LOCUS       NM_010432               8065 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus homeodomain interacting protein kinase 1 (Hipk1),
            transcript variant 1, mRNA.
ACCESSION   NM_010432
VERSION     NM_010432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8065)
  AUTHORS   Liu,B., Du,R., Zhou,L., Xu,J., Chen,S., Chen,J., Yang,X., Liu,D.X.,
            Shao,Z.M., Zhang,L., Yu,Z., Xie,N., Guan,J.L. and Liu,S.
  TITLE     miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via
            Targeting HIPK1/beta-Catenin Axis
  JOURNAL   Theranostics 8 (21), 5801-5813 (2018)
   PUBMED   30613263
  REMARK    GeneRIF: The miR-200c/141 cluster regulated breast cancer stem
            cells heterogeneity and promoted the epithelial-mesenchymal
            transformation-like breast cancer stem cells generation, which
            resulted in increased tumor metastasis and inhibited tumor growth
            by directly upregulating the target gene homeodomain-interacting
            protein kinase 1 (HIPK1) and sequential beta-catenin activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8065)
  AUTHORS   Shang,Y., Doan,C.N., Arnold,T.D., Lee,S., Tang,A.A., Reichardt,L.F.
            and Huang,E.J.
  TITLE     Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis
            via TGF-beta-TAK1-dependent mechanism
  JOURNAL   PLoS Biol 11 (4), e1001527 (2013)
   PUBMED   23565059
REFERENCE   3  (bases 1 to 8065)
  AUTHORS   Marinaro,C., Pannese,M., Weinandy,F., Sessa,A., Bergamaschi,A.,
            Taketo,M.M., Broccoli,V., Comi,G., Gotz,M., Martino,G. and Muzio,L.
  TITLE     Wnt signaling has opposing roles in the developing and the adult
            brain that are modulated by Hipk1
  JOURNAL   Cereb Cortex 22 (10), 2415-2427 (2012)
   PUBMED   22095214
  REMARK    GeneRIF: Therefore, our data confirm that the beta-Catenin
            signaling plays a dual role in controlling cell
            proliferation/differentiation in the brain and indicate that Hipk1
            is the crucial interactor able to revert the outcome of
            beta-Catenin signaling in cells.
REFERENCE   4  (bases 1 to 8065)
  AUTHORS   Lee,D., Park,S.J., Sung,K.S., Park,J., Lee,S.B., Park,S.Y.,
            Lee,H.J., Ahn,J.W., Choi,S.J., Lee,S.G., Kim,S.H., Kim,D.H.,
            Kim,J., Kim,Y. and Choi,C.Y.
  TITLE     Mdm2 associates with Ras effector NORE1 to induce the degradation
            of oncoprotein HIPK1
  JOURNAL   EMBO Rep 13 (2), 163-169 (2012)
   PUBMED   22173032
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8065)
  AUTHORS   Guerra,F.M., Gommerman,J.L., Corfe,S.A., Paige,C.J. and Rottapel,R.
  TITLE     Homeodomain-interacting protein kinase (HIPK)-1 is required for
            splenic B cell homeostasis and optimal T-independent type 2 humoral
            response
  JOURNAL   PLoS One 7 (4), e35533 (2012)
   PUBMED   22545114
  REMARK    GeneRIF: Despite the expanded marginal zone B cell population in
            the HIPK1(-/-) mice, the T-independent type 2 humoral response was
            impaired.
REFERENCE   6  (bases 1 to 8065)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 8065)
  AUTHORS   Ecsedy,J.A., Michaelson,J.S. and Leder,P.
  TITLE     Homeodomain-interacting protein kinase 1 modulates Daxx
            localization, phosphorylation, and transcriptional activity
  JOURNAL   Mol Cell Biol 23 (3), 950-960 (2003)
   PUBMED   12529400
  REMARK    GeneRIF: HIPK1 and Daxx collaborate in regulating transcription.
REFERENCE   8  (bases 1 to 8065)
  AUTHORS   Rochat-Steiner,V., Becker,K., Micheau,O., Schneider,P., Burns,K.
            and Tschopp,J.
  TITLE     FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that
            induces FADD phosphorylation and inhibits fas-mediated Jun
            NH(2)-terminal kinase activation
  JOURNAL   J Exp Med 192 (8), 1165-1174 (2000)
   PUBMED   11034606
REFERENCE   9  (bases 1 to 8065)
  AUTHORS   Shang,E., Wang,X., Huang,J., Yoshida,W., Kuroiwa,A. and
            Wolgemuth,D.J.
  TITLE     Murine Myak, a member of a family of yeast YAK1-related genes, is
            highly expressed in hormonally modulated epithelia in the
            reproductive system and in the embryonic central nervous system
  JOURNAL   Mol Reprod Dev 55 (4), 372-378 (2000)
   PUBMED   10694743
REFERENCE   10 (bases 1 to 8065)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134408.1, AF170304.1, AC132567.3 and AW125573.1.
            
            On Oct 30, 2007 this sequence version replaced NM_010432.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript ans encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF170304.1, AF077658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AK134408.1         2-201
            201-3953            AF170304.1         1-3753
            3954-7554           AC132567.3         95224-98824         c
            7555-8065           AW125573.1         1-511               c
FEATURES             Location/Qualifiers
     source          1..8065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     gene            1..8065
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /note="homeodomain interacting protein kinase 1"
                     /db_xref="GeneID:15257"
                     /db_xref="MGI:MGI:1314873"
     exon            1..281
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            282..1359
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1483
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1603
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1690
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1875
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2038
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2264
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2386
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2521
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2664
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2847
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3054
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3296
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3427
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..8049
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7687..7692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /note="hexamer: ATTAAA"
     polyA_site      7708
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /note="major polyA site"
     regulatory      8027..8032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /note="hexamer: AATAAA"
     polyA_site      8046
                     /gene="Hipk1"
                     /gene_synonym="1110062K04Rik; Myak"
                     /note="major polyA site"
ORIGIN      
        1 agggccgggc cgtggccccg gaccgcaggg gaggccgagg cgggagcgct cggcgctgag
       61 gcggcggcgg cgggaagggg ccgggtggca gggcaggcgg gaggctggcg aggctccggc
      121 cgcaggacgg gcgcggggac ggctccgggg ggcgggggcc ggggccgggg ccggctcgtg
      181 cggggggtat gatgacccgg ctgcggggcc ccggatcgcc tctcctccgc cgcctcctcg
      241 cggcggcccc gactcgaggc tgagaactac acacaccggc ggtatggcct cacagctgca
      301 ggtgttttcg cccccatcag tgtcgtcgag tgccttctgc agtgcaaaga aactgaaaat
      361 agagccctct ggctgggatg tttcaggaca gagcagcaac gacaaatact atacccacag
      421 caaaaccctc ccagctacac aagggcaagc cagctcctct caccaggtag caaatttcaa
      481 tcttcctgct tacgaccagg gcctccttct cccagctcct gccgtggagc atattgtggt
      541 aacagctgct gatagctcag gcagcgccgc tacagcaacc ttccaaagca gccagaccct
      601 gactcacagg agcaacgttt ctttgcttga gccatatcaa aaatgtggat tgaagagaaa
      661 gagtgaggaa gtggagagca acggtagcgt gcagatcata gaagaacacc cccctctcat
      721 gctgcagaac agaaccgtgg tgggtgctgc tgccacgacc accactgtga ccaccaagag
      781 tagcagttcc agcggagaag gggattacca gctggtccag catgagatcc tttgctctat
      841 gaccaacagc tatgaagtcc tggagttcct aggccggggg acatttggac aggtggcaaa
      901 gtgctggaag cggagcacca aggaaattgt ggccattaag atcttgaaga accacccctc
      961 ctatgccaga caaggacaga ttgaagtgag catcctttcc cgcctaagca gtgaaaatgc
     1021 tgatgagtat aactttgtcc gttcttatga gtgttttcag cacaagaatc atacctgcct
     1081 tgtgtttgag atgttggagc agaacttgta cgattttcta aagcagaaca agtttagccc
     1141 actgccactc aagtacataa gaccaatctt gcagcaggtg gccacagccc tgatgaagct
     1201 gaagagtctt ggtctgattc atgctgacct taaacctgaa aacataatgc tagtcgatcc
     1261 agttcgccaa ccctaccgag tgaaggtcat tgactttggt tctgctagtc atgtttccaa
     1321 agccgtgtgt tcaacctacc tgcaatcacg ctactacaga gctcctgaaa ttatccttgg
     1381 attaccattc tgtgaagcta ttgacatgtg gtcactgggc tgtgtaatag ctgagctgtt
     1441 cctgggatgg cctctttatc ctggtgcttc agaatacgat cagattcgct atatttcaca
     1501 aacacaaggc ctgccagctg agtatcttct cagtgccgga acaaaaacaa ccaggttttt
     1561 taacagagat cctaatttgg ggtacccact gtggaggctt aagacacctg aagaacatga
     1621 attggaaact ggaataaagt caaaagaagc tcggaagtac atttttaact gtttagatga
     1681 catggctcag gtaaatatgt ctacagactt agaggggaca gatatgttag cagagaaagc
     1741 agatcggaga gagtatattg atcttctaaa gaaaatgctg acgattgatg cagataagag
     1801 aatcacgcct ctgaagactc ttaaccacca atttgtgacg atgagtcacc tcctggactt
     1861 tcctcacagc agccacgtta agtcctgttt ccagaacatg gagatctgca agcggagggt
     1921 tcacatgtat gacacagtga gtcagatcaa gagtcccttc actacacatg tcgctccaaa
     1981 tacaagcaca aatctaacca tgagcttcag caaccagctc aacacagtgc acaatcaggc
     2041 cagtgttcta gcttccagct ctactgcagc agcagctacc ctttctctgg ctaattcaga
     2101 tgtctcgctg ctaaactacc aatcggcttt gtacccatcg tcggcagcgc cagttcctgg
     2161 agttgcccag cagggtgttt ccttacaacc tggaaccacc cagatctgca ctcagacaga
     2221 tccattccag caaacattta tagtatgccc acctgctttt cagactggac tacaagcaac
     2281 aacaaagcat tctggattcc ctgtgaggat ggataatgct gtgccaattg taccccaggc
     2341 gcctgctgct cagccgctgc agatccagtc aggagtactc acacagggaa gctgtacacc
     2401 actaatggta gcaactctcc accctcaagt agccaccatc acgccgcagt atgcggtgcc
     2461 ctttaccctg agctgcgcag caggccggcc ggcgctggtt gaacagactg ctgctgtact
     2521 gcaagcctgg cctggaggaa cccaacaaat tctcctgcct tcagcctggc agcagctgcc
     2581 cggggtagct ctgcacaact ctgtccagcc tgctgcagtg attccagagg ccatggggag
     2641 cagccaacag ctagctgact ggaggaatgc ccactctcat ggcaaccagt acagcactat
     2701 tatgcagcag ccatctttgc tgaccaacca tgtgaccttg gccactgctc agcctctgaa
     2761 tgttggtgtt gcccatgttg tcagacaaca acagtctagt tccctccctt caaagaagaa
     2821 taagcagtct gctccagttt catccaaatc ctctctggaa gtcctgcctt ctcaagttta
     2881 ttctctggtt gggagtagtc ctcttcgtac cacatcttct tataattccc tagttcctgt
     2941 ccaagaccag catcagccaa tcatcattcc agataccccc agccctcctg tgagtgtcat
     3001 cactatccgt agtgacactg atgaagaaga ggacaacaaa tacaagccca atagctcgag
     3061 cctgaaggcg aggtctaatg tcatcagtta tgtcactgtc aatgattctc cagactctga
     3121 ctcctccctg agcagcccac atcccacaga cactctgagt gctctgcggg gcaacagtgg
     3181 gacccttctg gagggacctg gcagacctgc agcagatggc attggcaccc gtactatcat
     3241 tgtgcctcct ttgaaaacac agcttggcga ctgcactgta gcaacacagg cctcaggtct
     3301 ccttagcagt aagaccaagc cagtggcctc agtgagtggg cagtcatctg gatgctgtat
     3361 cactcccacg gggtaccggg ctcagcgagg gggagccagc gcggtgcagc cactcaacct
     3421 tagccagaac cagcagtcat cgtcagcttc aacctcgcag gaaagaagca gcaaccctgc
     3481 tccccgcaga cagcaggcat ttgtggcccc gctctcccaa gccccctacg ccttccagca
     3541 tggcagccca ctgcactcga cggggcaccc acacttggcc ccagcccctg ctcacctgcc
     3601 aagccagcct cacctgtata cgtacgctgc ccccacttct gctgctgcat tgggctccac
     3661 cagttccatt gctcatctgt tctcccccca gggttcctca aggcatgctg cagcttatac
     3721 cacacaccct agcactctgg tgcatcaggt tcctgtcagt gtcgggccca gcctcctcac
     3781 ttctgccagt gtggcccctg ctcagtacca acaccagttt gccactcagt cctacatcgg
     3841 gtcttcccga ggctcaacaa tttacactgg atacccgctg agtcctacca agatcagtca
     3901 gtattcttac ttgtagttga tgagcacgag gagggctccg tggctgcctg ctactagccc
     3961 tgagttctta atgggctctg gagagcacct ccattatctc ctcttgaaag ttcctagcca
     4021 gcagcgcgtt ctgcggggcc cactgaagca gaaggctttt ccctggggaa cagctctcgg
     4081 tgttgactgc attgttgcag tctcccaagt ctgccctgtt tttttaattc tttattcttg
     4141 tgacagcatt tttggacgtt ggaagagctc agaagcccat cttctgcagt taccaaggaa
     4201 gaaagatcgt tctgaagtta ccctctgtca tacatttggt ctctttgact tggtttctat
     4261 aaatgttttt aaaatgaagt aaagctcttc tttacgaggg gaaatgctga cttgaaatcc
     4321 tgtaacagat gagaaagagt cattactttt tgtttgctta aaaaactaaa acacaagact
     4381 tccttgtctt ttattttgaa agcagcttag caaggctgtg cttatggcgt atggaaacag
     4441 agtgatttca ttttcatgtc gtgctgtcct tactgggcag ttgttagagt tttagtacaa
     4501 cgagtactga aacctgtgca gctgctgctg agctgctcgc agagcagcac tgaacaggca
     4561 gccagcgctg ctgggaagga aggtgagggt gaggactgtg cccaccagga ttcattctaa
     4621 atgaagacca tgagttcaag tcctcctcct ctctctagtt taacttaaat tctccttata
     4681 gaaaagccag tgaggtggta agtgtatggt ggtggtttgc atacaatagt atgcaaaatc
     4741 tctctctaga atgagatact ggcactgata aacattgcct aagatttcta tgaattttca
     4801 ataatacacg tctgtgtttt cctcatctct cccttctgtt tcatgtgact tatttgaggg
     4861 gaaaactaaa gaaactaaaa ccagataagt tgtgtatagc ttttatactt taaagtagct
     4921 tcctttgtat gccaacagca aattgaatgc tctcttacta agacttatgt aataagtgca
     4981 tgtaggaatt gcagaaaata ttttaaaagt ttattactga atttaaaaat attttagaag
     5041 ttttgtaatg gtggtgtttt aatattttgc ataattaaat atgtacatat tgattagaag
     5101 aaatataaca atttttcctc taacccaaaa tgttatttgt aatcaaatgt gtagtgatta
     5161 cacttgaatt gtgtatttag tgtgtatctg atcctccagt gttaccccgg agatggatta
     5221 tgtctccatt gtatttaaac caaaatgaac tgatacttgt tggaatgtat gtgaactaat
     5281 tgcaattcta ttagagcata ttactgtagt gctgagagag caggggcatt gcctgcagag
     5341 aggagacctt gggattgttt tgcacaggtg tgtctggtga ggagttgttc agtgtgtgtc
     5401 ttttccttcc ccctctcctc tctcccctta ttgtagtgcc ttatatgata atgtagtggt
     5461 taatagagtt tacagtgagc ttgccttagg atgaccagca agccccagtg accccaagct
     5521 gttcgctggg atttaacaga gcaggttgag tagctgtgtt gtgtaaatgc gttcgtgttc
     5581 tcagtctccc taccgacagt gacaagtcaa agccgcagct ttcctcctta actgccacct
     5641 ctgtcccgtt ccattttgga tcttcagctc agttctcaca gaagcattcc ctaacgtggc
     5701 tctctcactg tgccttgcta cctggcttct gtgagagttc aggaagcagg cgagaagagt
     5761 gacgccagtg ctaaatatgc atatttgaag gtttgtgcat cacttaggat gggattcctt
     5821 ttctctcctc catgtgatat gatagtcctt tctgcatagc tgtcgttcct ggtaaacttt
     5881 gcttggcttt ttttttttgt ttgttttttg tttttttttt aaagcatgta acagatgtgt
     5941 ttataccaaa gagcctgttg tattgcttaa tatgtcccca tactacgaga agggttttgt
     6001 agaactactg gtgacaagaa gctcacagaa aggtttctta attagtgacg aatatgaaaa
     6061 agaaagcaaa acctcttgaa tctgaacaat tcctgaggtt tctttgggac aacatgttgt
     6121 tcttggggcc cttcacactg taaaattgtc ctagtattca acccctccat ggatttgggt
     6181 caagttgaag gtactagggg tggggacatt cttgcccgtg agggatttgt ggggagaagg
     6241 ttaaccctaa gctacagatg tggtccacct gaattaaatt atatcagagt ggtaattcta
     6301 ggattggttc tgtgtaggtg gtgtcaggga ggtgcaggat ggagatggga gatttcatgg
     6361 aacccggtca ggaaagctct gaaccaggtg gaacaccgag gggctgtcaa cgaacttgga
     6421 gtttcttcat catggggagg aagagtttcc agggcagggc aggtagtcag tttagcctgc
     6481 cggcaacgtg gtgtgtgttg tcttttcttt aatcattata ttaagctgtg cgttcagcag
     6541 tctgttggtt gagataacca cgcatcattg tgtagtttgt cactagtgtt ataccgttta
     6601 tgtcattctg tgtgtgatct ttgtgtttcc tttcccccaa gcattctggg tttttcctat
     6661 ttaaatacag ttctagtttc taggcaaaca tttttttttt taaccttttc tctataaggg
     6721 acaagattta ttgtttttat aggaatgaga tgcagggaaa aaacaaacca accctgtccc
     6781 cacctcctca cctccctaat ccaataagca gttattgaag atgggagtct taaatttatg
     6841 ggaaaagagg atgcctagga gtttgcatcg ttacctgaga catctggcta gcagtgtgac
     6901 tttacagact ttgaggttgt cactctgcaa actgacattt cagattttcc tagataaccc
     6961 atctgtgtct gctgaatgtg tatgcgccag acatagtttt acattcattc tggcctgggg
     7021 cttaacattg actgcttgcc ctgatggcat ggaggagagc cctacgaaca tagcgctgac
     7081 ctaggtcagc attgcctgac cttggaacag cttaaggctt taaaccttct cttagaacgt
     7141 gcatttccag tttctccctt cccaggtgag agaggaactg gaagggttgc ataggcacac
     7201 accaggacac ttagtcactc cagagtcccc agttgcaact aggaggtggt taccctgtta
     7261 accccaggaa gaagaacccc atttcaaaca gttccggcca ttgagagcct gcttttgtgg
     7321 ttgctcatcc gtcatcatcc gctagagggg cttagccagg ccagcacagt actggctgtc
     7381 ctattctgca ttagtatgca ggaatttact agttgagatg gtttgtttta ggataggaga
     7441 tgaaattgcc tctcggtgac aggaatggcc aagcctgctt tgtgtttttt tttaactgat
     7501 ggatggtgca gcatgtctcc acgtttccat ggttgtttgt tgctaaactt tatataatgt
     7561 gtggtttcaa ttcaattcag cttgaaaaat aatctcacta tatgtagcag tacattatat
     7621 gtacattata tgtaatgtta gtatttctgc tttgaatcct tgatattgca atggaattcc
     7681 tactttatta aatgtatttg atatgctagt tcctgtgtgt ggttaaactt tttttctttc
     7741 tcccttttct ggttgtgtgc ttcctttaca acaagcttct agaaacaggt agttctgaga
     7801 attactgatc tatgtttgta atgcaggtgt acttagggag tatgtaaaat cattttaaca
     7861 aaagaaatag ctatttaaaa tttaatacta actatgggaa aagggtccat tgtgtaaaac
     7921 atagtttatc tttggattcg ttgttgtctt tggttttaca aagtagcttg tattttcagt
     7981 attttctaca taatatggta aaaaagtaga gcagttgcaa tgcatcaata aaatgggtaa
     8041 attttctgaa aaaaaaaaaa aaaaa
//
