LOCUS       NM_001166477            1566 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus high mobility group AT-hook 1B (Hmga1b), transcript
            variant 2, mRNA.
ACCESSION   NM_001166477
VERSION     NM_001166477.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1566)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   2  (bases 1 to 1566)
  AUTHORS   Sweet,S.M., Bailey,C.M., Cunningham,D.L., Heath,J.K. and
            Cooper,H.J.
  TITLE     Large scale localization of protein phosphorylation by use of
            electron capture dissociation mass spectrometry
  JOURNAL   Mol Cell Proteomics 8 (5), 904-912 (2009)
   PUBMED   19131326
REFERENCE   3  (bases 1 to 1566)
  AUTHORS   Zanivan,S., Gnad,F., Wickstrom,S.A., Geiger,T., Macek,B., Cox,J.,
            Fassler,R. and Mann,M.
  TITLE     Solid tumor proteome and phosphoproteome analysis by high
            resolution mass spectrometry
  JOURNAL   J Proteome Res 7 (12), 5314-5326 (2008)
   PUBMED   19367708
REFERENCE   4  (bases 1 to 1566)
  AUTHORS   Zhou,H., Ye,M., Dong,J., Han,G., Jiang,X., Wu,R. and Zou,H.
  TITLE     Specific phosphopeptide enrichment with immobilized titanium ion
            affinity chromatography adsorbent for phosphoproteome analysis
  JOURNAL   J Proteome Res 7 (9), 3957-3967 (2008)
   PUBMED   18630941
REFERENCE   5  (bases 1 to 1566)
  AUTHORS   Smith,J.C., Duchesne,M.A., Tozzi,P., Ethier,M. and Figeys,D.
  TITLE     A differential phosphoproteomic analysis of retinoic acid-treated
            P19 cells
  JOURNAL   J Proteome Res 6 (8), 3174-3186 (2007)
   PUBMED   17622165
REFERENCE   6  (bases 1 to 1566)
  AUTHORS   Pierantoni,G.M., Fedele,M., Pentimalli,F., Benvenuto,G., Pero,R.,
            Viglietto,G., Santoro,M., Chiariotti,L. and Fusco,A.
  TITLE     High mobility group I (Y) proteins bind HIPK2, a serine-threonine
            kinase protein which inhibits cell growth
  JOURNAL   Oncogene 20 (43), 6132-6141 (2001)
   PUBMED   11593421
REFERENCE   7  (bases 1 to 1566)
  AUTHORS   Pedulla,M.L., Treff,N.R., Resar,L.M. and Reeves,R.
  TITLE     Sequence and analysis of the murine Hmgiy (Hmga1) gene locus
  JOURNAL   Gene 271 (1), 51-58 (2001)
   PUBMED   11410365
REFERENCE   8  (bases 1 to 1566)
  AUTHORS   Ferranti,P., Malorni,A., Marino,G., Pucci,P., Goodwin,G.H.,
            Manfioletti,G. and Giancotti,V.
  TITLE     Mass spectrometric analysis of the HMGY protein from Lewis lung
            carcinoma. Identification of phosphorylation sites
  JOURNAL   J Biol Chem 267 (31), 22486-22489 (1992)
   PUBMED   1429598
REFERENCE   9  (bases 1 to 1566)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Chromosomal localization of the murine gene and two related
            sequences encoding high-mobility-group I and Y proteins
  JOURNAL   Genomics 12 (3), 503-509 (1992)
   PUBMED   1559701
REFERENCE   10 (bases 1 to 1566)
  AUTHORS   Johnson,K.R., Lehn,D.A., Elton,T.S., Barr,P.J. and Reeves,R.
  TITLE     Complete murine cDNA sequence, genomic structure, and tissue
            expression of the high mobility group protein HMG-I(Y)
  JOURNAL   J Biol Chem 263 (34), 18338-18342 (1988)
   PUBMED   3192537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663090.15.
            
            Transcript Variant: This variant (2) lacks an in-frame segment of
            the 5' coding region compared to variant 1. It encodes isoform 2,
            which is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008125.1, AA870235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AL663090.15        8523-8719
            198-1566            AL663090.15        8753-10121
FEATURES             Location/Qualifiers
     source          1..1566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.51 cM"
     gene            1..1566
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
                     /note="high mobility group AT-hook 1B"
                     /db_xref="GeneID:111241"
                     /db_xref="MGI:MGI:96161"
     exon            1..197
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..386
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
                     /note="isoform 2 is encoded by transcript variant 2; high
                     mobility group protein HMG-I/HMG-Y; HMG-I(Y); high
                     mobility group protein A1; high mobility group AT-hook
                     protein 1; high mobility group AT-hook I, related sequence
                     1"
                     /codon_start=1
                     /product="high mobility group protein HMG-I/HMG-Y isoform
                     2"
                     /protein_id="NP_001159949.1"
                     /db_xref="GeneID:111241"
                     /db_xref="MGI:MGI:96161"
                     /translation="MSESGSKSSQPLASKQEKDGTEKRGRGRPRKQPPKEPSEVPTPK
                     RPRGRPKGSKNKGAAKTRKVTTAPGRKPRGRPKKLEKEEEEGISQESSEEEQ"
     exon            198..1566
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1259
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
                     /note="major polyA site"
     regulatory      1538..1543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
                     /note="hexamer: AATAAA"
     polyA_site      1558
                     /gene="Hmga1b"
                     /gene_synonym="Hmga1-rs1; Hmgi-rs1"
ORIGIN      
        1 cctctaattg ggactccgag tcggggctat ttctggtgtt ggcgcggctc caagaaggca
       61 ctcactgtgt gctgccccac acatagagaa ggagaatgag cgagtcgggc tcaaagtcca
      121 gccagcccct ggcctccaag caggaaaagg atgggactga gaagcgaggc cggggcaggc
      181 cacgcaagca gcctccgaaa gagcccagtg aagtgccaac tccgaagaga cctcggggcc
      241 gaccaaaggg aagcaagaat aagggcgccg ccaagacccg gaaagtcacc acagctccag
      301 ggaggaaacc aaggggcaga cccaagaaac tggagaagga ggaagaggag ggcatctccc
      361 aggagtcctc tgaggaggag cagtgatcac cactcgcagt gccgcctgct ccatagccac
      421 tgaggagcag ctgtcccctg ggactggaag ccctgctccc aggcccctcc ccgcccccac
      481 tgcacactac cgcaccaggc accagctgca ggctctgctc cgcagcaccc aagggagcag
      541 gattcggctc agtccctgtg ccctcctccc gaacacacct gccccatcct gacaaggcta
      601 acttcccatt tagccgcagc ccggcctgct gcgcacctcc ctcagagccg tggctctctg
      661 ggcgctttgt tttgcgggtc ccttctgccc tgctgttcct ggcttccccg tagagggtcc
      721 tgggagcatt ccctggcctt aaggggcccc ggccccatct cactctgaca aggcccagtg
      781 gctgacctag cagcagcagt gtggtcaggg caggggatgc ttagatccca gcatgtcccc
      841 accaaagtat caccgggtgg gtttctcagc ccctcctgcc ccaccctaca gagatcatgc
      901 actgggttgg ctgagcccct tgacaacagg aagtaggatg atgttggctc cacccacttt
      961 aatgttctca cctgagacta gacagatggg gttaccgccc atctccagag taagggcctg
     1021 ttctcgcctc caccaaaggc aaacgggcac caacacgcct cccccagtcc actctaggct
     1081 gttccttcct cccgcagggc actaaggagc tagccttgcc gccccctcct tttcgctcct
     1141 ccctgccccc catggttctg gttccatctt ctcctctgtt cacaaactac ctctggacgg
     1201 ttgtgttgtt ttttttttgt tccatgttca ttcttagata cccactattg ctgctgctac
     1261 cagcgtcaga tgttcatcct cctgaatttg cctgtattct ctcccccaca caatacactc
     1321 gaggggaagg ggggctgggg cgcagcagac tggttaccta ccccacacta aggaagatgg
     1381 ggccccaccc cgtggatgct gcagcagagt gaggatgggg gcccactttg atgggaaaag
     1441 ggtgtagggc cacctcccct tgttctgtgg gggaggggtg gccagtattt gtcccagcct
     1501 ggggcttcct ccctggtttc ttatttgcag ttacttgaat aaaaaacaaa tagccttttc
     1561 tggaca
//
