LOCUS       NM_010435               4553 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus histone cell cycle regulator (Hira), mRNA.
ACCESSION   NM_010435
VERSION     NM_010435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4553)
  AUTHORS   Halter,K., Chen,J., Priklopil,T., Monfort,A. and Wutz,A.
  TITLE     Cdk8 and Hira mutations trigger X chromosome elimination in naive
            female hybrid mouse embryonic stem cells
  JOURNAL   Chromosome Res 32 (4), 12 (2024)
   PUBMED   39390295
  REMARK    GeneRIF: Cdk8 and Hira mutations trigger X chromosome elimination
            in naive female hybrid mouse embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4553)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4553)
  AUTHORS   Kleijwegt,C., Bressac,F., Seurre,C., Bouchereau,W., Cohen,C.,
            Texier,P., Simonet,T., Schaeffer,L., Lomonte,P. and Corpet,A.
  TITLE     Interplay between PML NBs and HIRA for H3.3 dynamics following type
            I interferon stimulus
  JOURNAL   Elife 12, e80156 (2023)
   PUBMED   37227756
  REMARK    GeneRIF: Interplay between PML NBs and HIRA for H3.3 dynamics
            following type I interferon stimulus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4553)
  AUTHORS   Smith,R., Susor,A., Ming,H., Tait,J., Conti,M., Jiang,Z. and
            Lin,C.J.
  TITLE     The H3.3 chaperone Hira complex orchestrates oocyte developmental
            competence
  JOURNAL   Development 149 (5) (2022)
   PUBMED   35112132
REFERENCE   5  (bases 1 to 4553)
  AUTHORS   Yang,Y., Zhang,L., Xiong,C., Chen,J., Wang,L., Wen,Z., Yu,J.,
            Chen,P., Xu,Y., Jin,J., Cai,Y. and Li,G.
  TITLE     HIRA complex presets transcriptional potential through coordinating
            depositions of the histone variants H3.3 and H2A.Z on the poised
            genes in mESCs
  JOURNAL   Nucleic Acids Res 50 (1), 191-206 (2022)
   PUBMED   34893908
  REMARK    GeneRIF: HIRA complex presets transcriptional potential through
            coordinating depositions of the histone variants H3.3 and H2A.Z on
            the poised genes in mESCs.
REFERENCE   6  (bases 1 to 4553)
  AUTHORS   Wilming,L.G., Snoeren,C.A., van Rijswijk,A., Grosveld,F. and
            Meijers,C.
  TITLE     The murine homologue of HIRA, a DiGeorge syndrome candidate gene,
            is expressed in embryonic structures affected in human CATCH22
            patients
  JOURNAL   Hum Mol Genet 6 (2), 247-258 (1997)
   PUBMED   9063745
REFERENCE   7  (bases 1 to 4553)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399.. PMID: 9110179]
REFERENCE   8  (bases 1 to 4553)
  AUTHORS   Scamps,C., Lorain,S., Lamour,V. and Lipinski,M.
  TITLE     The HIR protein family: isolation and characterization of a
            complete murine cDNA
  JOURNAL   Biochim Biophys Acta 1306 (1), 5-8 (1996)
   PUBMED   8611624
REFERENCE   9  (bases 1 to 4553)
  AUTHORS   Mattei,M.G., Halford,S. and Scambler,P.J.
  TITLE     Mapping of the Tuple1 gene to mouse chromosome 16A-B1
  JOURNAL   Genomics 23 (3), 717-718 (1994)
   PUBMED   7851908
REFERENCE   10 (bases 1 to 4553)
  AUTHORS   Halford,S., Wadey,R., Roberts,C., Daw,S.C., Whiting,J.A.,
            O'Donnell,H., Dunham,I., Bentley,D., Lindsay,E., Baldini,A. et al.
  TITLE     Isolation of a putative transcriptional regulator from the region
            of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and
            familial congenital heart disease
  JOURNAL   Hum Mol Genet 2 (12), 2099-2107 (1993)
   PUBMED   8111380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA323899.1, BC060181.1 and AK168963.1.
            
            On Sep 22, 2004 this sequence version replaced NM_010435.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060181.1, X92590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               CA323899.1         1-316
            317-3664            BC060181.1         1-3348
            3665-4382           AK168963.1         693-1410
            4383-4553           BC060181.1         4066-4236
FEATURES             Location/Qualifiers
     source          1..4553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.69 cM"
     gene            1..4553
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /note="histone cell cycle regulator"
                     /db_xref="GeneID:15260"
                     /db_xref="MGI:MGI:99430"
     exon            1..770
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     CDS             734..3781
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /note="TUP1-like enhancer of split gene 1; TUP1-like
                     enhancer of split protein 1; histone cell cycle regulation
                     defective homolog A"
                     /codon_start=1
                     /product="protein HIRA"
                     /protein_id="NP_034565.2"
                     /db_xref="CCDS:CCDS28031.1"
                     /db_xref="GeneID:15260"
                     /db_xref="MGI:MGI:99430"
                     /translation="MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
                     MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATY
                     IGPSTVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNA
                     VKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDE
                     CGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKF
                     NPKIFKKKQKNGSSTKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDI
                     SWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLS
                     TAVIENPEMLKYQRRQQQQQLDQKNATTRETSSASSVTGVVNGESLEDIRKNLLKKQV
                     ETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSST
                     PSFGASKPCTEPVAATSARPTGESVSKDSMNATSTPAASSPSVLTTPSKIEPMKAFDS
                     RFTERSKATPGAPSLTSVIPTAVERLKEQNLVKELRSRELESSSDSDEKVHLAKPSSL
                     SKRKLELEVETVEKKKKGRPRKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALALKLP
                     IPGPQRAFTLQVSSDPSMYIEVENEVTTVGGIRLSRLKCNREGKEWETVLSSRVLTAA
                     GSCDVVCVACEKRMLSVFSTCGRRLLPPILLPSPISTLHCTGPYVMALTAAATLSVWD
                     VHRQVVVVKEESLHSILSGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVS
                     DKQDSLAQCADFRNSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTL
                     AYLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICKDLLGPVHCSTGSQW
                     ESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK"
     exon            771..833
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..944
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1035
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1130
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1226
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1387
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1555
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1669
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1740
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1846
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2062
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2148
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2343
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2505
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2707
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2812
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2961
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3123
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3182
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3288
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3411
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3575
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3664
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..4534
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4511..4516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /note="hexamer: AATGAA"
     polyA_site      4534
                     /gene="Hira"
                     /gene_synonym="D16Ertd95e; Gm15797; Tuple1"
                     /note="major polyA site"
ORIGIN      
        1 gcggtgtttt cctgctctct gctccgcctg gcctatgtgt ttacatctat gaaaacgccc
       61 cgctcttcta ataaatgcgc ccgtctggcc ccctatcctt caccagccta gttcttttat
      121 gcatgcaatc gagctcaggg cccgctgccg tctgccgcta gatgcatgct ggcgcccgcc
      181 cggctggcgc tcgcgagatg cccaatagcg cgaattgatg gatggcggaa gctagttact
      241 aagctggact cggagccgcg gaggtagaac tagagatctg cacaccaccc tggttctgca
      301 tcgccgggcg ggatctcaag gctttgccag cctgctcaca ccgaccctca tcggcgacca
      361 catcagtggc agcggagtat ccccgtcctc ccccccctgt ctaccgaaga accgaggcgg
      421 cccggtccgc gtagggagcg gtttcccgcc ggggcgattt ggcaggtgcg cgccgtgact
      481 tccggcgttg cccgggagcc gccggaggag gagcggcgca ggggatgcgg ctgtggcggc
      541 ggcggcggcg gccgagcgca ggaggcggct gtggcggcgg ctgggggcac gggccggcga
      601 tggcgcggcg gcgctgaggg caagggtggg cggcggccgg agggcgggcg gcgcgggagg
      661 aagctgcggc agctccatgg cccaggcgtg ctgagggaca cggctctggc ttcagcccgg
      721 cagcggccga acaatgaagc tcttgaagcc aacctgggtc aaccacaatg ggaagccaat
      781 tttttcagtt gatattcacc ctgatgggac caagtttgca actggaggac aagggcagga
      841 ttctgggaag gttgtgatct ggaatatgtc tccagtcctc caggaggatg acgagaagga
      901 tgaaaatatt cccaagatgc tttgccagat ggacaatcac ttagcatgtg tgaactgtgt
      961 gcggtggtca aacagtggga tgtatttagc ttctggggga gatgacaaac tgattatggt
     1021 gtggaagcgg gctacgtaca ttgggcccag cactgtgttt ggttccagtg gtaagcttgc
     1081 caatgtggag caatggcggt gtgtctccat cctccggagt cactcaggcg atgtgatgga
     1141 tgtagcatgg tctccccacg acgcctggct ggcctcatgc agcgtggata acactgttgt
     1201 catttggaat gccgtgaagt tcccagaaat tcttgcaact ctgagaggtc attctggctt
     1261 agtaaaaggt ttgacttggg atcccgttgg taaatatatt gcctctcaag ctgatgatcg
     1321 aagtttgaag gtatggagga cgctggactg gcagctagag actagcatca ccaagccttt
     1381 tgatgagtgt ggaggaacga cgcatgttct ccggcttagt tggtcacctg atggccatta
     1441 cctggtatct gcccatgcca tgaataattc tggccccact gctcagatca tcgaaagaga
     1501 gggctggaag accaacatgg actttgtggg tcaccggaaa gctgtgactg ttgtgaaatt
     1561 caacccaaaa atcttcaaga agaagcagaa gaatgggagc tctacaaagc ccagctgccc
     1621 atactgctgc tgtgctgttg gcagcaagga ccgctcactc tctgtctggc tcacatgttt
     1681 gaaacggcct ctggttgtca tccatgaact gtttgacaag tccatcatgg atatttcctg
     1741 gactctgaat gggttgggta tcctggtgtg ctccatggac ggctctgtgg cgttccttga
     1801 tttctctcag gatgaactcg gagaccccct gagtgaggag gaaaagagcc gaattcacca
     1861 gtctacctat ggcaagagcc tggcaataat gactgaggcc cagctttcca cagctgttat
     1921 tgagaaccct gagatgctca agtaccagcg gagacagcaa cagcagcagc tggatcagaa
     1981 gaatgccact actagggaga caagctcagc atcctcagtc acgggtgtgg tcaatgggga
     2041 aagtctagaa gatatcagaa agaatctttt gaagaaacaa gtggaaactc ggacagcaga
     2101 tggtcggagg agaatcacgc ctctttgcat agcacagctg gacactgggg acttctccac
     2161 ggcattcttc aacagcatcc cactctccag ctccctagca ggcaccatgc tctcctctcc
     2221 tagtggtcag cagctactac cactggactc cagtaccccc tccttcggcg cctcaaagcc
     2281 ttgcacagaa ccagtggcag ccaccagtgc caggcctaca ggcgaatctg tcagtaagga
     2341 cagtatgaat gctacctcta ctcctgctgc atcgtcaccc tctgtgttaa caaccccatc
     2401 caagattgaa cccatgaaag catttgattc ccggttcaca gaacggtcca aagccacacc
     2461 aggtgctcct tccttgacca gtgtgattcc aacagctgtt gaaaggttga aagagcagaa
     2521 cctcgtcaag gagctgaggt cccgggaact ggagagcagc agtgacagcg atgagaaggt
     2581 ccacctagcc aagccctctt cactgtccaa gcgcaaactt gagcttgagg tagagacggt
     2641 ggaaaagaag aagaaaggtc gccctaggaa ggattcacgt cttttaccca tgtctctgtc
     2701 cgtccagtct ccagctgccc tgtctacaga gaaggaggcc atgtgtctgt ctgcaccagc
     2761 acttgcactg aagctgccaa ttccaggccc acagagagcg ttcaccctcc aggtgagctc
     2821 tgacccctcc atgtacattg aggtggagaa tgaagtgacc accgttgggg ggataaggct
     2881 gagtcgcctg aagtgcaacc gtgaagggaa ggagtgggag acagtgctca gcagtcgcgt
     2941 cctcactgct gccggcagct gtgatgtggt atgtgttgcc tgtgaaaaga ggatgctgtc
     3001 ggtgttctct acctgtggtc gccgtctcct ccctcccatc ctccttccat ctccaatctc
     3061 tactttgcac tgcacgggcc cctacgtcat ggcactcacc gctgcagcca cactgtctgt
     3121 ctgggatgtt cacagacagg tggttgtggt gaaagaagaa tctctacact ccatcttgtc
     3181 aggaagtgat atgacggtgt cacagatctt gctaacacag catggaatcc cagtgatgaa
     3241 tttgtctgat gggaaagcat actgctttaa tccatccctc tccacatgga acctggtttc
     3301 tgacaagcaa gattcattgg cccagtgtgc agacttcagg aacagcctgc cgtcccagga
     3361 tgccatgctt tgttcaggac cgttagccat aattcagggc cgcacctcca actctggaag
     3421 gcaagctgcc cggctcttct ccgtgcctca tgtggtacag caggagacca cactggccta
     3481 cctagagaac caggttgctg cggcacttac cctgcagtca agccacgagt atcgtcactg
     3541 gctcctcctt tatgctcggt accttgtgaa tgaagggttt gaataccgcc tccgtgaaat
     3601 atgcaaggac ttgctgggtc cagttcactg ctccactgga agtcagtggg agtcaacagt
     3661 agtgggtctg cggaaaaggg agctgctgaa ggaactgttg ccagtcattg ggcagaatct
     3721 tcgattccag cgcctcttta ctgagtgcca ggaacaactg gacatcctga gagacaagta
     3781 gtctgtcctg gcttgcctca gctgctgcaa gggcaggacc acactattgc cactggcagg
     3841 ttgcccaggg ctagccccac ctgtcagggc ggtagtagga agagagacct tggcagaaga
     3901 tgtgttgtcc tgcaccagca ctagcccagt tccctgggtg gacatggact atatcccaag
     3961 cctccatgac tccaaaaggg ggcagcttgt ccctccatgt aggcccagct gtggacttgg
     4021 ggctgggact ggggctctgc cttgctgcca gcagggatct cttgagcctg tctccagctt
     4081 gaccccaagg tagacactgg catctgccac tgcaggtgct gtgctgcttc agctgtaacg
     4141 aatgagccat ttgtgagagc aggagccggg gagtgttagg gatgatgcag tcggcagacg
     4201 gacccgaagc ctgtgtgaat gctaagctgt tctgacacat ggactatttt tgtactagaa
     4261 tttgctaact tggaatatgg agtttctgtt ggttgatcag gatatcccta taagttactt
     4321 ggacattggt cacttgtagg aaatttaaac tctaattatg acagctacac tgaaaaaaaa
     4381 ataattgtac tgaaattaac ttgtctatct tcatttggtt taatttttaa atgtttgtaa
     4441 aaagagacac tttgtgtggg gggtggggtg ggacagaggg gagggcaatt tcttttctaa
     4501 gtgtaaaata aatgaacatg cattggatac caaaaaaaaa aaaaaaaaaa aaa
//
