LOCUS       NP_001139572             918 aa            linear   ROD 05-MAY-2025
DEFINITION  hexokinase-1 isoform HK1 [Mus musculus].
ACCESSION   NP_001139572
VERSION     NP_001139572.1
DBSOURCE    REFSEQ: accession NM_001146100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 918)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 918)
  AUTHORS   Borbely,E., Kecskes,A., Kun,J., Kepe,E., Fulop,B.,
            Kovacs-Rozmer,K., Scheich,B., Renner,E., Palkovits,M. and Helyes,Z.
  TITLE     Hemokinin-1 is a mediator of chronic restraint stress-induced pain
  JOURNAL   Sci Rep 13 (1), 20030 (2023)
   PUBMED   37973885
  REMARK    GeneRIF: Hemokinin-1 is a mediator of chronic restraint
            stress-induced pain.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 918)
  AUTHORS   Martinez-Garza,U., Choi,J., Scafidi,S. and Wolfgang,M.J.
  TITLE     Proteomics identifies the developmental regulation of HKDC1 in
            liver of pigs and mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (4), R389-R400 (2023)
   PUBMED   37545422
REFERENCE   4  (residues 1 to 918)
  AUTHORS   Tixi,W., Maldonado,M., Chang,Y.T., Chiu,A., Yeung,W., Parveen,N.,
            Nelson,M.S., Hart,R., Wang,S., Hsu,W.J., Fueger,P., Kopp,J.L.,
            Huising,M.O., Dhawan,S. and Shih,H.P.
  TITLE     Coordination between ECM and cell-cell adhesion regulates the
            development of islet aggregation, architecture, and functional
            maturation
  JOURNAL   Elife 12, e90006 (2023)
   PUBMED   37610090
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 918)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 918)
  AUTHORS   Griffin,L.D., Gelb,B.D., Wheeler,D.A., Davison,D., Adams,V. and
            McCabe,E.R.
  TITLE     Mammalian hexokinase 1: evolutionary conservation and structure to
            function analysis
  JOURNAL   Genomics 11 (4), 1014-1024 (1991)
   PUBMED   1783373
REFERENCE   7  (residues 1 to 918)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA10 homologous loci in cattle
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 123-126 (1991)
   PUBMED   1655359
REFERENCE   8  (residues 1 to 918)
  AUTHORS   Kozak,C.A., Peyser,M., Krall,M., Mariano,T.M., Kumar,C.S.,
            Pestka,S. and Mock,B.A.
  TITLE     Molecular genetic markers spanning mouse chromosome 10
  JOURNAL   Genomics 8 (3), 519-524 (1990)
   PUBMED   1981053
REFERENCE   9  (residues 1 to 918)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   10 (residues 1 to 918)
  AUTHORS   Lalley,P.A., Francke,U. and Minna,J.D.
  TITLE     Assignment of the genes coding for pyrophosphatase and hexokinase-1
            to mouse chromosome 10: implications for comparative gene mapping
            in man and mouse
  JOURNAL   Cytogenet Cell Genet 22 (1-6), 570-572 (1978)
   PUBMED   752542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145297.3.
            
            Transcript Variant: This variant (1) represents the ubiquitously
            expressed transcript and encodes isoform HK1. Its 5' end includes
            an exon that is unique to this transcript and encodes a distinct
            N-terminus containing the porin binding domain (PBD). The porin
            binding domain mediates association with the mitochondrial
            membrane.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072628.1, AK167468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.37 cM"
     Protein         1..918
                     /product="hexokinase-1 isoform HK1"
                     /EC_number="2.7.1.1"
                     /note="HK I; hexokinase type I; hexokinase, tumor isozyme;
                     downeast anemia"
                     /calculated_mol_wt=102171
     Region          2..474
                     /region_name="ASKHA_ATPase-like"
                     /note="ATPase-like domain of the ASKHA (Acetate and Sugar
                     Kinases/Hsc70/Actin) superfamily; cl49607"
                     /db_xref="CDD:483947"
     Region          478..911
                     /region_name="ASKHA_NBD_HK1_meta_rpt2"
                     /note="nucleotide-binding domain (NBD) of the second
                     repeat of type I hexokinase from metazoan hexokinase (HK)
                     domain family; cd24127"
                     /db_xref="CDD:466977"
     CDS             1..918
                     /gene="Hk1"
                     /gene_synonym="dea; Hk-1; Hk1-s; mHk1-s"
                     /coded_by="NM_001146100.2:69..2825"
                     /note="isoform HK1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48577.1"
                     /db_xref="GeneID:15275"
                     /db_xref="MGI:MGI:96103"
ORIGIN      
        1 miaaqllayy ftelkddqvk kidkylyamr lsdeilidil trfkkemkng lsrdynptas
       61 vkmlptfvrs ipdgsekgdf ialdlggssf rilrvqvnhe ksqnvsmese vydtpenivh
      121 gsgsqlfdhv aeclgdfmek rkikdkklpv gftfsfpcrq skideavlit wtkrfkasgv
      181 egadvvklln kaikkrgdyd anivavvndt vgtmmtcgyd dqqcevglii gtgtnacyme
      241 elrhidlveg degrmcinte wgafgddgsl edirtefdre ldrgslnpgk qlfekmvsgm
      301 ymgelvrlil vkmakesllf egritpellt rgkfttsdva aietdkegvq nakeiltrlg
      361 vepshddcvs vqhvctivsf rsanlvaatl gailnrlrdn kgtprlrttv gvdgslykmh
      421 pqysrrfhkt lrrlvpdsdv rfllsesgsg kgaamvtava yrlaeqhrqi eetlshfrls
      481 kqalmevkkk lrsememglr ketnsratvk mlpsyvrsip dgtehgdfla ldlggtnfrv
      541 llvkirsgkk rtvemhnkiy sipleimqgt gdelfdhivs cisdfldymg ikgprmplgf
      601 tfsfpckqts ldcgilitwt kgfkatdcvg hdvatllrda vkrreefdld vvavvndtvg
      661 tmmtcayeep sceiglivgt gsnacymeem knvemvegnq gqmcinmewg afgdngcldd
      721 irtdfdkvvd eyslnsgkqr fekmisgmyl geivrnilid ftkkgflfrg qiseplktrg
      781 ifetkflsqi esdrlallqv railqqlgln stcddsilvk tvcgvvskra aqlcgagmaa
      841 vvekirenrg ldhlnvtvgv dgtlyklhph fsrimhqtvk elspkctvsf llsedgsgkg
      901 aalitavgvr lrgdptna
//
