LOCUS       NM_145070               4402 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus huntingtin interacting protein 1 related (Hip1r),
            mRNA.
ACCESSION   NM_145070
VERSION     NM_145070.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4402)
  AUTHORS   Yang Q, Peng L, Wu Y, Li Y, Wang L, Luo JH and Xu J.
  TITLE     Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking
            of Epidermal Growth Factor Receptor in Neuronal Dendritic
            Development
  JOURNAL   Front Mol Neurosci 11, 447 (2018)
   PUBMED   30574069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4402)
  AUTHORS   Wijayatunge R, Holmstrom SR, Foley SB, Mgbemena VE, Bhargava V,
            Perez GL, McCrum K and Ross TS.
  TITLE     Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3
            Expression, Low Phosphocholine, and Kypholordosis
  JOURNAL   Mol Cell Biol 38 (23), e00385-18 (2018)
   PUBMED   30224518
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4402)
  AUTHORS   Kasowitz SD, Ma J, Anderson SJ, Leu NA, Xu Y, Gregory BD, Schultz
            RM and Wang PJ.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4402)
  AUTHORS   Qu Z and D'Mello SR.
  TITLE     Proteomic analysis identifies NPTX1 and HIP1R as potential targets
            of histone deacetylase-3-mediated neurodegeneration
  JOURNAL   Exp Biol Med (Maywood) 243 (7), 627-638 (2018)
   PUBMED   29486577
  REMARK    GeneRIF: Nptx1, Hip1r, and Hdac9 as genes whose expression is
            altered by HDAC3.
REFERENCE   5  (bases 1 to 4402)
  AUTHORS   Lindstrom NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G,
            Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA,
            Smith AD and McMahon AP.
  TITLE     Conserved and Divergent Features of Mesenchymal Progenitor Cell
            Types within the Cortical Nephrogenic Niche of the Human and Mouse
            Kidney
  JOURNAL   J Am Soc Nephrol 29 (3), 806-824 (2018)
   PUBMED   29449449
REFERENCE   6  (bases 1 to 4402)
  AUTHORS   Kowanetz K, Husnjak K, Holler D, Kowanetz M, Soubeyran P, Hirsch D,
            Schmidt MHH, Pavelic K, De Camilli P, Randazzo PA and Dikic I.
  TITLE     CIN85 associates with multiple effectors controlling intracellular
            trafficking of epidermal growth factor receptors
  JOURNAL   Mol Biol Cell 15 (7), 3155-3166 (2004)
   PUBMED   15090612
REFERENCE   7  (bases 1 to 4402)
  AUTHORS   Engqvist-Goldstein AE, Zhang CX, Carreno S, Barroso C, Heuser JE
            and Drubin DG.
  TITLE     RNAi-mediated Hip1R silencing results in stable association between
            the endocytic machinery and the actin assembly machinery
  JOURNAL   Mol Biol Cell 15 (4), 1666-1679 (2004)
   PUBMED   14742709
REFERENCE   8  (bases 1 to 4402)
  AUTHORS   Okano A, Usuda N, Furihata K, Nakayama K, Bao Tian Q, Okamoto T and
            Suzuki T.
  TITLE     Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is
            localized in the postsynaptic regions
  JOURNAL   Brain Res 967 (1-2), 210-225 (2003)
   PUBMED   12650982
REFERENCE   9  (bases 1 to 4402)
  AUTHORS   Engqvist-Goldstein AE, Warren RA, Kessels MM, Keen JH, Heuser J and
            Drubin DG.
  TITLE     The actin-binding protein Hip1R associates with clathrin during
            early stages of endocytosis and promotes clathrin assembly in vitro
  JOURNAL   J Cell Biol 154 (6), 1209-1223 (2001)
   PUBMED   11564758
REFERENCE   10 (bases 1 to 4402)
  AUTHORS   Engqvist-Goldstein AE, Kessels MM, Chopra VS, Hayden MR and Drubin
            DG.
  TITLE     An actin-binding protein of the Sla2/Huntingtin interacting protein
            1 family is a novel component of clathrin-coated pits and vesicles
  JOURNAL   J Cell Biol 147 (7), 1503-1518 (1999)
   PUBMED   10613908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ082429.1, AK146663.1 and BP763532.1.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_145070.4.
            
            On Aug 5, 2009 this sequence version replaced NM_145070.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065101.1, AK129182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               CJ082429.1         2-122
            122-4376            AK146663.1         3-4257
            4377-4402           BP763532.1         30-55               c
FEATURES             Location/Qualifiers
     source          1..4402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..4402
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /note="huntingtin interacting protein 1 related"
                     /db_xref="GeneID:29816"
                     /db_xref="MGI:MGI:1352504"
     exon            1..228
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3342
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /note="HIP1-related protein"
                     /codon_start=1
                     /product="huntingtin-interacting protein 1-related
                     protein"
                     /protein_id="NP_659507.3"
                     /db_xref="CCDS:CCDS39276.1"
                     /db_xref="GeneID:29816"
                     /db_xref="MGI:MGI:1352504"
                     /translation="MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEA
                     PVKEKHARRIILGTHHEKGAFTFWSYAIGLPLSSSSILSWKFCHVLHKVLRDGHPNVL
                     HDYQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFPAGLEVTDEV
                     LEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQ
                     VIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLKNFFRRASDMLYFKRL
                     IQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSAPPAGEPVVVA
                     DLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNGLE
                     AELEEQRKQKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSKL
                     KEKHSELINTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQAKRESEMKME
                     EQSDQLEKLKRELAARAGELARAQEALSRTEQSGSELSSRLDTLNAEKEALSGVVRQR
                     EAELLAAQSLVREKEEALSQEQQRSSQEKGELRGQLAEKESQEQGLRQKLLDEQLAVL
                     RSAAAEAEAILQDAVSKLDDPLHLRCTSSPDYLVSRAQAALDSVSGLEQGHTQYLASS
                     EDASALVAALTRFSHLAADTIVNGAATSHLAPTDPADRLMDTCRECGARALELVGQLQ
                     DQTVLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDAV
                     RRIEDMMSQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAA
                     TQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAAST
                     AQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLS
                     LIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPSEEEPSRPSPAP
                     RSGATKKPPLAQKPSIAPRTDNQLDKKDGVYPAQLVNY"
     exon            229..292
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            293..435
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            436..492
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            493..573
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            574..650
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            651..712
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            713..853
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            854..911
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            912..987
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1128
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1190
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1263
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1447
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1536
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1653
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1755
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1950
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2098
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2185
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2293
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2430
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2541
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2600
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2631
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2694
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2795
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2901
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3025
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3087
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3294
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..4392
                     /gene="Hip1r"
                     /gene_synonym="mKIAA0655"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccggagtg actggcggga ggggctgcgg ctcctccccg tgcggcgcgg cgcgcggcct
       61 ccgtgtgcct aggcttgagg cgggcggtga cgcctcattc gcgcggagcc gggccgggac
      121 acggtcggcg gcagcatgaa cagcatcaag aatgtgccgg cgcgggtgct gagccgcagg
      181 ccgggccaca gcctagaggc cgagcgcgag cagttcgaca agacgcaggc catcagtatc
      241 agcaaagcca tcaacagcca ggaggcccca gtgaaggaga agcatgcccg gcgtatcatc
      301 ctgggcacgc atcatgagaa gggagccttt accttctggt cctatgccat cggcctgccg
      361 ctgtccagca gctccatcct cagctggaag ttctgtcacg tccttcacaa ggtcctccgg
      421 gacggacacc ccaacgtcct gcatgactat cagcggtacc ggagcaacat acgtgagatc
      481 ggtgacttgt ggggccacct tcgtgaccag tatggacacc tggtgaatat ctataccaaa
      541 ctgttgctga ctaagatctc cttccacctt aagcatcccc agtttcctgc aggcctggag
      601 gtaacagatg aggtgttgga gaaggcggcg ggaactgatg tcaacaacat ttttcagctt
      661 accgtggaga tgtttgacta catggactgt gaactgaagc tttctgagtc agttttccgg
      721 cagctcaaca cggccatcgc agtgtcccag atgtcttctg gccagtgtcg cctagcgccg
      781 ctcatccagg tcattcagga ctgcagccac ctgtaccact acacagtgaa gctcatgttt
      841 aagctgcact cctgtctccc ggcagacacc ctgcaaggcc acagggatcg gttccacgag
      901 cagtttcaca gcctcaaaaa cttcttccgc cgagcttcag acatgctgta cttcaagagg
      961 ctcatccaga tcccgcggct gcctgaggga ccccccaatt tcctgcgggc ttcagccctg
     1021 gctgagcaca tcaagccggt ggtggtgatt cccgaggagg ccccagagga agaggagcct
     1081 gagaacctaa ttgaaatcag cagtgcaccc cctgctgggg agccagtggt ggtggctgac
     1141 ctctttgatc agacctttgg accccccaat ggctccatga aggatgacag ggacctccaa
     1201 atcgagaact tgaagagaga ggtggagacc ctccgtgctg agctggagaa gattaagatg
     1261 gaggcacagc ggtacatctc ccagctgaag ggccaggtga atggcctgga ggcagagctg
     1321 gaggagcagc gcaagcagaa gcagaaggcc ctggtggaca acgagcagct gcgccacgag
     1381 ctggcccagc tcaaggccct gcagctggag ggcgcccgca accagggcct tcgagaggaa
     1441 gcagagagga aggccagtgc cacggaggca cgctacagca agctgaagga gaaacacagc
     1501 gaactcatta acacccacgc cgagctgctc aggaagaacg cagacacggc caagcagctg
     1561 acagtgacac agcagagcca ggaggaggtg gcacgggtaa aggaacagct ggccttccag
     1621 atggagcaag cgaagcgtga gtctgagatg aagatggaag agcagagcga ccagttggag
     1681 aagctcaaga gggagctggc ggccagggca ggagagctgg cccgtgcgca ggaggccctg
     1741 agccgcacag aacagagtgg gtcagagctg agctcacggc tggacacact gaatgcggag
     1801 aaggaagctc tgagtggagt cgttcggcag cgtgaggcag agctgctggc cgctcagagc
     1861 ctggtgcggg agaaggagga ggcacttagc caagagcagc agcggagctc ccaggagaag
     1921 ggcgagctac gggggcagct ggcagaaaag gagtctcagg agcaggggct tcggcagaag
     1981 ctgctggatg agcagttggc ggtgttgcga agtgcagccg ccgaggcaga ggccatccta
     2041 caggatgcag tgagcaagct ggacgacccc ctgcacctcc gctgcaccag ctccccagac
     2101 tacttggtga gccgggctca ggcagccctg gacagcgtga gcggcctgga gcagggccac
     2161 acccagtacc tggcttcctc tgaagatgct tctgccctgg tggcagcgct gacccgcttc
     2221 tcccatttgg ctgcggacac cattgtcaat ggtgccgcca cctcccacct ggcccccacc
     2281 gaccccgccg accgcctgat ggacacatgc agggagtgtg gagcccgggc tctggagctg
     2341 gtgggacagc tgcaagacca gacagtgcta ccgagggctc agcccagcct gatgcgggcc
     2401 cccctgcagg gcattctgca gttgggccag gacttgaagc ctaagagcct ggatgtacgg
     2461 caagaggagc taggggccat ggtggacaag gagatggcgg ccacctcggc agccattgag
     2521 gacgctgtgc ggaggatcga ggacatgatg agccaggccc gccacgagag ctcgggcgtg
     2581 aaactggagg tgaatgagag gatcctcaac tcctgcacag acctgatgaa ggctatccgg
     2641 ctcctggtga tgacctccac cagcctgcag aaggaaattg tggagagcgg caggggggca
     2701 gcaacgcagc aggaatttta tgccaagaat tcacggtgga ctgaaggcct catctcagcc
     2761 tctaaggcag tgggctgggg agccacacag ctggtggagt cagctgacaa ggttgtgctt
     2821 cacatgggca aatacgagga actcatcgtc tgctcccatg agattgcggc cagcacggcc
     2881 cagctggtgg cagcctcgaa ggtgaaagcc aacaagaaca gtccccactt gagccgcctg
     2941 caggaatgtt cccgcactgt caacgagagg gctgccaacg tcgtggcctc caccaaatct
     3001 ggccaggagc agattgagga cagagacacc atggatttct ctggcctgtc cctcatcaag
     3061 ttgaagaagc aggagatgga gacacaggtg cgagtcttgg agctggagaa gacactagag
     3121 gcagagcgtg tccggctcgg ggagcttcgg aaacagcact atgtactggc tggggggatg
     3181 ggaacaccta gcgaagaaga acccagcaga cccagcccag ctccccgaag tggggccact
     3241 aagaagccac cgctggccca gaaacccagc atagccccca ggacagacaa ccagctcgac
     3301 aaaaaggatg gtgtctaccc agctcaactt gtgaactact aggcccctaa ggtgttcagc
     3361 aggatggttg gtggttgtgc ctgggcttca cgtggctgtc tggcagtggt caaggggcct
     3421 ctgagaagcc tccaactcct gtccaagggg cctagtctgt gggacagttc atctggatgt
     3481 gaatctattt atcttaagta ggaactgcct cgagcagctg ggacccagca ggcctgagcc
     3541 acaaatctgc agcggacatc agagatagtc tgaatgctgc gaggtatttc tttcttcgta
     3601 agtttagtca gcacactggg aaaaggtcac ataagccagg agcctccttg tctctggact
     3661 taaaagtctg aggccttaag tgaacaacag aaagagggtc cctgctggct accagggata
     3721 aggggatgac ctgtgaccct tgagccaggg agagcaggta agctgggtag tgtcatcacc
     3781 tgggggcctg gtgctagggc atccatgctg ggagccccag gagaccaggc tttgtgtggg
     3841 agcctggcat catcgtggct ggggcagccc ctgctcaggt gctgcctctg cccgtgacct
     3901 cgaagccacc ctcccccgta cagttttcca ttctcctggc tactagtgtg gctgttcatt
     3961 gcctaccttg atgagtagat ttcagccctc ctaaagctgg ggcctttcag ccagacaaaa
     4021 gctattaaaa aaaaaagagc agatgccata gcccacattt ctggaggctc aagagttctt
     4081 gctggagcag cccagacatg gagggctggc cttgcctgcc cctgacagtt tgaataaatt
     4141 tgtgtgtctt gagcctgagg aggagtggct gggggtagaa gatatccagg ccaccaataa
     4201 agccagcagc tggtctggga caagtgccca gcctccctcc agctgcatgc cctgcaccct
     4261 gggaaggcta ccaaccatgg accaaggtcc ggggctttgg gagggagccg gctcctttgc
     4321 tctgtctagt gttccctgtg ttgagttcca ttggcaataa aaccctgact gttgttagca
     4381 gtgccctagt gaaaaaaaaa aa
//
