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            467
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            488
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            509
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            530
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            561
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Site            601
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     Region          636..789
                     /region_name="HMMR_C"
                     /note="Hyaluronan mediated motility receptor C-terminal;
                     pfam15908"
                     /db_xref="CDD:464934"
     Region          719..729
                     /region_name="Hyaluronic acid-binding.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00547.4)"
     Region          741..750
                     /region_name="Hyaluronic acid-binding.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00547.4)"
     Site            784
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75330; propagated from
                     UniProtKB/Swiss-Prot (Q00547.4)"
     CDS             1..794
                     /gene="Hmmr"
                     /gene_synonym="AA386826; CD168; Rhamm"
                     /coded_by="NM_013552.3:50..2434"
                     /db_xref="CCDS:CCDS24548.1"
                     /db_xref="GeneID:15366"
                     /db_xref="MGI:MGI:104667"
ORIGIN      
        1 msfpkaplkr fndpsgcaps pgaydvktse atkgpvsfqk sqrfknqres qqnlnidkdt
       61 tllasakkak ksvskkdsqk ndkdvkrlek eirallqerg tqdkriqdme selekteakl
      121 naavrektsl sasnaslekr lteltranel lkakfsedgh qknmralsle lmklrnkret
      181 kmrsmmvkqe gmelklqatq kdlteskgki vqlegklvsi ekekidekce teklleyiqe
      241 iscasdqvek ckvdiaqlee dlkekdreil slkqsleeni tfskqiedlt vkcqlleter
      301 dnlvskdrer aetlsaemqi lterlalerq eyeklqqkel qsqsllqqek elsarlqqql
      361 csfqeemtse knvfkeelkl alaeldavqq keeqserlvk qleeetksta eqltrldnll
      421 rekevelekh iaahaqaili aqekyndtaq slrdvtaqle svqekyndta qslrdvtaql
      481 eseqekyndt aqslrdvtaq leseqekynd taqslrdvta qlesvqekyn dtaqslrdvt
      541 aqlesyksst lkeiedlkle nltlqekvam aeksvedvqq qiltaestnq eyarmvqdlq
      601 nrstlkeeei keitssflek itdlknqlrq qdedfrkqle ekgkrtaeke nvmteltmei
      661 nkwrllyeel yektkpfqqq ldafeaekqa llnehgatqe qlnkirdsya qllghqnlkq
      721 kikhvvklkd ensqlksevs klrsqlvkrk qnelrlqgel dkalgirhfd pskafchask
      781 enftplkegn pncc
//
