LOCUS       NM_010439               2855 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus high mobility group box 1 (Hmgb1), transcript variant
            2, mRNA.
ACCESSION   NM_010439 XM_622971
VERSION     NM_010439.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Rao,Z., Liu,S., Li,Z., Wang,Q., Gao,F., Peng,H., Ren,D., Zang,Y.,
            Li,H., Li,Y., Hu,Q., He,D. and Xu,H.
  TITLE     Alarmin-loaded extracellular lipid droplets induce airway
            neutrophil infiltration during type 2 inflammation
  JOURNAL   Immunity 57 (11), 2514-2529 (2024)
   PUBMED   39366382
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Wu,T., Lu,Y., Yu,Y., Hua,Y., Ge,G., Zhao,W., Chen,K., Zhong,Z. and
            Zhang,F.
  TITLE     Long noncoding RNA AK144717 exacerbates pathological cardiac
            hypertrophy through modulating the cellular distribution of HMGB1
            and subsequent DNA damage response
  JOURNAL   Cell Mol Life Sci 81 (1), 432 (2024)
   PUBMED   39395058
  REMARK    GeneRIF: Long noncoding RNA AK144717 exacerbates pathological
            cardiac hypertrophy through modulating the cellular distribution of
            HMGB1 and subsequent DNA damage response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Wu,K., Zha,H., Wu,T., Liu,H., Peng,R., Lin,Z., Lv,D., Liao,X.,
            Sun,Y. and Zhang,Z.
  TITLE     Cytosolic Hmgb1 accumulation in mesangial cells aggravates diabetic
            kidney disease progression via NFkappaB signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 408 (2024)
   PUBMED   39287634
  REMARK    GeneRIF: Cytosolic Hmgb1 accumulation in mesangial cells aggravates
            diabetic kidney disease progression via NFkappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Rhodes,J.D., Devaraj,A., Robledo-Avila,F., Balu,S.,
            Mashburn-Warren,L., Buzzo,J.R., Partida-Sanchez,S., Bakaletz,L.O.
            and Goodman,S.D.
  TITLE     Noninflammatory 97-amino acid High Mobility Group Box 1 derived
            polypeptide disrupts and prevents diverse biofilms
  JOURNAL   EBioMedicine 107, 105304 (2024)
   PUBMED   39182358
  REMARK    GeneRIF: Noninflammatory 97-amino acid High Mobility Group Box 1
            derived polypeptide disrupts and prevents diverse biofilms.
            Erratum:[EBioMedicine. 2025 Jan 25;112:105589. doi:
            10.1016/j.ebiom.2025.105589.. PMID: 39864128]
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Yu,C., Huang,Y., Xie,J., Duan,C., Liu,S., Zhao,W., Wang,Y.,
            Zhuang,R., Li,J. and Yin,W.
  TITLE     HMGB1 released from pyroptotic vascular endothelial cells promotes
            immune disorders in exertional heatstroke
  JOURNAL   Int J Hyperthermia 41 (1), 2378867 (2024)
   PUBMED   39117343
  REMARK    GeneRIF: HMGB1 released from pyroptotic vascular endothelial cells
            promotes immune disorders in exertional heatstroke.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Melloni,E., Sparatore,B., Patrone,M., Pessino,A., Passalacqua,M.
            and Pontremoli,S.
  TITLE     Extracellular release of the 'differentiation enhancing factor', a
            HMG1 protein type, is an early step in murine erythroleukemia cell
            differentiation
  JOURNAL   FEBS Lett 368 (3), 466-470 (1995)
   PUBMED   7635200
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Stros,M., Retief,J.D. and Dixon,G.H.
  TITLE     cDNA sequence and structure of a trout HMG-2 gene. Evidence for a
            trout-specific 3'-untranslated region
  JOURNAL   Gene 158 (2), 181-187 (1995)
   PUBMED   7607539
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Baxevanis,A.D. and Landsman,D.
  TITLE     The HMG-1 box protein family: classification and functional
            relationships
  JOURNAL   Nucleic Acids Res 23 (9), 1604-1613 (1995)
   PUBMED   7784217
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Melloni,E., Sparatore,B., Patrone,M., Pessino,A., Passalacqua,M.
            and Pontremoli,S.
  TITLE     Identity in molecular structure between 'differentiation enhancing
            factor' of murine erythroleukemia cells and the 30 kD
            heparin-binding protein of developing rat brain
  JOURNAL   Biochem Biophys Res Commun 210 (1), 82-89 (1995)
   PUBMED   7741753
REFERENCE   10 (bases 1 to 2855)
  AUTHORS   Yotov,W.V. and St-Arnaud,R.
  TITLE     Nucleotide sequence of a mouse cDNA encoding the nonhistone
            chromosomal high mobility group protein-1 (HMG1)
  JOURNAL   Nucleic Acids Res 20 (13), 3516 (1992)
   PUBMED   1630928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158782.5, CJ050650.1,
            AK084841.1 and AK144428.1.
            
            On Sep 10, 2015 this sequence version replaced NM_010439.3.
            
            Summary: This gene encodes a protein that belongs to the High
            Mobility Group-box superfamily. The encoded non-histone, nuclear
            DNA-binding protein regulates transcription, and is involved in
            organization of DNA. This protein plays a role in several cellular
            processes, including inflammation, cell differentiation and tumor
            cell migration. Multiple pseudogenes of this gene have been
            identified. Alternative splicing results in multiple transcript
            variants that encode the same protein. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144428.1, AK084841.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC158782.5         211965-211975       c
            12-20               CJ050650.1         1-9
            21-1153             AK084841.1         2-1134
            1154-2327           AK084841.1         1136-2309
            2328-2562           AK144428.1         2287-2521
            2563-2563           AC158782.5         205912-205912       c
            2564-2855           AK144428.1         2523-2814
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.18 cM"
     gene            1..2855
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /note="high mobility group box 1"
                     /db_xref="GeneID:15289"
                     /db_xref="MGI:MGI:96113"
     exon            1..158
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..322
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..820
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /note="high mobility group protein 1; amphoterin"
                     /codon_start=1
                     /product="high mobility group protein B1"
                     /protein_id="NP_034569.1"
                     /db_xref="CCDS:CCDS19883.1"
                     /db_xref="GeneID:15289"
                     /db_xref="MGI:MGI:96113"
                     /translation="MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKK
                     CSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAF
                     FLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIA
                     AYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE"
     exon            323..468
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..643
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..2855
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /note="hexamer: AATACA"
     polyA_site      1332
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /note="major polyA site"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /note="hexamer: ATTACA"
     polyA_site      2335
                     /gene="Hmgb1"
                     /gene_synonym="HMG-1; Hmg1; p30; SBP-1"
                     /note="major polyA site"
ORIGIN      
        1 cgcgctggct ggagagtaat gttacagagc ggagagagtg aggaggctgc gtctggctcc
       61 cgctctcaca gccattgcag tacattgagc tccatagaga cagcgccggg gcaagcgcga
      121 gccggacggg cactgggcga ctctgtgcct cgcggaggaa aatcaactaa acatgggcaa
      181 aggagatcct aaaaagccga gaggcaaaat gtcctcatat gcattctttg tgcaaacttg
      241 ccgggaggag cacaagaaga agcacccgga tgcttctgtc aacttctcag agttctccaa
      301 gaagtgctca gagaggtgga agaccatgtc tgctaaagaa aaggggaaat ttgaagatat
      361 ggcaaaggct gacaaggctc gttatgaaag agaaatgaaa acctacatcc cccccaaagg
      421 ggagaccaaa aagaagttca aggaccccaa tgcacccaag aggcctcctt cggccttctt
      481 cttgttctgt tctgagtacc gccccaaaat caaaggcgag catcctggct tatccattgg
      541 tgatgttgca aagaaactag gagagatgtg gaacaacact gcagcagatg acaagcagcc
      601 ctatgagaag aaagctgcca agctgaagga gaagtatgag aaggatattg ctgcctacag
      661 agctaaagga aaacctgatg cagcgaaaaa gggggtggtc aaggctgaaa agagcaagaa
      721 aaagaaggaa gaggaagatg atgaggagga tgaagaggat gaggaagagg aggaagaaga
      781 ggaagacgaa gatgaagaag aagatgatga tgatgaataa gttggttcta gcgcagtttt
      841 tttttcttgt ctataaagca tttaaccccc ctgtacacaa ctcactcctt ttaaagaaaa
      901 aaattgaaat gtaaggctgt gtaagatttg tttttaaact gtacagtgtc tttttttgta
      961 tagttaacac actaccgaat gtgtctttag atagccctgt cctggtggta ttttcaatag
     1021 ccactaacct tgcctggtac agtctggggg ttgtaaattg gcatggaaat ttaaagcagg
     1081 ttcttgttgg tgcacagcac aaattagtta tatatgggga cagtagtttg gttttttgtt
     1141 tttttttttt tttcttttgg ttttcttttt gggttttatt tttttcatct tcagttgtct
     1201 ctgatgcagc ttatacgaag ataattgttg ttctgttaac tgaataccac tctgtaattg
     1261 caaaaaaaaa attgcggctg ttttgttgac attctgaatg cttctaagta aatacaattt
     1321 tttttattag tattgttgtc cttttcatag gtctgaaagt tttcttctca aggggaagct
     1381 agtcttttgc tttgcccatt ttgggtcaca tggattatta gtgtgttatc tttcatctag
     1441 ttagctggaa gagagctttt gtccacatgc cctgccattg tggtagggta acattttcat
     1501 ccatagttga agaatctcct aaatcgtgat agttggataa gagatattat ataacctact
     1561 tggcaaagca aggagtgatc aatactgtca caccgtggga ctattaggat caagcaatct
     1621 gaacgtctgt ccttgaagga ctgatagaaa agtaccttct aatccttaca cgaggactct
     1681 cctttaaccg ccattactgt gtaatgacag ttatattttg cagtttcccc tactaaagaa
     1741 gacctgagaa tgtatcccca aaagtgtgag cttaaaatac aagactgctg tactatttgt
     1801 tgaccttagt cccagcgaag gctatcacaa gaacgctggc tgtaaagcct ttgcccttct
     1861 atctagatat ggattgctca ggaaacttga ctgtttaaag gtatttttaa ttacttgagc
     1921 cagcttttaa aattatgcca catttaaaat gaagggtata ttttcctata ctgtggtttg
     1981 tccctttatg aatcagatac aagaggataa actttgcata ttagtaccat ttgtccaata
     2041 catttgcttt ttctttataa aacccaaact cattcattaa tcaggtttaa tctgcttagt
     2101 ttagggaaca atttggcaat tttgtggatt tttttttgag attatcgttc tcttaaagtg
     2161 ccagtgtttt aaatagcgtt cttgtaattt cacgcgcttt tgtgatggag tgctgttata
     2221 taattttgac ttgggttctt tacatttgcg ttgttaatgt aatttgagga ggaatactga
     2281 acatgagtcc tggatgatac taataaacta ataattacag aggttttaaa tattagttaa
     2341 atgactttca cttaagaatt taagcttttg gtcacacttt ataatagtgc cttatagtat
     2401 aaacaactga aaggctcttt cccattaaca acccttgatg ctggggccag tgagatagtg
     2461 ggtaaaaagg cagttggctg ccaaccctga caaccgatgg caaaaggagg gaaccagctt
     2521 ccaaaatgct ttgaccaaat gctccctcca ttcatgaaca cagttttaaa atgttaaata
     2581 ggctagaggg cagtaaaaac aggttttttt atcgagcatc cctaatctat acatatgagg
     2641 agccataatc tgaatgttaa gtgaaaagcg aggttggtct taaagattgc acgtgtgttc
     2701 ttaagcctgt agaggacctc cgcaggccgt aatggtctcg attaccaact taagaacaag
     2761 tgactggctt ggaaacttgt actgttgctt tagaactacc attgtggaca tctgttgtta
     2821 gtaagtgatc catttaaaag tgaactctgc ctcaa
//
