LOCUS       NM_027126               2021 bp    mRNA    linear   ROD 27-FEB-2024
DEFINITION  Mus musculus hemojuvelin BMP co-receptor (Hjv), mRNA.
ACCESSION   NM_027126 XM_359250
VERSION     NM_027126.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Wang,X.F., Vigouroux,R., Syonov,M., Baglaenko,Y.,
            Nikolakopoulou,A.M., Ringuette,D., Rus,H., DiStefano,P.V.,
            Dufour,S., Shabanzadeh,A.P., Lee,S., Mueller,B.K., Charish,J.,
            Harada,H., Fish,J.E., Wither,J., Walchli,T., Cloutier,J.F.,
            Zlokovic,B.V., Carlen,P.L. and Monnier,P.P.
  TITLE     The liver and muscle secreted HFE2-protein maintains central
            nervous system blood vessel integrity
  JOURNAL   Nat Commun 15 (1), 1037 (2024)
   PUBMED   38310100
  REMARK    GeneRIF: The liver and muscle secreted HFE2-protein maintains
            central nervous system blood vessel integrity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Charlebois,E., Li,Y., Wagner,V., Pantopoulos,K. and Olivier,M.
  TITLE     Genetic Iron Overload Hampers Development of Cutaneous
            Leishmaniasis in Mice
  JOURNAL   Int J Mol Sci 24 (2), 1669 (2023)
   PUBMED   36675185
  REMARK    GeneRIF: Genetic Iron Overload Hampers Development of Cutaneous
            Leishmaniasis in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Allameh,A., Huttmann,N., Charlebois,E., Katsarou,A., Gu,W.,
            Gkouvatsos,K., Pasini,E., Bhat,M., Minic,Z., Berezovski,M.,
            Guido,M., Fillebeen,C. and Pantopoulos,K.
  TITLE     Hemojuvelin deficiency promotes liver mitochondrial dysfunction and
            predisposes mice to hepatocellular carcinoma
  JOURNAL   Commun Biol 5 (1), 153 (2022)
   PUBMED   35194137
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Enns,C.A., Jue,S. and Zhang,A.S.
  TITLE     Hepatocyte neogenin is required for hemojuvelin-mediated hepcidin
            expression and iron homeostasis in mice
  JOURNAL   Blood 138 (6), 486-499 (2021)
   PUBMED   33824974
  REMARK    GeneRIF: Hepatocyte neogenin is required for hemojuvelin-mediated
            hepcidin expression and iron homeostasis in mice.
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Niederkofler,V., Salie,R., Sigrist,M. and Arber,S.
  TITLE     Repulsive guidance molecule (RGM) gene function is required for
            neural tube closure but not retinal topography in the mouse visual
            system
  JOURNAL   J Neurosci 24 (4), 808-818 (2004)
   PUBMED   14749425
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Schmidtmer,J. and Engelkamp,D.
  TITLE     Isolation and expression pattern of three mouse homologues of chick
            Rgm
  JOURNAL   Gene Expr Patterns 4 (1), 105-110 (2004)
   PUBMED   14678836
  REMARK    GeneRIF: Exclusive expression in the muscle cell lineage.
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Papanikolaou,G., Samuels,M.E., Ludwig,E.H., MacDonald,M.L.,
            Franchini,P.L., Dube,M.P., Andres,L., MacFarlane,J.,
            Sakellaropoulos,N., Politou,M., Nemeth,E., Thompson,J.,
            Risler,J.K., Zaborowska,C., Babakaiff,R., Radomski,C.C., Pape,T.D.,
            Davidas,O., Christakis,J., Brissot,P., Lockitch,G., Ganz,T.,
            Hayden,M.R. and Goldberg,Y.P.
  TITLE     Mutations in HFE2 cause iron overload in chromosome 1q-linked
            juvenile hemochromatosis
  JOURNAL   Nat Genet 36 (1), 77-82 (2004)
   PUBMED   14647275
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Ramamoorthy,S., Leibach,F.H., Mahesh,V.B., Han,H., Yang-Feng,T.,
            Blakely,R.D. and Ganapathy,V.
  TITLE     Functional characterization and chromosomal localization of a
            cloned taurine transporter from human placenta
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 893-900 (1994)
   PUBMED   8010975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ557515.1 and AI503400.1.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_027126.5.
            
            On Jan 31, 2008 this sequence version replaced NM_027126.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ557515.1, AK014082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2014              AJ557515.1         1-2014
            2015-2021           AI503400.1         5-11                c
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.91 cM"
     gene            1..2021
                     /gene="Hjv"
                     /gene_synonym="2310035L15Rik; 5230400G09Rik; DL-M;
                     hemojuvelin; Hfe2; Rgmc"
                     /note="hemojuvelin BMP co-receptor"
                     /db_xref="GeneID:69585"
                     /db_xref="MGI:MGI:1916835"
     exon            1..146
                     /gene="Hjv"
                     /gene_synonym="2310035L15Rik; 5230400G09Rik; DL-M;
                     hemojuvelin; Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
     exon            147..320
                     /gene="Hjv"
                     /gene_synonym="2310035L15Rik; 5230400G09Rik; DL-M;
                     hemojuvelin; Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1495
                     /gene="Hjv"
                     /gene_synonym="2310035L15Rik; 5230400G09Rik; DL-M;
                     hemojuvelin; Hfe2; Rgmc"
                     /note="repulsive guidance molecule C; RGM domain family
                     member C; hemochromatosis type 2 protein homolog;
                     hemochromatosis type 2 (juvenile) (human homolog);
                     hemojuvelin BMP coreceptor"
                     /codon_start=1
                     /product="hemojuvelin precursor"
                     /protein_id="NP_081402.3"
                     /db_xref="CCDS:CCDS51003.1"
                     /db_xref="GeneID:69585"
                     /db_xref="MGI:MGI:1916835"
                     /translation="MGQSPSPRSPHGSPPTLSTLTLLLLLCGQAHSQCKILRCNAEYV
                     SSTLSLRGGGSPDTPRGGGRGGLASGGLCRALRSYALCTRRTARTCRGDLAFHSAVHG
                     IEDLMIQHNCSRQGPTAPPPARGPALPGAGPAPLTPDPCDYEARFSRLHGRAPGFLHC
                     ASFGDPHVRSFHNQFHTCRVQGAWPLLDNDFLFVQATSSPVSSGANATTIRKITIIFK
                     NMQECIDQKVYQAEVDNLPAAFEDGSINGGDRPGGSSLSIQTANLGSHVEIRAAYIGT
                     TIIIRQTAGQLSFSIRVAEDVARAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAIAID
                     TARRLCKEGLPVEDAYFQSCVFDVSVSGDPNFTVAAQTALDDARIFLTDLENLHLFPS
                     DAGPPLSPAICLVPLLSALFVLWLCFSK"
     exon            321..868
                     /gene="Hjv"
                     /gene_synonym="2310035L15Rik; 5230400G09Rik; DL-M;
                     hemojuvelin; Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
     exon            869..2021
                     /gene="Hjv"
                     /gene_synonym="2310035L15Rik; 5230400G09Rik; DL-M;
                     hemojuvelin; Hfe2; Rgmc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctctga cctgagtgag actgcagcca ttccggggca atcatggaga aagagatggg
       61 ggaccccctg gctggagcag accaacagaa taggcaacta tggctcgaga acccagtatc
      121 agagtaatgc ttgacctcgg gaaacatcac agaagtaccc agagaaattc actaggtagg
      181 aggctcatca tctgggaaga accggtgcct ggggggacct ggctggatag gtatgggcca
      241 gtcccctagt ccccggtccc cccacggcag ccctccaact ctaagcaccc tcactctcct
      301 gctgctcctc tgtggacagg ctcactccca gtgcaagatc ctccgctgca atgccgagta
      361 tgtctcgtcc actctgagtc ttcggggagg tggctcaccg gacacgccgc gtggaggcgg
      421 ccgtggtggg ctggcctcag gtggcttgtg tcgcgccctg cgctcctacg ctctctgcac
      481 gcggcgcacg gcccgcacct gccgcgggga ccttgctttc cactctgcgg tgcatggcat
      541 agaggacctg atgatccagc acaactgctc acgccagggt cccacggccc cgcccccggc
      601 ccggggcccc gccctgcccg gggccgggcc agcgcccctg accccagatc cctgtgacta
      661 tgaggcccgg ttttccaggc tgcacggtcg agccccgggc ttcttgcatt gcgcatcctt
      721 tggagatccc catgtgcgca gtttccacaa ccaatttcac acatgccgtg tccaaggagc
      781 ttggcccttg ctagataacg acttcctctt tgtccaggcc accagctccc cggtttcgtc
      841 gggagccaac gctaccacca tccggaagat cactatcata tttaaaaaca tgcaggaatg
      901 cattgaccag aaagtctacc aggctgaggt ggacaatctt cctgcagcct ttgaagatgg
      961 ttctatcaat gggggcgacc gacctggggg ctcgagtttg tccattcaaa ctgctaacct
     1021 tgggagtcac gtggagattc gagctgccta cattggaaca actatcatca ttcgacagac
     1081 agctgggcag ctctccttct ccatcagggt agcagaggat gtggcgcggg ccttctccgc
     1141 agagcaggac ctacagctgt gtgttggggg atgccctccg agccagcgac tctctcgctc
     1201 agagcgcaac cgccgtgggg ctatagccat agatactgcc agaaggctgt gtaaggaagg
     1261 gcttccggtt gaagatgcct acttccaatc ctgcgtcttt gatgtttcag tctccggtga
     1321 ccccaacttt actgtggcag ctcagacagc tctggacgat gcccgaatct tcttgacgga
     1381 tttagagaac ttacatctct ttccctcaga tgcggggcct cccctctctc ctgccatctg
     1441 cctagtcccg cttctttcgg ccctctttgt tctgtggctt tgcttcagta agtaggccag
     1501 caacccatga ctggtttgga aacgatttga ggatagaggt tggtgtgaga aaccacaaag
     1561 atgtgccaaa ggaaacagcg gggacaggag acaacactta ctcaatcaga tgaggttgca
     1621 gtccagggct gaaatgaccc tagaataaag attctgggcc agggttttgc actccagacc
     1681 ttggtgtggg ctattcacca tggatttccc agttagtgat ttcccacttg taatgaaatt
     1741 ccactctcca tacacctgat accactccta caagcctaga gattgtgaga gtgctaatga
     1801 ccagtgaaac attaaaggac tgagatatcg taaaggcaaa aacatgattc tctttgagaa
     1861 agtcaaaaga ggagaagcta attaggaaaa gcttttggtt cagaaacgaa gtgggcattg
     1921 tctggcagag gaagtcagct tttggagact ggcaccaact cagaaacggg catttccatc
     1981 ccttcctaat ctgttattaa agcgattagt tctccatcct g
//
