LOCUS       NM_001358782            9870 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus human immunodeficiency virus type I enhancer binding
            protein 2 (Hivep2), transcript variant 2, mRNA.
ACCESSION   NM_001358782 XM_011243133
VERSION     NM_001358782.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9870)
  AUTHORS   Zhou,L., Su,S., Yu,J., Wan,S., Xu,X., Li,X., Xiong,M., Tian,W.,
            Wang,L., Wu,Y. and Ke,C.
  TITLE     Schnurri-2 Promotes the Expression of Excitatory Glutamate
            Receptors and Contributes to Neuropathic Pain
  JOURNAL   Neuroscience 488, 20-31 (2022)
   PUBMED   35218885
  REMARK    GeneRIF: Schnurri-2 Promotes the Expression of Excitatory Glutamate
            Receptors and Contributes to Neuropathic Pain.
REFERENCE   2  (bases 1 to 9870)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   3  (bases 1 to 9870)
  AUTHORS   Murano,T., Hagihara,H., Tajinda,K., Matsumoto,M. and Miyakawa,T.
  TITLE     Transcriptomic immaturity inducible by neural hyperexcitation is
            shared by multiple neuropsychiatric disorders
  JOURNAL   Commun Biol 2, 32 (2019)
   PUBMED   30675529
  REMARK    Erratum:[Commun Biol. 2019 Mar 4;2:94. doi:
            10.1038/s42003-019-0358-x.. PMID: 30854486]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9870)
  AUTHORS   Kobayashi,K., Takagi,T., Ishii,S., Suzuki,H. and Miyakawa,T.
  TITLE     Attenuated bidirectional short-term synaptic plasticity in the
            dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia
  JOURNAL   Mol Brain 11 (1), 56 (2018)
   PUBMED   30285890
  REMARK    GeneRIF: the Shn2 deficiency attenuates bidirectional short-term
            synaptic plasticity at the medial perforant path-granule cell
            synapse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9870)
  AUTHORS   Nakao,A., Miyazaki,N., Ohira,K., Hagihara,H., Takagi,T., Usuda,N.,
            Ishii,S., Murata,K. and Miyakawa,T.
  TITLE     Immature morphological properties in subcellular-scale structures
            in the dentate gyrus of Schnurri-2 knockout mice: a model for
            schizophrenia and intellectual disability
  JOURNAL   Mol Brain 10 (1), 60 (2017)
   PUBMED   29233179
  REMARK    GeneRIF: Shn2 knockout mice serve as a unique tool for
            investigating morphological abnormalities of subcellular-scale
            structures in schizophrenia, intellectual disability, and its
            related disorders.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9870)
  AUTHORS   Takagi,T., Jin,W., Taya,K., Watanabe,G., Mori,K. and Ishii,S.
  TITLE     Schnurri-2 mutant mice are hypersensitive to stress and hyperactive
  JOURNAL   Brain Res 1108 (1), 88-97 (2006)
   PUBMED   16836985
  REMARK    GeneRIF: Shn-2 plays a critical role in locomotion and anxiety-like
            behavior. Stress-induced corticosterone levels were significantly
            higher in Shn-2(-/-) mice compared to wild-type controls.
REFERENCE   7  (bases 1 to 9870)
  AUTHORS   Kimura,M.Y., Hosokawa,H., Yamashita,M., Hasegawa,A., Iwamura,C.,
            Watarai,H., Taniguchi,M., Takagi,T., Ishii,S. and Nakayama,T.
  TITLE     Regulation of T helper type 2 cell differentiation by murine
            Schnurri-2
  JOURNAL   J Exp Med 201 (3), 397-408 (2005)
   PUBMED   15699073
  REMARK    GeneRIF: Data suggest that Schnurri-2 plays a crucial role in the
            control of T helper type 2 cell differentiation by regulating
            NF-kappaB function.
REFERENCE   8  (bases 1 to 9870)
  AUTHORS   Campbell,D.B. and Levitt,P.
  TITLE     Regionally restricted expression of the transcription factor c-myc
            intron 1 binding protein during brain development
  JOURNAL   J Comp Neurol 467 (4), 581-592 (2003)
   PUBMED   14624490
REFERENCE   9  (bases 1 to 9870)
  AUTHORS   Takagi,T., Harada,J. and Ishii,S.
  TITLE     Murine Schnurri-2 is required for positive selection of thymocytes
  JOURNAL   Nat Immunol 2 (11), 1048-1053 (2001)
   PUBMED   11668343
REFERENCE   10 (bases 1 to 9870)
  AUTHORS   Dorflinger,U., Pscherer,A., Moser,M., Rummele,P., Schule,R. and
            Buettner,R.
  TITLE     Activation of somatostatin receptor II expression by transcription
            factors MIBP1 and SEF-2 in the murine brain
  JOURNAL   Mol Cell Biol 19 (5), 3736-3747 (1999)
   PUBMED   10207097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ119019.1, AK147244.1, AC091764.35 and CF747636.1.
            
            On Dec 12, 2017 this sequence version replaced XM_011243133.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               CJ119019.1         1-266
            267-454             AK147244.1         266-453
            455-455             AC091764.35        129587-129587       c
            456-8518            AK147244.1         455-8517
            8519-8519           AC091764.35        97092-97092         c
            8520-9844           AK147244.1         8519-9843
            9845-9870           CF747636.1         700-725
FEATURES             Location/Qualifiers
     source          1..9870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 5.14 cM"
     gene            1..9870
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="human immunodeficiency virus type I enhancer
                     binding protein 2"
                     /db_xref="GeneID:15273"
                     /db_xref="MGI:MGI:1338076"
     exon            1..319
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..421
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..503
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..548
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..6054
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             916..8208
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="myc intron-binding protein 1; human
                     immunodeficiency virus type I enhancer-binding protein 2
                     homolog"
                     /codon_start=1
                     /product="transcription factor HIVEP2"
                     /protein_id="NP_001345711.1"
                     /db_xref="CCDS:CCDS23704.1"
                     /db_xref="GeneID:15273"
                     /db_xref="MGI:MGI:1338076"
                     /translation="MDTGDTALGQKATSRSGETDSVSGRWRQEQSAVLKMSTFSSQEG
                     PRQPQIDPEQIGNAASAQLFGSGKLASPGEGLHQVTEKQYPPHRPSPYPCQHSLSFPQ
                     HSLSQGMTHSHKPHQSLEGPPWLFPGPLPSVASEDLFPFPMHGHSGGYPRKKISNLNP
                     AYSQYSQKSIEQAEDAHKKEHKPKKPGKYICPYCSRACAKPSVLKKHIRSHTGERPYP
                     CIPCGFSFKTKSNLYKHRKSHAHAIKAGLVPFTESSVSKLDLEAGFIDVEAEIHSDGE
                     QSTDTDEESSLFAEASDKVSPGPPVPLDIASRGGYHGSLEESLGGPMKVPILIIPKSG
                     IPLASEGSQYLSSEMLPNPSLNAKADDSHTVKQKLALRLSEKKGQDSEPSLNLLSPHS
                     KGSTDSGYFSRSESAEQQISPPNTNAKSYEEIIFGKYCRLSPRNTLSVTPTGQERTAM
                     GRRGIMEPLPHLNTRLEVKMFEDPISQLNPSKGEMDPGQINMLKTTKFNSECRQPQAI
                     PSSVRNEGKPYPGNFLGSNPMLLEAPVDSSPLIRSNSMPTSSATNLSVPPSLRGSHSF
                     DERMTGSDDVFYPGTVGIPPQRMLRRQAAFELPSVQEGHMESEHPARVSKGLASPSLK
                     EKKLLPGDRPGYDYDVCRKPYKKWEDSETLKQSYLGSFKQGGEYFMDPSVPVQGVPTM
                     FGTTCENRKRRKEKSVGDEEDVPMICGGMGNAPVGMMSSEYDPKLQDGGRSGFAMTAH
                     ESLAHGHSDRLDPARPQLPSRSPSLGSEDLPLAADPDKMTDLGKKPPGNVISVIQHTN
                     SLSRPNSFERSESTEMVACPQDKTPSPAETCDSEVLEAPVSPEWAPPGDGGESGSKPT
                     PSQQVPQHSYHAQPRLVRQHNIQVPEIRVTEEPDKPEKEKEAPTKEPEKPVEEFQWPQ
                     RSETLSQLPAEKLPPKKKRLRLADLEHSSGESSFESTGTGLSRSPSQESNLSHSSSFS
                     MSFDREETVKLTAPPKQDESGKHSEFLTVPAGSYSLSVPGHHHQKEMRRCSSEQMPCP
                     HPTEVPEIRSKSFDYGNLSHAPVAGTSPSTLSPSRERKKCFLVRQASFSGSPEIAQGE
                     AGVDPSVKQEHMEHLHAGLRAAWSSVLPPLPGDDPGKQVGTCGPLSSGPPLHLTQQQI
                     MHMDSQESLRNPLIQPTSYMTSKHLPEQPHLFPHQDAVPFSPIQNALFQFQYPTVCMV
                     HLPAQQPPWWQTHFPHPFAPHPQNSYSKPPFQADLHSSYPLEHVAEHTGKKSADYPHA
                     KEQTYPCYSGTSGLHSKNLPLKFPSDPGSKSTETPTEQLLREDFASENAGPLQSLPGT
                     VVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTLVTNAAMQGIGLN
                     IAQVLGQHTGLEKYPLWKVPQTLPLGLESSIPLCLPSTSDNAASLGGSKRMLSPASSL
                     ELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKGLSRPQKPQLVRQGCASEPKD
                     GCFQSRSSSFSSLSPSSSQDHPSASGPFPPNREILPGSRAPPRRKFSGPSESRESSDE
                     LDMDETSSDMSMSPQSSALPTGGGQQEEEGKARKLPVSMLVHMASGPGGNVANSTLLF
                     TDVADFQQILQFPSLRTTTTVSWCFLNYTKPSFVQQATFKSSVYASWCISSCNPNPSG
                     LNTKTTLALLRSKQKITAEIYTLAAMHRPGAGKLTSSSVWKQFAQMKPDAPFLFGNKL
                     ERKLAGNVLKERGKGEIHGDKDLGSKQTEPIRIKIFEGGYKSNEDYVYVRGRGRGKYI
                     CEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNLTKHMKSKAHMKKCLEL
                     GVSMTSVDDTETEEAENMEELHKTSEKHSMSGISTDHQFSDAEESDGEDGDDNDDDDE
                     DDDDFDDQGDLTPKTRSRSTSPQPPRFSSLPVNVGAVAHGVPSDSSLGHSSLISYLVT
                     LPSIQVTQLMTPSDSCDDTQMTEYQRLFQSKSTDSEPDKDRLDIPSSMDEEAMLSSEP
                     SSSPRDFSPSSYRSSPGYDSSPCRDNSPKRYLIPKGDLSPRRHLSPRRDLSPMRHLSP
                     RKEAALRREMSQGDASPRRHLSPRRPLSPGKDITARRDLSPRRERRYMTTIRAPSPRR
                     ALYPNPPLSMGQYLQTEPIVLGPPNLRRGIPQVPYFSLYGDQEGAYEHHGSSLFPEGP
                     TDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSLPPALSGLHPPPTLPLPTEGSEEKK
                     GAPGEAFAKDPYILSRRHEKQAPQVLQSSGLPSSPSSPRLLMKQSTSEDSLNSTEREQ
                     EENIQTCTKAIASLRIATEEAALLGADPPTWVQESPQKPLESAHVSIRHFGGPEPGQP
                     CTSAAHPDLHDGEKDTFGTSQTAVAHPTFYSKSSVDEKRVDFQSSKELSLSTEEGNEP
                     SPEKNQLH"
     exon            6055..6209
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6210..6385
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6386..6487
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6488..7383
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7384..9850
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9794..9799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="hexamer: ATTACA"
     regulatory      9825..9830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="hexamer: AATAAA"
     regulatory      9829..9834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="hexamer: AATATA"
     polyA_site      9830
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="major polyA site"
     polyA_site      9846
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /note="major polyA site"
     polyA_site      9850
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
ORIGIN      
        1 gtggagagct ggagagcggg gcgccgccgt gcgctgtctc tccccggtgg aggagggtct
       61 ccgcaaaaag agaaagaaaa aggaaaaaga aaaaaaaaaa aagacatctt cggtgactgt
      121 ggcacaagta tttgccaagt tgagtcttgg acattgaagc ttgcccggag cccgagcaac
      181 ttgaaaggtc ctctggctgg gtagcagcct ccctccacgc ttcgactctt gggtactggg
      241 tgcagccctg gggtgcgtgg agggcgcacc ggccgctggc agagcagagc ggcgggaatc
      301 taggtccctt ctcggctcgg tgaagtctgt gagttttgtc aaagccaacg ataatcagac
      361 ctacttgaaa gattaagtga attgatttca ttggaacatt ctctcaacag ccagccagta
      421 gtattctgat gtcctgtgta gcccagattg acttagaatt tgcttatctt ctgccctcag
      481 cttcctgagt tctgggattg caggaagcgt caggacaatc atgcccatga gaactctcaa
      541 ctgttcaggc cgttgtactt cagtgagact ggctgttgaa ctttgctgta gttgatgagc
      601 agaatttctg ggctcttcat catcccagcc ccatcctagt tgaaaaagat tcaaatgccc
      661 taactttgca ctttgctttt gaagaaggac atttctagga tggagagaac tgtgttatag
      721 tttggttcca ggacactggc atccaatgcc cactgactcc agtgtgagcg cggaaggttc
      781 cagagagagg gatcagtccg cgagttcaca accaggaacc cagaaacaac ctggctttaa
      841 aaagcacagc attggagaca ctccatgagt ctgcttggct tccgggcaaa gtagcattta
      901 agaccttgtg ttaaaatgga caccggggac acagctctag gacaaaaagc tacctcaagg
      961 tctggagaaa ctgacagcgt gtctggtaga tggaggcagg aacaatcagc tgttcttaag
     1021 atgagcactt tcagcagtca ggaagggcca agacaaccac agatagatcc tgagcagatc
     1081 ggaaatgcag cttcggcgca gctgtttggt tctgggaagc tggcctcgcc tggcgagggc
     1141 ctacatcaag tcacagagaa gcaataccca cctcaccgtc cgagtcccta cccatgccaa
     1201 cactcgctct ctttccctca gcattcacta tcccagggca tgacgcacag ccacaagcca
     1261 caccagagcc tagagggccc tccctggctt ttccctggcc ctttgccatc tgtcgcctct
     1321 gaggacctat ttccttttcc aatgcacggc cacagcggtg gttatcctag aaaaaagatc
     1381 tcaaatctca accctgctta cagccaatac tcccagaaaa gtatcgaaca ggcagaagat
     1441 gctcacaaga aagagcacaa acccaaaaag ccaggcaagt atatctgccc gtactgcagc
     1501 agggcatgtg cgaaacccag cgtcttaaag aaacacatca ggtcccatac tggtgagcgg
     1561 ccgtatccat gtataccttg tggcttctct ttcaagacaa agagtaattt gtacaagcac
     1621 aggaagtctc atgcccatgc aattaaggca ggcttggtac ccttcactga gtcgtctgta
     1681 tccaaattgg acctcgaggc tggttttatc gatgtagaag cagagatcca ctcagacggt
     1741 gagcagagca cagacacgga tgaggagagc tctttatttg ctgaggcttc tgacaaagtg
     1801 agccctggcc ctcccgtccc tttggacatt gctagcagag gtggctacca tgggtccttg
     1861 gaagaatctt tgggaggtcc catgaaggtg ccaattttga ttattcccaa aagtgggatc
     1921 ccactagcca gtgagggctc tcagtatctg agctctgaaa tgctccccaa tccgtctctg
     1981 aatgctaagg cggatgactc tcacacggtg aaacagaaac ttgcgctgag actgtcagag
     2041 aagaaaggac aagactctga gccatccctt aacctcctga gcccgcacag caaggggagt
     2101 acggactctg gttacttttc tcgctcagaa agtgcggagc agcagatcag cccacccaac
     2161 acaaacgcca agtcttatga agaaatcatt tttggaaaat actgtcgact tagtccaagg
     2221 aatacactta gtgttactcc caccggtcag gagcgcaccg ccatggggcg caggggcatc
     2281 atggaaccat tacctcattt aaacacccgg ttggaggtca agatgtttga agatcctatc
     2341 tctcaactga atcccagcaa aggagaaatg gaccccggtc aaatcaacat gttgaagacc
     2401 acgaaattca acagtgagtg tcggcaacca caagccatcc cgtcctctgt taggaatgaa
     2461 ggaaaacctt acccaggcaa cttcctaggc agcaatccaa tgctcttaga agctcctgtg
     2521 gactcttcac cccttattag aagcaactcg atgccaacgt cttcagcaac aaatttaagt
     2581 gtccctcctt ctttgagagg aagccactcg tttgatgaaa ggatgacagg gtctgatgat
     2641 gtgttctatc ccggcactgt gggcatacct ccccagcgca tgctcagacg gcaagcagcc
     2701 ttcgagctgc cgtcggtcca ggagggccac atggagtctg agcaccctgc acgggtatcc
     2761 aagggccttg ccagtccatc cctgaaggaa aagaaattac ttcccggaga caggcccggc
     2821 tatgactacg atgtctgccg taaaccatac aagaaatggg aagactctga aacactgaaa
     2881 cagagctacc tgggttcctt caagcaagga ggggaatatt ttatggaccc ctcggtgcca
     2941 gtgcagggag tgccaaccat gttcgggact acctgtgaga acagaaaacg caggaaagag
     3001 aagagcgtgg gagatgaaga ggatgttccc atgatctgtg gtggcatggg aaatgctccc
     3061 gtgggcatga tgtcctcaga gtacgacccc aagctgcagg acggaggaag gagtggcttt
     3121 gccatgactg cacacgagag ccttgctcat ggtcactccg accgtctaga cccagctcga
     3181 ccccagctgc catctagaag tccatccctt gggtctgagg atttgccctt ggctgctgat
     3241 ccagacaaga tgacagacct gggcaagaag cctccaggaa atgtgatttc agtgatccag
     3301 cacacaaact cgctgagccg gcccaattcc tttgaaagat ctgagtcaac agaaatggtg
     3361 gcctgcccac aggacaagac cccttcacct gctgagacat gtgacagtga ggttttggaa
     3421 gcccctgtaa gcccagagtg ggctcctcca ggggatggtg gagaaagcgg aagcaagcca
     3481 accccttcac agcaggtacc acagcactcc taccatgcac agccaaggct tgttcgccag
     3541 cacaatatcc aggttcctga aatcagagtc acagaggaac ctgacaagcc cgagaaggag
     3601 aaggaagctc ctaccaagga gcctgagaag ccagtggagg aattccagtg gcctcagaga
     3661 agcgaaactc tttcccaact ccctgctgag aagttgcctc ccaaaaagaa acgcttgagg
     3721 cttgcagatt tggaacactc ctcaggggaa tccagctttg agtccacagg caccggcctc
     3781 tctaggagtc ccagccaaga aagcaactta tcccacagtt ccagtttctc catgtccttt
     3841 gatagagaag aaacggttaa gctcactgca cctcctaagc aggatgagag cgggaagcat
     3901 tctgagtttc tgactgtccc tgcgggttca tactcattgt ctgttccggg tcatcaccac
     3961 cagaaagaaa tgcggcgttg ctcctccgag cagatgccct gtcctcaccc gacggaagtc
     4021 ccagaaatac ggagtaaatc gtttgattat gggaacctgt cccacgctcc agtggctgga
     4081 acatccccat caacactatc accgtcccgg gagaggaaga aatgcttttt ggtgcgtcag
     4141 gcttccttca gtggctcccc agaaattgcc caaggtgaag ccggcgtgga ccccagcgtc
     4201 aagcaggagc acatggagca cttgcacgct ggcctcaggg ctgcgtggtc ctctgtgctt
     4261 ccacctctgc caggggatga cccaggaaag caggtcggta cttgtggccc actgagctca
     4321 gggccaccac tccaccttac ccagcagcag atcatgcaca tggacagtca ggaatctctg
     4381 agaaatccgt tgattcaacc aacatcctac atgacgagca agcacttacc cgaacagcca
     4441 catctgtttc cacatcaaga tgcggtccca ttttctccta tccagaatgc cttgtttcag
     4501 tttcagtacc cgactgtgtg tatggttcat ctgccagctc agcagcctcc ctggtggcag
     4561 acacatttcc cccatccctt cgctccacac cctcagaaca gctacagtaa gcctcccttc
     4621 caagctgacc ttcattctag ctacccctta gagcatgtag cagaacacac tggaaagaaa
     4681 tctgctgact atccccatgc gaaagagcag acttacccgt gttattccgg aacatcaggg
     4741 ctacactcca agaacctccc tctgaagttt ccatcagacc cgggcagtaa gtccactgaa
     4801 acgcccacgg agcagctcct tcgagaagat ttcgcctcag aaaatgctgg gcctttgcag
     4861 tccctaccgg gaacagtggt tcctgttcgg atccagaccc acgttccatc ctacggaagt
     4921 gtcatgtaca caagcatttc tcagatactt ggacagaaca gccccgccat cgtcatatgc
     4981 aaggtcgatg agaatatgac ccaaagaaca ctggtaacca atgcagccat gcaagggata
     5041 ggattaaaca tagctcaagt gcttgggcag cacacgggct tggaaaaata ccctctttgg
     5101 aaagtacctc agaccttacc cctgggctta gagtcctcta tccccttgtg tttaccgtcc
     5161 acctcagaca acgcagcctc tctcggagga agcaagcgga tgctctctcc agccagcagt
     5221 ttggagctct tcatggaaac caagcaacag aaacgggtga aagaggagaa gatgtacggg
     5281 cagattgtgg aagaactcag tgccgtggag ctaaccaact cagacatcaa gaagggcctt
     5341 tcccggcccc agaagcccca gctcgtgagg caggggtgtg cttcggagcc aaaggatggc
     5401 tgcttccagt caaggtcttc ttccttctcc tccctgtcac cctcctcttc tcaagaccat
     5461 ccgtctgcca gcgggccctt ccctcccaac agggagattc ttccagggtc cagggctccg
     5521 ccgcgacgga agttcagcgg gccctcagaa agcagagagt cctccgatga gctggacatg
     5581 gatgagacgt cgtcagacat gagcatgagc cctcagagct ctgcactgcc caccggaggc
     5641 ggtcagcagg aagaggaagg gaaagcccgc aagctgcccg tcagcatgct ggtccacatg
     5701 gcctctggtc ctggaggaaa tgtggcaaat tccactcttc ttttcacaga cgtggccgat
     5761 ttccagcaga tacttcagtt ccccagtctg cggacaacta ctactgtgag ttggtgcttc
     5821 ttaaattata caaaacccag ttttgtgcaa caggccacct tcaaatcctc cgtttatgct
     5881 tcatggtgca ttagttcctg taacccaaac ccatcaggat tgaacaccaa gaccacgctg
     5941 gcccttctga gatccaaaca aaaaattact gcagaaattt atactctggc tgctatgcac
     6001 aggcccggag ctggtaagct cacttcatcc agcgtctgga agcagtttgc acagatgaag
     6061 cctgatgcgc ccttcttgtt tggcaacaaa ctagaaagga aattagcagg aaatgtccta
     6121 aaggaaagag ggaaaggaga gattcacgga gataaagatc ttggatccaa acaaactgag
     6181 ccaatccgaa ttaagatctt tgaagggggg tacaaatcca atgaagatta tgtgtatgtc
     6241 agaggacgtg gacggggaaa gtatatttgt gaagagtgtg gaattcgctg taagaagcca
     6301 agtatgctca aaaaacacat acgcactcat actgatgttc ggccttatgt atgcaagtta
     6361 tgtaattttg ccttcaaaac gaaaggaaac ctaacaaaac acatgaaatc taaggcccac
     6421 atgaaaaagt gtctggagct gggcgtgtcg atgacatcag tagatgacac agaaacagaa
     6481 gaagcagaaa atatggaaga gttgcacaaa acatctgaga agcacagcat gtccggcatc
     6541 tccactgatc accagttctc cgatgcggag gaatcggatg gggaagatgg agatgacaac
     6601 gatgatgatg atgaagatga cgatgacttt gatgaccaag gagatttgac acccaaaaca
     6661 aggtcaagaa gcaccagtcc tcagcctcct aggttctcct ccttgcctgt caatgttggc
     6721 gctgtagccc atggcgtccc ttcagatagc tctctgggac attcgtcatt gatcagctat
     6781 ttggtcactc taccgagtat tcaggttact cagctcatga cacccagtga ctcttgtgat
     6841 gacactcaga tgacagaata tcagaggctg ttccagagca aaagcacaga ctctgaaccg
     6901 gacaaagaca ggttagacat cccaagctcc atggacgaag aggccatgtt gtcttcagag
     6961 ccaagctcct ccccaaggga cttctccccc tcaagctacc gttcctcccc aggctatgat
     7021 tcttcaccct gtcgagataa ttcgccaaag aggtatctga tacccaaagg agatttgtca
     7081 cccagaagac atttatcacc tagacgagac ctgtcgccga tgaggcatct gtcaccaaga
     7141 aaagaagctg cattgaggag agagatgtcc caaggggatg cctcaccaag aaggcacttg
     7201 tccccaagga gaccattgtc tcctggaaag gacattacag caagaagaga tctctctccc
     7261 agaagagaga gaagatatat gaccaccatc agagcaccgt ctcccagaag ggctttatat
     7321 cctaaccctc cattatccat gggacagtat ctacaaacag agccaattgt attggggcct
     7381 cctaatctaa gaagaggaat acctcaggtt ccttacttca gtctctatgg agaccaagaa
     7441 ggtgcttatg aacatcacgg ctccagcctt ttccctgagg gtcctactga ctatgtcttc
     7501 agtcatcttc cactacactc tcagcagcaa gtacgagctc ctatacccat ggtgccagtt
     7561 ggtgggatcc aaatggttca ctccttgccg cctgcccttt ccggtttaca tcctccaccc
     7621 acattgcctc tgcccacaga gggctctgag gagaagaaag gagcaccagg ggaggccttt
     7681 gccaaggatc cctacatcct ttccaggcgg catgagaaac aagcccctca agttttgcag
     7741 tcatctggtc tacctagttc tccctcctcc ccacggctat tgatgaaaca gagtacttca
     7801 gaagacagcc taaattccac ggagagagaa caggaggaaa acatacagac ttgtacaaaa
     7861 gccattgcct cactccggat tgcaacagaa gaggcagctc tgcttggggc tgaccctccc
     7921 acatgggtac aagagtcccc ccagaaaccc ttggaaagtg cacacgtcag cattagacac
     7981 tttggcgggc ctgagccagg tcagccctgt acctcagccg cccaccctga cttacatgat
     8041 ggtgaaaagg acacttttgg tacatcacag actgcagtag ctcaccccac gttttacagc
     8101 aagagcagtg tggatgagaa gcgggtggac tttcagagca gcaaggaatt atctttaagc
     8161 acagaggaag gcaatgaacc ttcaccagaa aagaatcaac tccattgatc tgcaatgcat
     8221 ggacacattc atttccacat ttccccctcc cctgttttgt ttttgttttt ctaggaatag
     8281 aagtaaacaa gttgatagca tgcctgtcct aagttacagt agttggctat tataaatact
     8341 tttgttattt tgaaaacaat taggtaaatt aacaagtcat cttgagcctg accaaaacaa
     8401 aatttgaaat taacctattg ggtctggtac tttgaaaatt gtacagatgt ttgtgccttt
     8461 tctttacttt gcttatattc ttataagcat tttttagcag taatttgtac atattttaga
     8521 atttgtgtat ctgctttgta ataaatgtaa tctctttcct cttttggaca cttggatcta
     8581 aacgatgtaa agcaaagcag catctatata tatgtgaggt tgcactaaaa catattttta
     8641 tatgataaaa actgaacagc ttttatgtac agctctgatt ctgtaatact aatatttatt
     8701 ttatttcata aactgtacat ttttcttaat gttgtggatt gcttttctat gtgacgcatg
     8761 gatttaactg ttgcgaaact agaacggaaa tgtccattgt aagcaagata tttaaactag
     8821 aatatcttat tctgcactta tgcattagtt acaaaaaaaa gataaagaac gtatcagtcg
     8881 gttcttaact tgtaaattct ttttgtctct tgtttgctgg attgacaata acttaagtgc
     8941 tggttgtgat tttaaatgga tagtaccgta aagcattaaa gtaaacaatg tgctattgtg
     9001 agttttttca aagctttata aatcagttat aaataatatt aaaagtattt ggtcttatgt
     9061 gaacatgttg atctatatac tcatctaaaa atatgggaaa aacattccgc cccatgtaaa
     9121 tatgtacaag tgcatcactg gtacaatttt ctgttactcg gttggacacg aggttgccac
     9181 agacctatgc tagagtgtct ttaaaattaa agtgagaaag cacatggact gtgtagagct
     9241 tggttatcgg ccggcccggt ggcttggtag gcagtgctgt gcactgccca tggagaagac
     9301 ctgggcttaa aaaaatcttg gttcttgctg cacaggatag tgactggaac tatggctgca
     9361 gggagggttc gcacttggac tcgagggttg ggtgtggaag tggggaaagg ggatggagac
     9421 ctgctcccca gctcttccca tcagccagtc cacatggtta cagggttacc atcagcatta
     9481 ggaaatgtca ccttaccctt ctgtacaggg aaagagtgtc actcctggct gtctcagggg
     9541 gaatgaagaa gagaagcctt caagagaaag cagctcttgg taggaggaag ttttttttgt
     9601 atataacctt cagaatggct tttgatcagt gttgaaggtg ggaagagcct ttgcaggtcc
     9661 agaagagcgg agcagagggg tacagcaaca tgtgcacacg catgcacatg tttgtgcatg
     9721 cgcacacaca atctgggtta tctttgtgct atatagtgga ttataattct gtgaaaccaa
     9781 gtttgtatat tgaattacat taaggagtgt tctttaaaaa gagaaataaa tatacaatta
     9841 aatgcttgaa aaaaaaaaaa aaaaaaaaaa
//
