LOCUS       NM_001412733            1608 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus high mobility group AT-hook 1 (Hmga1), transcript
            variant 25, mRNA.
ACCESSION   NM_001412733
VERSION     NM_001412733.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Zhong,C., Zhang,Q., Bao,H., Li,Y. and Nie,C.
  TITLE     Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern
            to Promote Neural Impairment in MPTP Model of Parkinson's Disease
  JOURNAL   Appl Biochem Biotechnol 196 (7), 4008-4023 (2024)
   PUBMED   37815624
  REMARK    GeneRIF: Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA
            Pattern to Promote Neural Impairment in MPTP Model of Parkinson's
            Disease.
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Xu,J., Li,X., Lu,Q., Li,X. and Shan,H.
  TITLE     HMGA1 regulates the mitochondrial apoptosis pathway in
            sepsis-induced cardiomyopathy
  JOURNAL   Cell Biochem Biophys 82 (2), 849-858 (2024)
   PUBMED   38430408
  REMARK    GeneRIF: HMGA1 regulates the mitochondrial apoptosis pathway in
            sepsis-induced cardiomyopathy.
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Li,L., Kim,J.H., Lu,W., Williams,D.M., Kim,J., Cope,L.,
            Rampal,R.K., Koche,R.P., Xian,L., Luo,L.Z., Vasiljevic,M.,
            Matson,D.R., Zhao,Z.J., Rogers,O., Stubbs,M.C., Reddy,K.,
            Romero,A.R., Psaila,B., Spivak,J.L., Moliterno,A.R. and
            Resar,L.M.S.
  TITLE     HMGA1 chromatin regulators induce transcriptional networks involved
            in GATA2 and proliferation during MPN progression
  JOURNAL   Blood 139 (18), 2797-2815 (2022)
   PUBMED   35286385
  REMARK    GeneRIF: HMGA1 chromatin regulators induce transcriptional networks
            involved in GATA2 and proliferation during MPN progression.
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Zhou,X., Benson,K.F., Ashar,H.R. and Chada,K.
  TITLE     Mutation responsible for the mouse pygmy phenotype in the
            developmentally regulated factor HMGI-C
  JOURNAL   Nature 376 (6543), 771-774 (1995)
   PUBMED   7651535
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Ferranti,P., Malorni,A., Marino,G., Pucci,P., Goodwin,G.H.,
            Manfioletti,G. and Giancotti,V.
  TITLE     Mass spectrometric analysis of the HMGY protein from Lewis lung
            carcinoma. Identification of phosphorylation sites
  JOURNAL   J Biol Chem 267 (31), 22486-22489 (1992)
   PUBMED   1429598
REFERENCE   7  (bases 1 to 1608)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Chromosomal localization of the murine gene and two related
            sequences encoding high-mobility-group I and Y proteins
  JOURNAL   Genomics 12 (3), 503-509 (1992)
   PUBMED   1559701
REFERENCE   8  (bases 1 to 1608)
  AUTHORS   Bustin,M., Lehn,D.A. and Landsman,D.
  TITLE     Structural features of the HMG chromosomal proteins and their genes
  JOURNAL   Biochim Biophys Acta 1049 (3), 231-243 (1990)
   PUBMED   2200521
  REMARK    Review article
REFERENCE   9  (bases 1 to 1608)
  AUTHORS   Disney,J.E., Johnson,K.R., Magnuson,N.S., Sylvester,S.R. and
            Reeves,R.
  TITLE     High-mobility group protein HMG-I localizes to G/Q- and C-bands of
            human and mouse chromosomes
  JOURNAL   J Cell Biol 109 (5), 1975-1982 (1989)
   PUBMED   2808516
REFERENCE   10 (bases 1 to 1608)
  AUTHORS   Johnson,K.R., Lehn,D.A., Elton,T.S., Barr,P.J. and Reeves,R.
  TITLE     Complete murine cDNA sequence, genomic structure, and tissue
            expression of the high mobility group protein HMG-I(Y)
  JOURNAL   J Biol Chem 263 (34), 18338-18342 (1988)
   PUBMED   3192537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127341.3.
            
            Summary: This locus encodes a member of the nuclear, non-histone
            high mobility group protein family. This architectural
            transcription factor binds to A-T rich DNA sequences and
            participates in enhanceosome formation, chromatin remodeling and
            regulation of transcription. This protein functions in many
            cellular processes, including cell growth and differentiation.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2539572.1,
                                           SRR17784646.1283209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC127341.3         176296-176386
            92-235              AC127341.3         179235-179378
            236-319             AC127341.3         180603-180686
            320-370             AC127341.3         181136-181186
            371-1608            AC127341.3         182113-183350
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.5 cM"
     gene            1..1608
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="high mobility group AT-hook 1"
                     /db_xref="GeneID:15361"
                     /db_xref="MGI:MGI:96160"
     exon            1..91
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            92..235
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..424
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="isoform a is encoded by transcript variant 25; high
                     mobility group protein HMG-I/HMG-Y; high mobility group
                     protein A1; high mobility group AT-hook protein 1; high
                     mobility group protein I"
                     /codon_start=1
                     /product="high mobility group protein HMG-I/HMG-Y isoform
                     a"
                     /protein_id="NP_001399662.1"
                     /db_xref="GeneID:15361"
                     /db_xref="MGI:MGI:96160"
                     /translation="MSESGSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGS
                     QKEPSEVPTPKRPRGRPKGSKNKGAAKTRKVTTAPGRKPRGRPKKLEKEEEEGISQES
                     SEEEQ"
     exon            236..319
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            320..370
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            371..1608
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="hexamer: AACAAA"
     polyA_site      1608
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="major polyA site"
ORIGIN      
        1 ctttttaagc tcccctgagc cggggctgcg ctcctctaat tgggactccg agtcggggct
       61 atttctggtg ttggcgcggc tccaagaagg cagaaggaga atgagcgagt cgggctcaaa
      121 gtccagccag cccctggcct ccaagcagga aaaggatggg actgagaagc gaggccgggg
      181 caggccacgc aagcagcctc cggtgagtcc tgggacggcg ctggtcggga gtcagaaaga
      241 gcccagtgaa gtgccaactc cgaagagacc tcggggccga ccaaagggaa gcaagaataa
      301 gggcgccgcc aagacccgga aagtcaccac agctccaggg aggaaaccaa ggggcagacc
      361 caagaaactg gagaaggagg aagaggaggg catctcccag gagtcctctg aggaggagca
      421 gtgatcacca ctcgcagtgc cgcctgctcc atagccactg aggagcagct gtcccctggg
      481 actggaagcc ctgctcccag gcccctcccc gcccccactg cacactaccg caccaggcac
      541 cagctgcagg ctctgctccg cagcacccaa gggagcagga ttcggctcag tccctgtgcc
      601 ctcctcccga acacacctgc cccatcctga caaggctaac ttcccattta gccgcagccc
      661 gacctgctgc gcacctccct cagagccgtg gctctctggg cgctttgttt tgcgggtccc
      721 ttctgccctg ctgttcctgg cttccccgta gagggtcctg ggagcattcc ctggccttaa
      781 ggggccccag ccccatctca ctctgacaag gcccagtggc tgacctagca gcagcagtgt
      841 ggtcagggca ggggatgctt agatcccagc atgtccccac caaagtatca ccgggtgggt
      901 ttctcagccc ctcctgcccc accctacaga gatcatgcac tgggttggct gagccccttg
      961 acaacaggaa gtaggatgat gttggctcca cccactttaa tgttctcacc tgagactaga
     1021 cagatggggt taccgcccat ctccagagta agggcctgtt ctcgcctcca ccaaaggcaa
     1081 acgggcacca acacgcctcc cccagtccac tctaggctgt tccttcctcc cgcagggcac
     1141 taaggagcta gccttgccgc cccctccttt tcgctcctcc ctgcccccca tggttctggt
     1201 tccatcttct cctctgttca caaactacct ctggacggtt gtgttgtttt gtttttgttc
     1261 catgttcatt cttagatacc cactattgct gctgctacca gcgtcagatg ttcatcctcc
     1321 tgaatttgcc tgtattctct cccccacaca atacactcga ggggaagggg ggctggggcg
     1381 cagcagactg gttacctacc ccacactaag gaagatgggg ccccaccccg tggatgctgc
     1441 agcagagtga ggatgggggc ccactttgat gggaaaaggg tgtagggcca cctccccttg
     1501 ttctgtgggg gaggggtggc cagtatttgt cccagcctgg ggcttcctcc ctggtttctt
     1561 atttgcagtt acttgaataa aaaacaaata gccttttctg gacagtct
//
