LOCUS       NM_008255               4444 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
            (Hmgcr), transcript variant 1, mRNA.
ACCESSION   NM_008255 XM_127496
VERSION     NM_008255.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4444)
  AUTHORS   Liepinsh,E., Zvejniece,L., Clemensson,L., Ozola,M., Vavers,E.,
            Cirule,H., Korzh,S., Skuja,S., Groma,V., Briviba,M., Grinberga,S.,
            Liu,W., Olszewski,P., Gentreau,M., Fredriksson,R., Dambrova,M. and
            Schioth,H.B.
  TITLE     Hydroxymethylglutaryl-CoA reductase activity is essential for
            mitochondrial beta-oxidation of fatty acids to prevent lethal
            accumulation of long-chain acylcarnitines in the mouse liver
  JOURNAL   Br J Pharmacol 181 (16), 2750-2773 (2024)
   PUBMED   38641905
  REMARK    GeneRIF: Hydroxymethylglutaryl-CoA reductase activity is essential
            for mitochondrial beta-oxidation of fatty acids to prevent lethal
            accumulation of long-chain acylcarnitines in the mouse liver.
REFERENCE   2  (bases 1 to 4444)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   3  (bases 1 to 4444)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4444)
  AUTHORS   Edwards,W., Greco,T.M., Miner,G.E., Barker,N.K., Herring,L.,
            Cohen,S., Cristea,I.M. and Conlon,F.L.
  TITLE     Quantitative proteomic profiling identifies global protein network
            dynamics in murine embryonic heart development
  JOURNAL   Dev Cell 58 (12), 1087-1105 (2023)
   PUBMED   37148880
REFERENCE   5  (bases 1 to 4444)
  AUTHORS   Yogev,Y., Shorer,Z., Koifman,A., Wormser,O., Drabkin,M.,
            Halperin,D., Dolgin,V., Proskorovski-Ohayon,R., Hadar,N.,
            Davidov,G., Nudelman,H., Zarivach,R., Shelef,I., Perez,Y. and
            Birk,O.S.
  TITLE     Limb girdle muscular disease caused by HMGCR mutation and statin
            myopathy treatable with mevalonolactone
  JOURNAL   Proc Natl Acad Sci U S A 120 (7), e2217831120 (2023)
   PUBMED   36745799
  REMARK    GeneRIF: Limb girdle muscular disease caused by HMGCR mutation and
            statin myopathy treatable with mevalonolactone.
REFERENCE   6  (bases 1 to 4444)
  AUTHORS   Goodrum,J.F., Bouldin,T.W., Zhang,S.H., Maeda,N. and Popko,B.
  TITLE     Nerve regeneration and cholesterol reutilization occur in the
            absence of apolipoproteins E and A-I in mice
  JOURNAL   J Neurochem 64 (1), 408-416 (1995)
   PUBMED   7798939
REFERENCE   7  (bases 1 to 4444)
  AUTHORS   Myohanen,S., Wahlfors,J., Alhonen,L. and Janne,J.
  TITLE     Nucleotide sequence of mouse spermidine synthase cDNA
  JOURNAL   DNA Seq 4 (5), 343-346 (1994)
   PUBMED   7803821
REFERENCE   8  (bases 1 to 4444)
  AUTHORS   Hwa,J.J., Zollman,S., Warden,C.H., Taylor,B.A., Edwards,P.A.,
            Fogelman,A.M. and Lusis,A.J.
  TITLE     Genetic and dietary interactions in the regulation of HMG-CoA
            reductase gene expression
  JOURNAL   J Lipid Res 33 (5), 711-725 (1992)
   PUBMED   1352323
REFERENCE   9  (bases 1 to 4444)
  AUTHORS   Helmberg,A., Fassler,R., Geley,S., Johrer,K., Kroemer,G., Bock,G.
            and Kofler,R.
  TITLE     Glucocorticoid-regulated gene expression in the immune system.
            Analysis of glucocorticoid-regulated transcripts from the mouse
            macrophage-like cell line P388D1
  JOURNAL   J Immunol 145 (12), 4332-4337 (1990)
   PUBMED   2258621
REFERENCE   10 (bases 1 to 4444)
  AUTHORS   Sundaresan,S., Yang-Feng,T.L. and Francke,U.
  TITLE     Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse
            chromosome 13
  JOURNAL   Somat Cell Mol Genet 15 (5), 465-469 (1989)
   PUBMED   2781417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154851.3, BY124492.1, AK159899.1, AK048784.1, AK079302.1 and
            BM899288.1.
            
            On Nov 16, 2007 this sequence version replaced NM_008255.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159899.1, BC085083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC154851.3         89686-89726         c
            42-112              BY124492.1         2-72
            113-1161            AK159899.1         2-1050
            1162-1326           AK048784.1         2065-2229
            1327-3408           AK159899.1         1215-3296
            3409-3952           AK079302.1         1610-2153
            3953-4403           AK159899.1         3840-4290
            4404-4444           BM899288.1         1-41                c
FEATURES             Location/Qualifiers
     source          1..4444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.65 cM"
     gene            1..4444
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /note="3-hydroxy-3-methylglutaryl-Coenzyme A reductase"
                     /db_xref="GeneID:15357"
                     /db_xref="MGI:MGI:96159"
     exon            1..126
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            127..314
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2813
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /EC_number="1.1.1.34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HMG-CoA reductase; 3-hydroxy-3-methylglutaryl-CoA
                     reductase"
                     /codon_start=1
                     /product="3-hydroxy-3-methylglutaryl-coenzyme A reductase
                     isoform 1"
                     /protein_id="NP_032281.2"
                     /db_xref="CCDS:CCDS26706.1"
                     /db_xref="GeneID:15357"
                     /db_xref="MGI:MGI:96159"
                     /translation="MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKIC
                     GWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFS
                     SFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARG
                     MAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL
                     VLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIAD
                     PSPQNSTAEQAKVSLGLDEDVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLAFLLAV
                     KYIFFEQAETESTLSLKNPITSPVVTSKKAQDNCCRREPLLVRRNQKLSSVEEDPGAN
                     QERKVEVIKPLVVEAETTSRATFVLGASVASPPSALGTQEPGIELPIEPRPNEECLQI
                     LENAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLAEPSSL
                     QYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTN
                     RGCRAISLGGGASSRVLADGMTRGPVVRLPRACDSAEVKTWLETPEGFAVIKEAFDST
                     SRFARLQKLHVTMAGRNLYIRFQSRTGDAMGMNMISKGTEKALLKLQEFFPDMQILAV
                     SGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSA
                     MAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPS
                     IEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAAL
                     AAGHLVRSHMVHNRSKINLQDLQGTCTKKAA"
     exon            315..426
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            427..514
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            515..599
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            600..705
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            706..812
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            813..929
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1090
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1338
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1514
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1709
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1868
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2026
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2132
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2303
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2444
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2603
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2758
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..4430
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4031..4036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /note="hexamer: AATAAA"
     polyA_site      4058
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /note="major polyA site"
     regulatory      4399..4404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /note="hexamer: AGTAAA"
     polyA_site      4430
                     /gene="Hmgcr"
                     /gene_synonym="HMG-CoAR; Red"
                     /note="major polyA site"
ORIGIN      
        1 gacgatcctt ccttattggc ggcccgctgg cggcctggag cgtgcgtaag cgcagttcct
       61 tccgcccggg gctccgttgg ctggagacgg cagctgggcc ggcttggcct ccattgagat
      121 ccggaggatc caaggactgt gaggctacaa tgttgtcaag acttttccgg atgcatggcc
      181 tcttcgtggc ctcccacccc tgggaagtta ttgtgggaac agtgacactt acaatctgta
      241 tgatgtccat gaacatgttc accggcaaca acaagatctg tggctggaat tatgagtgcc
      301 ctaaatttga agaggacgtg ctgagcagcg acatcatcat cctgacgata acgcggtgca
      361 tcgccatcct gtacatttac ttccagttcc agaacctacg gcagcttggg tccaagtaca
      421 ttctgggtat tgctggcctc ttcacaattt tctcaagctt tgtcttcagt acagtcgtca
      481 ttcatttcct cgacaaagaa ctgacaggct taaatgaagc tttgcccttt tttctgctct
      541 tgattgacct ttctagagcg agtgcattag caaagtttgc cctcagttca aattcacagg
      601 atgaagtaag ggaaaatata gctcgtggaa tggcaatcct gggccccaca ttcactcttg
      661 acgctcttgt ggaatgcctt gtgattggag ttggcaccat gtcaggcgtc cgccagctgg
      721 agatcatgtg ctgcttcggc tgcatgtcag tgttggccaa ctactttgtg ttcatgacat
      781 tcttcccggc ctgtgtgtcg ctggtcctag agctttctcg tgaaagccgt gagggtcgtc
      841 caatttggca gctcagccat tttgccagag ttttagaaga agaagaaaat aaaccaaacc
      901 ccgtaaccca aagggtcaag atgattatgt ctttaggctt ggtccttgtt cacgctcata
      961 gtcgctggat agctgatcct tctcctcaga acagcacagc ggagcaggct aaggtttcct
     1021 tgggtctgga cgaagatgtg tccaagagaa ttgaaccaag tgtttctctc tggcagtttt
     1081 atctctccaa gatgatcagc atggacattg agcaagtgat taccctgagt ttagccttcc
     1141 ttttggctgt caagtatatt ttctttgaac aagcagagac agaatcgaca ctgtcattaa
     1201 aaaatcctat cacgtctccc gtcgtgacct caaagaaagc tcaagacaac tgttgtagac
     1261 gtgagcctct gcttgtgaga aggaaccaga agctttcgtc agtagaggag gatccaggag
     1321 cgaaccaaga gagaaaagtt gaggttataa aaccattagt ggtggaagca gagactacaa
     1381 gcagagctac gtttgtgctt ggggcttctg tagccagccc tccatccgcc ctggggacac
     1441 aggagcctgg aattgaactc cccatcgagc cacgacctaa tgaagaatgt ctgcagatac
     1501 tggagaatgc agagaaaggt gcaaagttcc ttagtgatgc agagatcatc cagttggtca
     1561 atgccaagca tatcccagct tacaaattgg aaactctaat ggaaactcat gaacgtggtg
     1621 tgtctattcg ccggcagctc ctctccacaa agcttgcaga gccgtcctct ctacagtacc
     1681 tgccttacag agattataat tattccttgg tgatgggagc ttgctgtgag aatgtgatcg
     1741 gatatatgcc catccctgtt ggagtggcag ggcctctgtg cctggatggg aaggagtacc
     1801 aggtgccgat ggcaacgacg gaaggctgtc ttgtggccag cactaacaga ggctgcagag
     1861 ccataagcct tggtggaggt gccagcagcc gggtccttgc agatgggatg actcgaggcc
     1921 cagtggtgcg tcttccacgt gcttgtgact ctgcagaagt aaagacctgg cttgaaacac
     1981 ctgaagggtt tgcagtgata aaggaggcct ttgatagcac cagcagattt gctcgtctac
     2041 agaaactcca cgtgacgatg gcaggacgca acctctatat ccgtttccag tccaggacgg
     2101 gggacgccat gggcatgaac atgatctcta agggtacgga gaaagcactg ctgaagcttc
     2161 aggagttctt tcctgacatg cagattctgg cagtcagtgg gaactattgc accgacaaga
     2221 agcctgctgc cataaattgg atcgaaggac gaggaaagac tgtggtttgt gaagccgtca
     2281 ttccagccaa ggtggtgaga gaggtgttaa agacaactac ggaagctatg gttgacgtaa
     2341 acattaacaa gaatcttgtg ggctcggcca tggctgggag cataggcggc tacaacgccc
     2401 acgcagcaaa cattgtcact gctatctaca tcgcatgtgg ccaggatgca gcacagaatg
     2461 tggggagttc aaactgtatt actttaatgg aagccagtgg tcccacaaat gaagacttat
     2521 atatcagctg caccatgcca tcgatagaga taggaaccgt gggtggtggg accaaccttc
     2581 tacctcagca agcctgcctg cagatgctag gtgttcaagg agcatgcaaa gacaatcctg
     2641 gagaaaacgc acggcagctt gcccgaattg tatgtggcac tgtgatggct ggtgagctgt
     2701 ccttgatggc agccttggca gcaggacatc ttgtcagaag tcacatggtt cacaacagat
     2761 caaagataaa tttacaagat cttcaaggaa cgtgcaccaa gaaggcagct tgaggatcct
     2821 gacactgaac tgaagcgcgg gcattgggtt ctcaaggact aacatgcaat ctgtgaatta
     2881 aaaatctcaa tgcactgtct agtggaagat gaatggacat gatcagtgac acccctgctt
     2941 ggtttctggc gctttcagag acgtctgagg ttctttgcac agagactcct cagatgtggg
     3001 aactctggtt ctttccgtgc tgtgttctgg agagatctca cgtggatggt accggtgctc
     3061 tgagcaccac agatgtgagc tacagttcgt ttctgaaagc taccacaagc tggaaactgg
     3121 tgatcagtgt ggggctcacc tctccgtggg ttaaaaatgg ttttaaatga cactgtagct
     3181 gacagaactt ctgatcttta tttattcagt ctgggttgta gaactttgca atctaagttt
     3241 attttttgta aactaataat tcatttggtg ctggtctatt gattgggggc ctacttcttc
     3301 atggaagaat tacttttatt ctcaaactac agaataatgt gctaagtagt gctaaatagt
     3361 tcttgacgaa gaaaacagtc actgcattta tctctgtgag tctttgttca gagaggcctt
     3421 tagtctagat tctgccagct gtgccacact ctgcactaaa gatatcagag ctcttagtgt
     3481 tacttagagg agagtacaag caagtcggac ctctcagaac ttagagtgtg ggaacagttt
     3541 tttttttttt tttaaaaaaa acaaaaaaca aacgaccatt tctctaagcc aagtttcttt
     3601 tagagacatt ttaacttatt tagctgaact ctagattttt tggtaaacta tcaatctgta
     3661 tatgttgtaa ttaagtgtct aatgctagga gtttattgga agtgtttaag aaataaaaga
     3721 actcaacttt tacactgata aaatactcta gcttgggcca gagaagacag tgctcgttag
     3781 cactggtcca ggaaaccctg gcttgctttc caagcccaat gaagggaaag tcagcttaca
     3841 gagccaatga tggagccaca tgaatggccc tggagctgtg tgccttgttc ctgtggccag
     3901 gagtttggtg actgaatcat ttatgggctc ctttaatggg cccataaaag ctcttagctt
     3961 cctcaggggg tcagcagagt tgttgaatct taattttttt tttttaatgt accagttttg
     4021 tataaataat aataaagagc tccttatttt gtattctatc taatgcttca agtttggtct
     4081 tgggaagctg acatttgtgt agaagatgga ctctgaaaga cattccaaga gtgccgcggc
     4141 agcatgggag cctcttagtg attgtgtcag tattattgtg gaagattgcc tttgctgttg
     4201 tatgtaaagt ttcaaattgc tcctcttgtg acttttcagc cagtaccatt ttatttacct
     4261 gagcttgtca tggaagtggc agtaaaaagt attgagtgtt ttatgctggt gactgtaacc
     4321 aatgtcatct tgctaaattc atgttttgta caattactaa attgtataca ttttgttata
     4381 gaatactttt tccagttgag taaattatga aaggaagtta acattgaaaa aaaaaaaaaa
     4441 aaaa
//
