LOCUS       NM_025812               3768 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus high mobility group 20A (Hmg20a), mRNA.
ACCESSION   NM_025812
VERSION     NM_025812.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3768)
  AUTHORS   Nagai,M., Porter,R.S., Miyasato,M., Wang,A., Gavilan,C.M.,
            Hughes,E.D., Wu,M.C., Saunders,T.L. and Iwase,S.
  TITLE     Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A,
            prevents excessive synaptogenesis
  JOURNAL   J Biol Chem 300 (11), 107881 (2024)
   PUBMED   39395799
REFERENCE   2  (bases 1 to 3768)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3768)
  AUTHORS   Yang,J., Xu,J., Zhang,L., Li,Y. and Chen,M.
  TITLE     Identifying key m6A-methylated lncRNAs and genes associated with
            neural tube defects via integrative MeRIP and RNA sequencing
            analyses
  JOURNAL   Front Genet 13, 974357 (2022)
   PUBMED   36482889
  REMARK    Erratum:[Front Genet. 2023 Jul 10;14:1198975. doi:
            10.3389/fgene.2023.1198975.. PMID: 37496715]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3768)
  AUTHORS   Zhou,J., Hamdan,H., Yalamanchili,H.K., Pang,K., Pohodich,A.E.,
            Lopez,J., Shao,Y., Oses-Prieto,J.A., Li,L., Kim,W., Durham,M.A.,
            Bajikar,S.S., Palmer,D.J., Ng,P., Thompson,M.L., Bebin,E.M.,
            Muller,A.J., Kuechler,A., Kampmeier,A., Haack,T.B.,
            Burlingame,A.L., Liu,Z., Rasband,M.N. and Zoghbi,H.Y.
  TITLE     Disruption of MeCP2-TCF20 complex underlies distinct
            neurodevelopmental disorders
  JOURNAL   Proc Natl Acad Sci U S A 119 (4) (2022)
   PUBMED   35074918
REFERENCE   5  (bases 1 to 3768)
  AUTHORS   Lorenzo,P.I., Martin Vazquez,E., Lopez-Noriega,L.,
            Fuente-Martin,E., Mellado-Gil,J.M., Franco,J.M.,
            Cobo-Vuilleumier,N., Guerrero Martinez,J.A., Romero-Zerbo,S.Y.,
            Perez-Cabello,J.A., Rivero Canalejo,S., Campos-Caro,A.,
            Lachaud,C.C., Crespo Barreda,A., Aguilar-Diosdado,M., Garcia
            Fuentes,E., Martin-Montalvo,A., Alvarez Dolado,M., Martin,F.,
            Rojo-Martinez,G., Pozo,D., Bermudez-Silva,F.J., Comaills,V.,
            Reyes,J.C. and Gauthier,B.R.
  TITLE     The metabesity factor HMG20A potentiates astrocyte survival and
            reactive astrogliosis preserving neuronal integrity
  JOURNAL   Theranostics 11 (14), 6983-7004 (2021)
   PUBMED   34093866
  REMARK    GeneRIF: The metabesity factor HMG20A potentiates astrocyte
            survival and reactive astrogliosis preserving neuronal integrity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3768)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   7  (bases 1 to 3768)
  AUTHORS   Wynder,C., Hakimi,M.A., Epstein,J.A., Shilatifard,A. and
            Shiekhattar,R.
  TITLE     Recruitment of MLL by HMG-domain protein iBRAF promotes neural
            differentiation
  JOURNAL   Nat Cell Biol 7 (11), 1113-1117 (2005)
   PUBMED   16227968
  REMARK    GeneRIF: Ectopic expression of iBRAF induces neuronal
            differentiation through recruitment of MLL, resulting in increased
            histone H3K4 trimethylation and activation of neuronal-specific
            genes.
REFERENCE   8  (bases 1 to 3768)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   9  (bases 1 to 3768)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3768)
  AUTHORS   Sumoy,L., Carim,L., Escarceller,M., Nadal,M., Gratacos,M.,
            Pujana,M.A., Estivill,X. and Peral,B.
  TITLE     HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and
            constitute a distinct class of HMG-box genes with ubiquitous
            expression
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 62-67 (2000)
   PUBMED   10773667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159819.2.
            
            On Oct 25, 2017 this sequence version replaced NM_025812.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ182735.1, BC013804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC159819.2         37509-37821
            314-406             AC159819.2         86248-86340
            407-551             AC159819.2         93421-93565
            552-764             AC159819.2         96072-96284
            765-897             AC159819.2         100488-100620
            898-929             AC159819.2         101498-101529
            930-1005            AC159819.2         106506-106581
            1006-1221           AC159819.2         107504-107719
            1222-1364           AC159819.2         108712-108854
            1365-3768           AC159819.2         113423-115826
FEATURES             Location/Qualifiers
     source          1..3768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     gene            1..3768
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /note="high mobility group 20A"
                     /db_xref="GeneID:66867"
                     /db_xref="MGI:MGI:1914117"
     exon            1..313
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            314..406
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1358
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /note="inhibitor of BRAF35; HMG box-containing protein
                     20A; HMG domain-containing protein HMGX1"
                     /codon_start=1
                     /product="high mobility group protein 20A"
                     /protein_id="NP_080088.1"
                     /db_xref="CCDS:CCDS23208.1"
                     /db_xref="GeneID:66867"
                     /db_xref="MGI:MGI:1914117"
                     /translation="MESLMASSTLPPLFADEDGSKESNDLATSGLTHPEGPYGSAATS
                     TTNPEFVEDLSQGQLLQSEASNAVEGNEQRPEDEQRSKRGGWSKGRKRKKPLRDSNAP
                     KSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKE
                     RYMKELEQYQKTEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETEVKERSVFDIP
                     IFTEEFLNHSKAREAELRQLRKSNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSR
                     NTVLQQHLETLRQMLTSSFASMPLPGSGEIPTVDTIDSYMNRLHSIILANPQDNENFI
                     ATVREVVNRLDR"
     exon            407..551
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            552..764
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            765..897
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            898..929
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1005
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1221
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1364
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..3768
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3692..3697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /note="hexamer: ATTAAA"
     polyA_site      3718
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /note="major polyA site"
     regulatory      3747..3752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
                     /note="hexamer: ATTAAA"
     polyA_site      3768
                     /gene="Hmg20a"
                     /gene_synonym="1200004E06Rik; 5730490E10Rik; Hmgxb1;
                     Ibraf"
ORIGIN      
        1 agtccttcgc cgcattgggc aaaataatcc cttcatttct ctgaaagtat cgggtataac
       61 atttcacgtc tctcctcaac ggaacaattc tcagtattac cacgttaaaa gaagttacct
      121 atctggaggt gactaagtga ttaggtaaag agtaagaaaa gacaccaaaa taaagtactg
      181 cggaggaatt tctgtcaagc tgtgagacga cggagtgaag agtgaaggcg attgcgaggg
      241 gctgagggaa ttgtcctctg tgcaagggac tttcattagt ccccaggccc ctgcctgctc
      301 ctgccgtcag cagggagatg gagagcttga tggccagttc taccctgccg cccctgtttg
      361 cagatgaaga tggctccaag gagagcaatg atctggctac atctgggtta acacaccccg
      421 agggtccgta tggcagtgca gccacatcaa caaccaaccc agagtttgtg gaggatctct
      481 cccaaggcca gctgcttcag agtgaggctt ccaatgctgt agaaggcaat gagcaaaggc
      541 ctgaagatga gcaaagaagt aaacgaggag gttggtccaa agggagaaaa aggaagaaac
      601 ctcttcgaga cagcaatgca cctaaatccc cccttacagg atatgttcga ttcatgaacg
      661 agcgtagaga acagcttcga gcaaagagac cagaggttcc atttccagaa atcacaagga
      721 tgttgggcaa tgagtggagt aaactgcctc ctgaggaaaa gcagcgctac cttgatgaag
      781 cagacagaga taaggagcgt tacatgaagg aactggagca gtatcagaag accgaggcct
      841 acaaggtctt cagtaggaaa acacaggacc gtcagaaagg caaatctcat aggcaagatg
      901 cagcccgaca ggccactcat gatcatgaga aagaaacaga ggtaaaggaa cgctctgttt
      961 ttgatatccc tatatttacc gaagaattcc tgaaccacag caaagctcgt gaggcagagc
     1021 tccgccagct tcgtaaatcc aacatggagt ttgaagagag gaacgcagcc ctacagaagc
     1081 acgtggagag catgcgcaca gcagtggaga agctggaggt tgacgtgatc caggagcgga
     1141 gccgaaacac cgtccttcag cagcacctgg agaccctgcg gcagatgttg accagcagct
     1201 tcgccagcat gcccttgcct ggaagtggag aaataccaac agtggacacc attgactcat
     1261 acatgaacag attgcacagt ataattttag ctaatcccca agacaacgaa aacttcatag
     1321 ctacagtccg agaggttgtg aacaggcttg atcgttaagc gctgatctta gtgctccaag
     1381 atgtagtgtg tgcacttgtg cagaatgaga agcttcccat gaacatttga actgagacgg
     1441 ggcagaggac agatccctcc ctgtgaaaga attgtcagta agtgaagtgc tttcatccca
     1501 ggaagctgtg tgagggagca acaaagatgg atgcgtgaac tctgtagaaa tgccctgtgt
     1561 gcagctctgg aagtgtccag cccctcactc tcttcaaagt cttcctggag tcctctcatt
     1621 tccatttctg ctgaagtgga gctgcataca ttcttctgac aacagcgacc ccgagactga
     1681 catcctcctt ctctccccag caaaaaggaa gatttctcat tgttacaatc ccactccagt
     1741 tttcttaccc agatgtcact tttttaaatg cctctggggg actgcttttc ttcactccca
     1801 ccaagtcaca catctccatt ttctgacctc tgggttttgt ggctcagcgg gactttgaag
     1861 gagaattctc attggatggg cccaatcttc tccatcacta ccctgctggg actccaaaga
     1921 acagagcttc ttgttgacag tgccctgtgg agccaggcac tgtttcgtgc cctgcgtggt
     1981 gctcagtggg tgccagcccc tcagcaggct ctgtggttgc tgccctaaag gacaatgctc
     2041 cctccatcct tcctggtcct gcctgctgat ctctgagcat tactcctgct cagacatgga
     2101 atcccagcca cagcaaagcc gccagtcccc atctgttggc agtgtcttgt ggagcacttt
     2161 tgctgaggaa aaggtcattg gcagagaggg aggaggaaag ttaatgcaca tttggtgttg
     2221 gaaagcagcc gacatctgac taagtggaaa ctcagcagca ctgtcctcgg tgcgcaggtc
     2281 catgcgttag gatgatggga acttctgtgg aagaagtctc ttgagctcac aaaaaggcat
     2341 ggtggactct gcttatgttt tgctttcctc tgtagccacc aactgccgaa tctatgaaat
     2401 ctgtggaaaa gacagcttcc ttctctccct ctccttacta aggaattttg ttgttgttgt
     2461 tgttgttgtt taaccacaaa aacaaacagg ttctgtttct ctcctcaggg ttggttctcg
     2521 gtttttgggt tggatttggg gttttgggtt agttttaggg tttggtttgg ttgtaggttt
     2581 tgggttggat ttgttttttt atttttcttt tatgctctag agcacaagga tagaggtggc
     2641 agctgagatc tttggaacca aagcagagca tgctgagccc attatctagg cactaggcca
     2701 ccaaaggcag ggggatggag tatggtccct cacaatctgc ccataagcca gagcccccat
     2761 gctgtggctg caccacactt ctccacactg cgttctctcc tgtgtgctct attagatagt
     2821 ccaaagggag cagcagtagt aacgagctat gtgagcacat tgaactccat gcactgaaaa
     2881 gacccagtca tcactcactg ctgcacagcc agccagcttt gcagcctgtg tgctgccccg
     2941 gctccccacc ctcgtctgct gttttttgct tcttagattg cttgcctgct aagcccatgc
     3001 tagaactcac tgtctgtggc agaaggacac ccaagccggt tctgggagtt tgtctgtctt
     3061 caaccagatg cttcctgccc tttcttcctt cctcctctta ttgctgtttc tctctgtatg
     3121 cagttccgag ccgtttccat agcactgatc ttcacggcca gataaagcta tggcttggtc
     3181 caaagatgat cgatcattct cctctttaca gatgtgatac ctcatctcgt ctagacacat
     3241 tcgcatagcc agaattcagt aggatagcaa gggaatctcc acgatggagt tcttgtcaca
     3301 gcagtagctt cctttcaaat actgcctctc tctcccagca gctgccataa gtggctgggc
     3361 ttcagtcagg ttgtatagag ctggtctgtt ccaccttctc tcactccatg ctcaacacag
     3421 aagagaggat gtcagggtgc aagctggcac aagggtttat ttccctggaa ggttcatcca
     3481 tcgctgatcc tgcgcctgca agctctcctc aagaaggaag cagttaccaa ctcagtgtta
     3541 cacattccat tcttgctttt tttcttaaaa cacaggagca gctggggaag ggagatgagg
     3601 gcctttattt ctgacacatt ttagaaaacg aaatattgtg tacatgtgtt tggagctgtt
     3661 gaattgccag gtttctgtac aagcgttcgt aattaaaatt ttggattttc tctaagaagt
     3721 tgatgtgctt gcctgacatt tgtctcatta aaagttttct gtgtggaa
//
