LOCUS       NM_027036                697 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus high-mobility group box 4 (Hmgb4), mRNA.
ACCESSION   NM_027036
VERSION     NM_027036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 697)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 697)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   3  (bases 1 to 697)
  AUTHORS   Rouhiainen,A., Zhao,X., Vanttola,P., Qian,K., Kulesskiy,E.,
            Kuja-Panula,J., Gransalke,K., Gronholm,M., Unni,E., Meistrich,M.,
            Tian,L., Auvinen,P. and Rauvala,H.
  TITLE     HMGB4 is expressed by neuronal cells and affects the expression of
            genes involved in neural differentiation
  JOURNAL   Sci Rep 6, 32960 (2016)
   PUBMED   27608812
  REMARK    GeneRIF: In conclusion, the data suggest that HMGB4 is a factor
            that regulates chromatin and expression of neuronal differentiation
            markers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 697)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 697)
  AUTHORS   Park,S. and Lippard,S.J.
  TITLE     Binding interaction of HMGB4 with cisplatin-modified DNA
  JOURNAL   Biochemistry 51 (34), 6728-6737 (2012)
   PUBMED   22901013
  REMARK    GeneRIF: Phe37 plays a critical role in stabilizing the binding
            complex of HMGB4 with the cisplatin-modified DNA.
REFERENCE   6  (bases 1 to 697)
  AUTHORS   Itou,J., Taniguchi,N., Oishi,I., Kawakami,H., Lotz,M. and
            Kawakami,Y.
  TITLE     HMGB factors are required for posterior digit development through
            integrating signaling pathway activities
  JOURNAL   Dev Dyn 240 (5), 1151-1162 (2011)
   PUBMED   21384471
REFERENCE   7  (bases 1 to 697)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   8  (bases 1 to 697)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 697)
  AUTHORS   Catena,R., Escoffier,E., Caron,C., Khochbin,S., Martianov,I. and
            Davidson,I.
  TITLE     HMGB4, a novel member of the HMGB family, is preferentially
            expressed in the mouse testis and localizes to the basal pole of
            elongating spermatids
  JOURNAL   Biol Reprod 80 (2), 358-366 (2009)
   PUBMED   18987332
REFERENCE   10 (bases 1 to 697)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN840046.1, BC061030.1 and CA465179.1.
            
            On May 23, 2007 this sequence version replaced NM_027036.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BU938291.1, CA463434.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CN840046.1         4-7
            5-680               BC061030.1         1-676
            681-697             CA465179.1         681-697
FEATURES             Location/Qualifiers
     source          1..697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.97 cM"
     gene            1..697
                     /gene="Hmgb4"
                     /gene_synonym="1700001F22Rik"
                     /note="high-mobility group box 4"
                     /db_xref="GeneID:69317"
                     /db_xref="MGI:MGI:1916567"
     exon            1..684
                     /gene="Hmgb4"
                     /gene_synonym="1700001F22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..668
                     /gene="Hmgb4"
                     /gene_synonym="1700001F22Rik"
                     /codon_start=1
                     /product="high mobility group protein B4"
                     /protein_id="NP_081312.2"
                     /db_xref="CCDS:CCDS18671.1"
                     /db_xref="GeneID:69317"
                     /db_xref="MGI:MGI:1916567"
                     /translation="MGEKDQLRPKVNVSSYIHFMLNFRNKFKEQQPNTYLGFKEFSRK
                     CSEKWRSISKHEKAKYEALAELDKARYQQEMMNYIGKRRKRRKRDPKAPRKPPSSFLL
                     FSRDHYAMLKQENPDWTVVQVAKAAGKMWSTTDEAEKKPYEQKAALMRAKYFEEQEAY
                     RNQCQGRKGNFLESAKTSLKQ"
     regulatory      664..669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgb4"
                     /gene_synonym="1700001F22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      684
                     /gene="Hmgb4"
                     /gene_synonym="1700001F22Rik"
                     /note="major polyA site"
ORIGIN      
        1 acacacagag gaaatttcac cataagtagg gcaccttcta gattgctcct cgggtgcaga
       61 gacagaaatc tctgctatcc agatcagcag ggtccagcga aggacattat ggttgtataa
      121 acatggggga aaaagaccag ctaaggccca aggtgaatgt gtcttcttac atccatttta
      181 tgctgaattt cagaaacaaa ttcaaggagc aacagccaaa tacctacctt ggctttaaag
      241 aattctctag aaagtgttca gaaaaatgga gatccatctc aaagcacgaa aaggcaaagt
      301 atgaagccct agcagagctc gataaagccc ggtaccagca agaaatgatg aattacatag
      361 gcaagagaag aaagagaaga aagagggacc caaaggcacc gcggaagccc ccatcctcct
      421 tcctgctctt ctcccgggac cactatgcta tgctgaagca agagaacccc gactggaccg
      481 tggtgcaggt ggccaaggct gctgggaaaa tgtggtccac aactgacgaa gcagaaaaaa
      541 agccctatga acagaaggct gcacttatgc gggcaaagta tttcgaggaa caggaggcct
      601 accgcaacca atgtcaaggc aggaagggga atttcttgga atcagccaag accagtttga
      661 aacaataaaa catcattcaa ttgaaaaaaa aaaaaaa
//
