LOCUS       NP_001345711            2430 aa            linear   ROD 07-FEB-2025
DEFINITION  transcription factor HIVEP2 [Mus musculus].
ACCESSION   NP_001345711 XP_011241435
VERSION     NP_001345711.1
DBSOURCE    REFSEQ: accession NM_001358782.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2430)
  AUTHORS   Zhou,L., Su,S., Yu,J., Wan,S., Xu,X., Li,X., Xiong,M., Tian,W.,
            Wang,L., Wu,Y. and Ke,C.
  TITLE     Schnurri-2 Promotes the Expression of Excitatory Glutamate
            Receptors and Contributes to Neuropathic Pain
  JOURNAL   Neuroscience 488, 20-31 (2022)
   PUBMED   35218885
  REMARK    GeneRIF: Schnurri-2 Promotes the Expression of Excitatory Glutamate
            Receptors and Contributes to Neuropathic Pain.
REFERENCE   2  (residues 1 to 2430)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   3  (residues 1 to 2430)
  AUTHORS   Murano,T., Hagihara,H., Tajinda,K., Matsumoto,M. and Miyakawa,T.
  TITLE     Transcriptomic immaturity inducible by neural hyperexcitation is
            shared by multiple neuropsychiatric disorders
  JOURNAL   Commun Biol 2, 32 (2019)
   PUBMED   30675529
  REMARK    Erratum:[Commun Biol. 2019 Mar 4;2:94. doi:
            10.1038/s42003-019-0358-x.. PMID: 30854486]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2430)
  AUTHORS   Kobayashi,K., Takagi,T., Ishii,S., Suzuki,H. and Miyakawa,T.
  TITLE     Attenuated bidirectional short-term synaptic plasticity in the
            dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia
  JOURNAL   Mol Brain 11 (1), 56 (2018)
   PUBMED   30285890
  REMARK    GeneRIF: the Shn2 deficiency attenuates bidirectional short-term
            synaptic plasticity at the medial perforant path-granule cell
            synapse.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2430)
  AUTHORS   Nakao,A., Miyazaki,N., Ohira,K., Hagihara,H., Takagi,T., Usuda,N.,
            Ishii,S., Murata,K. and Miyakawa,T.
  TITLE     Immature morphological properties in subcellular-scale structures
            in the dentate gyrus of Schnurri-2 knockout mice: a model for
            schizophrenia and intellectual disability
  JOURNAL   Mol Brain 10 (1), 60 (2017)
   PUBMED   29233179
  REMARK    GeneRIF: Shn2 knockout mice serve as a unique tool for
            investigating morphological abnormalities of subcellular-scale
            structures in schizophrenia, intellectual disability, and its
            related disorders.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2430)
  AUTHORS   Takagi,T., Jin,W., Taya,K., Watanabe,G., Mori,K. and Ishii,S.
  TITLE     Schnurri-2 mutant mice are hypersensitive to stress and hyperactive
  JOURNAL   Brain Res 1108 (1), 88-97 (2006)
   PUBMED   16836985
  REMARK    GeneRIF: Shn-2 plays a critical role in locomotion and anxiety-like
            behavior. Stress-induced corticosterone levels were significantly
            higher in Shn-2(-/-) mice compared to wild-type controls.
REFERENCE   7  (residues 1 to 2430)
  AUTHORS   Kimura,M.Y., Hosokawa,H., Yamashita,M., Hasegawa,A., Iwamura,C.,
            Watarai,H., Taniguchi,M., Takagi,T., Ishii,S. and Nakayama,T.
  TITLE     Regulation of T helper type 2 cell differentiation by murine
            Schnurri-2
  JOURNAL   J Exp Med 201 (3), 397-408 (2005)
   PUBMED   15699073
  REMARK    GeneRIF: Data suggest that Schnurri-2 plays a crucial role in the
            control of T helper type 2 cell differentiation by regulating
            NF-kappaB function.
REFERENCE   8  (residues 1 to 2430)
  AUTHORS   Campbell,D.B. and Levitt,P.
  TITLE     Regionally restricted expression of the transcription factor c-myc
            intron 1 binding protein during brain development
  JOURNAL   J Comp Neurol 467 (4), 581-592 (2003)
   PUBMED   14624490
REFERENCE   9  (residues 1 to 2430)
  AUTHORS   Takagi,T., Harada,J. and Ishii,S.
  TITLE     Murine Schnurri-2 is required for positive selection of thymocytes
  JOURNAL   Nat Immunol 2 (11), 1048-1053 (2001)
   PUBMED   11668343
REFERENCE   10 (residues 1 to 2430)
  AUTHORS   Dorflinger,U., Pscherer,A., Moser,M., Rummele,P., Schule,R. and
            Buettner,R.
  TITLE     Activation of somatostatin receptor II expression by transcription
            factors MIBP1 and SEF-2 in the murine brain
  JOURNAL   Mol Cell Biol 19 (5), 3736-3747 (1999)
   PUBMED   10207097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ119019.1, AK147244.1, AC091764.35 and CF747636.1.
            
            On Dec 12, 2017 this sequence version replaced XP_011241435.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 5.14 cM"
     Protein         1..2430
                     /product="transcription factor HIVEP2"
                     /note="myc intron-binding protein 1; human
                     immunodeficiency virus type I enhancer-binding protein 2
                     homolog"
                     /calculated_mol_wt=266575
     Region          1..127
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          189..211
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          191..211
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          204..228
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          219..239
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          271..302
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          374..418
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          744..995
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          <753..929
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            811
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q00900; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          929..935
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            942
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            947
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            1040
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            1431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            1435
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          1472..1584
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          1783..1805
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          1785..1805
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Site            order(1790,1792,1794,1796..1797,1800..1801,1804,1818,
                     1820..1822,1824..1825,1829)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          1797..1822
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          1813..1831
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          1836..1870
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Region          1848..1931
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          1986..2117
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          <2017..>2160
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          2037..2132
                     /region_name="10 X 4 AA tandem repeats of
                     S-P-[RGMKC]-[RK]"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            2102
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31629; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          2226..2252
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          2268..2309
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            2281
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31629; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            2285
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31629; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Region          2352..2430
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            2413
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     Site            2415
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHF7.1)"
     CDS             1..2430
                     /gene="Hivep2"
                     /gene_synonym="Gm20114; MIBP-1; MIBP1; Schnurri-2; Shn-2"
                     /coded_by="NM_001358782.1:916..8208"
                     /db_xref="CCDS:CCDS23704.1"
                     /db_xref="GeneID:15273"
                     /db_xref="MGI:MGI:1338076"
ORIGIN      
        1 mdtgdtalgq katsrsgetd svsgrwrqeq savlkmstfs sqegprqpqi dpeqignaas
       61 aqlfgsgkla spgeglhqvt ekqypphrps pypcqhslsf pqhslsqgmt hshkphqsle
      121 gppwlfpgpl psvasedlfp fpmhghsggy prkkisnlnp aysqysqksi eqaedahkke
      181 hkpkkpgkyi cpycsracak psvlkkhirs htgerpypci pcgfsfktks nlykhrksha
      241 haikaglvpf tessvskldl eagfidveae ihsdgeqstd tdeesslfae asdkvspgpp
      301 vpldiasrgg yhgsleeslg gpmkvpilii pksgiplase gsqylsseml pnpslnakad
      361 dshtvkqkla lrlsekkgqd sepslnllsp hskgstdsgy fsrsesaeqq isppntnaks
      421 yeeiifgkyc rlsprntlsv tptgqertam grrgimeplp hlntrlevkm fedpisqlnp
      481 skgemdpgqi nmlkttkfns ecrqpqaips svrnegkpyp gnflgsnpml leapvdsspl
      541 irsnsmptss atnlsvppsl rgshsfderm tgsddvfypg tvgippqrml rrqaafelps
      601 vqeghmeseh parvskglas pslkekkllp gdrpgydydv crkpykkwed setlkqsylg
      661 sfkqggeyfm dpsvpvqgvp tmfgttcenr krrkeksvgd eedvpmicgg mgnapvgmms
      721 seydpklqdg grsgfamtah eslahghsdr ldparpqlps rspslgsedl plaadpdkmt
      781 dlgkkppgnv isviqhtnsl srpnsferse stemvacpqd ktpspaetcd sevleapvsp
      841 ewappgdgge sgskptpsqq vpqhsyhaqp rlvrqhniqv peirvteepd kpekekeapt
      901 kepekpveef qwpqrsetls qlpaeklppk kkrlrladle hssgessfes tgtglsrsps
      961 qesnlshsss fsmsfdreet vkltappkqd esgkhseflt vpagsyslsv pghhhqkemr
     1021 rcsseqmpcp hptevpeirs ksfdygnlsh apvagtspst lspsrerkkc flvrqasfsg
     1081 speiaqgeag vdpsvkqehm ehlhaglraa wssvlpplpg ddpgkqvgtc gplssgpplh
     1141 ltqqqimhmd sqeslrnpli qptsymtskh lpeqphlfph qdavpfspiq nalfqfqypt
     1201 vcmvhlpaqq ppwwqthfph pfaphpqnsy skppfqadlh ssyplehvae htgkksadyp
     1261 hakeqtypcy sgtsglhskn lplkfpsdpg skstetpteq llredfasen agplqslpgt
     1321 vvpvriqthv psygsvmyts isqilgqnsp aivickvden mtqrtlvtna amqgiglnia
     1381 qvlgqhtgle kyplwkvpqt lplglessip lclpstsdna aslggskrml spasslelfm
     1441 etkqqkrvke ekmygqivee lsaveltnsd ikkglsrpqk pqlvrqgcas epkdgcfqsr
     1501 sssfsslsps ssqdhpsasg pfppnreilp gsrapprrkf sgpsesress deldmdetss
     1561 dmsmspqssa lptgggqqee egkarklpvs mlvhmasgpg gnvanstllf tdvadfqqil
     1621 qfpslrtttt vswcflnytk psfvqqatfk ssvyaswcis scnpnpsgln tkttlallrs
     1681 kqkitaeiyt laamhrpgag kltsssvwkq faqmkpdapf lfgnklerkl agnvlkergk
     1741 geihgdkdlg skqtepirik ifeggyksne dyvyvrgrgr gkyiceecgi rckkpsmlkk
     1801 hirthtdvrp yvcklcnfaf ktkgnltkhm kskahmkkcl elgvsmtsvd dteteeaenm
     1861 eelhktsekh smsgistdhq fsdaeesdge dgddndddde ddddfddqgd ltpktrsrst
     1921 spqpprfssl pvnvgavahg vpsdsslghs slisylvtlp siqvtqlmtp sdscddtqmt
     1981 eyqrlfqsks tdsepdkdrl dipssmdeea mlssepsssp rdfspssyrs spgydsspcr
     2041 dnspkrylip kgdlsprrhl sprrdlspmr hlsprkeaal rremsqgdas prrhlsprrp
     2101 lspgkditar rdlsprrerr ymttirapsp rralypnppl smgqylqtep ivlgppnlrr
     2161 gipqvpyfsl ygdqegayeh hgsslfpegp tdyvfshlpl hsqqqvrapi pmvpvggiqm
     2221 vhslppalsg lhppptlplp tegseekkga pgeafakdpy ilsrrhekqa pqvlqssglp
     2281 sspssprllm kqstsedsln stereqeeni qtctkaiasl riateeaall gadpptwvqe
     2341 spqkplesah vsirhfggpe pgqpctsaah pdlhdgekdt fgtsqtavah ptfyskssvd
     2401 ekrvdfqssk elslsteegn epspeknqlh
//
