LOCUS       NM_001291439            3518 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            (Hmgcs1), transcript variant 2, mRNA.
ACCESSION   NM_001291439 XM_006517577
VERSION     NM_001291439.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Chen,L., Huang,D., Huang,Z., Liu,X., He,M., Luo,M., Tang,Z.,
            Tan,G., Guo,Q. and Xiong,H.
  TITLE     Decreased HMGCS1 inhibits proliferation and inflammatory response
            of keratinocytes and ameliorates imiquimod-induced psoriasis via
            the STAT3/IL-23 axis
  JOURNAL   Int Immunopharmacol 133, 112033 (2024)
   PUBMED   38608446
  REMARK    GeneRIF: Decreased HMGCS1 inhibits proliferation and inflammatory
            response of keratinocytes and ameliorates imiquimod-induced
            psoriasis via the STAT3/IL-23 axis.
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Angelozzi,M., Pellegrino da Silva,R., Gonzalez,M.V. and Lefebvre,V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Shimano,H., Horton,J.D., Hammer,R.E., Shimomura,I., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Overproduction of cholesterol and fatty acids causes massive liver
            enlargement in transgenic mice expressing truncated SREBP-1a
  JOURNAL   J Clin Invest 98 (7), 1575-1584 (1996)
   PUBMED   8833906
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Valera,A., Pelegrin,M., Asins,G., Fillat,C., Sabater,J., Pujol,A.,
            Hegardt,F.G. and Bosch,F.
  TITLE     Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA
            synthase in transgenic mice causes hepatic hyperketogenesis
  JOURNAL   J Biol Chem 269 (9), 6267-6270 (1994)
   PUBMED   7907092
REFERENCE   10 (bases 1 to 3518)
  AUTHORS   Myohanen,S., Wahlfors,J., Alhonen,L. and Janne,J.
  TITLE     Nucleotide sequence of mouse spermidine synthase cDNA
  JOURNAL   DNA Seq 4 (5), 343-346 (1994)
   PUBMED   7803821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ071929.1, AK044835.1 and AK031297.1.
            
            On Apr 16, 2014 this sequence version replaced XM_006517577.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.78489.1,
                                           SRR1660811.162073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               CJ071929.1         3-381
            380-2105            AK044835.1         329-2054
            2106-3518           AK031297.1         2054-3466
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..3518
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /note="3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1"
                     /db_xref="GeneID:208715"
                     /db_xref="MGI:MGI:107592"
     exon            1..163
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            164..621
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1736
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /EC_number="2.3.3.10"
                     /note="HMG-CoA synthase; 3-hydroxy-3-methylglutaryl
                     coenzyme A synthase"
                     /codon_start=1
                     /product="hydroxymethylglutaryl-CoA synthase, cytoplasmic"
                     /protein_id="NP_001278368.1"
                     /db_xref="CCDS:CCDS56901.1"
                     /db_xref="GeneID:208715"
                     /db_xref="MGI:MGI:107592"
                     /translation="MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDA
                     GKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERHSLSYDCIGRLEVGTETIIDKSK
                     SVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWVESSSWDGRYALVVAGDI
                     AIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDG
                     KLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLA
                     RMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKAS
                     LLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRVGVFSYGSGLAATLYSLKVTQDA
                     TPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFE
                     GTWYLVRVDEKHRRTYARRPFTNDHSLDEGMGLVHSNTATEHIPSPAKKVPRLPATSA
                     ESESAVISNGEH"
     exon            622..747
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            748..912
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1078
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1249
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1356
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1482
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1646
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..3518
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3321..3326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3340
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /note="major polyA site"
     regulatory      3499..3504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="Hmgcs1"
                     /gene_synonym="B130032C06Rik"
ORIGIN      
        1 gagtcccggg attggcagag gtagccgctg tcccgccctc tgtcccctcc cggcgctgcc
       61 cgagtcgggt gggtcggtgg ctataaagct gcggagggcg ggaggcacag tctgcggtct
      121 ccttgctttg ctcgttcttc ttccagggtc tgatcccctt tggctctttc accatgcctg
      181 ggtcacttcc tttgaatgca gaggcttgct ggccaaaaga tgtgggaatc gttgcccttg
      241 aaatctactt tccttctcaa tatgtcgatc aagctgagtt ggaaaaatac gatggtgtag
      301 atgctggaaa gtataccatc ggcctgggcc aggccaggat gggcttctgc acggatcgtg
      361 aagacatcaa ctctctttgc ctgactgtgg ttcagaaact gatggagaga catagccttt
      421 cctatgattg cattgggcgg ctagaagttg gaacagagac aatcatcgac aaatcgaaat
      481 cagtgaagtc taatttgatg cagctgtttg aggagtctgg gaatacagat atagaaggaa
      541 tagatacaac caatgcatgc tatgggggca cagctgcagt cttcaatgcc gtgaactggg
      601 tcgaatccag ctcttgggat ggacgatatg ctctggtagt tgcaggagac attgctatat
      661 atgccacagg aaatgccaga cctacaggtg gagttggagc tgtggccctg ctaattgggc
      721 caaacgctcc tctaattttt gaccgagggc tccgtgggac acacatgcag catgcctatg
      781 acttttacaa gcctgacatg ctctccgagt accctgtggt cgacggaaag ctctccatac
      841 agtgctacct cagcgccctg gaccgctgct attctgtcta ccgcaaaaag atccgtgccc
      901 agtggcagaa agagggaaag gataaagatt ttaccctgaa tgattttggc ttcatgatct
      961 ttcactcacc atattgtaaa ctggtgcaga aatctctagc tcggatgttc ctgaatgact
     1021 ttcttaatga tcaaaacaga gataaaaaca gtatttacag tggactggaa gcctttgggg
     1081 acgttaaatt agaagatact tactttgaca gagatgtaga aaaggcattt atgaaggcta
     1141 gttctgagct attcaaccag aaaacaaagg cgtctttgct tgtgtctaat cagaatggaa
     1201 atatgtacac atcctctgtc tatggttccc tggcttctgt cctggcacag tactcacctc
     1261 agcagttggc agggaagagg gttggagtgt tctcttacgg ttctggcttg gctgccacgc
     1321 tgtactccct taaagtcaca caagacgcca caccaggatc tgcccttgat aaaataacag
     1381 caagtttatg tgaccttaaa tcaaggcttg actcgagaac ttgtgtggca ccggatgtct
     1441 ttgctgaaaa catgaagctc agagaggaca cacatcactt agccaactat attccccagt
     1501 gttcaataga ctcactcttt gaaggaacgt ggtatctggt cagagtggat gaaaaacaca
     1561 gaaggactta cgcccggcgc cccttcacaa atgaccacag tttggatgaa ggaatggggc
     1621 tcgtgcatag taacacagca acagagcata ttccaagccc tgctaagaaa gtgccaagac
     1681 tccctgcaac ctcggccgaa tctgaatcag ctgtcatcag taacggggag cactgagagt
     1741 ctgtggcctt tacagaggct cggggccggg atggggtatg gaaacggttg gaggaatgga
     1801 tgtcttggga caattttgca gattatgtgt tgcttaaaat gtaatgtaac tgacacagag
     1861 cccagaaagc tattgtgttt ttggaaaagt ctctgctgaa ctgaacttgc taacatgctt
     1921 cctgttgtgg tctggccagt ggtaaatgta ctgcagtgat gttaaagggc tctgtagaac
     1981 tttatacctc tctggatgtt tatacgcatg cagtttagtt ttcagatgtg gtatgaactg
     2041 agtgcttctg acagcaaaag gcagaggtac tagtgtccaa tttttaaaaa aacgtttttt
     2101 tttttctttt tttatgtgta agaattttat acttaaagta tctgtagctt ttggggtgaa
     2161 aaaaaacttt tctaggttgg gggttgtgaa atttaaatgt tacacacaag accctgtttg
     2221 aaaatggcaa ggcaaacatt tatctttttc aaagatttgt aaatcctgaa gagaaaaaag
     2281 agggtatggt tctaagatct ggatgaacca tcagtgagag gaaggttagc tgtaatcacg
     2341 tgagcagaaa gatgctggca ctgagcaggc ctccatcgtg ttgggcaggg tacacctggg
     2401 cgttgtggac acagctgcgg gaactttttg gccaggtctc cgtggcagtg ctcagcagca
     2461 ctgagagatg gcgctggagc ttgctgccct cctgagcacc ctccctgggg gataaagtgt
     2521 gaagtaggaa ggatggggca ggcattatta ggttagtgtt acagatccag tttatagact
     2581 gacagcttca attcacggga cacctttttt cctttgtggt ttgtgtattt ctgtgttttg
     2641 tttgtttttg tatccgttcg aaaatttaac ccacattttc acatagtgaa aatttcacat
     2701 ggtctgatta gccaaaaaag aataagatct agaagtagaa ctcacaccat tttttttctt
     2761 aactttgatt tctaaaacaa caaaaactac cacatgagct gaataagaaa attcactagc
     2821 aagttctctg gatgattttt ggtgctgaac aatgacatga gcctcagact gtaaaataga
     2881 ggtagttgga actaatgtac agaactaaat ttcttaacct tatttgcgtt taattctgtg
     2941 aagtttcagt tatctaaaat aaatgtgtaa tgtttcagat tgcaaggtga taagtaatgt
     3001 agcatttgta agatactctt gtcaatatta actagtagga ttttgatttg tacagtttta
     3061 attggttaaa atgatctcat tttaacatcc actgctatag atgaataatg taagttcaga
     3121 tttaatgaat ggtggggaga tggtgcatgt aatttttttg caagtattga gagttctgta
     3181 tgttttgaaa agagtaattt taacgtttgg gtgccaagaa gtgggttttc tcagagtcca
     3241 ttgccggcaa tgggcaagcc tggcggtact ggcacggagc gttaaccaca ccttactaat
     3301 agcaaggcca ataactttga aataaagttt tagacaaata tttcagctct ttgagtgttt
     3361 tttttttccc tgagggaaca gtttgtttat ggagtcagca aataggtatt ttaaacgtgg
     3421 gccttcagtt ggttactcat ttgcttagtc ttcaaacatt tccaaaccca gtataaataa
     3481 cacactcttt ataccagaaa taaactgtat tgcctgtg
//
