LOCUS       NM_001033315            2415 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus homeodomain interacting protein kinase 4 (Hipk4),
            mRNA.
ACCESSION   NM_001033315 XM_133316 XM_897077 XM_897086 XM_911292 XM_921952
            XM_921955
VERSION     NM_001033315.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2415)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2415)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 2415)
  AUTHORS   Crapster,J.A., Rack,P.G., Hellmann,Z.J., Le,A.D., Adams,C.M.,
            Leib,R.D., Elias,J.E., Perrino,J., Behr,B., Li,Y., Lin,J., Zeng,H.
            and Chen,J.K.
  TITLE     HIPK4 is essential for murine spermiogenesis
  JOURNAL   Elife 9, e50209 (2020)
   PUBMED   32163033
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2415)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2415)
  AUTHORS   Arai,S., Matsushita,A., Du,K., Yagi,K., Okazaki,Y. and Kurokawa,R.
  TITLE     Novel homeodomain-interacting protein kinase family member, HIPK4,
            phosphorylates human p53 at serine 9
  JOURNAL   FEBS Lett 581 (29), 5649-5657 (2007)
   PUBMED   18022393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084855.1, AB354583.1, AC158304.11, CB248531.1, CJ235960.1 and
            CR521665.1.
            
            On Nov 29, 2007 this sequence version replaced NM_001033315.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB354583.1, SRR11927934.7118862.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               BY084855.1         2-257
            257-1396            AB354583.1         1-1140
            1397-1397           AC158304.11        43191-43191         c
            1398-1750           AB354583.1         1142-1494
            1751-2101           CB248531.1         295-645
            2102-2412           CJ235960.1         139-449
            2413-2415           CR521665.1         4-6                 c
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.92 cM"
     gene            1..2415
                     /gene="Hipk4"
                     /gene_synonym="Gm162"
                     /note="homeodomain interacting protein kinase 4"
                     /db_xref="GeneID:233020"
                     /db_xref="MGI:MGI:2685008"
     exon            1..721
                     /gene="Hipk4"
                     /gene_synonym="Gm162"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2107
                     /gene="Hipk4"
                     /gene_synonym="Gm162"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 4"
                     /protein_id="NP_001028487.2"
                     /db_xref="CCDS:CCDS21024.2"
                     /db_xref="GeneID:233020"
                     /db_xref="MGI:MGI:2685008"
                     /translation="MATIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKN
                     DAYRSRIIKNELKLLRCVRGLDPDEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKE
                     NNFAPLPARHIRTVTLQVLRALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFG
                     SASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGN
                     NEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSSADYLAETKVR
                     PLERRKYMLKSLDQIETVNGGGAVSRLSFPDREALAEHADLKSMVELIKRMLTWESHE
                     RISPSAALRHPFVSMQQLRSAHEATRYYQLSLRGCRLSLQVDGKPPPPVIASAEDGPP
                     YYRLAEEEETAGLGGVTGSGSFFREDKAPGMQRAIDQLDDLSLQEARRGLWSDTRADM
                     VSDMLVPLKVASTSHRVPDSGPEPILAFYGSRLTGRHKARKAPAGSKSDSNFSNLIRL
                     SQASPEDAGPCRGSGWEEGEGRTTSTEPSVIPQREGDGPGIKDRPMDAERPGPELFDP
                     SSCPGEWLSEPEWTLEGIRGSRAQGLPAHHPHPHGPPRTTSFLQHVGGHH"
     exon            722..1078
                     /gene="Hipk4"
                     /gene_synonym="Gm162"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1927
                     /gene="Hipk4"
                     /gene_synonym="Gm162"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2415
                     /gene="Hipk4"
                     /gene_synonym="Gm162"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggggcct gagccccctc atcccaagcc aagagggctt tgggggaggg gtgcagcccc
       61 tggtagactc actgtgtggc caagggggtc aaggggcgtc agggagacag gggctgaact
      121 catataagga gagacacgag tgtggttatc ttccccctgc taggaggact agctaggggc
      181 catcatcagg gtgggaggtc taggcaacca agccagttgt tgtaaaggca gagtagtgac
      241 tggcagccaa ggtaccatgg ccaccatcca gtcagagact gactgctacg acatcattga
      301 agttctgggc aagggcactt ttggagaggt ggccaagggc tggcgtcgga gtacaggtga
      361 aatggtggcc atcaagatcc tgaagaacga tgcgtaccga agccgcatca tcaagaatga
      421 gctgaagctg ctgcgctgcg tgcgaggcct ggaccctgac gaggcccacg ttatccgctt
      481 ccttgagttc ttccacgatg ccctcaagtt ctacctggtc ttcgagcttt tggagcaaaa
      541 cctctttgag ttccagaaag agaacaactt cgcacccctt cctgccaggc acatccgcac
      601 ggtcacactg caggtactaa gagcgctggc ccggctcaag gaactggcca tcatccacgc
      661 tgacctcaag cctgaaaaca ttatgttggt agaccagacg cgctgcccct tcagggtcaa
      721 ggtgatcgac tttggctcgg ccagcatatt cagtgaggta cgctatgtga aggagcctta
      781 catccagtcc cgcttctaca gggccccaga gatcctgctg gggctgccct tctgtgagaa
      841 ggtggacgtg tggtctctgg gctgtgtcat ggccgagcta catctgggct ggcctctcta
      901 cccaggcaac aatgagtatg accaggtgcg ctacatctgt gagacccagg gcttacccaa
      961 gccccatttg ctgcatgcgg ctcgcaaggc tcaccacttc ttcaagcgta acccccaccc
     1021 cgatgccacc aacccctggc agctgaagtc ctctgctgac tacctagctg agaccaaggt
     1081 acgtcctctg gagcgccgca agtacatgct caaatccttg gaccagattg agacagtgaa
     1141 tggtggtgga gctgtgagcc ggctgagttt tccagaccgg gaggccctgg cggaacacgc
     1201 agacctcaag agcatggtgg agctgatcaa acgcatgctg acatgggagt cgcacgaacg
     1261 catcagtccc agtgcggccc tgcgtcaccc cttcgtgtcc atgcagcagc tgcggagtgc
     1321 ccacgaggcc acccgctact accagctgtc gctcagaggc tgtcggctgt ccctgcaggt
     1381 ggatggcaag ccacccccac ctgtcatagc cagcgcagag gacgggcctc cctactaccg
     1441 cctggctgag gaggaggaga ctgcaggcct gggtggtgtg acaggcagtg ggtccttctt
     1501 cagggaggac aaggctccgg gaatgcagag ggccatcgac cagctcgatg acctgagtct
     1561 gcaagaggcc agacgggggc tgtggagcga cacacgggcc gacatggtct ctgacatgct
     1621 ggttccactc aaagtggcca gtaccagcca ccgagtccct gactcaggcc cagagcctat
     1681 cctggccttc tacggcagcc gattgaccgg ccgccataag gcccgcaagg ccccagcagg
     1741 ctccaaatct gactccaact tcagtaacct cattcggctg agccaggcct cacctgagga
     1801 tgccgggccc tgtcggggca gtggctggga ggaaggagaa ggccgcacga cctccacaga
     1861 gccgtctgtc atcccacaac gggaaggaga tgggcctggc atcaaagaca ggcccatgga
     1921 tgccgagagg ccaggccctg agctctttga tcccagcagc tgtcctggag agtggctgag
     1981 tgagccagaa tggaccctag agggcatccg ggggtctcga gctcaagggc tcccagctca
     2041 ccatccccac ccccacgggc cacccaggac caccagcttt ctgcagcatg ttggagggca
     2101 ccactgatgg ggactcaccc ctatcgtttc atggggtctg agctagctgg gctggcgttc
     2161 cccttcttga tccgaaatgg caccttagag ccatcctctg aacctacaga ttattcttac
     2221 agaaaaatag aaatccagat gttcctattc ccctgcccct ggcacatgcc tgtatcccac
     2281 cctaaatgtt ggaggtcgtc agggtctggc ctgaggccct gaggccagtg agttgggaag
     2341 aggctgcacc ctggtggcca tgactgtgcc tgggcctgcc tgcctctgtg tatttcaata
     2401 aataactgtt ccaaa
//
