LOCUS       NM_008256               3294 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
            (Hmgcs2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_008256 XM_979229
VERSION     NM_008256.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3294)
  AUTHORS   Yang,J., Pan,X., Xu,M., Li,Y., Liang,C., Liu,L., Li,Z., Wang,L. and
            Yu,G.
  TITLE     Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration
            promotes pulmonary fibrosis by activating fibroblasts
  JOURNAL   Respir Res 25 (1), 176 (2024)
   PUBMED   38658970
  REMARK    GeneRIF: Downregulation of HMGCS2 mediated AECIIs lipid metabolic
            alteration promotes pulmonary fibrosis by activating fibroblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3294)
  AUTHORS   Sun,X., Zhang,B., Sun,K., Li,F., Hu,D., Chen,J., Kong,F. and Xie,Y.
  TITLE     Liver-Derived Ketogenesis via Overexpressing HMGCS2 Promotes the
            Recovery of Spinal Cord Injury
  JOURNAL   Adv Biol (Weinh) 8 (2), e2300481 (2024)
   PUBMED   37990936
  REMARK    GeneRIF: Liver-Derived Ketogenesis via Overexpressing HMGCS2
            Promotes the Recovery of Spinal Cord Injury.
REFERENCE   3  (bases 1 to 3294)
  AUTHORS   Ma,W., Arima,Y., Umemoto,T., Yokomizo,T., Xu,Y., Miharada,K.,
            Tanaka,Y. and Suda,T.
  TITLE     Metabolic regulation in erythroid differentiation by systemic
            ketogenesis in fasted mice
  JOURNAL   Exp Hematol 129, 104124 (2024)
   PUBMED   37898316
REFERENCE   4  (bases 1 to 3294)
  AUTHORS   Zou,X.Z., Hao,J.F. and Hou,M.X.
  TITLE     Hmgcs2 regulates M2 polarization of macrophages to repair
            myocardial injury induced by sepsis
  JOURNAL   Aging (Albany NY) 15 (15), 7794-7810 (2023)
   PUBMED   37561521
  REMARK    GeneRIF: Hmgcs2 regulates M2 polarization of macrophages to repair
            myocardial injury induced by sepsis.
REFERENCE   5  (bases 1 to 3294)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3294)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
REFERENCE   7  (bases 1 to 3294)
  AUTHORS   Castellani,L.W., Weinreb,A., Bodnar,J., Goto,A.M., Doolittle,M.,
            Mehrabian,M., Demant,P. and Lusis,A.J.
  TITLE     Mapping a gene for combined hyperlipidaemia in a mutant mouse
            strain
  JOURNAL   Nat Genet 18 (4), 374-377 (1998)
   PUBMED   9537422
REFERENCE   8  (bases 1 to 3294)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 3294)
  AUTHORS   Boukaftane,Y., Duncan,A., Wang,S., Labuda,D., Robert,M.F.,
            Sarrazin,J., Schappert,K. and Mitchell,G.A.
  TITLE     Human mitochondrial HMG CoA synthase: liver cDNA and partial
            genomic cloning, chromosome mapping to 1p12-p13, and possible role
            in vertebrate evolution
  JOURNAL   Genomics 23 (3), 552-559 (1994)
   PUBMED   7851882
REFERENCE   10 (bases 1 to 3294)
  AUTHORS   Valera,A., Pelegrin,M., Asins,G., Fillat,C., Sabater,J., Pujol,A.,
            Hegardt,F.G. and Bosch,F.
  TITLE     Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA
            synthase in transgenic mice causes hepatic hyperketogenesis
  JOURNAL   J Biol Chem 269 (9), 6267-6270 (1994)
   PUBMED   7907092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121771.3, AK004865.1 and AC147476.3.
            
            On Jun 16, 2009 this sequence version replaced NM_008256.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004865.1, BC014714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC121771.3         180684-180687
            5-2627              AK004865.1         3-2625
            2628-3294           AC147476.3         63510-64176         c
FEATURES             Location/Qualifiers
     source          1..3294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.74 cM"
     gene            1..3294
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /note="3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2"
                     /db_xref="GeneID:15360"
                     /db_xref="MGI:MGI:101939"
     exon            1..157
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            158..612
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            613..738
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            739..903
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1069
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1240
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1347
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1473
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1585
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..3294
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /note="hexamer: ATTAAA"
     polyA_site      1998
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /note="major polyA site"
     regulatory      3267..3272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /note="hexamer: AATAAA"
     polyA_site      3288
                     /gene="Hmgcs2"
                     /gene_synonym="1300002P16; mHS"
                     /note="major polyA site"
ORIGIN      
        1 gggcatctct cccaagggct gtggactgct ggctttctgt tgatacctta gagatgcagc
       61 ggcttttggc tccagcgagg cgggtcctgc aagtgaagag agcgatgcag gaaacttcgc
      121 tcacacctgc tcacctgctc tcagcagccc agcagaggtt ttctacaatc cctcctgctc
      181 ccctggccaa aacagataca tggccaaaag atgtgggcat ccttgccctg gaggtctatt
      241 ttccagccca atatgtggac caaactgacc tggaaaagtt caacaatgtg gaagcaggga
      301 agtatacagt gggcttgggc cagacccgta tgggcttctg ttcagtccag gaggacatca
      361 actccctgtg cctgacagtg gtacagaggc tgatggaacg cacaaagctg ccgtgggatg
      421 ctgtgggccg tctggaagtg ggcaccgaga ccatcattga caagtccaag gctgtcaaaa
      481 cagtgctcat ggaactgttc caggattcag gcaacactga catcgagggc atagatacca
      541 ccaacgcctg ttatggcggc acagcctccc tcttcaatgc tgccaactgg atggagtcca
      601 gctactggga tggtcgctat gccctggtgg tctgtggtga cattgcagtc tacccgagtg
      661 gtaacgcccg ccccacaggt ggtgctgggg ctgtggcaat gctgatcggg cccaaggccc
      721 ctctggtcct cgagcaaggg ctgaggggaa ctcacatgga gaacgcgtac gacttctaca
      781 aaccaaactt ggcctcagag tatccactgg tggatgggaa gctgtctatc cagtgctacc
      841 tgcgggcctt ggatcgatgc tatgcagcct accgcaagaa gatccagaat cagtggaagc
      901 aagctggaaa caaccagcct ttcaccctcg atgatgtgca gtatatgatc ttccacacac
      961 ccttttgcaa gatggtccag aaatccctgg ctcggttgat gttcaatgac ttcctgtcat
     1021 ccagcagtga caaacagaac aacttataca agggcctaga ggccttcagg ggtctaaagc
     1081 tggaagaaac ctacaccaac aaggatgtag acaaggctct tttgaaggcc tccctggaca
     1141 tgttcaacca gaagaccaag gcctcccttt acctctccac aaataatggg aacatgtaca
     1201 cctcttccct ctatggctgc ctggcctcac ttctctctca ccactctgcc caagaattgg
     1261 ctggctccag gattggagcc ttctcctacg gctcaggctt agcagcaagt ttcttttcat
     1321 tccgagtgtc caaggatgct tccccaggtt cccccctgga gaaactggtg tctagtgtgt
     1381 cagatctgcc caaacgtcta gactcccgga gacgcatgtc ccctgaggaa ttcacagaaa
     1441 taatgaacca gagagagcaa ttttaccaca aggtgaactt ctctccacct ggagacacaa
     1501 gcaatctctt cccaggtact tggtaccttg aacgagtgga tgagatgcat cgcaggaagt
     1561 atgcccggtg tcccgtctaa tggagatcca tgcaacaatt ccccggggaa agaaggtgag
     1621 ccgagctgct acccaaacag catctgctta aaatcccacc cacagcagta aatagggact
     1681 agacacagca gcctcatagg atctgctctg tggtgaacgg cctccctctg tgaatcctgg
     1741 gtgtctctcc ctgacacaat cagcgccaca ggctcatgct gctgtggacc agagctcccc
     1801 tgtgaagagg gagatgaaag aaaggggagc cgctgacctg cagggatgca gatctttccc
     1861 cacagcccgg cagagcagcc atttgttaca gcttattctc agactctggg ctattatagt
     1921 ttatgcttgt ttcttaaagt ttctaaattt tgtatcttgt tctaaaataa tatgtggcaa
     1981 ttaaaaagag agaagaaatt acttgtattt tctagaaggc aagacctact tactcagagg
     2041 actgaacact tacgtcacca ccccattaat taattctcca caagtctggc cagttctgca
     2101 aaggagtgtg gcagatacaa ggcaaataaa gacagtggca cagaacaccc actgcttact
     2161 tctctgtcct acagacacca tatccagatg gagccagcag gtactcagta gataactccc
     2221 cttgacatag gtggccagta ttagttaccg agactaaagg caaagcaaaa tccataaggt
     2281 tggccaggca tgatcatgca gaactgaaat ctcagcactt gggaagccga ggcagggctg
     2341 agttcaaggc tgatacatgt gaacttggtc tacagagcaa gttccaggac atccaaggct
     2401 ataaagagaa acagtcttga aaagcaacaa caacaacaga aacaaactca aaaggatgac
     2461 gcagaagtag aatcctctct tctttgggta aagagaacac agagtcctca taaaacagca
     2521 atgttttagg aatgtgagca ttgggcacaa gcaaagggga gaaaagaggg caggggaggg
     2581 ataggaagga caaggggttc tagtcttcca ttgtctttta gaaaaagctc tggacagagg
     2641 ttctgttgaa ccttgaggga agccagctgg ccgaggagcc tcaaacacac acatgaaatg
     2701 cggtgacggc catgtcccac caccagcagt aaagccgggc gaggcccagg ctgagcagct
     2761 aatccagccc tagcccctcc tcagcccctc catgcacatg agaccctcga tctttccaga
     2821 acttcttgca ggaccgtgct cccttcttag gtcactgcag ccatgtctgt ctacacgaaa
     2881 gagaagccag tgtccccctg gttcaagaca gggacacaga acccacgaag agctctctgc
     2941 agggtcttga cagccccccc tttctgtgtc ccattgttgg gccctggtat tcctctacca
     3001 gaagtcacat ggattcaact aggggatgat ctcaaagtaa cactgtggaa ctgggaagat
     3061 ggcccaggga gttaaggcac ctgctactaa ccttgacaac ctgagttcca tccctgggac
     3121 ccccatggta aagagataac ccattcctga aagtgtcctc ttgttaccaa acttggggtc
     3181 actgtttcta ctataagaaa tcaagttcag ccacctgtcc ccaagaagcc acctgtgcac
     3241 tttggcatga atgtgttcta tccctcaata aaatgcattt caaaattgtg tcaa
//
