LOCUS       NM_145419               3497 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus hexokinase domain containing 1 (Hkdc1), mRNA.
ACCESSION   NM_145419
VERSION     NM_145419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3497)
  AUTHORS   Zhang,Y., Wang,M., Ye,L., Shen,S., Zhang,Y., Qian,X., Zhang,T.,
            Yuan,M., Ye,Z., Cai,J., Meng,X., Qiu,S., Liu,S., Liu,R., Jia,W.,
            Yang,X., Zhang,H., Zhong,X. and Gao,P.
  TITLE     HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by
            coupling cytoskeleton to STAT1 activation and PD-L1 expression
  JOURNAL   Nat Commun 15 (1), 1314 (2024)
   PUBMED   38351096
  REMARK    GeneRIF: HKDC1 promotes tumor immune evasion in hepatocellular
            carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1
            expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3497)
  AUTHORS   Martinez-Garza,U., Choi,J., Scafidi,S. and Wolfgang,M.J.
  TITLE     Proteomics identifies the developmental regulation of HKDC1 in
            liver of pigs and mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (4), R389-R400 (2023)
   PUBMED   37545422
  REMARK    GeneRIF: Proteomics identifies the developmental regulation of
            HKDC1 in liver of pigs and mice.
REFERENCE   3  (bases 1 to 3497)
  AUTHORS   Pusec,C.M., Ilievski,V., De Jesus,A., Farooq,Z., Zapater,J.L.,
            Sweis,N., Ismail,H., Khan,M.W., Ardehali,H., Cordoba-Chacon,J. and
            Layden,B.T.
  TITLE     Liver-specific overexpression of HKDC1 increases hepatocyte size
            and proliferative capacity
  JOURNAL   Sci Rep 13 (1), 8034 (2023)
   PUBMED   37198225
  REMARK    GeneRIF: Liver-specific overexpression of HKDC1 increases
            hepatocyte size and proliferative capacity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3497)
  AUTHORS   Khan,M.W., Terry,A.R., Priyadarshini,M., Ilievski,V., Farooq,Z.,
            Guzman,G., Cordoba-Chacon,J., Ben-Sahra,I., Wicksteed,B. and
            Layden,B.T.
  TITLE     The hexokinase 'HKDC1' interaction with the mitochondria is
            essential for liver cancer progression
  JOURNAL   Cell Death Dis 13 (7), 660 (2022)
   PUBMED   35902556
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3497)
  AUTHORS   Zapater,J.L., Wicksteed,B. and Layden,B.T.
  TITLE     Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male
            Mice Fed a High-fat Diet
  JOURNAL   Endocrinology 163 (6) (2022)
   PUBMED   35435980
REFERENCE   6  (bases 1 to 3497)
  AUTHORS   Ludvik,A.E., Pusec,C.M., Priyadarshini,M., Angueira,A.R., Guo,C.,
            Lo,A., Hershenhouse,K.S., Yang,G.Y., Ding,X., Reddy,T.E., Lowe,W.L.
            Jr. and Layden,B.T.
  TITLE     HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use
  JOURNAL   Endocrinology 157 (9), 3452-3461 (2016)
   PUBMED   27459389
REFERENCE   7  (bases 1 to 3497)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   8  (bases 1 to 3497)
  AUTHORS   Yoshida,T., Murata,K., Shiraki,N., Kume,K. and Kume,S.
  TITLE     Analysis of gene expressions of embryonic stem-derived
            Pdx1-expressing cells: implications of genes involved in pancreas
            differentiation
  JOURNAL   Dev Growth Differ 51 (4), 463-472 (2009)
   PUBMED   19382941
REFERENCE   9  (bases 1 to 3497)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   10 (bases 1 to 3497)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC016235.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016235.1, AK145980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.4 cM"
     gene            1..3497
                     /gene="Hkdc1"
                     /note="hexokinase domain containing 1"
                     /db_xref="GeneID:216019"
                     /db_xref="MGI:MGI:2384910"
     exon            1..160
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2845
                     /gene="Hkdc1"
                     /EC_number="2.7.1.1"
                     /note="putative hexokinase HKDC1; hexokinase
                     domain-containing protein 1"
                     /codon_start=1
                     /product="hexokinase HKDC1"
                     /protein_id="NP_663394.1"
                     /db_xref="CCDS:CCDS23888.1"
                     /db_xref="GeneID:216019"
                     /db_xref="MGI:MGI:2384910"
                     /translation="MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQ
                     AEMEKGLGKDTNPTASVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSQEGQ
                     QNVQMESQFYPMPNEITRGNGTELFDYVADCLADFMKTKNLTHKKLPLGFTFSFPCRQ
                     NKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCA
                     YDDPNCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTE
                     FDRELDLGSLNPGKQLFEKMISGLYMGELVRLILLKMAKVGLLFGGAKSSALHTKGKI
                     ETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIAVQHVCTIVSFRSANLCAAALAT
                     ILTRLRENKKLARLRTTVGMDGTLYKTHPQYPKRLHKVVRRLVPNCDVRFLLSESGST
                     KGAAMVTAVASRVQAQRKQIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLAT
                     VKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMYNKIFAIPLEIMQG
                     TGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKGTLVGWTKGFKATD
                     CEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDPRCEIGLIAGTGSNVC
                     YMEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDIRTQYDKEVDEGSLNAGKQRYEK
                     MTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVR
                     RILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKVTVG
                     VDGTLYKLHPHFSRILQETVKELAPQCDVTFMLSEDGSGKGAALITAVAKRLQQPRKD
                     I"
     exon            161..323
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..472
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..592
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..688
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..788
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..972
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1128
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1362
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1667
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1807
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1927
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2023
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2123
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2307
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2463
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2697
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..3483
                     /gene="Hkdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hkdc1"
                     /note="hexamer: AAGAAA"
     polyA_site      3483
                     /gene="Hkdc1"
                     /note="major polyA site"
ORIGIN      
        1 cacccacctc cccgcccaaa ctagaggcgt gcagcactcc gcagacagag agtgtactga
       61 agactcggcg ctctcgggaa caaccgcact tgggaacatg tttgcagtac acttggtggc
      121 gttttacttc accaagctga aggaggacca gatcaagaag gtggacaggt tcctgtatca
      181 catgcggctc tcggatgaga ccctggtgga catcatggcc cgcttccagg ccgagatgga
      241 gaaaggcttg gggaaggaca ccaaccccac tgcctctgtg aagatgctgc ccacattcgt
      301 cagggccatt ccagatggct cagaaaacgg ggaattcctt tccctggatc tcggaggatc
      361 caagtttcgg gtcttgaagg tgcaagtctc ccaagagggc cagcaaaatg ttcagatgga
      421 gagccagttc tacccaatgc ccaatgaaat cacccgtggg aatggcacgg agctttttga
      481 ctacgtagcc gactgcctgg cagatttcat gaagaccaaa aatctgacac ataagaagct
      541 gcctctgggc ttcacctttt cttttccctg cagacagaat aagttggagg agggtgttct
      601 gctttcgtgg accaagaagt tcaaggcccg gggagttcag gacacagacg tggtgaaccg
      661 cctggccact gccatgaaga agcacaagga cctggacgtg gacatcctgg ctttggttaa
      721 cgacactgtg gggaccatga tgacttgtgc ttatgatgat cccaactgtg aagtcggcgt
      781 tatcatcgga acaggcacca acgcgtgtta catggaggac atgagcaaca tcgacctcgt
      841 ggaaggggac gagggaagga tgtgtatcaa cacggagtgg ggggcctttg gggacgatgg
      901 ggctttggag gacatccgca ccgagtttga cagagagctg gacctgggct cgctcaaccc
      961 cgggaagcag ctgttcgaga agatgatcag cgggctgtac atgggggagc tggtcaggct
     1021 tatcttgctg aagatggcca aagttggtct cctgtttggg ggtgcaaaat cctctgctct
     1081 ccatacaaag ggcaagatcg aaacacagca cgtggctgcc atggagatga gtaaagaagg
     1141 cctggccaac actcgagaga tcctggtgga tttgggcctg gagccctctg agtcagactg
     1201 catcgctgtc cagcacgtgt gcaccatcgt ctcttttcgc tcagccaatc tctgcgcagc
     1261 ggctctggca accatcctga ctcgactccg agagaacaag aagctggccc ggctccgcac
     1321 cacagtgggc atggatggaa ctctctacaa aacacaccct cagtacccca aacgcctaca
     1381 caaggtggtg aggagactgg tcccaaactg tgatgtccgc ttcctcctgt cagagagtgg
     1441 aagcaccaag ggggccgcca tggtgaccgc agtggcctct cgggtacagg cccagcgcaa
     1501 gcagatcgac aaggtgctgg ctttgttcca gttgacccga gagcaactcc tgggtgtgcg
     1561 ggacaagatg cgggctgaac tagagtacgg gctgaagaaa aagacccact ctctggctac
     1621 cgtgaagatg cttcccacct atgtctatgg gatgccggat ggcacagaga aaggaaagtt
     1681 ccttgccctg gatttggggg gaaccaactt ccgagtcctc ctggtaaaga tcaggcggag
     1741 gtctgtgcgc atgtacaaca agatcttcgc catccctctg gagatcatgc agggcactgg
     1801 ggaggagctc tttgaccaca tcgtacagtg catcgctgac ttcctggact acatgggcct
     1861 caagggcgcc cagctgcctt tgggcttcac cttctccttc ccctgcagac agacatgcat
     1921 cgacaagggg actctagtag ggtggaccaa aggcttcaag gccaccgact gtgaagggga
     1981 ggacgtggtg gacatgctca gagaagccat caagaggaga aacgagtttg acctggacat
     2041 tgttgcaatc gtgaacgaca cagtggggac catgatgacc tgtggctatg aagatcccag
     2101 gtgtgagatt ggcttgattg cagggacagg aagcaacgtg tgctacatgg aggaaatgag
     2161 gaacatcgag ctggtggatg gggacgaagg ccggatgtgc gtcaacacgg agtggggcgg
     2221 gtttggtgac aatggctgca tcgatgacat ccgcacccag tatgacaagg aggtggatga
     2281 gggctccctg aacgccggca agcagagata cgagaaaatg accagtggaa tgtacctggg
     2341 ggagattgtg aggcggatcc tgatcgacct cacccggcag gggctcctct tccgagggca
     2401 gatttcagag cgactccgga ccaggggcat ctttgaaacc aaattcctgt cccagattga
     2461 aagtgaccgg ctggccctcc tgcaggtcag gaggatcctg cagcagctgg gcctggacag
     2521 cacgtgcgaa gacagtattg tggtgaagga ggtgtgtggg gctgtgtctc ggagggccgc
     2581 ccagatgtgt ggtgccggca tggctgccat cgtggagaag aggagagaag accaaggcct
     2641 ccagcacttc aaggtcaccg tgggcgtgga tggcacactg tacaagctgc acccgcactt
     2701 ctcccggata ctgcaggaga cggtgaaaga gctggcccct cagtgtgatg tgacatttat
     2761 gttgtcagaa gacggcagcg ggaagggagc agctctgatc acagctgtag ccaagaggtt
     2821 acagcagcca cggaaggaca tctaggtggc ccagccgggt gatgaccagg gaccaccaga
     2881 cgacctcctg gctcaccttc ctctctccgt actctaagca tcctggtgct tgcttggcag
     2941 tgacactggg tggcacctcc atttggcata ttttagccaa agatgggctg actttcaaaa
     3001 tcaaaggatc tggccccaaa gatccccctt ttggcaagtc acttgagctg tgagcgttca
     3061 gtagtatcag gtcttgggtt gctggagtgt ccctttcagg ccttatgcta cctctggtgg
     3121 gagattgggt ctgaaccctt gagagggaga aaggcttagt gaactagggg atctaggtta
     3181 acatggcctc acttgtcatg ttgactttat aggcaccagg gaagccaggg cattggcccc
     3241 tgcatctctg agtgtggagg agcccactgc cctggagcca ggaggaatct cacccactca
     3301 gggcgctctg tgagcatctg gggtgtcacc cccccatgtt tgtatcatgg ggcgggacac
     3361 catcccaggt actgtttatc attcatgtga cacagtaggt gtcgctgttt tctgcatttc
     3421 tttcaaggac tgttaggtat acaaatattg tccatgaata aaagaaactt gagtttccag
     3481 gaaaaaaaaa aaaaaaa
//
