LOCUS       NM_010441               3742 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus high mobility group AT-hook 2 (Hmga2), transcript
            variant 1, mRNA.
ACCESSION   NM_010441 NM_178057
VERSION     NM_010441.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3742)
  AUTHORS   Zhu,Y., Huang,Y., Tang,T. and Xie,Y.
  TITLE     HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural
            progenitor transition during brain development
  JOURNAL   iScience 27 (9), 110600 (2024)
   PUBMED   39224519
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3742)
  AUTHORS   Ke,Z., Huang,Z., He,R., Zhang,Q., Chen,S., Cui,Z.K. and Ding,J.
  TITLE     [Hmga2 knockdown enhances osteogenic differentiation of
            adipose-derived mesenchymal stem cells and accelerates bone defect
            healing in mice]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (7), 1227-1235 (2024)
   PUBMED   39051068
  REMARK    GeneRIF: [Hmga2 knockdown enhances osteogenic differentiation of
            adipose-derived mesenchymal stem cells and accelerates bone defect
            healing in mice].
REFERENCE   3  (bases 1 to 3742)
  AUTHORS   Kubota,S., Sun,Y., Morii,M., Bai,J., Ideue,T., Hirayama,M.,
            Sorin,S., Eerdunduleng, Yokomizo-Nakano,T., Osato,M., Hamashima,A.,
            Iimori,M., Araki,K., Umemoto,T. and Sashida,G.
  TITLE     Chromatin modifier Hmga2 promotes adult hematopoietic stem cell
            function and blood regeneration in stress conditions
  JOURNAL   EMBO J 43 (13), 2661-2684 (2024)
   PUBMED   38811851
  REMARK    GeneRIF: Chromatin modifier Hmga2 promotes adult hematopoietic stem
            cell function and blood regeneration in stress conditions.
REFERENCE   4  (bases 1 to 3742)
  AUTHORS   Maharaj,A.V., Cottrell,E., Thanasupawat,T., Joustra,S.D.,
            Triggs-Raine,B., Fujimoto,M., Kant,S.G., van der Kaay,D.,
            Clement-de Boers,A., Brooks,A.S., Aguirre,G.A., Martin Del
            Estal,I., Castilla de Cortazar Larrea,M.I., Massoud,A., van
            Duyvenvoorde,H.A., De Bruin,C., Hwa,V., Klonisch,T.,
            Hombach-Klonisch,S. and Storr,H.L.
  TITLE     Characterization of HMGA2 variants expands the spectrum of
            Silver-Russell syndrome
  JOURNAL   JCI Insight 9 (6), e169425 (2024)
   PUBMED   38516887
  REMARK    GeneRIF: Characterization of HMGA2 variants expands the spectrum of
            Silver-Russell syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3742)
  AUTHORS   Qian,S., Wang,F., Liao,W. and Liu,J.
  TITLE     The role of HMGA2 in activating the IGFBP2 expression to promote
            angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling
            pathway
  JOURNAL   Neoplasma 71 (1), 22-36 (2024)
   PUBMED   38506034
  REMARK    GeneRIF: The role of HMGA2 in activating the IGFBP2 expression to
            promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA
            signaling pathway.
REFERENCE   6  (bases 1 to 3742)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
REFERENCE   7  (bases 1 to 3742)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   8  (bases 1 to 3742)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   9  (bases 1 to 3742)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Cho,B.C., Donovan,P.J., Jenkins,N.A.,
            Cosman,D., Anderson,D., Lyman,S.D. and Williams,D.E.
  TITLE     Mast cell growth factor maps near the steel locus on mouse
            chromosome 10 and is deleted in a number of steel alleles
  JOURNAL   Cell 63 (1), 175-183 (1990)
   PUBMED   1698554
REFERENCE   10 (bases 1 to 3742)
  AUTHORS   Sinha,Y.N., Wolff,G.L., Baxter,S.R. and Domon,O.E.
  TITLE     Serum and pituitary concentrations of growth hormone and prolactin
            in pygmy mice
  JOURNAL   Proc Soc Exp Biol Med 162 (1), 221-223 (1979)
   PUBMED   504232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052158.1 and CX567918.1.
            
            On Nov 17, 2016 this sequence version replaced NM_010441.2.
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052158.1, AK028346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3282              BC052158.1         1-3282
            3283-3742           CX567918.1         13-472
FEATURES             Location/Qualifiers
     source          1..3742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 67.94 cM"
     gene            1..3742
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /note="high mobility group AT-hook 2"
                     /db_xref="GeneID:15364"
                     /db_xref="MGI:MGI:101761"
     exon            1..517
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..733
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /note="isoform 1 is encoded by transcript variant 1; high
                     mobility group protein HMGI-C; high mobility group AT-hook
                     protein 2; high mobility group protein I"
                     /codon_start=1
                     /product="high mobility group protein HMGI-C isoform 1"
                     /protein_id="NP_034571.1"
                     /db_xref="CCDS:CCDS36073.1"
                     /db_xref="GeneID:15364"
                     /db_xref="MGI:MGI:101761"
                     /translation="MSARGEGAGQPSTSAQGQPAAPVPQKRGRGRPRKQQQEPTCEPS
                     PKRPRGRPKGSKNKSPSKAAQKKAETIGEKRPRGRPRKWPQQVVQKKPAQETEETSSQ
                     ESAEED"
     exon            518..604
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /inference="alignment:Splign:2.1.0"
     exon            605..655
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /inference="alignment:Splign:2.1.0"
     exon            656..688
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /inference="alignment:Splign:2.1.0"
     exon            689..3717
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /note="hexamer: AATAAA"
     polyA_site      3717
                     /gene="Hmga2"
                     /gene_synonym="9430083A20Rik; HMGI-C; Hmgic; pg; pygmy"
                     /note="major polyA site"
ORIGIN      
        1 cgcaactccc gagcctttgc ggagagagca accctctccg cctccaactc ttccctctcc
       61 ttcgcttccc gcctcctctc cctacctcca cctctacctc cgccacccac tgcccgcagc
      121 gcctcctcct ttcctcctcc tcctctcctc ctcctctctt cctcctcccc tctctctttt
      181 tggcagccgc tggacgtccg gtgttgatgg tggcagcggc ggcagcctaa gcagcagcag
      241 tagtccccgg cgcactcgcc agctcgcctg ctctcgccgc tcttgccctc tccagctctc
      301 tacatcccgt ctcccgaaag gtgctgggcg gattcggggc ggcggaggcc gagcggctgc
      361 agcggcggta ccggtagagg cagtggtagc ggcggcggga ggcaggatga gcgcacgcgg
      421 tgagggcgcc gggcagccgt ccacatcagc ccagggacaa cctgccgccc cggtgccaca
      481 gaagcgagga cgcggccgac ccaggaagca gcagcaagag ccaacctgtg agccctctcc
      541 taagagaccc agaggaagac ccaaaggcag caaaaacaag agcccctcta aagcagccca
      601 gaagaaagca gagaccattg gagaaaaacg gccaagaggc agacctagga aatggccaca
      661 acaagtcgtt cagaagaagc ctgctcagga gactgaagag acatcctcgc aagagtccgc
      721 agaggaggat tagggggcgc cgacattcaa tttctacctc agcatcagtt ggatcttttg
      781 aagggagaag acactgcagt gaccagttat tcttaactgc cacggtcttt ctacttcctg
      841 cggggtgggg cgggggcggg gctgggcgag gggcggggcc ggggtgggcg aaatcgcata
      901 accttgagaa ggactatatt aatcactttg taatcccttc acagtcccag gtttagtgaa
      961 aaactgctgt aaacacgggg gacacagttt aacaatgcaa cttttaatga ctgttttctt
     1021 tttccttaac ttactaatag tttgtggatc tgataagcaa gggtgtgtgg ttgaagaaaa
     1081 cctctgtggt gggcttaatc agtcactaca tgcaaaccct aaaccggcac cctggtgacc
     1141 gggggcattc gtataagaaa agcattgtgt gtgactctgt gtccactcag atgccacccc
     1201 caccatgatc atagaaaatc tgcttaggac accaaagatg agaactagac actactctcc
     1261 tttctttgtg tataatcttg tagacactta cttgattttt ttttcttttt ttacttttca
     1321 attctgaatg agacaaaatg ctggtgtatc ttttcataca gctagcaaac cagaataggt
     1381 tatgctcgtt ttttgctttg ttttgttttt caaaaaggga agtaaacgag aaccgttgac
     1441 tcctccattt atggactcat acacagcagc aggagtgata agcccacaag ctctctttcc
     1501 cgcctcggga aatctacaca gccaaaagcc acttagccat aaatgacact tgtcagcctt
     1561 gaagcatcgg agataactag ctgagtaaaa tgatcctgtt ttggaattta atgaaaaggt
     1621 taacagtacc caatgaaccc acccaagtga tgacatggga ggagcgaaac cgaaatctct
     1681 tttgctatat aaaggacact attttttaaa aaaaaataat aaaaacagct cccgctctct
     1741 gtcctctctc cctcccttct ctccctcgcc tctctctcct ctctatattc cctgttcttc
     1801 attgtgtacc agtgtccgtg aaagaccgca gtaccactta cctcagatga agcctgcgtg
     1861 ttacatcctg taacaccttt cattttgaca taagatggct agccgaggtg cattatcttg
     1921 gttcggactg ccatctctgc attcacgctg cacttttagc cagagatgca ataatcccca
     1981 ctcctcaata ctacctctga atgctacagt gaatttacag ccctgcactt gttacacgct
     2041 gctagacaca agccctgcaa gagaaaggaa aaaaaaaagc ccaccaaaac caaaccaaac
     2101 cttactgggt cggcatctca gccatcccca gttctcgacc attcttctct gtactcttac
     2161 tccgtctcag caggctatgc atgtttctat gacttttttt ttttttaatt aaaatgttac
     2221 aaatgcttgt ggcagctttc ctgctagatt gttacattaa tttgaaacag ttttgagtca
     2281 agttgctcct aggttcttaa ggagaatttt tttttcagtg acactacttt gtatcacaca
     2341 cacacatctg tagtgttcaa atataagtct ccaagtttgt acctcaaatg aattattgaa
     2401 acaaatggac ttcctgattt gcaaggaact acctccacac ttccaaagga acgaacttgc
     2461 agcctatatc actcattgat ttccttcccc catgtttgaa ggagctcaaa cctcacctct
     2521 ccctcattga aacatttttt ttggtaaaag acacttgata gaaacacaat ttttttacat
     2581 acttttgcaa aaataaatga attaaaatca agccaacctt caaagaaact tgaaattttg
     2641 ctacaaccag ctcagccttt tgcctaatgc aatgaaaaag gaaaaaaata gatttctaag
     2701 atttgttgcc tagaagaata tgcttgaccg atattttttc atgtatttta cacaatgtga
     2761 tttttgtaaa aaaatgtctc aagcagattt gttttggacg cttcttgtgt agagtttcta
     2821 tgcctttctc tcctattaag tgtgctgact ttccagagtg ttacccactg ggccaggagg
     2881 tagtttctca tagtggcttg tgtcagtata agttaatact gaagccaaat gaaacaaaca
     2941 aacaaccatg tctcttccag ctgttttcag ggaggttact tcaaaggcca cgtgccgctc
     3001 tgagactggc agatggctca ctgttgtgag tcgccaaagg agctatggag agattaaaat
     3061 tcaacatgac tgttaacaat gcattaaata atcaaataaa cagtggctta taaatatcag
     3121 attctcattc cgggtcttcg gatgggcctt acagaaacct cattttggcc agctcataaa
     3181 aactgaagca gcttctcgtg ttggccagac tcggcacacc gagcaatttc catctctgat
     3241 gaagttattc cttatttcct gtatgttgta caatcaaaac acactactac ctcttaagtc
     3301 ccagtatacc tcatttttca tactgaaaaa aaagaaaaaa aagagaaaaa aaaaggcttg
     3361 tgtccaatgg aacagtgaga acatcataaa atttttatat atatagttta tttttgtggg
     3421 agataaattt tataagactg ttttttactg ttgttggtca cagctaagta agactggaca
     3481 tctaacttct ctaccatttc tgcaagctaa gtatgtttgc aggagaaact tatcaagacg
     3541 attaactgca tccaactttc tccccgttcc tttgtgtgcc ctctgacttc gttctctgtt
     3601 ccttgtgtag agtcgctgtc tgtgattgta cttggacggc ttgcttgtgg caataccttc
     3661 tctagtggat tatcactgtc tgcacaataa acataacagc ctctgtgggc cccgtggaaa
     3721 aaaaaaaaaa aaaaaaaaaa aa
//
