LOCUS       NM_173731               3626 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
            1 (Hmgcll1), transcript variant 1, mRNA.
ACCESSION   NM_173731
VERSION     NM_173731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Soulez,M., Saba-El-Leil,M.K., Turgeon,B., Mathien,S., Coulombe,P.,
            Klinger,S., Rousseau,J., Levesque,K. and Meloche,S.
  TITLE     Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
            in Perinatal Survival and Postnatal Growth Using New Genetically
            Engineered Mouse Models
  JOURNAL   Mol Cell Biol 39 (6), e00527-18 (2019)
   PUBMED   30642949
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Dietrich,J.E., Panavaite,L., Gunther,S., Wennekamp,S., Groner,A.C.,
            Pigge,A., Salvenmoser,S., Trono,D., Hufnagel,L. and Hiiragi,T.
  TITLE     Venus trap in the mouse embryo reveals distinct molecular dynamics
            underlying specification of first embryonic lineages
  JOURNAL   EMBO Rep 16 (8), 1005-1021 (2015)
   PUBMED   26142281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079244.29.
            
            On Jul 28, 2022 this sequence version replaced NM_173731.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037381.1, AK141622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC079244.29        200197-200413       c
            218-298             AC079244.29        159128-159208       c
            299-406             AC079244.29        158820-158927       c
            407-502             AC079244.29        142657-142752       c
            503-651             AC079244.29        140563-140711       c
            652-715             AC079244.29        133925-133988       c
            716-904             AC079244.29        130888-131076       c
            905-1030            AC079244.29        84942-85067         c
            1031-3626           AC079244.29        79029-81624         c
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.43 cM"
     gene            1..3626
                     /gene="Hmgcll1"
                     /note="3-hydroxymethyl-3-methylglutaryl-Coenzyme A
                     lyase-like 1"
                     /db_xref="GeneID:208982"
                     /db_xref="MGI:MGI:2446108"
     exon            1..217
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1141
                     /gene="Hmgcll1"
                     /EC_number="4.1.3.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2;
                     3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1;
                     3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic;
                     3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1;
                     3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic"
                     /codon_start=1
                     /product="3-hydroxy-3-methylglutaryl-CoA lyase,
                     cytoplasmic isoform 1"
                     /protein_id="NP_776092.1"
                     /db_xref="CCDS:CCDS23349.1"
                     /db_xref="GeneID:208982"
                     /db_xref="MGI:MGI:2446108"
                     /translation="MGNLPSAAKHCLNYQQLLREHLWSGDSVAGALDAAQEASQLPGL
                     PEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSRWVPQMAD
                     HAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNINCSIEE
                     SMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLG
                     DTIGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVS
                     GLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVA
                     QASFNARLE"
     exon            218..298
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..406
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..502
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..651
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..715
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..904
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1030
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..3626
                     /gene="Hmgcll1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcll1"
                     /note="hexamer: AATATA"
     polyA_site      2011
                     /gene="Hmgcll1"
     regulatory      3605..3610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgcll1"
                     /note="hexamer: AATAAA"
     polyA_site      3626
                     /gene="Hmgcll1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcagc tcggaccccg ggcacccgcg ggacgcgctc ccggctctca cccggctctc
       61 ggctccggcc gtgggatcca gcaccgccca cggcacctag gctgctgcta tggggaatct
      121 accatctgct gcgaagcact gcctcaacta ccagcagctt ctccgcgaac atctctggag
      181 cggagactca gtggcagggg cgctggatgc ggcgcaggaa gcatctcagt tacctggact
      241 ccctgaatat gtgaaaatag tcgaagttgg accaagggat ggattgcaga atgaaaaggt
      301 tatagttccc acagacataa aaattgaact catcaatcaa ctttcccaaa ctggcttgtc
      361 tgtaatagaa gtaaccagct ttgtgtcttc cagatgggta ccacagatgg ctgaccatgc
      421 tgaagtgatg cgaggcattc gtcagtatcc aggagttcgc tatcctgtcc ttacacctaa
      481 tcttcagggt tttcagcatg ctgttgctgc tggagccacg gagatagcag tttttggtgc
      541 tgcttcagaa tcttttagca agaagaatat taactgctcc attgaagaaa gtatgggaag
      601 gtttcaggag gtcatcagct ctgcaagaca catggacatc ccagtgcgag ggtacgtgtc
      661 ctgcgccctg ggctgcccat atgaaggaag catcacacca cagaaagtca cagaagtttc
      721 aaagagattg tatggtatgg gctgctatga aatatctttg ggcgacacga ttggagttgg
      781 tactccaggc agcatgaaga tgatgttgga aagtgtcatg aaagaaatcc ctccaggggc
      841 tcttgctgtt cattgccatg acacatatgg acaagccctc gcaaatatcc taacagctct
      901 tcagatgggg attaatgtgg tggattctgc tgtatccgga ttaggtggct gcccttatgc
      961 aaaaggtgct tctgggaatg tagccactga ggatttgata tatatgctca atggcatggg
     1021 gctcaataca ggtgtggatc tctacaaggt gatggaagct ggtgagttta tttgcaaggc
     1081 agtgaacaaa actacaaact ctaaagtcgc acaagcctcc ttcaacgctc gccttgaatg
     1141 agtttgtgat ttaagaaaga gcagagccct tccagcccta gttcatcaca gtgtcattag
     1201 tgccaacaca ttctgaagtg gaagttaata aaaagagctg ggagaggagc tatgcttgga
     1261 tagaccgtga agtggatggg gcaagacaag gcgtctgttc aactgcaagc tgagaatgag
     1321 ccccactgct tgcccttctg gtggtggaca aagcctgctc gtttgctctt acagaaatca
     1381 ttatattttt tagcttagta gaactgaaaa ttgacttcag atttctctaa gtatcaagtg
     1441 ctgtgttaat gcctcctcaa gccaccttac cgcagggtac acattgttag tggtttatga
     1501 gcctcgacac aatgcagagt gtgtggccct gaagttgtgt ttcccccccc ccctctggat
     1561 cctaactctc catttgccaa gtttgttaag ttgtggacca agagccaaag tttcatccga
     1621 cccaacatat tttttagcaa tagaactttt atatttcgag tgcggctaac atctgttaac
     1681 tatttcaatg actttattgt gctccaagat gctgtggtca atggcaagaa gccacatcct
     1741 gaaaacacac catacctccc atgtttgttc tgtgcatcca gtttgctgtg ttttacattt
     1801 aatcaattgt agaaaaaaaa tccacaatgt tatttaaata tggagaaact ctatggtatg
     1861 gtttttattc tggtgtctaa gggacagtaa caatagtaga ctgatataga caccctagtc
     1921 tatttccata atatctagtt tacttttaaa tggcccaagg aaatactact gtgattttaa
     1981 gaatgttaat ataattttta actgatgaaa agtctgtttt cattgactta ttatttgtat
     2041 tctatatctg tttgttttta tttgactgta gaatatttat tttaaagttg aatgacagaa
     2101 atattatctc cagtgccaga aagcattgcc agggataatg aaaattaata cattaaagat
     2161 caaggcctgg gatatggctc agtggttaag agcattgact gttcttttag aggacataga
     2221 tttgattcca agcacctgta tggtgattca atagtatttg taaatccagt ttcaggaaat
     2281 ctaatgactt cttctagcct ctgcatgact agtcaggcaa gcaagataca gtcatatatg
     2341 caggtaaatt accaattaac aaaaaacagc acagacatcc tagaaaatag taaaaccatt
     2401 gaaatgaaaa tattacagaa aataaaaggg atattgatta gaagcaaaat atcattaaag
     2461 gtatatagta ggaaaaattg gaacagaaac atacgagttg acaaagaaac ctaaatttcc
     2521 atggaagact ccaacttgtc agcttgtaac ctttcttctg taggttttgt tccagcatcc
     2581 ttttcttcta gagtactgaa agcagttctg tgcttggggg ctcaggttgg aatatggatg
     2641 acacagaggc agcaaagtgt catccaactg tggatctgcc ttagtcctag ctccctgctc
     2701 atctctcttt cagactaggg cactgacagg cggcagtggt ggcggcggtg gcaaaagtgc
     2761 acttcttcct tcattttctg aggaagttga tttttccctc tcagagacct ggagtgctca
     2821 gttttgagat atttgtgaga acatgtgttt atgcagacta cttgtaaaaa cagtgaccag
     2881 catttttgtc ttgaaatgaa gctcaaagtt ctttcaaaga cagtgcaaat agaaacctca
     2941 gaaatagtgt tatacagtta tatggtgcct acctcagtgt accagttgac tttcatgacc
     3001 accttgatat tatctaattg cacttgacac agactagttt atatgttctt atctctccct
     3061 ctttctctcc ctatactgtc ttaatttctt aggaagagta ttctcaactt ctttcagcta
     3121 tccaggaaac cttgcagtca ttgcatgacc cattggaaaa aacaaaccaa aaagctcacc
     3181 cacatgtatt ttgataccaa agtttgcttt ggttttacct agaaaggctt aagaatgaca
     3241 aggcaagtat gacttttgtt gaaatgtgaa tgaaaataat ctttcttcac atctctcctt
     3301 aaggtaagac tagctattct gtctcctgga acttgaagta tgttttatca tagagatatg
     3361 ttgctgttct attattgcta ggactgttgg taagtagctg atcactctac ctaggatgtg
     3421 taagaacctg tgtttgatcc ctcagcccaa caaaccaaca agcagaaata attttgcttt
     3481 ctgaaaatta agaattttta aatctgatgt tcatgaactt agagcaaaaa aatttaatct
     3541 ggtaactttc tagtaaattt gatgttctct ttacattttt agcattttgt ttaccataaa
     3601 atttaataaa gactttttta gctgta
//
