LOCUS       NM_016710               1911 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus high-mobility group nucleosome binding domain 5
            (Hmgn5), mRNA.
ACCESSION   NM_016710
VERSION     NM_016710.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Mou,J., Huang,M., Wang,F., Xu,X., Xie,H., Lu,H., Li,M., Li,Y.,
            Kong,W., Chen,J., Xiao,Y., Chen,Y., Wang,C. and Ren,J.
  TITLE     HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin
            Landscape in Breast Cancer Tumorigenesis
  JOURNAL   Mol Cancer Res 20 (12), 1724-1738 (2022)
   PUBMED   36066963
  REMARK    GeneRIF: HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the
            Chromatin Landscape in Breast Cancer Tumorigenesis.
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Yao,K., He,L., Gan,Y., Liu,J., Tang,J., Long,Z. and Tan,J.
  TITLE     HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of
            bladder cancer by interacting with Hsp27
  JOURNAL   Aging (Albany NY) 12 (8), 7282-7298 (2020)
   PUBMED   32315283
  REMARK    GeneRIF: HMGN5 promotes IL-6-induced epithelial-mesenchymal
            transition of bladder cancer by interacting with Hsp27.
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   Li,D.D., Zhao,S.Y., Yang,Z.Q., Duan,C.C., Guo,C.H., Zhang,H.L.,
            Geng,S., Yue,Z.P. and Guo,B.
  TITLE     Hmgn5 functions downstream of Hoxa10 to regulate uterine
            decidualization in mice
  JOURNAL   Cell Cycle 15 (20), 2792-2805 (2016)
   PUBMED   27579887
  REMARK    GeneRIF: Hmgn5 might act downstream of Hoxa10 to regulate the
            expression of Cox-2, Vegf and Mmp2.
REFERENCE   4  (bases 1 to 1911)
  AUTHORS   Moretti,F., Rolando,C., Winker,M., Ivanek,R., Rodriguez,J., Von
            Kriegsheim,A., Taylor,V., Bustin,M. and Pertz,O.
  TITLE     Growth Cone Localization of the mRNA Encoding the Chromatin
            Regulator HMGN5 Modulates Neurite Outgrowth
  JOURNAL   Mol Cell Biol 35 (11), 2035-2050 (2015)
   PUBMED   25825524
  REMARK    GeneRIF: HMGN5 overexpression induces neurite outgrowth.
REFERENCE   5  (bases 1 to 1911)
  AUTHORS   Furusawa,T., Rochman,M., Taher,L., Dimitriadis,E.K., Nagashima,K.,
            Anderson,S. and Bustin,M.
  TITLE     Chromatin decompaction by the nucleosomal binding protein HMGN5
            impairs nuclear sturdiness
  JOURNAL   Nat Commun 6, 6138 (2015)
   PUBMED   25609380
  REMARK    GeneRIF: Mice overexpressing HMGN5, either globally or only in the
            heart, are normal at birth but develop hypertrophic heart with
            large cardiomyoctyes, deformed nuclei and disrupted lamina, and die
            of cardiac malfunction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1911)
  AUTHORS   Rochman,M., Postnikov,Y., Correll,S., Malicet,C., Wincovitch,S.,
            Karpova,T.S., McNally,J.G., Wu,X., Bubunenko,N.A., Grigoryev,S. and
            Bustin,M.
  TITLE     The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin
            counteracts linker histone-mediated chromatin compaction and
            modulates transcription
  JOURNAL   Mol Cell 35 (5), 642-656 (2009)
   PUBMED   19748358
  REMARK    GeneRIF: NSBP1 is an architectural protein that binds
            preferentially to euchromatin and modulates the fidelity of the
            cellular transcription profile by counteracting the
            chromatin-condensing activity of linker histones.
REFERENCE   7  (bases 1 to 1911)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   8  (bases 1 to 1911)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   9  (bases 1 to 1911)
  AUTHORS   King,L.M. and Francomano,C.A.
  TITLE     Characterization of a human gene encoding nucleosomal binding
            protein NSBP1
  JOURNAL   Genomics 71 (2), 163-173 (2001)
   PUBMED   11161810
REFERENCE   10 (bases 1 to 1911)
  AUTHORS   Shirakawa,H., Landsman,D., Postnikov,Y.V. and Bustin,M.
  TITLE     NBP-45, a novel nucleosomal binding protein with a tissue-specific
            and developmentally regulated expression
  JOURNAL   J Biol Chem 275 (9), 6368-6374 (2000)
   PUBMED   10692437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279928.1, AK146755.1 and BY387611.1.
            
            On Mar 20, 2007 this sequence version replaced NM_016710.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW259877.1, AF213454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY279928.1         26-50
            26-807              AK146755.1         2-783
            808-1900            AK146755.1         785-1877
            1901-1911           BY387611.1         440-450
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.92 cM"
     gene            1..1911
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /note="high-mobility group nucleosome binding domain 5"
                     /db_xref="GeneID:50887"
                     /db_xref="MGI:MGI:1355295"
     exon            1..129
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1335
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /note="nucleosome binding protein 1; nucleosome binding
                     protein 45"
                     /codon_start=1
                     /product="high mobility group nucleosome-binding
                     domain-containing protein 5"
                     /protein_id="NP_057919.2"
                     /db_xref="CCDS:CCDS41101.1"
                     /db_xref="GeneID:50887"
                     /db_xref="MGI:MGI:1355295"
                     /translation="MPKRKAAGDVSQEPKRRSARLSAMPVPFTPELKPKRASTSRKTK
                     TTNVVEENKDASTIPIPETKPEDVKDECNMENAENGEAKIMEAPIPKMEAEEVKEQIN
                     EDTEEDGGEKKEAVAAEAKDDELKANIQDVEKDEDGKEHKDTGEEVEDGKIEEEGLNE
                     KPGTAKSEDAEVSKDEEEKGDNEKGEDGKEEGDEKEEEKDDKEGDTGTEKEVKEQNKE
                     AEEDDGKCKEEENKEVGKEGQPEEDGKEDLHEEVGKEDLHEEDGKEGQPEEDGKEIHH
                     EEDGKEGQPEEDGKEYLHEEDGEEGQPKEDQKEGQPEEDGKEDQPEEDGKEGQCKEDG
                     KEGHHEEGGKEDLHEEDGKEKDGGKEDRKEEGEQEVAVDEGSDENKVEAEEEGAENKD
                     FKQDGEKEEPLSIV"
     exon            130..153
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..183
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..237
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..372
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1907
                     /gene="Hmgn5"
                     /gene_synonym="GARP45; NBP-45; Nsbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatcgtgctg caattagttc attgaaaact cagtcgctcg cggagcggtc aggcagagac
       61 tcctctcggc ttttttccct cctgcctaag gatctccaac ggagagctgc aacaatgccc
      121 aaaagaaagg ctgcaggtga tgtgagccag gagccaaaga gaagatcagc ccgactgtct
      181 gctatgcctg tgccctttac accggagttg aaacctaaaa gagcatcaac ttcaaggaaa
      241 accaagacca caaatgtcgt ggaagaaaac aaagatgcaa gtaccatacc aattcctgaa
      301 accaagccag aagatgttaa agacgaatgc aacatggaaa atgctgaaaa tggagaagcc
      361 aagattatgg aggcacccat tcctaaaatg gaagctgagg aagtaaaaga acagataaat
      421 gaagacactg aagaagatgg aggagaaaag aaagaagcag tggcagcaga agccaaagat
      481 gatgagctaa aagcaaacat tcaagatgtg gagaaagatg aagatggaaa agagcacaaa
      541 gatacaggtg aggaggtgga agacggaaaa atagaagaag aaggcctaaa cgagaaacca
      601 ggtacagcca aaagtgaaga tgcagaggtg tccaaagatg aagaagagaa aggagacaat
      661 gaaaaaggag aagatggcaa agaagaaggt gatgagaagg aagaagagaa agatgacaaa
      721 gagggggaca ctggaacaga aaaagaagta aaagaacaaa acaaggaagc cgaggaggat
      781 gatgggaaat gcaaagagga ggaaaacaag gaagttggaa aggaaggtca gcctgaggaa
      841 gatggaaagg aagatctgca tgaggaagtt ggaaaggaag atctgcatga ggaagatgga
      901 aaggaaggtc agcctgagga agatgggaag gaaattcatc atgaggaaga tggaaaggaa
      961 ggtcagcctg aagaagatgg aaaggaatat ctgcatgagg aagatggaga ggaaggtcag
     1021 cctaaggaag atcaaaagga aggtcagcct gaggaagatg gaaaggaaga tcagcctgag
     1081 gaagatggaa aggaaggtca gtgtaaggaa gatgggaagg aaggtcatca tgaggaaggt
     1141 ggaaaggaag atctgcatga ggaagatgga aaggagaaag atggtggaaa agaggataga
     1201 aaggaagaag gagagcaaga ggttgctgta gatgaaggga gtgatgaaaa caaggtggag
     1261 gcagaagaag aaggagccga aaacaaagac ttcaaacaag acggagagaa agaggagcct
     1321 ctgagtattg tctaaaactg ccctctgtga gatcataatt cggtaacacg taccttcctg
     1381 ttgtaatgtt aatagagata aatattttta tcagatattt tataaacagt gcttttcttt
     1441 agcatcattc aatcttagat catcatcatc atacaggtta ttagttgcaa aatgcctaac
     1501 atgacacctt tatacatttt gtgattatag tagtgcaaaa tataaaatgt atacttgcaa
     1561 ctttgtgaat ttcatcatgt gtaagttatg tattaaatct ttgagtttca attttattct
     1621 tatacgtggt aaatttgcag agtaggagaa ttccaaaaga aagagtttgg cacaactttg
     1681 atgtagttct ctaggttgct tttataaaga aggtcaacta ttttcaggta atgctaagag
     1741 tcggaattga cattaccaaa tacaactgta ttagtagctt ggaaagtata aaattttaat
     1801 ttcatttttg aagaaatttg aatgtttatt tcaggagggc agttttgatt atatgtgtat
     1861 gcacaaagtt ttgctggatt tatcataata aaagagttcc acaaataaaa a
//
