LOCUS       NM_001025427            1679 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus high mobility group AT-hook 1 (Hmga1), transcript
            variant 2, mRNA.
ACCESSION   NM_001025427
VERSION     NM_001025427.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Zhong,C., Zhang,Q., Bao,H., Li,Y. and Nie,C.
  TITLE     Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern
            to Promote Neural Impairment in MPTP Model of Parkinson's Disease
  JOURNAL   Appl Biochem Biotechnol 196 (7), 4008-4023 (2024)
   PUBMED   37815624
  REMARK    GeneRIF: Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA
            Pattern to Promote Neural Impairment in MPTP Model of Parkinson's
            Disease.
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Xu,J., Li,X., Lu,Q., Li,X. and Shan,H.
  TITLE     HMGA1 regulates the mitochondrial apoptosis pathway in
            sepsis-induced cardiomyopathy
  JOURNAL   Cell Biochem Biophys 82 (2), 849-858 (2024)
   PUBMED   38430408
  REMARK    GeneRIF: HMGA1 regulates the mitochondrial apoptosis pathway in
            sepsis-induced cardiomyopathy.
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Li,L., Kim,J.H., Lu,W., Williams,D.M., Kim,J., Cope,L.,
            Rampal,R.K., Koche,R.P., Xian,L., Luo,L.Z., Vasiljevic,M.,
            Matson,D.R., Zhao,Z.J., Rogers,O., Stubbs,M.C., Reddy,K.,
            Romero,A.R., Psaila,B., Spivak,J.L., Moliterno,A.R. and
            Resar,L.M.S.
  TITLE     HMGA1 chromatin regulators induce transcriptional networks involved
            in GATA2 and proliferation during MPN progression
  JOURNAL   Blood 139 (18), 2797-2815 (2022)
   PUBMED   35286385
  REMARK    GeneRIF: HMGA1 chromatin regulators induce transcriptional networks
            involved in GATA2 and proliferation during MPN progression.
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Zhou,X., Benson,K.F., Ashar,H.R. and Chada,K.
  TITLE     Mutation responsible for the mouse pygmy phenotype in the
            developmentally regulated factor HMGI-C
  JOURNAL   Nature 376 (6543), 771-774 (1995)
   PUBMED   7651535
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Ferranti,P., Malorni,A., Marino,G., Pucci,P., Goodwin,G.H.,
            Manfioletti,G. and Giancotti,V.
  TITLE     Mass spectrometric analysis of the HMGY protein from Lewis lung
            carcinoma. Identification of phosphorylation sites
  JOURNAL   J Biol Chem 267 (31), 22486-22489 (1992)
   PUBMED   1429598
REFERENCE   7  (bases 1 to 1679)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Chromosomal localization of the murine gene and two related
            sequences encoding high-mobility-group I and Y proteins
  JOURNAL   Genomics 12 (3), 503-509 (1992)
   PUBMED   1559701
REFERENCE   8  (bases 1 to 1679)
  AUTHORS   Bustin,M., Lehn,D.A. and Landsman,D.
  TITLE     Structural features of the HMG chromosomal proteins and their genes
  JOURNAL   Biochim Biophys Acta 1049 (3), 231-243 (1990)
   PUBMED   2200521
  REMARK    Review article
REFERENCE   9  (bases 1 to 1679)
  AUTHORS   Disney,J.E., Johnson,K.R., Magnuson,N.S., Sylvester,S.R. and
            Reeves,R.
  TITLE     High-mobility group protein HMG-I localizes to G/Q- and C-bands of
            human and mouse chromosomes
  JOURNAL   J Cell Biol 109 (5), 1975-1982 (1989)
   PUBMED   2808516
REFERENCE   10 (bases 1 to 1679)
  AUTHORS   Johnson,K.R., Lehn,D.A., Elton,T.S., Barr,P.J. and Reeves,R.
  TITLE     Complete murine cDNA sequence, genomic structure, and tissue
            expression of the high mobility group protein HMG-I(Y)
  JOURNAL   J Biol Chem 263 (34), 18338-18342 (1988)
   PUBMED   3192537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY270784.1, AK171334.1 and
            AV018894.1.
            
            On Nov 3, 2009 this sequence version replaced NM_001025427.2.
            
            Summary: This locus encodes a member of the nuclear, non-histone
            high mobility group protein family. This architectural
            transcription factor binds to A-T rich DNA sequences and
            participates in enhanceosome formation, chromatin remodeling and
            regulation of transcription. This protein functions in many
            cellular processes, including cell growth and differentiation.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 through 5 encode the same isoform (a),
            also known as isoform I.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.109754.1, AK171334.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY270784.1         2-48
            48-1671             AK171334.1         2-1625
            1672-1679           AV018894.1         227-234
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.5 cM"
     gene            1..1679
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="high mobility group AT-hook 1"
                     /db_xref="GeneID:15361"
                     /db_xref="MGI:MGI:96160"
     exon            1..138
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            139..309
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..498
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /note="isoform a is encoded by transcript variant 2; high
                     mobility group protein HMG-I/HMG-Y; high mobility group
                     protein A1; high mobility group AT-hook protein 1; high
                     mobility group protein I"
                     /codon_start=1
                     /product="high mobility group protein HMG-I/HMG-Y isoform
                     a"
                     /protein_id="NP_001020598.1"
                     /db_xref="CCDS:CCDS28564.1"
                     /db_xref="GeneID:15361"
                     /db_xref="MGI:MGI:96160"
                     /translation="MSESGSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGS
                     QKEPSEVPTPKRPRGRPKGSKNKGAAKTRKVTTAPGRKPRGRPKKLEKEEEEGISQES
                     SEEEQ"
     exon            310..393
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            394..444
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     exon            445..1679
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1650..1655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
     polyA_site      1678
                     /gene="Hmga1"
                     /gene_synonym="Hmga1a; Hmga1b; Hmgi; Hmgiy; Hmgy"
ORIGIN      
        1 gacacggctg gcgcgggcgg gcccgtcccc cctgcccctg ggtcgctctt tttaagctcc
       61 cctgagccgg ggctgcgctc ctctaattgg gactccgagt cggggctatt tctggtgttg
      121 gcgcggctcc aagaaggcac tcactgtgtg ctgccccaca catagagaag gagaatgagc
      181 gagtcgggct caaagtccag ccagcccctg gcctccaagc aggaaaagga tgggactgag
      241 aagcgaggcc ggggcaggcc acgcaagcag cctccggtga gtcctgggac ggcgctggtc
      301 gggagtcaga aagagcccag tgaagtgcca actccgaaga gacctcgggg ccgaccaaag
      361 ggaagcaaga ataagggcgc cgccaagacc cggaaagtca ccacagctcc agggaggaaa
      421 ccaaggggca gacccaagaa actggagaag gaggaagagg agggcatctc ccaggagtcc
      481 tctgaggagg agcagtgatc accactcgca gtgccgcctg ctccatagcc actgaggagc
      541 agctgtcccc tgggactgga agccctgctc ccaggcccct ccccgccccc actgcacact
      601 accgcaccag gcaccagctg caggctctgc tccgcagcac ccaagggagc aggattcggc
      661 tcagtccctg tgccctcctc ccgaacacac ctgccccatc ctgacaaggc taacttccca
      721 tttagccgca gcccgacctg ctgcgcacct ccctcagagc cgtggctctc tgggcgcttt
      781 gttttgcggg tcccttctgc cctgctgttc ctggcttccc cgtagagggt cctgggagca
      841 ttccctggcc ttaaggggcc ccagccccat ctcactctga caaggcccag tggctgacct
      901 agcagcagca gtgtggtcag ggcaggggat gcttagatcc cagcatgtcc ccaccaaagt
      961 atcaccgggt gggtttctca gcccctcctg ccccacccta cagagatcat gcactgggtt
     1021 ggctgagccc cttgacaaca ggaagtagga tgatgttggc tccacccact ttaatgttct
     1081 cacctgagac tagacagatg gggttaccgc ccatctccag agtaagggcc tgttctcgcc
     1141 tccaccaaag gcaaacgggc accaacacgc ctcccccagt ccactctagg ctgttccttc
     1201 ctcccgcagg gcactaagga gctagccttg ccgccccctc cttttcgctc ctccctgccc
     1261 cccatggttc tggttccatc ttctcctctg ttcacaaact acctctggac ggttgtgttg
     1321 ttttgttttt gttccatgtt cattcttaga tacccactat tgctgctgct accagcgtca
     1381 gatgttcatc ctcctgaatt tgcctgtatt ctctccccca cacaatacac tcgaggggaa
     1441 ggggggctgg ggcgcagcag actggttacc taccccacac taaggaagat ggggccccac
     1501 cccgtggatg ctgcagcaga gtgaggatgg gggcccactt tgatgggaaa agggtgtagg
     1561 gccacctccc cttgttctgt gggggagggg tggccagtat ttgtcccagc ctggggcttc
     1621 ctccctggtt tcttatttgc agttacttga ataaaaaaca aatagccttt tctggacag
//
