LOCUS       NM_178017               3876 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus HMG box domain containing 4 (Hmgxb4), transcript
            variant 1, mRNA.
ACCESSION   NM_178017
VERSION     NM_178017.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3876)
  AUTHORS   Wang,L., He,X., Hu,G., Liu,J., Kang,X., Yu,L., Dong,K., Zhao,J.,
            Zhang,A., Zhang,W., Brands,M.W., Su,H., Zheng,Z. and Zhou,J.
  TITLE     A novel mouse model carrying a gene trap insertion into the Hmgxb4
            gene locus to examine Hmgxb4 expression in vivo
  JOURNAL   Physiol Rep 12 (8), e16014 (2024)
   PUBMED   38644513
  REMARK    GeneRIF: A novel mouse model carrying a gene trap insertion into
            the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo.
REFERENCE   2  (bases 1 to 3876)
  AUTHORS   He,X., Dong,K., Shen,J., Hu,G., Liu,J., Kang,X., Wang,L.,
            Atawia,R.T., Osman,I., Caldwell,R.W., Xiang,M., Zhang,W., Zheng,Z.,
            Li,L., Fulton,D.J.R., Deng,K., Xin,H. and Zhou,J.
  TITLE     Deficiency of the novel high mobility group protein HMGXB4 protects
            against systemic inflammation-induced endotoxemia in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (7) (2021)
   PUBMED   33563757
  REMARK    GeneRIF: Deficiency of the novel high mobility group protein HMGXB4
            protects against systemic inflammation-induced endotoxemia in mice.
REFERENCE   3  (bases 1 to 3876)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 3876)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   5  (bases 1 to 3876)
  AUTHORS   Zhou,J., Hu,G. and Wang,X.
  TITLE     Repression of smooth muscle differentiation by a novel high
            mobility group box-containing protein, HMG2L1
  JOURNAL   J Biol Chem 285 (30), 23177-23185 (2010)
   PUBMED   20511232
  REMARK    GeneRIF: the first evidence of this novel HMG2L1 molecule playing
            an important role in attenuating smooth muscle differentiation
REFERENCE   6  (bases 1 to 3876)
  AUTHORS   Thoren,L.A., Norgaard,G.A., Weischenfeldt,J., Waage,J.,
            Jakobsen,J.S., Damgaard,I., Bergstrom,F.C., Blom,A.M., Borup,R.,
            Bisgaard,H.C. and Porse,B.T.
  TITLE     UPF2 is a critical regulator of liver development, function and
            regeneration
  JOURNAL   PLoS One 5 (7), e11650 (2010)
   PUBMED   20657840
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3876)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 3876)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603864.8.
            
            On Dec 20, 2022 this sequence version replaced NM_178017.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049800.1, SRR17253013.4266694.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL603864.8         81979-82051         c
            74-177              AL603864.8         76790-76893         c
            178-326             AL603864.8         76020-76168         c
            327-405             AL603864.8         75837-75915         c
            406-1340            AL603864.8         74144-75078         c
            1341-1422           AL603864.8         55403-55484         c
            1423-1487           AL603864.8         53861-53925         c
            1488-1593           AL603864.8         52424-52529         c
            1594-1763           AL603864.8         51561-51730         c
            1764-1886           AL603864.8         46118-46240         c
            1887-3876           AL603864.8         43750-45739         c
FEATURES             Location/Qualifiers
     source          1..3876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.57 cM"
     gene            1..3876
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="HMG box domain containing 4"
                     /db_xref="GeneID:70823"
                     /db_xref="MGI:MGI:1918073"
     exon            1..73
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..177
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1931
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="isoform 1 is encoded by transcript variant 1; high
                     mobility group box 2-like 1"
                     /codon_start=1
                     /product="HMG domain-containing protein 4 isoform 1"
                     /protein_id="NP_821136.1"
                     /db_xref="CCDS:CCDS22422.1"
                     /db_xref="GeneID:70823"
                     /db_xref="MGI:MGI:1918073"
                     /translation="MAYDDSMKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREE
                     EEVAAQVRSSSKKKSKDSDLFFLGTDTHKKKRKHSPDDYYYGDISTLESSQKKKKKSS
                     PQSPDTAMDLLKAITSPLAAGAKSSKKAGEKSSSSSSHPESRKEHHKKKGNGSSGELS
                     LDDSNAHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVEEEAFQYPAQQA
                     SLKKPSKKLARDEQGALLLGHELQSLLKTARKKHKSSSDSHSSPGPEGCGSDVSQLPE
                     PHSANLDITGLDPILVESESSSAGELEAGELVIDDSYREIKKKKKSKKSKKKKDKDRH
                     KEKRHSRTKRSSAREHGTAREHGLIPGPASSVPTLPLPALHTDGHGEKKKKREDKDRD
                     RERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWK
                     QKAQYLQHKQNKAEATTVKRKASSAEGSMKVRASSVGVLSPQKKSPPTTMLLPASPAK
                     APETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLT
                     TQLPELNGCPKQVLSNTLDNIAYIMPGL"
     exon            178..326
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..405
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1340
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1422
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1487
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1593
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1763
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1886
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..3876
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="hexamer: AATAAA"
     polyA_site      2590
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="major polyA site"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="hexamer: AATAAA"
     polyA_site      3812
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="major polyA site"
     regulatory      3849..3854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="hexamer: ATTAAA"
     polyA_site      3876
                     /gene="Hmgxb4"
                     /gene_synonym="4733401K04Rik; Hmgb2l1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcttttct ctccttctcc aagatggcgg ccgtcggcgg cgctgaggcg ggatccgagc
       61 gagccgagtg aagacctggt cctgtagacg ggaaggagcc tggacacagt gacacaacac
      121 attctcaaag gccctgcagg accaccatgg cttatgatga ctccatgaag aaagaagatt
      181 gctttgatgg tgatcacagc tttgaggaca taggacttgc agctggccga agccaacgag
      241 aaaagaagcg gtcttacaaa gacttcttaa gggaagagga agaagtcgcc gcgcaggtca
      301 ggagctcttc caagaagaag tcaaaggaca gtgatttgtt cttcttgggg acggacacac
      361 acaagaagaa gaggaagcac tcccctgacg attactacta tggagacatt tcgactttgg
      421 aatcatcaca gaagaaaaag aagaagtcta gcccacagtc tccggacaca gcaatggacc
      481 tgttgaaagc tatcacctcc ccactggcag cgggtgccaa gtcctctaag aaggcagggg
      541 agaaatcctc cagctcttca agccatccag agagcaggaa ggagcaccac aagaagaagg
      601 gcaatggcag cagtggagag ctctccctgg atgacagcaa tgcccacaaa tccaaaaaga
      661 tgaagccact ctatgtgaac acagagacac tgactcttcg tgagccagat ggcttaaaga
      721 tgaaactcat tctctcacca aaggagaagg gaagcagctc agtggaagag gaggcttttc
      781 agtaccctgc ccaacaagct tcgctgaaga agccctcgaa gaaactagct cgggacgagc
      841 aaggtgcttt actcctaggg cacgagctac agagcctcct gaaaacggcc cggaagaagc
      901 acaagtcatc ctcagactca cactcctctc ctggcccaga aggctgtggg tctgacgtct
      961 cccagcttcc agaaccccac agtgccaatc tcgacatcac agggcttgac ccaattctag
     1021 tagagtccga atcgtcctca gctggggagc tggaggccgg ggagctggtg atagatgact
     1081 cttacaggga gatcaagaag aagaagaagt caaaaaagag caaaaagaag aaggacaaag
     1141 acagacacaa ggagaagcgg cactcccgga ccaagagaag ctctgccaga gagcacggta
     1201 ctgctcggga gcacgggctg atacctggcc ctgcctccag tgtccccacc ctgccacttc
     1261 ctgctctaca cacagatgga cacggggaga agaaaaagaa aagggaagac aaagacagag
     1321 acagagagag gggagaaaag ccgaaaaaga agaacatgtc tgcctaccag gtattctgta
     1381 aggagtaccg ggtaaccatt gtggctgacc atccaggtat agattttggg gaacttagta
     1441 aaaaattggc tgaagtatgg aagcagttgc cagaaaaaga caaactgatc tggaagcaaa
     1501 aggctcagta tctgcagcac aaacagaaca aagctgaagc cacaactgtg aagagaaaag
     1561 catccagcgc agaaggttcc atgaaagtca gagcctcttc tgtaggagta ctgtcacccc
     1621 aaaagaagtc cccacccacc acaatgcttt tgccagcctc accagccaaa gctcctgaaa
     1681 cagagcccat tgatgtcgct gctcatctcc agttgctggg agagtccctc agcctcattg
     1741 gacaccgcct acaggagaca gagggcatgg tggcagtgtc tggaagcttg tcagtgctcc
     1801 tagattccat tatctgtgct cttggccctc tggcatgcct gaccacacaa ctacctgaac
     1861 tgaacggctg tcctaaacag gtcttgtcaa acacgctgga caacattgca tacattatgc
     1921 ctggactgtg acttccaaga cgcctgggac agaagactgt ctaccccttc gctagtctat
     1981 gtatagatga ctgttccaga ccctccactg acctctgggt gtaggtttta aatttttata
     2041 atctatatat acgtatataa tgtacagtat atacatagga tataactact ttgcttttaa
     2101 taattttatg aaatggcaaa ggtttagcta aaaggaaact ttagcatgaa tgtgggcttg
     2161 gaattatttt tttgtgaaaa aaaaatctgc cttaaaaaaa atcagtgtaa tttggggact
     2221 aggggcttat tctgggtgcc atgtatatct cctcatagac tgctaaaatg tgattttttt
     2281 tttttttcca agcttgggtt tacctccaga cccatcactg accatttgcc ttacctgtct
     2341 tataatcaga aatgtagtaa agatcttggg aggaggccag ctgactacaa acttttggac
     2401 atggagtaac ctgggtgggg aggtggagct taggtggact gggtagggga ctcattccaa
     2461 ttcctactaa agagatacct gtgtctccag ttttattgta accacggttc cacagagtca
     2521 tcggtaccat ctatagcctc agctatgtga ttcttggcag cagagaaata aataccttgc
     2581 agaaaccaaa gctgttggtg ccacctgttg aacctgcttg tctggccagc aaggcttggt
     2641 gtataaaaac caaagctgcc atcttccact agcagcattg gttgcccaac aaatcctgag
     2701 gattctgctg cttagctgtt tggtggttct tggttcagct ctggttcccc tggtgggtac
     2761 attgtgctct gcattccaca cagagctgga tcacaaagaa gttcttggtt ctcaggaggg
     2821 ttatctatat gtgcgtgtga gtgtatattt taattatgtg tatttaactc tttagaattt
     2881 cttagatttt aatttatcct gtaaatttct gtatatataa tttaataaca agcctccacc
     2941 agcaggagca tgtggagcat acagatttgt catttcttaa tgtctgtcta aaagctccaa
     3001 gacgtccata tgttaaggtg ttgtgactca gaaaggaact tcatggccct caataatgtt
     3061 aggaaagtga aatagaaagg aatgtcacca ttcctaattt cccttattcc caaagaccca
     3121 gacctgcttc cccattagag agaagatagc tgagtgctcc agggttgctt gggaactcgg
     3181 tgagagattc ccttccctgc caaaaccaag ctgagttaat aaccatgctt tcttctaatg
     3241 gcctggatgg aacgaggcag catcacagta aacctttggg gaccatgtag ccagctggca
     3301 tcctagggaa ctccttccca tagcccgact gctgtcacag ctaagcttct cacaggactg
     3361 tgtcagctca gagcagtttt gagatttaat ctgagaaata gggaaaggaa cagaaatatg
     3421 tgggaactga aatcaagcag agcagaaatt tccatttgag ttaacatgtc agaacctcat
     3481 ttgaccctgc agaagtttcc tgtgagaaat ggtatcaagg agaggccagg gaagacatgt
     3541 gtggtagagg aagcagccag tcctccattg cccttgctac agacagtagt gaactcctaa
     3601 ggagaaccgg ctttttcggg tttgttttcc tctgaagcct agccctgttg tatttgtatt
     3661 aaagatttgt acacatttgt ataataatct gtaccttgtg gtatttggta ctattagagg
     3721 aaaaattttg gattcaggcc ttcttgctgt ttttatatca ttgttttatt ttgttttttt
     3781 aaataaatcc tagtggtttg atccaaatcc tattacagtt gtataaagaa acaatatttt
     3841 gtacttatat taaagatctc atttttaata tttata
//
