LOCUS       NM_016957               1254 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus high mobility group nucleosomal binding domain 2
            (Hmgn2), mRNA.
ACCESSION   NM_016957
VERSION     NM_016957.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   He,B., Kram,V., Furusawa,T., Duverger,O., Chu,E.Y., Nanduri,R.,
            Ishikawa,M., Zhang,P., Amendt,B.A., Lee,J.S. and Bustin,M.
  TITLE     Epigenetic Regulation of Ameloblast Differentiation by HMGN
            Proteins
  JOURNAL   J Dent Res 103 (1), 51-61 (2024)
   PUBMED   37950483
  REMARK    GeneRIF: Epigenetic Regulation of Ameloblast Differentiation by
            HMGN Proteins.
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Nanduri,R., Furusawa,T., Lobanov,A., He,B., Xie,C., Dadkhah,K.,
            Kelly,M.C., Gavrilova,O., Gonzalez,F.J. and Bustin,M.
  TITLE     Epigenetic regulation of white adipose tissue plasticity and energy
            metabolism by nucleosome binding HMGN proteins
  JOURNAL   Nat Commun 13 (1), 7303 (2022)
   PUBMED   36435799
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Eliason,S., Su,D., Pinho,F., Sun,Z., Zhang,Z., Li,X., Sweat,M.,
            Venugopalan,S.R., He,B., Bustin,M. and Amendt,B.A.
  TITLE     HMGN2 represses gene transcription via interaction with
            transcription factors Lef-1 and Pitx2 during amelogenesis
  JOURNAL   J Biol Chem 298 (9), 102295 (2022)
   PUBMED   35872015
  REMARK    GeneRIF: HMGN2 represses gene transcription via interaction with
            transcription factors Lef-1 and Pitx2 during amelogenesis.
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Du,Y., Guo,H., Guo,L., Miao,J., Ren,H., Liu,K., Ren,L., He,J.,
            Wang,X., Chen,J., Li,J., Wang,Y., Wang,J. and Huang,N.
  TITLE     The regulatory effect of acetylation of HMGN2 and H3K27 on
            pyocyanin-induced autophagy in macrophages by affecting Ulk1
            transcription
  JOURNAL   J Cell Mol Med 25 (15), 7524-7537 (2021)
   PUBMED   34278675
  REMARK    GeneRIF: The regulatory effect of acetylation of HMGN2 and H3K27 on
            pyocyanin-induced autophagy in macrophages by affecting Ulk1
            transcription.
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Identification and genetic mapping of 151 dispersed members of 16
            ribosomal protein multigene families in the mouse
  JOURNAL   Mamm Genome 5 (11), 670-687 (1994)
   PUBMED   7873877
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Pash,J., Popescu,N., Matocha,M., Rapoport,S. and Bustin,M.
  TITLE     Chromosomal protein HMG-14 gene maps to the Down syndrome region of
            human chromosome 21 and is overexpressed in mouse trisomy 16
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3836-3840 (1990)
   PUBMED   2140193
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Johnson,K.R., Disney,J.E., Wyatt,C.R. and Reeves,R.
  TITLE     Expression of mRNAs encoding mammalian chromosomal proteins HMG-I
            and HMG-Y during cellular proliferation
  JOURNAL   Exp Cell Res 187 (1), 69-76 (1990)
   PUBMED   2404776
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Landsman,D., Zavou,S., Soares,N., Goodwin,G.H. and Bustin,M.
  TITLE     Mouse non-histone chromosomal protein HMG-17 cDNA sequence
  JOURNAL   Nucleic Acids Res 16 (21), 10386 (1988)
   PUBMED   3194220
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Vartiainen,E., Palvimo,J., Mahonen,A., Linnala-Kankkunen,A. and
            Maenpaa,P.H.
  TITLE     Selective decrease in low-Mr HMG proteins HMG I and HMG Y during
            differentiation of mouse teratocarcinoma cells
  JOURNAL   FEBS Lett 228 (1), 45-48 (1988)
   PUBMED   3342876
  REMARK    Erratum:[FEBS Lett 1989 Jul 17;251(1-2):283]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ053675.1, AK146999.1 and BC090836.1.
            
            On Jan 31, 2006 this sequence version replaced NM_016957.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090836.1, AK146999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               CJ053675.1         3-403
            402-1251            AK146999.1         405-1254
            1252-1254           BC090836.1         1152-1154
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.47 cM"
     gene            1..1254
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /note="high mobility group nucleosomal binding domain 2"
                     /db_xref="GeneID:15331"
                     /db_xref="MGI:MGI:96136"
     exon            1..197
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..455
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /note="high mobility group nucleosome-binding
                     domain-containing protein 2; high mobility group protein
                     17"
                     /codon_start=1
                     /product="non-histone chromosomal protein HMG-17"
                     /protein_id="NP_058653.1"
                     /db_xref="CCDS:CCDS18759.1"
                     /db_xref="GeneID:15331"
                     /db_xref="MGI:MGI:96136"
                     /translation="MPKRKAEGDAKGDKTKVKDEPQRRSARLSAKPAPPKPEPKPKKA
                     PAKKGEKVPKGKKGKADAGKDANNPAENGDAKTDQAQKAEGAGDAK"
     exon            198..242
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            243..272
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            273..323
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            324..419
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1254
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1226..1231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /note="putative"
     polyA_site      1251
                     /gene="Hmgn2"
                     /gene_synonym="HMG-17; Hmg17"
                     /note="putative"
ORIGIN      
        1 atgagcggcg acgggaggtg aaatccggtt ctaaccggtc cggggctccc agcgctataa
       61 aaactttata aaccccccgg agcccgagca gtgtgaggaa gcagcgagga cgacccccgg
      121 acggagcaaa cccgcgcgcc gctgtatccc cgtgctcagc gccgacgtcc cctgccgcca
      181 ccatgcccaa aagaaaggct gaaggggatg ctaaaggaga caaaaccaag gtgaaggacg
      241 agccacagag aagatctgcg aggttgtctg ctaaacctgc tcctccaaag ccagagccca
      301 aacctaaaaa ggcccctgcg aagaagggag agaaggtacc caaggggaag aaggggaaag
      361 ctgacgccgg gaaggatgcg aataatcctg cagaaaatgg agatgccaaa acagaccagg
      421 cacagaaagc tgaaggtgct ggagatgcca agtgatgtgt gtgcattttt gataactgtg
      481 tacttctggt gactgtacag tttgaaatac tattttttat caagttttat aaaaatgcag
      541 aatttcgttt tacttttttt ttttaagcta tattgttagc acacagaaca cttcattact
      601 gggtggggga aggatcatgt gtcagtaaca aaatctctcc caagctggat tgaggacaga
      661 aaacctcttt ccctgataat tttggaaggc tcctgttggc tcccaggaga gagatcctgg
      721 tcttgaccta ggtggccacc aaggcacaac aatgccttgt ggtctgggga aactataaat
      781 tcacttttat atcctcttcc ccctgtacta tcaacataga cttaattccc ttaaaaacca
      841 gagacctgtt ggaaccgggc ccccaaaatt ggtttcccag tccattgagt gatggggact
      901 ttgcagtgac ttcattgagt gttctcaaaa gagcactggt tccttttata aaagattgtg
      961 gatcttcaga ttgataattc tgcctaaaag tcagggtcgg cttgtgaaaa gttgttaaaa
     1021 caacatcctt aatgtgaaat gtcaaccctc actctaagct acttccccct tttcaaagca
     1081 ttgaatgaag acttcattgg gttttatagt ggctttctga ttttggtagt ctatacaaga
     1141 agggaatttg gaagttcttg tatattgttg attgtctgcc catgtcctgc ctgaaatacc
     1201 atgattgttt atgaaaagaa tctttaataa agctggttac agttaggctt ggaa
//
