LOCUS       NM_010434               7497 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus homeodomain interacting protein kinase 3 (Hipk3),
            transcript variant 1, mRNA.
ACCESSION   NM_010434 XM_916879 XM_924547 XM_924550
VERSION     NM_010434.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7497)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7497)
  AUTHORS   Zhang,W.B., Qi,Y.F., Xiao,Z.X., Chen,H., Liu,S.H., Li,Z.Z.,
            Zeng,Z.F. and Wu,H.F.
  TITLE     CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via
            the miR-106a-5p/MFN2 Axis
  JOURNAL   J Cardiovasc Transl Res 15 (6), 1315-1326 (2022)
   PUBMED   35467292
  REMARK    GeneRIF: CircHIPK3 Regulates Vascular Smooth Muscle Cell
            Calcification Via the miR-106a-5p/MFN2 Axis.
REFERENCE   3  (bases 1 to 7497)
  AUTHORS   Ding,F., Lu,L., Wu,C., Pan,X., Liu,B., Zhang,Y., Wang,Y., Wu,W.,
            Yan,B., Zhang,Y., Yu,X.Y. and Li,Y.
  TITLE     circHIPK3 prevents cardiac senescence by acting as a scaffold to
            recruit ubiquitin ligase to degrade HuR
  JOURNAL   Theranostics 12 (17), 7550-7566 (2022)
   PUBMED   36438474
  REMARK    GeneRIF: circHIPK3 prevents cardiac senescence by acting as a
            scaffold to recruit ubiquitin ligase to degrade HuR.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7497)
  AUTHORS   Shang,J., Li,H., Wu,B., Jiang,N., Wang,B., Wang,D., Zhong,J.,
            Chen,Y., Xu,X. and Lu,H.
  TITLE     CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation
            by sponging miR-30a-3p and promoting PON2
  JOURNAL   Cell Prolif 55 (9), e13285 (2022)
   PUBMED   35716032
  REMARK    GeneRIF: CircHIPK3 prevents chondrocyte apoptosis and cartilage
            degradation by sponging miR-30a-3p and promoting PON2.
REFERENCE   5  (bases 1 to 7497)
  AUTHORS   Xu,Q., Cheng,D., Li,G., Liu,Y., Li,P., Sun,W., Ma,D. and Ni,C.
  TITLE     CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis
            in miR-30a-3p/FOXK2-dependent manner
  JOURNAL   Int J Biol Sci 17 (9), 2294-2307 (2021)
   PUBMED   34239356
  REMARK    GeneRIF: CircHIPK3 regulates pulmonary fibrosis by facilitating
            glycolysis in miR-30a-3p/FOXK2-dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7497)
  AUTHORS   Ecsedy,J.A., Michaelson,J.S. and Leder,P.
  TITLE     Homeodomain-interacting protein kinase 1 modulates Daxx
            localization, phosphorylation, and transcriptional activity
  JOURNAL   Mol Cell Biol 23 (3), 950-960 (2003)
   PUBMED   12529400
REFERENCE   7  (bases 1 to 7497)
  AUTHORS   Rochat-Steiner,V., Becker,K., Micheau,O., Schneider,P., Burns,K.
            and Tschopp,J.
  TITLE     FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that
            induces FADD phosphorylation and inhibits fas-mediated Jun
            NH(2)-terminal kinase activation
  JOURNAL   J Exp Med 192 (8), 1165-1174 (2000)
   PUBMED   11034606
REFERENCE   8  (bases 1 to 7497)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 7497)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
REFERENCE   10 (bases 1 to 7497)
  AUTHORS   Moilanen,A.M., Karvonen,U., Poukka,H., Janne,O.A. and Palvimo,J.J.
  TITLE     Activation of androgen receptor function by a novel nuclear protein
            kinase
  JOURNAL   Mol Biol Cell 9 (9), 2527-2543 (1998)
   PUBMED   9725910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140130.1 and AL844591.6.
            
            On Mar 12, 2009 this sequence version replaced NM_010434.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140130.1, AF077660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3869              AK140130.1         104-3972
            3870-7497           AL844591.6         131022-134649       c
FEATURES             Location/Qualifiers
     source          1..7497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.74 cM"
     gene            1..7497
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /note="homeodomain interacting protein kinase 3"
                     /db_xref="GeneID:15259"
                     /db_xref="MGI:MGI:1314882"
     exon            1..542
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            543..1641
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..4123
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HCMV-interacting protein; ANPK; FIST; nbak3; nuclear
                     body-associated kinase 3; fas-interacting
                     serine/threonine-protein kinase; androgen
                     receptor-interacting nuclear protein kinase"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 3 isoform
                     1"
                     /protein_id="NP_034564.2"
                     /db_xref="CCDS:CCDS16489.1"
                     /db_xref="GeneID:15259"
                     /db_xref="MGI:MGI:1314882"
                     /translation="MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERTYPQIH
                     VNGRNFGNSHPSTKGSAFQTKIPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQA
                     GVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGN
                     PVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRG
                     TNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFE
                     MLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPV
                     RQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL
                     FLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLE
                     EHEAETGMKSKEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLI
                     DADLRITPIETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSPSSCETNNHSKMSLL
                     RPVASNGTAALAANFTKVGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLI
                     ICPPAIQGIPAAHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQM
                     LIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIPHSNHYNSVMPPPLLTNQITLS
                     APQPISVGIAHVVWPQPATTKKNKLCQNRSNSLQNTNIPHSAFISPKIISGKEVEEVS
                     CVDTQDNHTSEGEAGTCREASVRQDSSVSDKQRQTIIIADSPSPAVSVITISSDSDDE
                     ETSPRPSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSM
                     SDDEQESGCETVDGSPTSDSSGHDSPFAENSFVEDAHQNTELGTCAGPEAKPAVGTAV
                     EPPVGRESGLSVDEHMANTDSTCQPLRKGQPAPGKLHQPPALGARQQKPAAAFPQQHL
                     NLSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGSTH
                     LGGQPTLLPYPSSASLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGIN
                     PRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM"
     exon            1642..1765
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1885
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1972
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2157
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2314
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2438
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2560
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2688
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2850
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3141
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3282
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3518
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3646
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..7497
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7478..7483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /note="hexamer: AATATA"
     polyA_site      7497
                     /gene="Hipk3"
                     /gene_synonym="DYRK6; FIST3; mir-1902; PKY"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccgag gccggcgggc gcgcggagga ggggcccgat atcggggcgg cctgccgcag
       61 ctgcccgggt gacgactgcc ggcagcgcgg cgccccgagg agtccgagcc gcaggccccg
      121 ggcgacgcgg cctcgcaagc agccctcgtc ctcgtctcaa ctccggggaa atgggccctc
      181 agcaccgcgg gccctgcatc ccttgttgcc cgtaggcccc ggtggcccgc cggcttgtca
      241 ctgcccctct ccccagtcga gcggtcccca ccccaggtcc ccgggaagga agatgaggga
      301 gacgggcccg gcgatcggca gccagagaag cagcagcagc ggtcggggga gggtgtttcg
      361 ccgtttcctc tcagccgcca ggacaagatg gcagcggccg ccgagagggg ctgagccccg
      421 gctgggtggc gccgcctgct gaagcgcttg gctccgggtc cccgcacggc ccccgcgacc
      481 caccccggac atgctcaggg ctgcggccgc ccgaagcggg gagagcgcgg gcctctagga
      541 aggtatggcc tcacaagtct tggtctaccc accgtatgtt tatcaaactc agtcaagtgc
      601 cttttgtagt gtgaagaaac tcaaagtaga gccaagcggt tgtgttttcc aggaaagaac
      661 ctatcctcag atccatgtga atggtagaaa ctttggcaat tctcatcctt ccacgaaagg
      721 tagtgctttc cagacaaaga taccatttac taaacctcga ggacacagct tttcattgca
      781 ggcaggtgcc attgttgtca aagacactgc cggtgctaca aaggtcctag cagctcaggc
      841 gcagcaggct ggagtggagg caccgcgggc cgtggtgtgg agaaacaggt tacatttcct
      901 agaagggccc cagcgatgcg ggttaaagcg caagagtgag gagttggaga atcacagcgg
      961 cgcgatgcag attgttgatg aactgtccat acttcctgca atgttgcaaa ccaacatggg
     1021 aaacccagtg acagttgtga cagcgaccac aggatcgaag cagaactgca ccagcgggga
     1081 aggcgactat cagttagtgc agcatgaagt cctttgctct atgaaaaaca cgtatgaagt
     1141 cctggatttt cttggtcgtg gcacttttgg ccaggttgtc aaatgctgga agagagggac
     1201 aaatgaaatt gtagccatta aaattttgaa gaatcaccct tcgtatgcac gtcaagggca
     1261 gatagaagtg agcatcttgg caaggctgag tacagagaac gctgatgagt ataactttgt
     1321 gcgagcctat gagtgcttcc agcaccgtaa ccacacctgc ctagtctttg agatgctgga
     1381 gcagaacctg tatgacttcc tgaaacagaa taaattcagt cccctgcccc tgaaggtgat
     1441 ccggcctgtt cttcagcaag tggccactgc actgaagaaa ttaaaaagtc ttggtttaat
     1501 tcatgctgac ctcaaaccag agaatattat gttggtggat cctgttcgcc agccgtacag
     1561 ggttaaagtg atagactttg gatcggccag tcatgtatca aagactgttt gctcaacgta
     1621 tcttcaatct cgctactaca gagctccaga gattatattg gggttgccgt tttgtgaagc
     1681 catagacatg tggtcactgg gatgcgtgat cgcagagtta ttccttggat ggccactcta
     1741 cccaggagcc ttggagtatg atcagatccg atacatttct cagactcaag gtttaccagg
     1801 agagcaattg ttgaatgtgg gtacaaaatc cacaagattt ttttgcagag aaacagatat
     1861 gtctcattct ggttggaggt taaagacact ggaagagcat gaggcagaga caggaatgaa
     1921 gtctaaagag gccagaaagt acatattcaa cagtctggac gatatagtgc atgtgaacac
     1981 agtgatggac ttggaaggag gtgatctctt ggctgagaaa gctgatagaa gagaatttgt
     2041 taatctgttg aagaaaatgt tgctgattga tgcagattta agaattactc caattgagac
     2101 tctgaaccac ccattcgtta atatgaagca tctactagat tttcctcaca gcaaccatgt
     2161 aaagtcctgt tttcatatca tggatatttg taagtctccg agttcatgtg aaacaaataa
     2221 ccacagtaaa atgtcactct tacgaccagt cgcatcgaat ggcactgctg ctctagcagc
     2281 aaactttact aaagtcggga cactaagaag tcaggcgtta accacatctg ctcactctgt
     2341 tgtgcaccat ggcatacctc tgcaggcggg gactgcacag ttcggttgtg gagatgcttt
     2401 tcatcagacc ctgattatct gtcccccagc tatccaaggt attcctgcag cacatggtaa
     2461 acccaccagt tattccataa gggtagacaa tacagttccg cttgtaactc aggccccagc
     2521 tgtgcagcct ctgcagatcc gacctggagt cctttcacag cagacatggt ctggtcgaac
     2581 acagcagatg ctaatacctg cctggcagca ggtaacaccc atggctcctg ctgccgcaac
     2641 actaacttct gaaggcatgg ctggttctca gaggcttgga gactggggga aaatgattcc
     2701 acacagcaat cattacaact cggtgatgcc accgcctctt ctaaccaacc agatcacatt
     2761 atcagcccct cagcctatca gcgtgggcat tgcacatgtt gtctggcctc agcctgccac
     2821 taccaagaaa aataagttgt gccagaacag gagtaattca ttgcagaaca ccaatatccc
     2881 acattcagca tttatttctc caaagataat cagtgggaaa gaggttgagg aagtaagttg
     2941 tgtagacaca caggacaatc atacctcaga aggagaggcc ggaacttgcc gtgaagcgtc
     3001 tgtcagacag gattcttcag tctcagacaa acagcggcaa accatcatca ttgccgactc
     3061 cccgagtcct gccgtgagtg tgatcaccat tagcagtgac agcgatgatg aagagacctc
     3121 acccagacct tcactccgag agtgtaaagg tagtctagat tgtgaagctt gccaaagcac
     3181 tttgaatatt gatcggatgt gttcactcag cagtcctgat agcactctga gcaccagctc
     3241 ctcagggcag tccagcccgt ccccttgcaa gagaccgaac agcatgtcag atgatgaaca
     3301 agaaagcggg tgtgagactg tggatggctc tccaacatca gactcctcgg ggcacgacag
     3361 tccatttgca gagaacagtt ttgtggagga tgctcatcag aacacagagc tggggacctg
     3421 tgctggccca gaagccaagc cagctgttgg cactgctgtg gagccaccgg tggggagaga
     3481 aagtggactg agtgttgacg agcacatggc aaacacggat tctacatgcc agccattgag
     3541 aaaaggccag cctgcccccg gaaagctgca ccagcctcct gccctgggcg ctcgtcagca
     3601 gaagcccgca gcagcgttcc ctcagcagca tttgaacctg agccaggttc agcatttcgg
     3661 aactgggcat caagaatgga atggaaactt tgggcatcga agacagcaag catatattcc
     3721 tactagtgtt accagtaatc cattcacgct ttctcatgga agtcctaacc acacagcagt
     3781 acatgcccat ctggctggaa gtacacacct cggaggacag cctactctgc ttccataccc
     3841 atcatcagcc tccctcagta gtgctgcacc cgtggcccac ctcctagcct ctccgtgtac
     3901 ctcaagacct atgttacagc atccaactta caatatctcc catcccagtg gcatagttca
     3961 ccaagtccca gtgggcataa acccccgcct gttaccatcc ccaaccattc atcagactca
     4021 gtacaaacca atcttccctc cacattctta cattgcagca tcacctgcgt atactggatt
     4081 tccattgagt ccaacaaaac tcagccagta tccatatatg tgaaaactcg aaagcagtct
     4141 attgaggaag ctcaatgata caaacgtttg attaaaaata aaaacatggt atttaataaa
     4201 tattagccat ggcacaagaa aattattttt gaatcatgta gacttgggtg caatttaaac
     4261 aactttgagc tttaaaaaaa ctcactttta atgtgttttg cacatttggt ataacttgtc
     4321 tttggtcatg tatcttctta tgtagtaact ctatagacag gtgacttatg ggagcaaaag
     4381 tccagttttg ctcctgctat tttttataaa attgccttct aactagtgca agacacgtcc
     4441 acatttggga agccattctg tgtctagact tagagcaaca gatgcacatg tgtcagaatt
     4501 acagcatatg agtgaattgt atcgtctgtg tcttagtgtg tacgtgttgg ggcacttaaa
     4561 ctaagcaatt gagctattgt tctttacatt tgcatgtgtc ttttgcatgg gcaaaacgtt
     4621 gcctagactt ggctcttaat gttgttgtaa tactctcagc tgcattgtaa ccgttcccac
     4681 acatagtgcc ttaaatattt gaggttgttg aagttattac ctatctgtaa atgttggact
     4741 gcagcactta taattcagac ctactctttc ctttcctttc agtagagtaa tgttcctttt
     4801 ggttttgtgt ggtatgattt cagatagtag ctgctttttc cttattaaga gggcagcatg
     4861 tttgctatag ctgaattctg ctgtctgatt tttttttttt ccagaatgat ctagcttcaa
     4921 gaaaagcaag cagttagtag tgcttaagaa aatttgattc agtaactaat ggatagttga
     4981 tatctgtcac agcacagcat tttatatact attaagtgaa actgcaatac aacctaagtt
     5041 tattttggga gtgtttgctg tataattgga cttgataaaa tgtttagagg tgcagtaggc
     5101 atgacttgag tagataatga gaggaaatgc aagtgctcat cgactcatga tgtgcgccct
     5161 ccttgcttgg gcagaccgtg cagtatttaa cacatagtag cagaatattt actgttgaag
     5221 cttgaaaaga tgtgagctct ttgtgtgcaa tttttcattt atgcatgtga gaaggttttt
     5281 ggtttttggt tatttttaag tatttttaca ttgtagtact cgtttttgct tgttggtggt
     5341 gtttgcttat ttaatacatt ccgtcaggga cagaaattac atgctttttc tcttaggaag
     5401 tgtgtattgg gtttttccct ccccctctcc ccttggtggt gatggtggtg atgtttaaat
     5461 gaagttgctt ttacagcacc aaagacttaa tcatccattt cttatataaa aggtagctac
     5521 tttttgcata gacctcaagt atattgtagt gtagaggtgg aatttaagga aaggtattaa
     5581 accaaggctg tgttttagct tacaggcaag taataaattg tatcatttat cttgaatgta
     5641 tcatagataa gctgctatat aacgattgcc acttcagata gctgtgaaat taggtgatta
     5701 actagttgtt atttagcttt ctaatttctg tataagtcta attacacaag atagaagctg
     5761 gggttttgat ttttttttac tttgcttttc tgtttggagt gtcattgtaa ctactgtatt
     5821 gtaaatgatg gaaacagttg cctatgttat tttggggtgt gttattgcat cagtatttta
     5881 tctctattaa tgtttgtgct catcactgca tataaaaact tggatgtatc aatgtaactt
     5941 aattttttta ttttcatact ggcattgtag acacgtgaga aagctgtatc ttgcaggctt
     6001 gacttaactt ttttttcctt caaagtctgg aatataatct tacagcattt actggaataa
     6061 acagtacaaa acatttgagt gtaaacctcc aaatgttttg gattgacaca tttccttact
     6121 aagcaggttg tgtaccacca gtacaactct cgcacacgct ggcgataagc taactctgat
     6181 acatgtttct ttactccatt gacacagcag tgttttattt aacaatcatc catgaaataa
     6241 acgtgcctga cgttgatttt aaattacagt attagatcat acagtgaaaa ccagcagcac
     6301 atttctagtc actgcaaatg aaggacttga ttcccccaca ggtctcagtg tttttagtaa
     6361 ttgattctat gcattttata taatagaaat atatataaca cacattacaa aatggagtag
     6421 actgagatta acttgcagac gtcatgtctg tggagtcact aagtagctgc tgccctccat
     6481 ggccttcgca tttgagctat agggtctaac aggcatctgc tcgtttcttg gaaacgattc
     6541 agtgctgccg acggatgttt cagagacacc aagtacacgg attgattgtg tcacgacagg
     6601 gaggaaagtg gcccagcaag ctgtgcttgc tgcctaggcg tgctctctct gtattaagtt
     6661 catgactgat cagccttgtt aaattgactg tggctggtag cagccaacat gttcatacac
     6721 agtaatgctc tctaaaggcg tgtcactgtt gcgtgcactg ctcttaatta actgtaatca
     6781 tgggcttttt aataggtttc aaaattgaag acttcaaaat tcccctgaag tctaatttta
     6841 gcatcctggc agaggacctg gattttaccc cctctaaaac tattttaata gttttgtttt
     6901 atgttttctt aaataaaaca ctgcatgatt tccaagttgc atattcgtgt gctaatttgc
     6961 aagtgaattt ttaatcagtt attttgatat ttaggttttt ttccttcagg gtatttaatg
     7021 ttactctatt agcaaacctt ttcattttaa tatctctact gctgatttta aacttggctt
     7081 gtgttctgta aaagttaaat catacactgc aaggtgtagg aagattcatt ttaacgatcc
     7141 caatgataga ttcaatggct tagtttgaac tattaactgt tgaacagttt tactcttgtg
     7201 gctcctttct ttggtttgtt tttgctttga cttctatgct acactagttt gccatgtagc
     7261 aattgcactg tgcaatatta caataaggac tggggaaact tttatggatg taatgtctat
     7321 tacagtttgc gatagtattt ctctctagtt ctcagtgatt taaatgtgac caagccttct
     7381 gtactttgtc acaaaaagcg ggttttccag gtgactattt tggtgagtgt caaaataaga
     7441 atttatggtg tattactgtt gattcacttt gaattaaaat atatatattg cggcaaa
//
