LOCUS       NM_001412729            1685 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus high mobility group AT-hook 1 (Hmga1), transcript
            variant 23, mRNA.
ACCESSION   NM_001412729
VERSION     NM_001412729.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Zhong,C., Zhang,Q., Bao,H., Li,Y. and Nie,C.
  TITLE     Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern
            to Promote Neural Impairment in MPTP Model of Parkinson's Disease
  JOURNAL   Appl Biochem Biotechnol 196 (7), 4008-4023 (2024)
   PUBMED   37815624
  REMARK    GeneRIF: Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA
            Pattern to Promote Neural Impairment in MPTP Model of Parkinson's
            Disease.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Xu,J., Li,X., Lu,Q., Li,X. and Shan,H.
  TITLE     HMGA1 regulates the mitochondrial apoptosis pathway in
            sepsis-induced cardiomyopathy
  JOURNAL   Cell Biochem Biophys 82 (2), 849-858 (2024)
   PUBMED   38430408
  REMARK    GeneRIF: HMGA1 regulates the mitochondrial apoptosis pathway in
            sepsis-induced cardiomyopathy.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Li,L., Kim,J.H., Lu,W., Williams,D.M., Kim,J., Cope,L.,
            Rampal,R.K., Koche,R.P., Xian,L., Luo,L.Z., Vasiljevic,M.,
            Matson,D.R., Zhao,Z.J., Rogers,O., Stubbs,M.C., Reddy,K.,
            Romero,A.R., Psaila,B., Spivak,J.L., Moliterno,A.R. and
            Resar,L.M.S.
  TITLE     HMGA1 chromatin regulators induce transcriptional networks involved
            in GATA2 and proliferation during MPN progression
  JOURNAL   Blood 139 (18), 2797-2815 (2022)
   PUBMED   35286385
  REMARK    GeneRIF: HMGA1 chromatin regulators induce transcriptional networks
            involved in GATA2 and proliferation during MPN progression.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Zhou,X., Benson,K.F., Ashar,H.R. and Chada,K.
  TITLE     Mutation responsible for the mouse pygmy phenotype in the
            developmentally regulated factor HMGI-C
  JOURNAL   Nature 376 (6543), 771-774 (1995)
   PUBMED   7651535
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Ferranti,P., Malorni,A., Marino,G., Pucci,P., Goodwin,G.H.,
            Manfioletti,G. and Giancotti,V.
  TITLE     Mass spectrometric analysis of the HMGY protein from Lewis lung
            carcinoma. Identification of phosphorylation sites
  JOURNAL   J Biol Chem 267 (31), 22486-22489 (1992)
   PUBMED   1429598
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Chromosomal localization of the murine gene and two related
            sequences encoding high-mobility-group I and Y proteins
  JOURNAL   Genomics 12 (3), 503-509 (1992)
   PUBMED   1559701
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Bustin,M., Lehn,D.A. and Landsman,D.
  TITLE     Structural features of the HMG chromosomal proteins and their genes
  JOURNAL   Biochim Biophys Acta 1049 (3), 231-243 (1990)
   PUBMED   2200521
  REMARK    Review article
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Disney,J.E., Johnson,K.R., Magnuson,N.S., Sylvester,S.R. and
            Reeves,R.
  TITLE     High-mobility group protein HMG-I localizes to G/Q- and C-bands of
            human and mouse chromosomes
  JOURNAL   J Cell Biol 109 (5), 1975-1982 (1989)
   PUBMED   2808516
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Johnson,K.R., Lehn,D.A., Elton,T.S., Barr,P.J. and Reeves,R.
  TITLE     Complete murine cDNA sequence, genomic structure, and tissue
            expression of the high mobility group protein HMG-I(Y)
  JOURNAL   J Biol Chem 263 (34), 18338-18342 (1988)
   PUBMED   3192537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127341.3.
            
            Summary: This locus encodes a member of the nuclear, non-histone
            high mobility group protein family. This architectural
            transcription factor binds to A-T rich DNA sequences and
            participates in enhanceosome formation, chromatin remodeling and
            regulation of transcription. This protein functions in many
            cellular processes, including cell growth and differentiation.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862051.2887085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC127341.3         176296-176424
            130-300             AC127341.3         179208-179378
            301-396             AC127341.3         180591-180686
            397-447             AC127341.3         181136-181186
            448-1685            AC127341.3         182113-183350
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.5 cM"
     gene            1..1685
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="high mobility group AT-hook 1"
                     /db_xref="GeneID:15361"
                     /db_xref="MGI:MGI:96160"
     exon            1..129
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            130..300
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..501
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="isoform d is encoded by transcript variant 23; high
                     mobility group protein HMG-I/HMG-Y; high mobility group
                     protein A1; high mobility group AT-hook protein 1; high
                     mobility group protein I"
                     /codon_start=1
                     /product="high mobility group protein HMG-I/HMG-Y isoform
                     d"
                     /protein_id="NP_001399658.1"
                     /db_xref="GeneID:15361"
                     /db_xref="MGI:MGI:96160"
                     /translation="MSESGSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGS
                     QTSLQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKVTTAPGRKPRGRPKKLEKEEEEGI
                     SQESSEEEQ"
     exon            301..396
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            397..447
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1685
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="hexamer: AACAAA"
     polyA_site      1685
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="major polyA site"
ORIGIN      
        1 ctttttaagc tcccctgagc cggggctgcg ctcctctaat tgggactccg agtcggggct
       61 atttctggtg ttggcgcggc tccaagaagg cgtgagttcg ccgccgctcg ggtggcttct
      121 ttttttccta ctcactgtgt gctgccccac acatagagaa ggagaatgag cgagtcgggc
      181 tcaaagtcca gccagcccct ggcctccaag caggaaaagg atgggactga gaagcgaggc
      241 cggggcaggc cacgcaagca gcctccggtg agtcctggga cggcgctggt cgggagtcag
      301 acatctttgc agaaagagcc cagtgaagtg ccaactccga agagacctcg gggccgacca
      361 aagggaagca agaataaggg cgccgccaag acccggaaag tcaccacagc tccagggagg
      421 aaaccaaggg gcagacccaa gaaactggag aaggaggaag aggagggcat ctcccaggag
      481 tcctctgagg aggagcagtg atcaccactc gcagtgccgc ctgctccata gccactgagg
      541 agcagctgtc ccctgggact ggaagccctg ctcccaggcc cctccccgcc cccactgcac
      601 actaccgcac caggcaccag ctgcaggctc tgctccgcag cacccaaggg agcaggattc
      661 ggctcagtcc ctgtgccctc ctcccgaaca cacctgcccc atcctgacaa ggctaacttc
      721 ccatttagcc gcagcccgac ctgctgcgca cctccctcag agccgtggct ctctgggcgc
      781 tttgttttgc gggtcccttc tgccctgctg ttcctggctt ccccgtagag ggtcctggga
      841 gcattccctg gccttaaggg gccccagccc catctcactc tgacaaggcc cagtggctga
      901 cctagcagca gcagtgtggt cagggcaggg gatgcttaga tcccagcatg tccccaccaa
      961 agtatcaccg ggtgggtttc tcagcccctc ctgccccacc ctacagagat catgcactgg
     1021 gttggctgag ccccttgaca acaggaagta ggatgatgtt ggctccaccc actttaatgt
     1081 tctcacctga gactagacag atggggttac cgcccatctc cagagtaagg gcctgttctc
     1141 gcctccacca aaggcaaacg ggcaccaaca cgcctccccc agtccactct aggctgttcc
     1201 ttcctcccgc agggcactaa ggagctagcc ttgccgcccc ctccttttcg ctcctccctg
     1261 ccccccatgg ttctggttcc atcttctcct ctgttcacaa actacctctg gacggttgtg
     1321 ttgttttgtt tttgttccat gttcattctt agatacccac tattgctgct gctaccagcg
     1381 tcagatgttc atcctcctga atttgcctgt attctctccc ccacacaata cactcgaggg
     1441 gaaggggggc tggggcgcag cagactggtt acctacccca cactaaggaa gatggggccc
     1501 caccccgtgg atgctgcagc agagtgagga tgggggccca ctttgatggg aaaagggtgt
     1561 agggccacct ccccttgttc tgtgggggag gggtggccag tatttgtccc agcctggggc
     1621 ttcctccctg gtttcttatt tgcagttact tgaataaaaa acaaatagcc ttttctggac
     1681 agtct
//
