LOCUS       NM_008251               1200 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus high mobility group nucleosomal binding domain 1
            (Hmgn1), mRNA.
ACCESSION   NM_008251
VERSION     NM_008251.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Mao,Y., Yu,J., Yuan,J., DA,J., Yu,F. and Zha,Y.
  TITLE     [High mobility group nucleosome binding protein 1 (HMGN1) induces
            activation of mouse BV2 microglia and upregulates their
            pro-inflammatory mediator expression by activating
            TLR4/MyD88/NF-kappaB p65/IKK-beta signal pathway]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (2), 135-141 (2024)
   PUBMED   38284254
  REMARK    GeneRIF: [High mobility group nucleosome binding protein 1 (HMGN1)
            induces activation of mouse BV2 microglia and upregulates their
            pro-inflammatory mediator expression by activating
            TLR4/MyD88/NF-kappaB p65/IKK-beta signal pathway].
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Ming,T., Yuting,L., Meiling,D., Shengtao,C., Jihua,R., Hui,Z.,
            Wanjin,C., Dian,L., Tingting,G., Juan,C. and Zhenzhen,Z.
  TITLE     Chromatin binding protein HMGN1 promotes HBV cccDNA transcription
            and replication by regulating the phosphorylation of histone 3
  JOURNAL   Antiviral Res 221, 105796 (2024)
   PUBMED   38181856
  REMARK    GeneRIF: Chromatin binding protein HMGN1 promotes HBV cccDNA
            transcription and replication by regulating the phosphorylation of
            histone 3.
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   He,B., Kram,V., Furusawa,T., Duverger,O., Chu,E.Y., Nanduri,R.,
            Ishikawa,M., Zhang,P., Amendt,B.A., Lee,J.S. and Bustin,M.
  TITLE     Epigenetic Regulation of Ameloblast Differentiation by HMGN
            Proteins
  JOURNAL   J Dent Res 103 (1), 51-61 (2024)
   PUBMED   37950483
  REMARK    GeneRIF: Epigenetic Regulation of Ameloblast Differentiation by
            HMGN Proteins.
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Nanduri,R., Furusawa,T., Lobanov,A., He,B., Xie,C., Dadkhah,K.,
            Kelly,M.C., Gavrilova,O., Gonzalez,F.J. and Bustin,M.
  TITLE     Epigenetic regulation of white adipose tissue plasticity and energy
            metabolism by nucleosome binding HMGN proteins
  JOURNAL   Nat Commun 13 (1), 7303 (2022)
   PUBMED   36435799
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1200)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Identification and genetic mapping of 151 dispersed members of 16
            ribosomal protein multigene families in the mouse
  JOURNAL   Mamm Genome 5 (11), 670-687 (1994)
   PUBMED   7873877
REFERENCE   7  (bases 1 to 1200)
  AUTHORS   Johnson,K.R., Cook,S.A., Bustin,M. and Davisson,M.T.
  TITLE     Genetic mapping of the murine gene and 14 related sequences
            encoding chromosomal protein HMG-14
  JOURNAL   Mamm Genome 3 (11), 625-632 (1992)
   PUBMED   1360278
REFERENCE   8  (bases 1 to 1200)
  AUTHORS   Landsman,D. and Bustin,M.
  TITLE     Mouse non-histone chromosomal protein HMG-14 cDNA sequence
  JOURNAL   Nucleic Acids Res 18 (17), 5311 (1990)
   PUBMED   2402471
REFERENCE   9  (bases 1 to 1200)
  AUTHORS   Pash,J., Popescu,N., Matocha,M., Rapoport,S. and Bustin,M.
  TITLE     Chromosomal protein HMG-14 gene maps to the Down syndrome region of
            human chromosome 21 and is overexpressed in mouse trisomy 16
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3836-3840 (1990)
   PUBMED   2140193
REFERENCE   10 (bases 1 to 1200)
  AUTHORS   Vartiainen,E., Palvimo,J., Mahonen,A., Linnala-Kankkunen,A. and
            Maenpaa,P.H.
  TITLE     Selective decrease in low-Mr HMG proteins HMG I and HMG Y during
            differentiation of mouse teratocarcinoma cells
  JOURNAL   FEBS Lett 228 (1), 45-48 (1988)
   PUBMED   3342876
  REMARK    Erratum:[FEBS Lett 1989 Jul 17;251(1-2):283]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010763.1 and BU923172.1.
            
            On Jan 30, 2004 this sequence version replaced NM_008251.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088834.1, AK010763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AK010763.1         7-94
            89-659              BU923172.1         30-600
            660-1200            AK010763.1         666-1206
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.83 cM"
     gene            1..1200
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /note="high mobility group nucleosomal binding domain 1"
                     /db_xref="GeneID:15312"
                     /db_xref="MGI:MGI:96120"
     exon            1..136
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..412
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /note="high mobility group nucleosome-binding
                     domain-containing protein 1; high mobility group protein
                     14"
                     /codon_start=1
                     /product="non-histone chromosomal protein HMG-14"
                     /protein_id="NP_032277.3"
                     /db_xref="CCDS:CCDS28353.1"
                     /db_xref="GeneID:15312"
                     /db_xref="MGI:MGI:96120"
                     /translation="MPKRKVSADGAAKAEPKRRSARLSAKPAPAKVDAKPKKAAGKDK
                     ASDKKVQIKGKRGAKGKQADVADQQTTELPAENGETENQSPASEEEKEAKSD"
     exon            137..166
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /inference="alignment:Splign:2.1.0"
     exon            167..196
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /inference="alignment:Splign:2.1.0"
     exon            197..247
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /inference="alignment:Splign:2.1.0"
     exon            248..370
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1200
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1177..1182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /note="hexamer: AATAAA"
     polyA_site      1200
                     /gene="Hmgn1"
                     /gene_synonym="HMG-14; Hmg14"
                     /note="major polyA site"
ORIGIN      
        1 ctcccaccgc ccccgcgacg ggtcgcagca gttcgtgtgg tggtggcggc ggcggcttgg
       61 cagtgcggct cctcggtgac agatccgacg acgcacgcgt ctcccacccc gcgccgccac
      121 gatgcccaag aggaaggtta gcgcggatgg agccgccaag gcggagccca agcgccgctc
      181 cgcgaggctg tcggccaagc ccgcccctgc caaggtggac gcgaagccga aaaaggccgc
      241 gggaaaggat aaagcatcag acaaaaaagt gcagataaaa gggaagaggg gagcgaaggg
      301 caaacaggct gacgtggctg accagcaaac cacagagctg cctgcagaaa atggagagac
      361 ggaaaaccag agtccagcct ctgaagaaga gaaagaagct aagtccgact aagcatccat
      421 cacgtctgtc agtggtcccg cctcccttct tgtacaatcc agaggaatat ttttatcaac
      481 tattttgtaa atgcgagttt tttagtagct ctagaaacat ttttaaaagg tgaggggatc
      541 ccacctcatc ccatttttta agtgtaaatg gtttttttaa gaggttaaat catttgctgg
      601 ttgtttattt tttggtacaa ccagaaaata gcaggatact gaatcaggag aggctgtgac
      661 tgtctcgggg gtcaccataa cattccgtag atggggctag ttttatatcc tataatacaa
      721 agtatactaa atggcaattt ggcgtctcag tcgtgcattc gtgtctgaaa tattttcagt
      781 tctatctggt cccgtgtttc tagtagaacc attttgtaag aaagccagtc cttggccctt
      841 gccctgtcag aactgtgatg tctgtggtca tggcagtcca ttttcctaac agttgtgata
      901 atgtgctgtg aaagatggaa gtcctgagtc tgttctgtgt gtggcgtaac attgtgaatt
      961 ggtgggactg aggattacag gcatttggtt gttgtgagag gtcttggggg aacttgccga
     1021 gtcactggaa caagttcaaa gaaaaacaat acgtagctct tcatttgtgt acatgaacac
     1081 aatgtgactt cagagtttgg gtacgtgaac acagtatatg gctctttttg ggtacatgta
     1141 ataaaaattg gaatgtctgt actctgctcc tcgaccaata aaatctgttg tgaaagagta
//
