LOCUS       NM_001347626            6076 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus homeobox containing 1 (Hmbox1), transcript variant 1,
            mRNA.
ACCESSION   NM_001347626 XM_011245030
VERSION     NM_001347626.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6076)
  AUTHORS   Jiang W, Jiang Y, Zhang X, Mu H, Song Y and Zhao H.
  TITLE     Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7
            cells proliferation based on UPLC-MS/MS
  JOURNAL   BMC Genomics 24 (1), 272 (2023)
   PUBMED   37208615
  REMARK    GeneRIF: Metabolomic analysis reveals the influence of HMBOX1 on
            RAW264.7 cells proliferation based on UPLC-MS/MS.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6076)
  AUTHORS   Zhu X, Fu H, Sun J, Di Q and Xu Q.
  TITLE     N6-methyladenosine modification on Hmbox1 is related to telomere
            dysfunction in DEHP-induced male reproductive injury
  JOURNAL   Life Sci 309, 121005 (2022)
   PUBMED   36174712
  REMARK    GeneRIF: N6-methyladenosine modification on Hmbox1 is related to
            telomere dysfunction in DEHP-induced male reproductive injury.
REFERENCE   3  (bases 1 to 6076)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6076)
  AUTHORS   Ma H, Su L, He X and Miao J.
  TITLE     Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits
            LPS-induced autophagy of vascular endothelial cells in mouse
  JOURNAL   Apoptosis 24 (11-12), 946-957 (2019)
   PUBMED   31583496
  REMARK    GeneRIF: HMBOX1 participated in the functional maintenance of mouse
            aortic endothelial cells, the aortic endothelial cells of HMBOX1 KO
            mouse showed increased apoptosis and decreased autophagy with
            lipopolysaccharidetreatment.
REFERENCE   5  (bases 1 to 6076)
  AUTHORS   Zhao H, Han Q, Lu N, Xu D, Tian Z and Zhang J.
  TITLE     HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by
            inhibiting macrophage infiltration and activation
  JOURNAL   Mol Immunol 101, 303-311 (2018)
   PUBMED   30032072
  REMARK    GeneRIF: HMBOX1 in hepatocytes acts as a key immunosuppressive
            factor for inflammation
REFERENCE   6  (bases 1 to 6076)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 6076)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 6076)
  AUTHORS   Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP
            and Kingston RE.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 6076)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   10 (bases 1 to 6076)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141425.3, AK052729.1, AC132602.2 and AW049636.1.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001347626.2.
            
            On Dec 3, 2016 this sequence version replaced XM_011245030.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.208030.1,
                                           SRR1660825.114534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC141425.3         52460-52460
            2-1368              AK052729.1         2-1368
            1369-1371           AC132602.2         20032-20034
            1372-1463           AK052729.1         1369-1460
            1464-5874           AC132602.2         22029-26439
            5875-6076           AW049636.1         1-202               c
FEATURES             Location/Qualifiers
     source          1..6076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.79 cM"
     gene            1..6076
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /note="homeobox containing 1"
                     /db_xref="GeneID:219150"
                     /db_xref="MGI:MGI:2445066"
     exon            1..281
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..361
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1601
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox-containing protein 1"
                     /codon_start=1
                     /product="homeobox-containing protein 1 isoform 1"
                     /protein_id="NP_001334555.1"
                     /db_xref="CCDS:CCDS84150.1"
                     /db_xref="GeneID:219150"
                     /db_xref="MGI:MGI:2445066"
                     /translation="MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEIL
                     HALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPS
                     NSYDTSPLPCTTNQNGRENNDRLSTSNGKMSPSRYHANSMGQRSYSFEASEEDLDVDD
                     KVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKK
                     RAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATPGTFRLRRGSRFTWRK
                     ECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRR
                     KEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAV
                     EMAAVNHTILALARQGANEIKTEALDDD"
     exon            362..838
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            839..924
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1035
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1189
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1272
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1368
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1463
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..6061
                     /gene="Hmbox1"
                     /gene_synonym="F830020C16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttgctatc aatatggcgg ttgtcagcca gacaaagaca gtcagtctga tgtgattgag
       61 acaagggagg ttttcagggg gagactggga gataggggcc tcccctcccc cctaggctct
      121 tcctgcgcgg gcctggagcc ctcctcagcc cctcccgcag ggcgccccgc ggtgaagatc
      181 ccctccccct cccgccttcc tcctccctcc ctcagccttg cactgggacg ctggggaggg
      241 ggctgagcag ggtgcagaga actctcagct ggatttccaa gaatggtaaa taaggctggc
      301 catctttgga aaggccattg atctgcctca tgtaaagtat gctcagctcc tttccagtgg
      361 ttttgctgga aaccatgtct cactacacag atgaacccag atttaccata gaacagatag
      421 acctgctcca gcgtcttcgg cgtaccggga tgaccaaaca tgaaatcctt catgcattag
      481 aaactttgga ccgtcttgat caagagcata gtgataaatt tggaaggagg tccagctacg
      541 ggggaagctc atatgggaac agtaccaaca acgttccagc atcttcctct acagccacag
      601 cttccacgca gacccagcac tcgggaatgt ccccatcacc cagcaacagt tacgatacct
      661 ccccactgcc ttgcactacc aatcaaaatg ggagggagaa caatgatcga ttgtccacat
      721 ccaatgggaa gatgtcacca tctcgctacc atgcaaacag catgggtcag aggtcatata
      781 gctttgaggc ctcagaagag gacctagatg tagatgataa agtggaggaa ttaatgagga
      841 gggacagcag tgtgataaaa gaggaaatca aagcctttct tgccaatcgg aggatttccc
      901 aagcagttgt tgcacaggta acaggaatca gtcagagtcg aatctctcac tggctgctgc
      961 agcagggatc agatctgagt gagcagaaga aaagggcgtt ctaccgatgg tatcaacttg
     1021 agaagacaaa ccctggggct acgctaagta tgagacctgc ccccattcca atagaggacc
     1081 ctgaatggag acaaacacct cccccagtct ccgccacacc tggaaccttc cggcttcgac
     1141 gagggagtag atttacctgg agaaaggagt gcctagctgt catggaaagt tacttcaatg
     1201 agaaccagta cccagatgaa gcaaagagag aagaaattgc caatgcttgc aatgcagtca
     1261 tacagaagcc aggcaaaaag ctgtctgacc tggaacgagt tacctctctg aaagtatata
     1321 attggtttgc taatcgacgg aaggagatca agagaagagc caatatcgaa gcagcaatcc
     1381 tggagagtca tgggatagat gtacagagtc caggaggcca ttccaacagt gacgatgtgg
     1441 acgggaacga ctactccgag caggatgaca gcaccagcca tagtgaccac caagatccca
     1501 tctcgctagc tgtggagatg gcggccgtca accacactat cttggcattg gcccggcagg
     1561 gagccaatga aatcaagaca gaggccctgg atgatgactg atcagggagt taaacagtta
     1621 acttagttta gacgtagcac cttagcagac tttcctcggt ccttaacatg tgttcttaca
     1681 gtataactta cagtttcttg tatgtcaggt agccattagg gtcttgttct gtgaagatgg
     1741 catggtgccc tcagcctttg catatactct ctcagtatta aaattccagt aagtaagaag
     1801 caaacaaaca cacttccctc tcccagcccc tgaggctaaa aaagaaaaat ctcgctgctc
     1861 cgttttagca ttccaagaaa gtgcttccag gtatttagat aaccctcagt tctcaaatat
     1921 taggctctgt gtaaaatctt gggtaccttt agattcatgt aacactaggc tgtaccccca
     1981 tctgtccctg ccctaagact gataggatgc aagctgaggt agtggcacag ggccgacaga
     2041 caccatctgg gaagtgtcca tggagcggag cacaaggaac actagcgccc gcctcggcgt
     2101 gagactcact gattcagctg caataagccg tgcctcctag tcacagtggc caggctctac
     2161 ttctttgggt gctgtgttaa gaatgtcatt ggaatcccaa gctcagatct tggttaatgc
     2221 taacatgccc aacacagaca tccttctctc ttacgagctg tgtgacctag tagataatat
     2281 actgccttct gcctttggga ccacgattct aaaacaaaaa ggacaaaaac caagttctga
     2341 aaagcaaagc ccagcttgag agcgagagca gtagggaaaa gcgagagctg aatgtcggat
     2401 ggatgctgag cccagttctc agagccgcta tacattccac agcgcgatgc cagcgcctgc
     2461 ccgggaaagt gttggaatta ccttggaagt tgcttggcct tctgtcggtg ccccctccct
     2521 gctaccaaaa aggatagagc tgaggtcctg agtgagtgaa agagcaggct tggtgcccgt
     2581 cacctgaagc ccacccagag tcattaggac tcttgctggg gactgtggca acttgactgt
     2641 cacacatgga ggtccttgcc tagctagggg cagaaaaagc aggggacatt taccacctac
     2701 agcaggatgt ctttgctgtc ttctctttat ctgtccttgt ggaggtgtga aagctatatt
     2761 gctacaggca atttatttaa taattggaag ccatattgat aatggatgtg gtgatatttg
     2821 tagtttaatc tactttaagt ggcagtaact aatggaattt ttttccttga tcatatatgt
     2881 agcacttttg ttacttttta aagatattta tatttgataa atcttttttt cattttgaga
     2941 actcaaaata ccaaacagtg aacttgcgtt atagagtcac cctgtggtca ccttgtcatc
     3001 tagtagcaaa atgatgaact attcatgcat caaagaaaat tacatctgct ggccttgtgt
     3061 gaaaatgatc tcctggagcc ctgattaaat agcacactgt cactgtgggt aagaagaacc
     3121 agccttcagt gaattggtgc agtgtgtgct gagaggctga gcgttccctg cctcctccca
     3181 ttttccctct gttgcgtctg aagaagcctt gcgtagaggg cggtgtgggg tgagcctgcg
     3241 agcgggcttc catctttttg tccatgcctg acccaatctc taagatagaa agtagatgcc
     3301 atctcctcac ccctgcttcc tcaccaagtg tgtccgaccc tcctcgcttc ccctgtgcgc
     3361 tgaccagata ctcgatatcc gcagggctta gctggtcttg ctgaggcact gaccagatac
     3421 tcgatatccg cagggcttag ctggtcttgc tgaggcacac gctgtctgga ctacccctta
     3481 ggtataagtc ttggttacag gggtgtgagg aatcacctca tctttgagga gctgaggatg
     3541 ctaccccacc ttcgtctgtg accttgaagg acactaggta gggcttggcc ctgttcctat
     3601 cagtagattt cagggggaaa tgtatgcatt ttttcccagc tctgagacgt gaagtaaaat
     3661 ggagccatct tctcttactg tattacttga accacaaatt taagagtagc atttcttatt
     3721 ctcaggaacg agtcccccgc acctacttag aatctcgcat ggtttctttg attcgtttgt
     3781 ctgtctgttt cacttaagag attgcattac ctttctttct ctccttcctt ttgtttactt
     3841 agaaggaata ttcctattat gtctatccat tttggttgag ttttgtctgc ttattctcag
     3901 ttgaatcaga aagaacagga gggggggggg aacgtatttt tctgacaagc cacatccatg
     3961 atttatcatg agattatgat gattgacagc ttctttaggg tgcggctgct cctgtctctc
     4021 ttgttctctc ttgccgtctt aaaggaacag gctccagctg ttaagacagc tccagtctct
     4081 aagggaactc tgactacagc cgaagagcag agtgttctgt catcctaggg ccttttagag
     4141 aaagcagtgc aacaggatac caagccctgg ctggtacagg cagtgccagc cctgtgtggc
     4201 agtgtggtgg tactggaaaa gtacaggtac catggaggct ggctctgtgc tgagctagct
     4261 agaaagtctg tcacatgccc acagactcac agccttacag ggaacctgcg ctgtctcacc
     4321 tacagcagga gtttgcttct ttgggatcaa ggttcaaaaa ctaccatcag tcggttttcc
     4381 ctggggtcac caggtttgat tctacttttg agtcctgttc cctcaactct tggaatggcc
     4441 acagaacatc cgcagtcaga ctcatccatc ctttgtgctt cttgctcacc ctgtctgctc
     4501 tcatctcctt ctgtatttct tgtggtcccg gagctctttt agattgtatc ttctcgacca
     4561 gtgactactg gaagcaggag aggaggggag caggcgctca tacatggact gtggtgatgt
     4621 ttatttaaga attactgttg ctggatagga aggaagggga gcaggcattt gtagactgtg
     4681 tgatggtgtt tatttaagaa ttactgttgc tggataagaa gagaggggag caggtgttca
     4741 tagaatgtgc tgtgacgttt atttaagaat tactgttgct ggataggaag gtaatttccc
     4801 accttctggt tccttacatg gcgggcggcc tgttaacaaa ggaccatctt aagatattcc
     4861 tgcctacctg agacagtcgc caggaagggc agtgcattgc tctcctgtgt gactatccag
     4921 ggccctcaga cccaggagac agtcattcac agcaggcatg tttatgtttg tgttgaacgc
     4981 cccatagggc aggttacagg aggagaaaac ctgggctggg aaggcagaca gcccgtgttc
     5041 ctttcgctcc agctcactag gtgaccttag aaagacgagg gcattggaag cctgctccag
     5101 agctctggtt cctaggatgt ttgtcactct cagccacacc cattattttt ggatcagaca
     5161 tctgggaatg tttttacttt atgggaacgg cacatggaaa gctgatatag tggtctgcgt
     5221 tctctctggc tttaggaact cttgctttaa actccttgga gatgagtcgt caggcacagg
     5281 ctacagcaga tgctgttccg gtgggatgct ccagcactct gtccatccac atggcttctc
     5341 ttccttccat tctgtgtctc agcactgcat ctttgtctcg agctgacatc actggacatt
     5401 ttctctcctc tgagcaccgg cttagtgggt agtgttagtc cactctgaat acggaccctc
     5461 gaggttccat ctaccaagcc tgttaccttt atctacacag tgaaaagcat cccgtcccat
     5521 ggtggcttct ctcttctgtg ttccctccaa gtcctctctc cctggtctca agaaggtcgt
     5581 ggttagatgc agcactccat ctaaccagct ctgctctggc cctgagcttt cttcctcttc
     5641 tgctcagaga acagcctgca ttttcctcta tgagcctcac caagttctta ggcaataact
     5701 tcttaggtgg tggcctcctg ctcagcggtt ctctgctcct gcatgagcat ccgtctctcc
     5761 acctctgtaa cgtcatcctc ttgctatgat tattagctat gttttactac tgtatttatt
     5821 gacgctgtac tgagactagc cgattccacg tacagcgtta ctgagccgaa tttatttttg
     5881 taagatttcc caagtgaagg ttgggcacat ggaccggttc tgctgtgtgt gtgagtggag
     5941 ctgggtgggg ataaactggg gcaggggcat gtgctgtgtt acattgcaga tgtgtttact
     6001 caggattggg ccaccagttg tcagccatac tggatttaac aaactgcact gctgctgtga
     6061 aaaaaaaaaa aaaaaa
//
