LOCUS       NM_010433               4259 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Mus musculus homeodomain interacting protein kinase 2 (Hipk2),
            transcript variant 2, mRNA.
ACCESSION   NM_010433
VERSION     NM_010433.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4259)
  AUTHORS   Huang,R., Sun,M., Wang,W., Yu,X. and Liu,F.
  TITLE     YTHDF2 alleviates microglia activation via promoting circHIPK2
            degradation
  JOURNAL   J Neuroimmunol 387, 578265 (2024)
   PUBMED   38147784
  REMARK    GeneRIF: YTHDF2 alleviates microglia activation via promoting
            circHIPK2 degradation.
REFERENCE   2  (bases 1 to 4259)
  AUTHORS   Wang,G., Ma,Z., Song,C., Wang,X. and Zhou,Z.
  TITLE     miR-147b is an oncomiR acting synergistically with HIPK2 to promote
            pancreatic carcinogenesis
  JOURNAL   Cell Signal 111, 110840 (2023)
   PUBMED   37543099
  REMARK    GeneRIF: miR-147b is an oncomiR acting synergistically with HIPK2
            to promote pancreatic carcinogenesis.
REFERENCE   3  (bases 1 to 4259)
  AUTHORS   Zhong,W., Hong,C., Dong,Y., Li,Y., Xiao,C. and Liu,X.
  TITLE     ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High
            Glucose-Induced Glomerular Mesangial Cells
  JOURNAL   Genes (Basel) 13 (12), 2244 (2022)
   PUBMED   36553510
  REMARK    GeneRIF: ASH2L Aggravates Fibrosis and Inflammation through HIPK2
            in High Glucose-Induced Glomerular Mesangial Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4259)
  AUTHORS   Zhou,Q., Meng,D., Li,F., Zhang,X., Liu,L., Zhu,Y., Liu,S., Xu,M.,
            Deng,J., Lei,Z., Sluijter,J.P.G. and Xiao,J.
  TITLE     Inhibition of HIPK2 protects stress-induced pathological cardiac
            remodeling
  JOURNAL   EBioMedicine 85, 104274 (2022)
   PUBMED   36182775
  REMARK    GeneRIF: Inhibition of HIPK2 protects stress-induced pathological
            cardiac remodeling.
REFERENCE   5  (bases 1 to 4259)
  AUTHORS   Cheung,K.L., Jaganathan,A., Hu,Y., Xu,F., Lejeune,A., Sharma,R.,
            Caescu,C.I., Meslamani,J., Vincek,A., Zhang,F., Lee,K., Zaware,N.,
            Qayum,A.A., Ren,C., Kaplan,M.H., He,J.C., Xiong,H. and Zhou,M.M.
  TITLE     HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2117112119 (2022)
   PUBMED   35344430
  REMARK    GeneRIF: HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation.
REFERENCE   6  (bases 1 to 4259)
  AUTHORS   Hofmann,T.G., Mincheva,A., Lichter,P., Droge,W. and Schmitz,M.L.
  TITLE     Human homeodomain-interacting protein kinase-2 (HIPK2) is a member
            of the DYRK family of protein kinases and maps to chromosome
            7q32-q34
  JOURNAL   Biochimie 82 (12), 1123-1127 (2000)
   PUBMED   11120354
REFERENCE   7  (bases 1 to 4259)
  AUTHORS   Wang,W., Link,V. and Green,J.M.
  TITLE     Identification and cloning of a CD43-associated serine/threonine
            kinase
  JOURNAL   Cell Immunol 205 (1), 34-39 (2000)
   PUBMED   11078605
REFERENCE   8  (bases 1 to 4259)
  AUTHORS   Ebling,F.J., Brooks,A.N., Cronin,A.S., Ford,H. and Kerr,J.B.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   9  (bases 1 to 4259)
  AUTHORS   Kim,Y.H., Choi,C.Y. and Kim,Y.
  TITLE     Covalent modification of the homeodomain-interacting protein kinase
            2 (HIPK2) by the ubiquitin-like protein SUMO-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12350-12355 (1999)
   PUBMED   10535925
REFERENCE   10 (bases 1 to 4259)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154016.2, AF170302.1 and BM122543.2.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_010433.3.
            
            On Apr 1, 2008 this sequence version replaced NM_010433.1.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF170302.1, AF077659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC154016.2         51854-52103
            251-4195            AF170302.1         1-3945
            4196-4259           BM122543.2         67-130
FEATURES             Location/Qualifiers
     source          1..4259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     gene            1..4259
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /note="homeodomain interacting protein kinase 2"
                     /db_xref="GeneID:15258"
                     /db_xref="MGI:MGI:1314872"
     exon            1..392
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..3964
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear body-associated kinase 1; sialophorin
                     tail-associated nuclear serine/threonine-protein kinase"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 2 isoform
                     2"
                     /protein_id="NP_034563.2"
                     /db_xref="CCDS:CCDS20017.2"
                     /db_xref="GeneID:15258"
                     /db_xref="MGI:MGI:1314872"
                     /translation="MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGY
                     GSHSKVYSQSKNIPPSQPASTTVSTSLPIPNPSLPYEQTIIFPGSTGHIVVTSASSTS
                     VTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASG
                     ATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWK
                     RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
                     FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD
                     PSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIA
                     ELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
                     PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKML
                     TIDADKRVTPIETLNHPFVTMTHLLDFPHSAHVKSCFQNMEICKRRVNMYDTVNQSKT
                     PFITHVAPSTSTNLTMTFNNQLTTVHNQAPTTSSATLSLANPEVSILNYQSALYQPSA
                     ASMAAVAPRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENA
                     VPIVTQAPGAQPLQIQPGLLAQQAWPGGAQQILLPPAWQQLTGVATHTSVQHAAVIPE
                     TMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTST
                     TSSRKSKQHQSSVRNVSTCEVTSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVT
                     CGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKN
                     VISCVTVHDSPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGGLENHCTGNPRTIIVPPL
                     KTQASEVLVECDSLGPAISASHHSSSFKSKSSSTVTSTSGHSSGSSSGAIAYRQQRPG
                     PHFQQQQPLNLSQAQQHMAADRTGSHRRQQAYITPTMAQAPYTFPHNSPSHGTVHPHL
                     AAAAHLPTQPHLYTYTAPTALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSM
                     GPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI"
     exon            393..1476
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1600
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1720
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1807
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1992
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2155
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2363
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2485
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2628
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2808
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..3090
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3338
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3502
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..4259
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccccgcct cacagccatg cggagctgag ctccggcccg ggccctggcc gccgcagccc
       61 gccccggctc ccgccctcgc ggacccgccc ggcccttggc ctcggcgcct tagccgcccc
      121 gggccggccg agccccccgc gcagggcccg ggccgcggct acggcggcgg cggcggcggc
      181 ggcgacgcgc ccgcccggcc ccctcccccg gcgccggcca agtgaggcgg tgatgcgggc
      241 gctggcggcc tgggctgcgc cgagagcgga gacacaggct caagatggca gattcccact
      301 gaggctgagg gggccgagct cgcgcgccgc gttcccttct ccgttgccat gaaccgcgga
      361 caccccggcc ccgatggccc ccgtgtacga aggtatggcc tcacatgtgc aagttttctc
      421 ccctcacacc cttcaatcaa gtgccttctg tagtgtgaag aaactaaaag tagagccaag
      481 ttccaactgg gacatgactg ggtacggctc ccacagcaaa gtgtacagcc agagcaagaa
      541 cataccacct tctcagccag cctccacaac cgtcagcacc tccttgccaa tccccaaccc
      601 aagcctacct tacgagcaga ccatcatctt cccaggaagt actggacaca tagttgtaac
      661 atcagcaagt agcacttctg tcaccgggca agtcctcggt ggaccacata acctaatgcg
      721 tcgaagcact gtgagcctcc ttgacaccta ccaaaaatgt ggactcaagc gcaagagtga
      781 ggagattgag aacacaagca gcgtgcagat cattgaagag catccaccca tgattcagaa
      841 taatgccagc ggggccactg tagccactgc caccacatcc actgccacct ccaaaaacag
      901 tggctccaac agtgaagggg actatcagct ggtgcagcat gaagtactgt gctccatgac
      961 caacacctat gaggttttag agttcttggg gcgagggaca tttgggcaag tggtcaagtg
     1021 ctggaaacgg ggcaccaatg aaattgtggc cattaagatc ctcaagaacc acccctccta
     1081 tgcccggcaa ggccagattg aagtgagcat cttggcccgg ctgagcacgg agagcgctga
     1141 tgactacaat tttgtgcggg cctatgagtg cttccagcac aagaaccaca cgtgcttagt
     1201 ctttgagatg ttggagcaga acctttatga ctttctgaaa cagaacaagt ttagtccctt
     1261 gcccctcaag tatattcgcc cagtcctcca gcaggtagcc acagccctga tgaaactcaa
     1321 aagcctgggt cttatccatg ctgacctcaa accagaaaac atcatgctgg tggatccatc
     1381 cagacaaccg taccgagtga aggtcattga ctttggttca gctagtcatg tgtccaaagc
     1441 tgtctgctct acgtacttgc aatccagata ctaccgggcc cctgagatca tccttggttt
     1501 gccattctgt gaggcaattg acatgtggtc ccttggttgt gtcattgctg aactgttcct
     1561 gggctggcca ttatacccag gtgcttctga gtatgatcag attcggtata tttcacaaac
     1621 acagggttta ccagctgaat atttattaag tgcagggaca aagacaacta ggtttttcaa
     1681 ccgtgacaca gactcaccgt atcctttgtg gaggctaaag acaccagatg accatgaagc
     1741 agagacggga attaagtcaa aggaagcaag aaagtacatt ttcaactgtt tggatgatat
     1801 ggcccaggtg aacatgacaa cagatttgga agggagtgac atgttagtag agaaggcaga
     1861 ccgacgggag ttcattgacc tgttaaagaa gatgctgacc atcgatgctg ataagagagt
     1921 cactcccatt gaaactctga accacccctt tgtcaccatg acacacctgc ttgacttccc
     1981 ccatagtgcc catgtcaaat cttgtttcca aaacatggag atttgcaagc gccgggtgaa
     2041 tatgtatgac acagtgaacc agagcaaaac acctttcatc actcacgtgg cccccagcac
     2101 atccaccaac ttgaccatga cctttaacaa ccagctgacc actgtccaca accaggctcc
     2161 caccacctcc agtgccactc tttccttagc caatcccgaa gtctccatac taaactacca
     2221 atctgcactc taccagccct cagcggcatc catggccgcg gtggccccgc ggagcatgcc
     2281 cctgcagacg ggaacagccc aaatttgtgc ccgacctgat cccttccagc aagctctcat
     2341 cgtgtgtccc cctggcttcc aaggcctgca ggcctctccc tccaagcacg ctggctactc
     2401 agtgcggatg gaaaatgctg tccccatcgt cacccaggcg ccaggagctc agcctcttca
     2461 gatccaacca ggcctgcttg ctcagcaggc ctggccaggt ggggcccaac agatcctact
     2521 tcctccagca tggcagcagc tgactggcgt ggccacccac acatctgtac agcatgcagc
     2581 tgtgattcct gagaccatgg caggcactca gcaactggct gactggagga acacgcatgc
     2641 tcatggaagt cattacaatc ccatcatgca gcagcctgca ctcttgactg gtcatgtgac
     2701 ccttccagct gcccagccct taaatgtggg tgtagcccat gtgatgaggc aacaaccaac
     2761 cagcaccacc tcctccagga agagtaagca gcaccagtca tctgtgagaa atgtctccac
     2821 ctgtgaggtg acctcttcac aggctatcag ctcccctcag cgatccaagc gtgtcaagga
     2881 gaacactccc ccacggtgcg ccatggtaca cagcagccca gcttgcagca cctcagtcac
     2941 ctgtgggtgg ggcgacgtgg cctccagcac cacccgggag cgacagcggc agacgattgt
     3001 catccccgac accccgagcc ccacagtcag tgtcatcacc atcagcagtg acaccgatga
     3061 agaagaggag cagaagcacg cccccaccag cacagtctcc aagcaaagaa aaaatgtcat
     3121 cagctgtgtc accgtccacg actctcccta ctctgactcc tccagcaaca ccagccccta
     3181 ctcggtgcag cagcgcacag ggcacaacgg caccaacacc ttggacacca aggggggcct
     3241 agagaatcac tgcactggca acccccgcac catcatcgta cccccactga agacccaggc
     3301 cagtgaagtg ttggtagaat gtgacagcct agggccagcg atcagtgcca gtcaccattc
     3361 gtcctccttc aagtccaagt cctccagcac cgtgacctcc accagtggac actcttcagg
     3421 gagctcttca ggagccatcg cctaccgtca gcagcggcca ggcccccact tccagcagca
     3481 gcagcccctc aatctcagcc aggcccagca gcacatggct gcggaccgca ccgggagtca
     3541 ccgtcgacag caggcctaca tcactccgac catggcgcaa gctccgtaca ccttcccgca
     3601 caacagcccc agccatggca ctgttcaccc ccacctggct gcggctgccc acctccccac
     3661 ccagcctcac ctctacacct atacagcgcc cacagcccta ggctccaccg gcactgtagc
     3721 ccacctggtg gcatcccaag gctcagcacg ccacaccgtg cagcacactg cctatccggc
     3781 cagcatcgtc caccaggtcc ctgtgagcat ggggccccgg gtcctgccct cgcccaccat
     3841 ccaccccagt cagtatccag cccagtttgc ccaccagacc tatatcagcg cctcgccagc
     3901 ctccaccgtc tacactggat acccactgag tcctgccaag gtcaaccaat acccttacat
     3961 ataaacactg gaggaggccc gccagggagg agggtggagg agctcccaga ccgacctgga
     4021 gagctgggat tttctactgc aggtgccgca cacaaacaat gcaatggggc agggaggggg
     4081 gcagtcgggg cacaaatgaa acttgaacta ggaagtggga ggacttagag cggagaagag
     4141 accattgtaa aaggaggggt aaggagggga aatctatgct ttttatttta aaaaagaaaa
     4201 aggaaaaaaa gaaaaagaaa aatgttagta acaaaagagg acaaaaagaa aaaaacaca
//
