LOCUS       NM_008252               2692 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus high mobility group box 2 (Hmgb2), transcript variant
            2, mRNA.
ACCESSION   NM_008252 XM_486109 XM_909895
VERSION     NM_008252.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Kong,D., Liu,J., Lu,J., Zeng,C., Chen,H., Duan,Z., Yu,K., Zheng,X.,
            Zou,P., Zhou,L., Lv,Y., Zeng,Q., Lu,L., Li,J. and He,Y.
  TITLE     HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity
            and Mortality of Patients With Pulmonary Arterial Hypertension
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), e172-e195 (2024)
   PUBMED   38572649
  REMARK    GeneRIF: HMGB2 Release Promotes Pulmonary Hypertension and Predicts
            Severity and Mortality of Patients With Pulmonary Arterial
            Hypertension.
REFERENCE   2  (bases 1 to 2692)
  AUTHORS   Choijookhuu,N., Yano,K., Lkham-Erdene,B., Shirouzu,S., Kubota,T.,
            Fidya, Ishizuka,T., Kai,K., Chosa,E. and Hishikawa,Y.
  TITLE     HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte
            Proliferation During Liver Regeneration
  JOURNAL   J Histochem Cytochem 72 (4), 245-264 (2024)
   PUBMED   38544368
  REMARK    GeneRIF: HMGB2 Promotes De Novo Lipogenesis to Accelerate
            Hepatocyte Proliferation During Liver Regeneration.
REFERENCE   3  (bases 1 to 2692)
  AUTHORS   Su,M., Chen,F., Han,D., Song,M. and Wang,Y.
  TITLE     PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates
            Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis
  JOURNAL   J Proteome Res 23 (3), 1075-1087 (2024)
   PUBMED   38376246
  REMARK    GeneRIF: PRMT7-Dependent Transcriptional Activation of Hmgb2
            Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced
            Ferroptosis.
REFERENCE   4  (bases 1 to 2692)
  AUTHORS   Ferguson,C.A., Firulli,B.A., Zoia,M., Osterwalder,M. and
            Firulli,A.B.
  TITLE     Identification and characterization of Hand2 upstream genomic
            enhancers active in developing stomach and limbs
  JOURNAL   Dev Dyn 253 (2), 215-232 (2024)
   PUBMED   37551791
REFERENCE   5  (bases 1 to 2692)
  AUTHORS   Mathai,C., Jourd'heuil,F., Pham,L.G.C., Gilliard,K., Howard,D.,
            Balnis,J., Jaitovich,A., Chittur,S.V., Rilley,M., Peredo-Wende,R.,
            Ammoura,I., Shin,S.J., Barroso,M., Barra,J., Shishkova,E.,
            Coon,J.J., Lopez-Soler,R.I. and Jourd'heuil,D.
  TITLE     Regulation of DNA damage and transcriptional output in the
            vasculature through a cytoglobin-HMGB2 axis
  JOURNAL   Redox Biol 65, 102838 (2023)
   PUBMED   37573836
  REMARK    GeneRIF: Regulation of DNA damage and transcriptional output in the
            vasculature through a cytoglobin-HMGB2 axis.
REFERENCE   6  (bases 1 to 2692)
  AUTHORS   Nightingale,K., Dimitrov,S., Reeves,R. and Wolffe,A.P.
  TITLE     Evidence for a shared structural role for HMG1 and linker histones
            B4 and H1 in organizing chromatin
  JOURNAL   EMBO J 15 (3), 548-561 (1996)
   PUBMED   8599938
REFERENCE   7  (bases 1 to 2692)
  AUTHORS   Stros,M., Retief,J.D. and Dixon,G.H.
  TITLE     cDNA sequence and structure of a trout HMG-2 gene. Evidence for a
            trout-specific 3'-untranslated region
  JOURNAL   Gene 158 (2), 181-187 (1995)
   PUBMED   7607539
REFERENCE   8  (bases 1 to 2692)
  AUTHORS   Baxevanis,A.D. and Landsman,D.
  TITLE     The HMG-1 box protein family: classification and functional
            relationships
  JOURNAL   Nucleic Acids Res 23 (9), 1604-1613 (1995)
   PUBMED   7784217
REFERENCE   9  (bases 1 to 2692)
  AUTHORS   Zwilling,S., Konig,H. and Wirth,T.
  TITLE     High mobility group protein 2 functionally interacts with the POU
            domains of octamer transcription factors
  JOURNAL   EMBO J 14 (6), 1198-1208 (1995)
   PUBMED   7720710
REFERENCE   10 (bases 1 to 2692)
  AUTHORS   Stolzenburg,F., Dinkl,E. and Grummt,F.
  TITLE     Nucleotide sequence of a mouse cDNA encoding the non-histone
            chromosomal high mobility group protein-2 (HMG-2)
  JOURNAL   Nucleic Acids Res 20 (18), 4927 (1992)
   PUBMED   1408807
  REMARK    Erratum:[Nucleic Acids Res 1992 Oct 11;20(19):5262]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY009449.1, AK012568.1, AK135297.1 and BX516410.1.
            
            On May 7, 2009 this sequence version replaced NM_008252.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All 4 variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135296.1, AK012568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BY009449.1         1-89
            90-1154             AK012568.1         57-1121
            1155-1610           AK135297.1         1061-1516
            1611-1907           BX516410.1         249-545
            1908-2692           AK135297.1         1813-2597
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.9 cM"
     gene            1..2692
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /note="high mobility group box 2"
                     /db_xref="GeneID:97165"
                     /db_xref="MGI:MGI:96157"
     exon            1..163
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /inference="alignment:Splign:2.1.0"
     exon            164..337
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..820
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /note="high mobility group protein 2"
                     /codon_start=1
                     /product="high mobility group protein B2"
                     /protein_id="NP_032278.1"
                     /db_xref="CCDS:CCDS40343.1"
                     /db_xref="GeneID:97165"
                     /db_xref="MGI:MGI:96157"
                     /translation="MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKK
                     CSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAF
                     FLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIA
                     AYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE"
     exon            338..483
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..658
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..2692
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /note="hexamer: AATAAA"
     polyA_site      1182
                     /gene="Hmgb2"
                     /gene_synonym="HMG-2; Hmg2"
                     /note="major polyA site"
ORIGIN      
        1 ggagggaggt gtggcccgcg actggtctgg tcaagttgcc gtggcgcgga gaactctgca
       61 aaacaagagg ctggggattg cgttagcgag aaaccagttc tcgccggagc ttggggaagg
      121 aagtctctct gcggaggtct gagggaagca gcgctcgcag caggtagaca gacgccgcgc
      181 cgtcgtcatg ggcaagggtg accccaacaa gccgcggggc aaaatgtcct cgtacgcctt
      241 cttcgtgcag acctgccgcg aggagcacaa gaagaagcat cccgactcgt cggtgaactt
      301 cgccgagttc tccaagaaat gctccgagag atggaagacc atgtctgcaa aggaaaagtc
      361 caagtttgaa gatttggcca agagcgacaa agctcgttat gacagggaga tgaagaacta
      421 tgttcctccc aaaggggata agaaaggaaa gaaaaaagac cccaatgctc cgaagagacc
      481 accgtctgcc ttcttcctgt tttgctctga aaatcgccca aagatcaaaa ttgaacaccc
      541 aggcctgtct attggagata ctgcgaagaa actgggtgag atgtggtctg agcaatctgc
      601 caaagataaa caaccgtatg agcagaaagc agctaaacta aaggagaagt atgaaaagga
      661 tattgctgca taccgtgcca agggcaaaag tgaagcagga aagaagggtc ctggtaggcc
      721 aacaggctca aagaagaaga acgaaccaga agatgaggag gaggaagaag aggaggaaga
      781 ggaggaagat gacgaggaag aagaggagga tgaagaataa gtggctgtcc taaagtgtgg
      841 agtatatttg ctcaggcaat tattttgcta agaatgtgaa attcaagtgc agctcaacat
      901 tagcttcagt ataaaaactg tacagatttt tgtatagctg atgagattct ttgtagagaa
      961 aatacttttt aagaagagtt tgtagctttt tcaggggcta caactacagt tagatttaaa
     1021 gcttttgatg ttgaatgttt ctaaatattt aatggtttct ttaatttctt atgctagcaa
     1081 aaaaaaaact tcataggaat ttgtattacc agtaaaaatt ttttttagga tgttgcattt
     1141 ttttgttttt ttttaaattt gtaataaaat aatgtatatt aatttgcatt gtgtttgtat
     1201 taatttttcc ttaaacagat acaggcatgt tagtcttttt acacagttaa gttttgtgtt
     1261 aaccatttac taatttgctt ctctgatttt tgtggttaga agggccaatt tcttttaatg
     1321 accacaagct aacatattag caacaggtta aagcgttaag gacatactgc cttgatttcc
     1381 agagcaaata gacttaaaaa aactttaaaa gttctgtgat tgtacaaata gtaagtctaa
     1441 aagattatcc actcaaattt ggagtcgggg tatgatcttt taaattttta ggctttgggt
     1501 agtttagtat actaaaatat tttggataat gtactagata cccaggtgtg gggatttaat
     1561 tattttgatt cactttttta tcagtatgga tgtgagatat ggacaggtct tagcttataa
     1621 gtcttagctt gtaccaaaat tggaagttac gagatgaggt gagttaaatg tgttgggaaa
     1681 cttgtgtaga tgttgaaagt agttatacca ggctgggtgt ggtggcaggt acatgcaatc
     1741 ccagagtgga aggtagagag agggcaggag ggttggagtt aggacaccac caccaaagta
     1801 catgcttcaa tggtatttaa aatgttaagg aaattatata tatatatcag atagttacat
     1861 cccttttcaa ctttggattt ttcaaaacta ctaacaaatc aagaatgagc ataatcatat
     1921 atttatgaca taagtattac acaaatgaat tcttagagca ctgactttgt taaatgtctg
     1981 catcttctca tgttgaatag gttgtaattt aactagttcc ctaaaaatct caacagattt
     2041 cctgaggcca gcctgtctac agagttctaa gatggccaag gctacacaga agttcttggc
     2101 atcactgtct ttcttgatag cagcctaccc aacttttaag aatattcctg tgactattta
     2161 tatgtgaaaa aagtcctaga aggaataaca gctaaaaggt atagataata cagaatttgc
     2221 tacttagaat aatctaaacc tttattttta tttaaatttt attttattta tttattttga
     2281 gatggtttct ctgtatagcc ctggctgtcc tagatcaggc tggcctcgaa ctcagttatc
     2341 cgcctgcctc tgcctcccaa gtgctgggtt taaaggcgtg caccaccact gcctggctta
     2401 aacctttact ttttgtttct gacaatgctg gagatagaac ccagagcctt atgcatgcca
     2461 ggcaagtgct gtacctctga gctcacttga atgcctttgc tattttctcc caaacctgta
     2521 cttgaagttt gttagaaagc tacactaagt aatagtatat agtctacact aaccatacta
     2581 gcagttttgt agttcccatt tgatcgaagt aatggttttc aaatttcagt ctttgttatt
     2641 ctgatgtata tctcacgtgt atcatattct aaaacaatat ttttttatac tt
//
