LOCUS       NM_172746               2299 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus HIRA interacting protein 3 (Hirip3), transcript
            variant 1, mRNA.
ACCESSION   NM_172746
VERSION     NM_172746.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2299)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   2  (bases 1 to 2299)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2299)
  AUTHORS   Magnaghi,P., Roberts,C., Lorain,S., Lipinski,M. and Scambler,P.J.
  TITLE     HIRA, a mammalian homologue of Saccharomyces cerevisiae
            transcriptional co-repressors, interacts with Pax3
  JOURNAL   Nat Genet 20 (1), 74-77 (1998)
   PUBMED   9731536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124505.4.
            
            On Jan 12, 2022 this sequence version replaced NM_172746.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045122.1, AK161657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC124505.4         203207-203284
            79-199              AC124505.4         203368-203488
            200-308             AC124505.4         203586-203694
            309-1390            AC124505.4         203937-205018
            1391-1556           AC124505.4         205088-205253
            1557-1655           AC124505.4         205331-205429
            1656-2299           AC124505.4         205502-206145
FEATURES             Location/Qualifiers
     source          1..2299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..2299
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /note="HIRA interacting protein 3"
                     /db_xref="GeneID:233876"
                     /db_xref="MGI:MGI:2142364"
     exon            1..78
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1819
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="HIRA-interacting protein 3 isoform 1"
                     /protein_id="NP_766334.1"
                     /db_xref="CCDS:CCDS21849.1"
                     /db_xref="GeneID:233876"
                     /db_xref="MGI:MGI:2142364"
                     /translation="MAPGDEMRKFTRSFFRACPDLSSVTHAIVRQKFLIHVGRDHLEP
                     EEKQALKRLVEEELPKMQADAGTREGKPDFIKVKRSPAPCSDPKKKRFRFNSESESSS
                     SPSSPDGSGPSTKNRTTKKTCLRRALKKAVESTDEDHQTDLDAKMGLEESSEGEAEGS
                     VRSGKVTEEEEDMKQEQKGQVRKQAGAKDKQVPLKADRKQVREESGSSEEEAVLQRAK
                     VEGSTGANCQEESEESGEESPAKKKELSEPRSRSNRAERTARERKSYKQKSRPGRPTG
                     GLRDSEAEKEGGTVGSGDSSEEGEAEKEGGTVGSGDSSEKGEAEKEEGTVGSGDSSEE
                     GEEHSVKRKSKVRTQTESGRRQNTSSRDDSNSTQEQAAAQGTTKSGSLGSSNGDSDTE
                     REVSDSQAGQNTKEERKSRSSNKSSKNGQARSCSSSSDSSPEPTGQKGKARSSSSSSD
                     SGPEPTGRKAASRCGEDHPAVARLKRYIRACGAHRNYKKLLGSCSSHKARLSVLRAEL
                     EALGMKGNPSLEKCRALKLQREEAAEVAALDVANIISSTGRPRRRNAWNPSGEGTSPG
                     ETYRRTLDSEEEQPRQAPPDWSHMRDIISSDGDSS"
     exon            79..199
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     exon            200..308
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1390
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1556
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1655
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..2299
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /note="hexamer: AATAAA"
     polyA_site      2051
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /note="major polyA site"
     regulatory      2269..2274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
                     /note="hexamer: AATAAA"
     polyA_site      2299
                     /gene="Hirip3"
                     /gene_synonym="B130036O03"
ORIGIN      
        1 ctggtgacgc aaaatggcgc cgggagatga gatgcgaaaa ttcactcgca gcttctttcg
       61 agcttgcccg gacctcagct cggttacgca cgccatcgtg cgacagaaat ttttgattca
      121 cgtgggtcgg gatcatcttg aacctgaaga gaagcaggcg ttgaagcggc tggtggagga
      181 ggagctgccg aaaatgcagg cggatgctgg taccagggaa ggaaagccag actttatcaa
      241 agtgaagagg tctcctgctc cctgcagtga cccaaagaag aaaaggttcc gctttaattc
      301 agagtcagaa tccagctctt caccatccag tccagatggc tcaggaccct caacaaagaa
      361 caggacaacc aagaagacat gtctaagaag agccttaaag aaagcagttg agagcacaga
      421 tgaagaccac caaacagacc tggatgcaaa gatgggattg gaggagagca gtgaggggga
      481 agcagagggc tctgttagat caggtaaggt caccgaggaa gaggaggaca tgaaacaaga
      541 acagaagggc caggttagaa agcaagctgg ggccaaagac aagcaagtac cactcaaggc
      601 agacaggaag caggttaggg aagagagtgg gagcagtgag gaggaggctg tgctgcagag
      661 agcaaaggtg gagggaagca caggtgctaa ctgccaggag gagagtgaag agagcggaga
      721 ggagagccca gctaagaaga aagagcttag tgagcccaga tccagaagta acagagcaga
      781 gagaacagcc agggagagaa agagctataa gcagaaaagc aggcctggga ggccaactgg
      841 aggcttgcga gacagcgagg cagagaagga agggggcaca gtgggcagtg gggacagcag
      901 tgaggagggg gaggcagaga aggaaggagg cacagtgggc agtggggaca gcagtgagaa
      961 gggggaggca gagaaggaag agggcacagt gggtagtggg gacagcagtg aggagggaga
     1021 agagcactcg gtgaagagaa agagcaaggt caggacccag accgagagtg ggaggaggca
     1081 gaacacaagc agcagggatg acagtaacag cacacaggag caagcagctg ctcaaggcac
     1141 tacaaagtca ggcagcctag gcagcagtaa tggtgacagt gacacagaga gggaagtgag
     1201 tgactcccag gcaggacaaa acaccaaaga ggagaggaag agccgctctt ccaacaagag
     1261 ctccaagaac ggccaggccc gaagttgttc atcttcatca gattcgagtc cagaacccac
     1321 aggtcagaag ggcaaggccc gaagttcctc atcttcatca gattcaggtc cagaacccac
     1381 aggtcggaag gctgcctctc gctgtggaga ggaccaccca gctgtggcta gactaaagcg
     1441 ttacattcga gcctgtggtg cccaccgaaa ctacaagaag ctgctgggct cctgcagctc
     1501 ccacaaggcg cgcctgagtg tcctcagggc tgagctggaa gcactgggca tgaaggggaa
     1561 cccttccttg gagaagtgtc gcgctctgaa gctgcagcgg gaagaggcag ctgaagtggc
     1621 tgccctggat gttgccaaca tcatcagcag tacaggccgg ccacgaagac gaaatgcctg
     1681 gaacccttca ggggaaggga cctccccagg agagacttat cgccgaaccc tggactcaga
     1741 agaggagcag ccgcgccaag cacctccaga ctggtcccat atgcgtgata tcatcagcag
     1801 tgacggtgac agcagctgaa ctcccgtgtc catggtggac cttaccctgt tatacaagag
     1861 cctggtcagt ggaagcaact tccaaagaca gactacagtg gcaggatcca agttattggc
     1921 acactactca atttcatgtt ctctaagatg gccttggggt tcatgtgcaa gcatcctctc
     1981 caggcatttg agtggactgt tgtttgtttt taaagactca ataaaaaatg tttgtaatta
     2041 cttcatccaa attggtccca aaccgtcatg ccctgtctgt cctttggggt caagaattta
     2101 gtagtcgaat tctctctctt atcgattcca gagttgtcct agcccctgta ctgtgtcatc
     2161 cagtctgtca ccagatggta tcagagaggg tatggctctc cctcctccag tgtggccaat
     2221 ctggccttag caatgtaaag ttgactccaa gaatgtatgc ctagcatgaa taaagccctg
     2281 ggtctcaacc ccaacaaca
//
