LOCUS       NM_001403985            5670 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus hepatic leukemia factor (Hlf), transcript variant 2,
            mRNA.
ACCESSION   NM_001403985 XM_006533004
VERSION     NM_001403985.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5670)
  AUTHORS   Wang,Y., Morishima,T., Sezaki,M., Sato,R., Nakato,G., Fukuda,S.,
            Kobiyama,K., Ishii,K.J., Li,Y. and Takizawa,H.
  TITLE     Akkermansia muciniphila induces slow extramedullary hematopoiesis
            via cooperative IL-1R/TLR signals
  JOURNAL   EMBO Rep 24 (12), e57485 (2023)
   PUBMED   37870318
REFERENCE   2  (bases 1 to 5670)
  AUTHORS   Valakh,V., Wise,D., Zhu,X.A., Sha,M., Fok,J., Van Hooser,S.D.,
            Schectman,R., Cepeda,I., Kirk,R., O'Toole,S.M. and Nelson,S.B.
  TITLE     A transcriptional constraint mechanism limits the homeostatic
            response to activity deprivation in mammalian neocortex
  JOURNAL   Elife 12, e74899 (2023)
   PUBMED   36749029
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5670)
  AUTHORS   Koui,Y., Ideue,T., Boylan,M., Anderson,M.J., Osato,M., Suda,T.,
            Yokomizo,T. and Mukouyama,Y.S.
  TITLE     Hepatic leukemia factor-expressing paraxial mesoderm cells
            contribute to the developing brain vasculature
  JOURNAL   Biol Open 11 (9) (2022)
   PUBMED   36017733
REFERENCE   4  (bases 1 to 5670)
  AUTHORS   Yokomizo,T., Ideue,T., Morino-Koga,S., Tham,C.Y., Sato,T.,
            Takeda,N., Kubota,Y., Kurokawa,M., Komatsu,N., Ogawa,M., Araki,K.,
            Osato,M. and Suda,T.
  TITLE     Independent origins of fetal liver haematopoietic stem and
            progenitor cells
  JOURNAL   Nature 609 (7928), 779-784 (2022)
   PUBMED   36104564
REFERENCE   5  (bases 1 to 5670)
  AUTHORS   Takihara,Y., Higaki,T., Yokomizo,T., Umemoto,T., Ariyoshi,K.,
            Hashimoto,M., Sezaki,M., Takizawa,H., Inoue,T., Suda,T. and
            Mizuno,H.
  TITLE     Bone marrow imaging reveals the migration dynamics of neonatal
            hematopoietic stem cells
  JOURNAL   Commun Biol 5 (1), 776 (2022)
   PUBMED   35918480
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5670)
  AUTHORS   Gachon,F., Fonjallaz,P., Damiola,F., Gos,P., Kodama,T., Zakany,J.,
            Duboule,D., Petit,B., Tafti,M. and Schibler,U.
  TITLE     The loss of circadian PAR bZip transcription factors results in
            epilepsy
  JOURNAL   Genes Dev 18 (12), 1397-1412 (2004)
   PUBMED   15175240
  REMARK    GeneRIF: mice deficient for all three PAR bZip proteins (DBP,HLF,&
            TEF) are highly susceptible to generalized spontaneous and
            audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a
            target gene of PAR bZip proteins in both liver and brain
REFERENCE   7  (bases 1 to 5670)
  AUTHORS   Liu,J., Lin,C., Gleiberman,A., Ohgi,K.A., Herman,T., Huang,H.P.,
            Tsai,M.J. and Rosenfeld,M.G.
  TITLE     Tbx19, a tissue-selective regulator of POMC gene expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8674-8679 (2001)
   PUBMED   11447259
REFERENCE   8  (bases 1 to 5670)
  AUTHORS   Smith,K.S., Rhee,J.W., Naumovski,L. and Cleary,M.L.
  TITLE     Disrupted differentiation and oncogenic transformation of lymphoid
            progenitors in E2A-HLF transgenic mice
  JOURNAL   Mol Cell Biol 19 (6), 4443-4451 (1999)
   PUBMED   10330184
REFERENCE   9  (bases 1 to 5670)
  AUTHORS   Hitzler,J.K., Soares,H.D., Drolet,D.W., Inaba,T., O'Connel,S.,
            MG,Rosenfeld., Morgan,J.I. and Look,A.T.
  TITLE     Expression patterns of the hepatic leukemia factor gene in the
            nervous system of developing and adult mice
  JOURNAL   Brain Res 820 (1-2), 1-11 (1999)
   PUBMED   10023025
REFERENCE   10 (bases 1 to 5670)
  AUTHORS   Inaba,T., Roberts,W.M., Shapiro,L.H., Jolly,K.W., Raimondi,S.C.,
            Smith,S.D. and Look,A.T.
  TITLE     Fusion of the leucine zipper gene HLF to the E2A gene in human
            acute B-lineage leukemia
  JOURNAL   Science 257 (5069), 531-534 (1992)
   PUBMED   1386162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691494.15 and AL626785.26.
            
            On Apr 7, 2022 this sequence version replaced XM_006533004.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.93497.1,
                                           SRR17784650.1242068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               AL691494.15        18212-18881         c
            671-1006            AL691494.15        15748-16083         c
            1007-1227           AL626785.26        144416-144636       c
            1228-5670           AL626785.26        135193-139635       c
FEATURES             Location/Qualifiers
     source          1..5670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 55.03 cM"
     gene            1..5670
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /note="hepatic leukemia factor"
                     /db_xref="GeneID:217082"
                     /db_xref="MGI:MGI:96108"
     exon            1..670
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..1446
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="hepatic leukemia factor isoform 2"
                     /protein_id="NP_001390914.1"
                     /db_xref="GeneID:217082"
                     /db_xref="MGI:MGI:96108"
                     /translation="MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKEK
                     DKGKKLDDESSSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPS
                     QHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNT
                     PSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVF
                     IPDDLKQDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLR
                     KELGKCKNILAKYEARHGPL"
     exon            671..1006
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1227
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..5670
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3620..3625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3640
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /note="major polyA site"
     regulatory      5648..5653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5670
                     /gene="Hlf"
                     /gene_synonym="E230015K02Rik"
ORIGIN      
        1 actcttgtca gggcagcggc acatggactg cctgatgcgc tgagcccggc gctgcggggc
       61 cgcggagcgc ggggagcagc ggccgcggcg gggagggggg tggggcggga cggcacagcc
      121 tccggtgctc gcgcgagggg ccggggcccg cgctttgcct tctgctcatc tgcagccgtc
      181 tacgttttca aaatttctct ctttcctttt tccccccacc tccttgcaat tttgaacatt
      241 ttgcaagact gagtgttgga ggcaggtgag aaagcatcct gcactgggtc ggaggagtcc
      301 gcggcgctag atgcgccttc cctggactgt cggcactgag aacacgaaag tttttttgtt
      361 tttgtttttg tttttttttg atatttgtat gctgatgtat ttacaaagac agaagtgatt
      421 tttttttttc ttccttgtct gcactgtttt gaaagcgagt acttttggtt ggcaaaggac
      481 ggaggaaaca aagctcatca acatttcggg gcggcgattg gccttctttt taaaaagaca
      541 attgagtgca tcacgatgga gaaaatgtcc cgacagctcc ccttgaaccc cacctttatc
      601 ccgcctccct acggcgtgct caggtccctg ctggagaacc cgctgaagct cccccttcat
      661 cctgaagacg catttagtaa agaaaaagac aaaggaaaga agctggacga tgagagcagc
      721 agcccgaccg tcccccagtc cgccttcttg ggacccacct tatgggacaa aacccttccc
      781 tatgacggag atactttcca gctggaatac atggacttgg aggaattcct gtcagagaat
      841 ggcatccccc cgagtccgtc gcagcacgac cacagccctc acccccctgg cttgcaacca
      901 gcttcctcca cggcgccctc ggtcatggat ctcagcagcc gggccacagc gcccctccac
      961 ccgggcatcc cgtctccgaa ctgtatgcag agccccatca gaccaggcca gctgttgcca
     1021 gcaaaccgca atacaccgag tcccattgac cctgacacca tccaggtacc agtcgggtat
     1081 gaaccagacc cggcagacct tgccctctcc agcatcccgg ggcaggaaat gtttgaccct
     1141 cgcaaacgga agttctctga ggaagaactg aagccacagc ccatgattaa gaaagctcgc
     1201 aaagtcttca ttcccgatga tttgaagcag gatgacaagt actgggcgag gcgcagaaag
     1261 aacaacatgg cggccaagcg ctcccgtgat gcccggcggc tgaaggagaa ccagatcgca
     1321 atccgggcct cattcctgga gaaggagaac tcggccctcc gccaggaggt ggctgattta
     1381 aggaaggagc tgggcaaatg caagaacata cttgccaagt acgaggccag gcacgggccc
     1441 ctgtaagatg gcatttttgt gggctggctt ttgaatagat ggacagcttg tttcctgtct
     1501 ggtagcccca cacccaaacc aacctttctg acatcagcac tttaccagag gcataaacgc
     1561 aactgactca tattttggtg tgcatctatg cgtatgtatg tatgtttgtg tgtgtgtata
     1621 tgtgcttatg gtcccatgtg tggtcagcgg tgtgcatgtg tgagcgtgta tatgtgtgta
     1681 ttccttcaca cttgtcgttt aaagatagtc ctcttgttgt cttttagttc caaacaagaa
     1741 aggtgccatg ttttttattc caccctggag actcccatgg ggtttcctcc ccttccttct
     1801 cccttcctgc ccctttctgc cttgctctgt gttctagcga tctcacttgg ccagggtctg
     1861 tgttgcttca ggaagcaggg ccctggatct cagtgatcaa gaccataagc tcttgtttct
     1921 gtttcagcca tgaattacca tgctggaaag gtgcatagca taccctagca ctgcgcgcag
     1981 ctgaattcct tcataggttg ccccacttcc cttccctttt tcctccccac cctttctcgt
     2041 tttttccttt cagttttggt gacacttgtc ttcaaattta aagtgctgtt tagatttagt
     2101 agagtcccat atttacttac tgctacctac taagtttcct tttaattcca ccaaccccag
     2161 ataagtaagt accattcctt atagaacaca gagtgtgttt tgcactgtct gtacctaaag
     2221 caataatcct agtgtacgct agagcatgct gcctgagtat taactagtgg acgtaggaaa
     2281 aaaaattccc tacctaggaa tttcactgtc ttttaaaaaa aaaactcaaa aatcaagtaa
     2341 tgcatttgtg catgaccaga atattctcag gacagggaag cagagggcaa gggaaggcct
     2401 aagaatgagg ggttaattta tcagtatgta tgccaaaaac ataataataa tgcatcttgg
     2461 agaagccttt gccacggtgt gcttcgtcgt gcgtctcccc ttcccacacc cagcccattc
     2521 ccacttttct agcccattca ctttctccat ttccctcttg atattcaaaa cgattgactt
     2581 aagattcagt ttacccactt tgttttataa tatatatatt tggggggggg acgatatttt
     2641 gctgttttta gaaatcagtt aattaagtga aaaagttgat gttttgaaaa gccctccctt
     2701 gacccccacc cccacccccc gtggtgtcct tttgaatgcc tcacaaatga atgattccgg
     2761 agcccgtgtt tctcatcctc tgtttgcttt tgaacatatg tgcgcctatc aagtggactt
     2821 ctgaaaaaaa aaatgaatgt aaaagacact ggtgtatctc agaatgggat ggtgttgtca
     2881 caaactgtgg tttctccgat caatttaaat gtttactata gaccaaaagg agagattatt
     2941 aaatcgttta atgtttatac agagtaatta taggaagttc tttttttgta cagtattttt
     3001 cagatataaa tactgacaat gtattttgga agacatatat tatatataga aaagagaaaa
     3061 aaaggaaaac tattccgtgt tttaaaatta tatagcaaag atatatattc accaatgctg
     3121 ttcagaggag tgcttggggg cttttgaaat ctttaatatt ttaaacctat tactgacaca
     3181 tcagcatgtt ttctgcttaa aattaaaatt ttatgacaat actgaggctt gctgtgacga
     3241 ctcctgctcc aacgctttct tgtttcttat taggtctcag aaggaagtca gttaacgtca
     3301 cccaaaagca caaaacgggt tttagtcaaa tatttattgg atgatccagt gttttttagg
     3361 aaaagcatct gccacataaa tgttcacttc aggattctga gtcgttggaa tggagtatgg
     3421 ctgccagagc cccagatgat tttgttcgct ttcggcctgt gtatctatct cacgcagtgt
     3481 aaggttgacc tcggtgctat gtgtacggct tagagtttga tagctgtttt gactttaaag
     3541 atggctgtta ttttgtttca ctgagttgta taatgtcaag agagtctgct gtttcttcaa
     3601 aagcacattt ttgtgctcga ttaaaatccc cttccatcca tggatgtttt ccggtctcct
     3661 gcctccacag tatctgactt ctctgcggat ccagtgatgc cctcccccct ccctcagcca
     3721 ctccgctgtc cagtgtcaca gatctggaaa acgagacctg taggtttctt cccaggttcc
     3781 tgttgtattc cacggtgaga gatgagagag tgagagaaat aaaatacatt ttgcaagcaa
     3841 attactgatt aaaaaaaatg tttcaaccat gttgtataga actgaataag agataattca
     3901 gtaatagcca tgggacacca aaaagttggt ccttttgaag atagagaaag agagggattg
     3961 cagaactgtt caatgacagt gcttgccagg gcacagatga gtacttaagg agagaagtgt
     4021 tcaagggttg cactgtggcc cacccagaca catggaacca tccagtactc gatgaagaaa
     4081 agcatgcctg gcctttcttg gaattgtttt taccaaataa acatcacaaa tgttttctgc
     4141 agaagatata aaaagatcat aataaaactt attcttttgt ataccaggaa aggtttgtag
     4201 aaaacctacc tcattcaaaa caaaacaaaa caaaaaactc aagagtttgg aatctccaca
     4261 ggtgccttat ctgtaggtaa ttatcagtcc cccaccccca ggctgacttc tctttgcccc
     4321 tggatattaa ctagatgaga aaatgccatt caatgccctg agaagctaga acctagggtc
     4381 agataactgc agcagaccat agccattagg aagtcccatt gtcaactgtc accatttcaa
     4441 ggtaggcatc tttccatggt taattatttg gtcattccaa atgcatctga aatgttgcat
     4501 gccctgccat tcagatgcaa agcacttcct ggtcaggtca tatcttttca ttagtcacat
     4561 ggattctcga agaaagtttt aaaaaaaaaa ggaatcaggg tttctctctg ctgatgctcc
     4621 cctgagggga tgggggggct ttggatgaca gtccccaact atagagggac tggtgctttg
     4681 ggtcattcac aaaccacatc aggcatgact tggccaggcc tttgtctcta aatagaacag
     4741 gccttgaagg gaccatcctt tgtagaagaa gaagaatggg cctatgtttg agaatagcat
     4801 gatgggactc agtcactggg tgagggggaa accagataaa agaacccaga ggctctttct
     4861 aacccattat cttaccgtgg gaatttacac tgagtctaaa cataccttcg aaagggctac
     4921 agcctcaggt ctggatgacc tgccgtgagt tgtaagtggc aatgtctctc ctgtccaggg
     4981 atgaaacaac tgatgatgtg taaaatacaa ggaatacttt gctctttcta aaagtttgtt
     5041 cagtttggcc cttagcattc ctttagaaaa aactcaaaac ttcctcagag ttaattagtg
     5101 agatcctcag gcatcgatgc ctgtggatct cagacagctc tgtgtgtggc ttgtccccac
     5161 cggctgggat tggcttcctg cagctgacta ggctgaggtg tgatgccctc cctccctggg
     5221 tacatacctt cttctctggc tctgattgca cttgcttcct actgagggct cctgagtaca
     5281 accctctggg gaagccaaat tcaactccag gtgttcggta aaaatcagtg tcaataataa
     5341 atgaacaaaa cttgtaggtc ttgatggact gaattttcaa taactactgt taatgcattt
     5401 ttgccaaaat ctgtgttggg gaatgtgtgt ttgtgtgtgg atgtttaagt ggagacagaa
     5461 aatctgtaat ttttttttta gcacctcacc agacataaca attaggtatt atcctttcga
     5521 caacaccaca aagattgcat ctgtcaaaca ggctcaagtt aacaagaggt tagtgtaatt
     5581 gtataccatg atattgctgg tatttatgct gtcaagtcca aaacttcatt tgttcttcta
     5641 aatgtttaat aaactaattt ttttcctttt
//
