LOCUS       NM_001293623            1776 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus high mobility group box 3 (Hmgb3), transcript variant
            1, mRNA.
ACCESSION   NM_001293623 XM_006527841
VERSION     NM_001293623.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1776)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   2  (bases 1 to 1776)
  AUTHORS   Angelozzi,M., Pellegrino da Silva,R., Gonzalez,M.V. and Lefebvre,V.
  TITLE     Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly
            proliferative, and myofibroblast-like osteodermal progenitors
  JOURNAL   Cell Rep 40 (2), 111045 (2022)
   PUBMED   35830813
REFERENCE   3  (bases 1 to 1776)
  AUTHORS   Wang,K., Yin,Y.H., Yang,Z.Q., Yu,H.F., Wang,Y.S., Guo,B. and
            Yue,Z.P.
  TITLE     Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through
            Targeting Ptn
  JOURNAL   Reprod Sci 26 (7), 891-899 (2019)
   PUBMED   30081728
  REMARK    GeneRIF: Hmgb3 may play an important role during embryo
            implantation and decidualization. Pleiotropin is a downstream
            target of Hmgb3 in the differentiation of uterine stromal cells.
REFERENCE   4  (bases 1 to 1776)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1776)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1776)
  AUTHORS   Nemeth,M.J., Curtis,D.J., Kirby,M.R., Garrett-Beal,L.J.,
            Seidel,N.E., Cline,A.P. and Bodine,D.M.
  TITLE     Hmgb3: an HMG-box family member expressed in primitive
            hematopoietic cells that inhibits myeloid and B-cell
            differentiation
  JOURNAL   Blood 102 (4), 1298-1306 (2003)
   PUBMED   12714519
REFERENCE   7  (bases 1 to 1776)
  AUTHORS   Fedele,M., Battista,S., Kenyon,L., Baldassarre,G., Fidanza,V.,
            Klein-Szanto,A.J., Parlow,A.F., Visone,R., Pierantoni,G.M.,
            Outwater,E., Santoro,M., Croce,C.M. and Fusco,A.
  TITLE     Overexpression of the HMGA2 gene in transgenic mice leads to the
            onset of pituitary adenomas
  JOURNAL   Oncogene 21 (20), 3190-3198 (2002)
   PUBMED   12082634
  REMARK    GeneRIF: Overexpression of the HMGA2 gene in transgenic mice leads
            to the onset of mixed growth hormone/prolactin cell pituitary
            adenomas.
            Erratum:[Oncogene. 2023 Jan;42(5):406. doi:
            10.1038/s41388-022-02535-z.. PMID: 36544045]
REFERENCE   8  (bases 1 to 1776)
  AUTHORS   Vaccari,T., Beltrame,M., Ferrari,S. and Bianchi,M.E.
  TITLE     Hmg4, a new member of the Hmg1/2 gene family
  JOURNAL   Genomics 49 (2), 247-252 (1998)
   PUBMED   9598312
REFERENCE   9  (bases 1 to 1776)
  AUTHORS   Wilke,K., Wiemann,S., Gaul,R., Gong,W. and Poustka,A.
  TITLE     Isolation of human and mouse HMG2a cDNAs: evidence for an
            HMG2a-specific 3' untranslated region
  JOURNAL   Gene 198 (1-2), 269-274 (1997)
   PUBMED   9370291
REFERENCE   10 (bases 1 to 1776)
  AUTHORS   Yuan,L., Liu,J.G. and Hoog,C.
  TITLE     Rapid cDNA sequencing in combination with RNA expression studies in
            mice identifies a large number of male germ cell-specific sequence
            tags
  JOURNAL   Biol Reprod 52 (1), 131-138 (1995)
   PUBMED   7536044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833776.9.
            
            On Aug 24, 2022 this sequence version replaced NM_001293623.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1304648.1,
                                           SRR13422601.794330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AL833776.9         113179-113499
            322-476             AL833776.9         115315-115469
            477-616             AL833776.9         115695-115834
            617-791             AL833776.9         116360-116534
            792-1776            AL833776.9         116929-117913
FEATURES             Location/Qualifiers
     source          1..1776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.92 cM"
     gene            1..1776
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /note="high mobility group box 3"
                     /db_xref="GeneID:15354"
                     /db_xref="MGI:MGI:1098219"
     exon            1..321
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /inference="alignment:Splign:2.1.0"
     exon            322..476
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..929
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /note="isoform 1 is encoded by transcript variant 1; high
                     mobility group protein B3; high mobility group protein 4;
                     high mobility group protein 2a; high mobilty group protein
                     2A"
                     /codon_start=1
                     /product="high mobility group protein B3 isoform 1"
                     /protein_id="NP_001280552.1"
                     /db_xref="CCDS:CCDS30180.1"
                     /db_xref="GeneID:15354"
                     /db_xref="MGI:MGI:1098219"
                     /translation="MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKK
                     CSERWKTMSSKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFL
                     FCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLSDNEKQPYVTKAAKLKEKYEKDVADY
                     KSKGKFDGAKGPAKVARKKVEEEEEEEEEEEEEEEEEEDE"
     exon            477..616
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..791
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1776
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /note="hexamer: AATAAA"
     polyA_site      1776
                     /gene="Hmgb3"
                     /gene_synonym="Hmg2a; Hmg4"
                     /note="major polyA site"
ORIGIN      
        1 caggcggctc tcgtggaggc agctagcgcg aggctgggga gcgctgagcc gcgcgtcgtg
       61 ccctgcgctg cccagactag cgaacaatac aggtacgact cgcaccgccc tcgcccgccg
      121 ccgccgctcc tgcagctgca gcggcgcccg cacaactttc cgcccgcgcc tccgcgagcg
      181 cgccgctacc actctggctg tctccactcc cgcgtccttg ccgccccctc tccttctctg
      241 ctgctaggtg gccaagaagg aagacgcaat tcaggtgcct caacttttcc agtgcctgcg
      301 ctccagcctg ctgcttctca gtcaggatgg ctaaaggtga ccccaagaaa ccaaagggca
      361 agatgtctgc ttatgccttc tttgtgcaga catgcaggga agaacataag aagaaaaacc
      421 cagaggttcc cgtcaatttt gctgagttct ccaagaagtg ctcggagagg tggaagacca
      481 tgtctagcaa agagaaatca aagtttgatg aaatggcaaa ggcagataaa gtccgatatg
      541 atcgggagat gaaagattat ggaccagcta aaggaggcaa gaagaagaag gacccaaatg
      601 cccccaaaag acctccgtct ggatttttct tattctgctc tgaattccgc cccaagatca
      661 aatccacaaa ccctggcatc tccattggag atgtggcaaa aaagctgggt gagatgtgga
      721 ataacttaag tgacaatgaa aagcagcctt atgtcaccaa ggcagcaaag ctgaaggaga
      781 agtatgagaa ggatgttgct gactataagt ctaaagggaa gtttgatggt gccaagggtc
      841 ctgctaaagt tgcccggaaa aaggtggaag aagaggaaga ggaggaggaa gaggaagaag
      901 aggaggagga agaggaggaa gatgaataaa agctctgtct ccttgtgaat accttagagt
      961 aggagagcgc tgtgattgac acatctctta tttgagtcgt gtctattgcc cttgttaggt
     1021 ttaattacaa aatttgatca cgatcatatt gtagtttctc aaagtgtcag tggtttacat
     1081 gaagtggccg tgggtgtccg gagcgccctg aaactgtatc aaagttgtac atagctccaa
     1141 acatttttaa aatgaaaagg cactctcgcg tcctcctcac tcagtgcact ttgctgttgg
     1201 tgtgacaagg catttgaaga tgtttctggc attttgttct caactcgtaa ggtagtgtta
     1261 actatatggt tattggctag caatcctgag ttgtcaactg tacatatcta tagtttgtaa
     1321 agagaatgaa acaacccaga cagattcttg atgctccttg tttggcgtgg aggctgtgag
     1381 gggaagatgc cttttggagg gggccgtagc tcagggcgtg cactgtgagg ctggacctgt
     1441 tgatactgcg gtgggcatcc atttagcttc aggttgtcct gtgtttgtat atagtggcat
     1501 agcattctgc tgacattctt agttgtggaa aggggggagg ggtcggccgg catgagaagt
     1561 gtttggagtt ttttctttag ttaagtgcag taggtttgaa actttttaaa gaaactgtag
     1621 gactcatcat tgtcagcaaa gcaaagaact actgcatcaa tggaagttca agaaccctct
     1681 ggacctaaac gcaatttgca acattctgtt attttttgta tgtttagaat gctgaaatgt
     1741 ttttgaagtt aaataaacag tattacattt ttaaaa
//
