LOCUS       NM_001360045            5132 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus holocarboxylase synthetase (biotin-
            [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
            (Hlcs), transcript variant 1, mRNA.
ACCESSION   NM_001360045 XM_006522850
VERSION     NM_001360045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5132)
  AUTHORS   Sadri M, Wang H, Kuroishi T, Li Y and Zempleni J.
  TITLE     Holocarboxylase synthetase knockout is embryonic lethal in mice
  JOURNAL   PLoS One 17 (4), e0265539 (2022)
   PUBMED   35385533
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5132)
  AUTHORS   Cheong A, Archambault D, Degani R, Iverson E, Tremblay KD and Mager
            J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5132)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 5132)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 5132)
  AUTHORS   Gitton Y, Dahmane N, Baik S, Ruiz i Altaba A, Neidhardt L, Scholze
            M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R,
            Herwig R, Lehrach H and Yaspo ML.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   6  (bases 1 to 5132)
  AUTHORS   Lund J, Chen F, Hua A, Roe B, Budarf M, Emanuel BS and Reeves RH.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   7  (bases 1 to 5132)
  AUTHORS   Lund J, Roe B, Chen F, Budarf M, Galili N, Riblet R, Miller RD,
            Emanuel BS and Reeves RH.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   8  (bases 1 to 5132)
  AUTHORS   Cabin DE, McKee-Johnson JW, Matesic LE, Wiltshire T, Rue EE,
            Mjaatvedt AE, Huo YK, Korenberg JR and Reeves RH.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
REFERENCE   9  (bases 1 to 5132)
  AUTHORS   Zhang XX, Leon-Del-Rio A, Gravel RA and Eydoux P.
  TITLE     Assignment of holocarboxylase synthetase gene (HLCS) to human
            chromosome band 21q22.1 and to mouse chromosome band 16C4 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 179 (1997)
   PUBMED   9186515
REFERENCE   10 (bases 1 to 5132)
  AUTHORS   Rajavashisth,T.B., Eng,R., Shadduck,R.K., Waheed,A.,
            Ben-Avram,C.M., Shively,J.E. and Lusis,A.J.
  TITLE     Cloning and tissue-specific expression of mouse macrophage
            colony-stimulating factor mRNA
  JOURNAL   Proc Natl Acad Sci U S A 84 (5), 1157-1161 (1987)
   PUBMED   3493488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT573086.9 and CU207273.8.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by
            NM_001360045.2.
            
            On Jan 26, 2018 this sequence version replaced XM_006522850.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052424.1, SRR13422603.460113.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               CT573086.9         75199-75427
            230-364             CT573086.9         77564-77698
            365-527             CT573086.9         96792-96954
            528-1459            CT573086.9         97183-98114
            1460-1642           CT573086.9         102716-102898
            1643-1914           CT573086.9         134155-134426
            1915-1982           CU207273.8         41696-41763         c
            1983-2143           CU207273.8         39156-39316         c
            2144-2258           CU207273.8         34996-35110         c
            2259-2472           CU207273.8         33348-33561         c
            2473-5132           CU207273.8         29653-32312         c
FEATURES             Location/Qualifiers
     source          1..5132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.12 cM"
     gene            1..5132
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /note="holocarboxylase synthetase (biotin-
                     [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)]
                     ligase)"
                     /db_xref="GeneID:110948"
                     /db_xref="MGI:MGI:894646"
     exon            1..229
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2644
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /EC_number="6.3.4.10"
                     /EC_number="6.3.4.11"
                     /EC_number="6.3.4.15"
                     /EC_number="6.3.4.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     biotin- [propriony-Coenzyme A-carboxylase
                     (ATP-hydrolysing)] ligase; biotin--protein ligase; biotin
                     apo-protein ligase"
                     /codon_start=1
                     /product="biotin--protein ligase isoform 1"
                     /protein_id="NP_001346974.1"
                     /db_xref="CCDS:CCDS88973.1"
                     /db_xref="GeneID:110948"
                     /db_xref="MGI:MGI:894646"
                     /translation="MLITLCYLYLWARWGRRPAALVLSTVRRLRASRCSFTFCRAAAQ
                     PRDARVCLSQGGRVFCVGESQSVDDLNKWALFLVSPFILEAEHIAFVTESIWIQGTSL
                     QEPSSSETVVKWSDCCLPLACRPGDPYQLIAKASVDNFSKLGVAFMEDRLQMDNGLIA
                     QKIVSVHLKDPALKELGKASDKQVQGPPPGPEASPEAQPAQGVMEHAGQGDCKAAGEG
                     PSPRRRGCAPESEPAADGDPGLSSPELCQLHLSICHECLELENSTIDSVRSASAENIP
                     DLPCDHSGVEGAAGELCPERKGKRVNISGKAPNILLYVGSGSEEALGRLQQVRSVLTD
                     CVDTDSYTLYHLLEDSALRDPWSDNCLLLVIASRDPIPKDIQHKFMAYLSQGGKVLGL
                     SSPFTLGGFRVTRRDVLRNTVQNLVFSKADGTEVRLSVLSSGYVYEEGPSLGRLQGHL
                     ENEDKDKMIVHVPFGTLGGEAVLCQVHLELPPGASLVQTADDFNVLKSSNVRRHEVLK
                     EILTALGLSCDAPQVPALTPLYLLLAAEETQDPFMQWLGRHTDPEGIIKSSKLSLQFV
                     SSYTSEAEITPSSMPVVTDPEAFSSEHFSLETYRQNLQTTRLGKVILFAEVTSTTMSL
                     LDGLMFEMPQEMGLIAIAVRQTQGKGRGPNAWLSPVGCALSTLLVFIPLRSQLGQRIP
                     FVQHLMSLAVVEAVRSIPGYEDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYIL
                     IGCGFNVTNSNPTICINDLIEEHNKQHGAGLKPLRADCLIARAVTVLEKLIDRFQDQG
                     PDGVLPLYYKYWVHGGQQVRLGSTEGPQASIVGLDDSGFLQVHQEDGGVVTVHPDGNS
                     FDMLRNLIVPKRQ"
     exon            230..364
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            365..527
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            528..1459
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1642
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1914
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1982
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2143
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2258
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2472
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..5132
                     /gene="Hlcs"
                     /gene_synonym="410I21.SP6; D16Jhu34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcctggc gcgagccggg cgcgggcgcc ggccatgctc atcacgctgt gctacctgta
       61 cctgtgggcg cgctgggggc gccggccggc cgcgctggtg ctgtccacgg tgcggcggct
      121 gcgtgcttcg cgctgctcct tcaccttctg ccgcgcggcc gcgcagccca gggacgcgcg
      181 cgtgtgcctg agccagggcg gccgcgtctt ctgcgtcggc gagagccagt ctgttgatga
      241 cttgaacaaa tgggccctgt ttctcgtgtc tcccttcata cttgaggcag aacatatagc
      301 atttgtgaca gagagcattt ggatacaagg taccagttta caagagccat catcttcaga
      361 aaccgttgta aaatggtctg actgctgtct gccgttagcc tgccgacccg gggaccccta
      421 ccagttaatt gctaaggcaa gcgtggacaa cttcagcaag cttggggtgg ccttcatgga
      481 ggacaggctc cagatggaca acggcctgat agcccagaag atcgtttcag tccacttaaa
      541 ggaccctgct ctgaaggaac tcggcaaagc ctccgacaag caagtgcagg gcccgccccc
      601 gggcccagaa gcttcccccg aggcccagcc tgcacaaggt gtcatggagc atgctggcca
      661 aggtgattgc aaggccgccg gtgaaggccc ttccccacgg aggaggggct gtgcccctga
      721 aagtgagcct gctgcagatg gggacccagg gctgagctcc ccggagctct gtcagctcca
      781 cctgtccatc tgtcacgagt gtctggagct cgagaacagt accattgact cggtgaggtc
      841 tgcgtctgcg gagaacattc cagaccttcc ctgtgatcac agcggcgtgg agggtgctgc
      901 gggcgaactc tgccccgaac ggaaagggaa gagagtcaac atttcgggaa aggcgcccaa
      961 tatcttgctg tatgtgggct ctggttccga ggaagccctg ggccggctcc agcaggtgcg
     1021 atctgtcctg actgactgtg tggacacgga cagctacact ctctaccacc tgctggaaga
     1081 cagcgctctg agggacccgt ggtctgacaa ctgcctcctg ctagttattg ccagcaggga
     1141 ccccatcccc aaagacatac agcacaagtt catggcctat ctttctcagg gagggaaggt
     1201 gctgggcctg tcttccccct tcacgttggg tggctttcgg gtgaccagga gagatgtgct
     1261 acggaacaca gtccagaact tggttttctc taaggctgat gggactgagg tacggctcag
     1321 tgtcctgagc agcggctacg tttatgaaga aggcccgagc ttgggcaggc tccagggcca
     1381 cctggagaat gaggacaagg ataaaatgat tgtgcacgtg ccttttggaa ccctcggagg
     1441 ggaagccgtt ctctgccagg tgcacctgga gctcccgccc ggcgcctccc tggtgcagac
     1501 tgcagacgac tttaacgtgc tcaaatccag caatgtgaga agacacgagg tccttaagga
     1561 gatcctgact gccctcggtc tgagctgtga cgcaccacag gttcctgcct taacgcccct
     1621 gtacttactg ctggccgctg aggaaaccca ggatccgttc atgcagtggc tcgggaggca
     1681 cacagatcct gaaggaatca taaaatccag caagctctcc cttcagtttg tttcctccta
     1741 cacatctgaa gcggagatca ccccgtcttc catgcctgtg gtcactgacc cagaagcctt
     1801 ttcatcagag cacttcagcc tagagaccta tcgacagaat ctgcagacca cgcgccttgg
     1861 gaaagtgatt ctgtttgcag aagtgacctc caccaccatg agtctcctgg atgggttgat
     1921 gtttgagatg ccgcaggaaa tgggcttaat tgccattgca gttcggcaga cccagggcaa
     1981 aggaaggggc ccgaatgcct ggctgagccc cgtgggatgt gctctttcca ctctgctggt
     2041 cttcatcccc ctgaggtcac aactgggaca gaggattcca tttgtccagc atttgatgtc
     2101 cttggctgtg gtggaggcag tgcggtctat cccagggtat gaggatatca acttgcgagt
     2161 gaagtggccc aacgatattt attacagcga tctcatgaag atcggtgggg ttctggttaa
     2221 ttcaacactt atgggagaaa cattttatat cctcatcggc tgtggattca atgtgacgaa
     2281 cagtaatcct accatttgta tcaacgacct catcgaagaa cacaataagc agcacggggc
     2341 gggcctgaag cccctgcgag cggactgtct catagccaga gccgtgaccg tgctggagaa
     2401 actgatcgac aggtttcagg accaagggcc cgacggcgtt cttcccctct attataaata
     2461 ctgggtgcac ggtggtcagc aagtccgcct gggcagcacg gaggggccac aggcatctat
     2521 tgtgggcctt gatgactccg ggttcctgca ggtccaccaa gaggatggtg gggttgtgac
     2581 ggtgcatcca gatggcaact ccttcgacat gctgagaaac ctcatcgtgc ccaagcgaca
     2641 gtaacacctt cctgtgtccc cagacagctt ggatctactg caacagggaa gctgctcctg
     2701 ggatctcctg ggagcactga gcaggcgcac tccgcttgca taactgttgt ctctgcctgc
     2761 ctagggcctg ggaagctaat gcagagttag aggccagttg ttaattcttc aggttgtggg
     2821 ttccctgccc ccaccccctc cccaccccgg gatttgggac acatatatgt ggttttactg
     2881 ggtgtttgaa ggtgcatctg gtgaggattg actcacaggc gaagaagggt cagtttagcc
     2941 taggagttta gtttgccttg tgaggtatag aagtgctctt ccccatgtgg gcttggattt
     3001 gtgtgtactg ggagggaaat gagaagcaag gggttaggaa tagcgctgag atagtacaaa
     3061 tatatcccaa ggagtgaagg cctttagccc tctgctgttg aaacagtgaa tgcccacagc
     3121 tcaggggcat gctcactgct gtcccagaac acacaagtgt tgacctgcac gtagggttgt
     3181 tgctggtttc ctttgtcaag ttgggcttct tgtagtagcc tggaacacag gactgaagga
     3241 tggccacaga aatgctgcta accagcgtta tctcctttcc aggatcagat gtgtcaggtt
     3301 ttagatgttt aagccatgat ggcagcttcc ttagagacaa aggcttgccc aggctgatgg
     3361 agacgtgggc tcaccctctt gcccacacaa gggaggattc ttggagcttt taagctgatc
     3421 agttgcaggc tctgttagaa tgccacatcc ccataagctt gtgtccccaa gcagggccga
     3481 gtgcagcact gtattgtaag tcatgacttt ctgcccccaa tttcataatg tcaggaagga
     3541 gagagagaga gactgacaca aaaatgccat cagtttggag agacgtatgt gcgtgcagag
     3601 catgcctgat tttgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tctttaaaag
     3661 aagatgttca aaacttgatg tgctaaaacg tctccgtgga agaacaaagg agaggaagcc
     3721 tttctgggct tgcgtttcca gatgtgctcc gtgctttccc gtgtacctcc cgtctctgtg
     3781 gagcttgtga atcataccca tcgctgccca gcctgaaaga actagttcct gtctgccctc
     3841 ctgcttcctg ccacttccac tgaagtgggc ggacggaaca gatcgcttcg cttagagcaa
     3901 gatcctcgtc ataaacgagt accatcttta tccagcttct gtagtcaggg ccaactccag
     3961 aaaccagagg tcttcggcat agaatccact caccctcagc ctagcagagt cagccccatt
     4021 tgaagcaaaa aataaaataa ataaataaca gggtgaacta taccaacctg acgtgtgttt
     4081 gaggggctgt gacactaaag gaacttgaaa gtaacttttc ttgcaaataa gactttgact
     4141 aatgtttttc tcaaaaaaag aaaaagatac atatataaaa tttagttccg ctattttttt
     4201 aaattcatgc gagtttaaat aaaactgtac gccaccccaa attataaagt gacaggccca
     4261 agagagagag agagagagag agagagagag agagagagag agagcgagag catctgtaaa
     4321 atatcatcaa gaatgaagat ctccaagctg gctgttgcaa aggttcattt ctcagacttt
     4381 gtaatataag gctgttcatc tctcagaacc gccatcatta catttgaaat ttctatgggg
     4441 gattatttaa tgaaaaacat gctatgtttt attttaagct gaaggcctat tctggatagt
     4501 tctactttgg ggaaaaaaat gttatcattt aatttccttt ctgtaagtta aaactaatga
     4561 agtgtggtca tgtcagagca gacagagatg ttctgggcat gctgattggc cctggggtag
     4621 ttacactgtt tgggggtatt cttgcgtatg cagacaggac actccttgtc tcgagagaca
     4681 gcacagcctg aagcactgaa gctgcattcc ccactggcct gacttggcct cacatgaacc
     4741 aaagacttca gatttcacat cgtagagagc atttctgccg atggggcgtg tgaaggctgc
     4801 cactgtaccc gccacatgcg agggtattca cactctcagt gtcccaggac ctccaagaac
     4861 tttacaagtc tcctaacctc gatgcctcct aatctggaga cgtggccacc taaccccgac
     4921 tctgtatttg ccgtaagcag gttactccta gtgttaacct gcttgcatat ctacccctgg
     4981 gtgttggaag gcacaggtaa gcaagcactg ggtctcacac aactcagctg aagcagtgag
     5041 cggctttgct accctgacat gccagcaacg gggcaacctc attcctggtt catctctatg
     5101 catctttgaa ataaacaaaa atgtaaacct tt
//
