LOCUS       NM_146001               7883 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus huntingtin interacting protein 1 (Hip1), transcript
            variant 1, mRNA.
ACCESSION   NM_146001
VERSION     NM_146001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7883)
  AUTHORS   Wang,H., Zheng,C., Lu,W., He,T., Fan,J., Wang,C., Jie,Q., Chan,D.,
            Cheah,K.S.E. and Yang,L.
  TITLE     Hedgehog signaling orchestrates cartilage-to-bone transition
            independently of Smoothened
  JOURNAL   Matrix Biol 110, 76-90 (2022)
   PUBMED   35472633
REFERENCE   3  (bases 1 to 7883)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 7883)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7883)
  AUTHORS   Wijayatunge,R., Holmstrom,S.R., Foley,S.B., Mgbemena,V.E.,
            Bhargava,V., Perez,G.L., McCrum,K. and Ross,T.S.
  TITLE     Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3
            Expression, Low Phosphocholine, and Kypholordosis
  JOURNAL   Mol Cell Biol 38 (23), e00385-18 (2018)
   PUBMED   30224518
  REMARK    GeneRIF: Gdpd3 compensates for Hip1 loss.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7883)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 7883)
  AUTHORS   Wang,Y.K., Sporle,R., Paperna,T., Schughart,K. and Francke,U.
  TITLE     Characterization and expression pattern of the frizzled gene Fzd9,
            the mouse homolog of FZD9 which is deleted in Williams-Beuren
            syndrome
  JOURNAL   Genomics 57 (2), 235-248 (1999)
   PUBMED   10198163
REFERENCE   8  (bases 1 to 7883)
  AUTHORS   Paperna,T., Peoples,R., Wang,Y.K., Kaplan,P. and Francke,U.
  TITLE     Genes for the CPE receptor (CPETR1) and the human homolog of RVP1
            (CPETR2) are localized within the Williams-Beuren syndrome deletion
  JOURNAL   Genomics 54 (3), 453-459 (1998)
   PUBMED   9878248
REFERENCE   9  (bases 1 to 7883)
  AUTHORS   Dragatsis,I., Efstratiadis,A. and Zeitlin,S.
  TITLE     Mouse mutant embryos lacking huntingtin are rescued from lethality
            by wild-type extraembryonic tissues
  JOURNAL   Development 125 (8), 1529-1539 (1998)
   PUBMED   9502734
REFERENCE   10 (bases 1 to 7883)
  AUTHORS   Himmelbauer,H., Wedemeyer,N., Haaf,T., Wanker,E.E., Schalkwyk,L.C.
            and Lehrach,H.
  TITLE     IRS-PCR-based genetic mapping of the huntingtin interacting protein
            gene (HIP1) on mouse chromosome 5
  JOURNAL   Mamm Genome 9 (1), 26-31 (1998)
   PUBMED   9434941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY309818.1, BC017516.1, AK147246.1 and CF746398.1.
            
            On Mar 17, 2009 this sequence version replaced NM_146001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147269.1, AK147246.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY309818.1         3-9
            8-6347              BC017516.1         1-6340
            6348-7833           AK147246.1         6304-7789
            7834-7883           CF746398.1         363-412
FEATURES             Location/Qualifiers
     source          1..7883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.18 cM"
     gene            1..7883
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="huntingtin interacting protein 1"
                     /db_xref="GeneID:215114"
                     /db_xref="MGI:MGI:1099804"
     exon            1..186
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..3156
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HIP-I; huntingtin-interacting protein I"
                     /codon_start=1
                     /product="huntingtin-interacting protein 1 isoform 1"
                     /protein_id="NP_666113.2"
                     /db_xref="CCDS:CCDS51663.1"
                     /db_xref="GeneID:215114"
                     /db_xref="MGI:MGI:1099804"
                     /translation="MDRMASSMKQVSNPLPKVLSRRGVGAGMEAAERESFERTQTVSV
                     NKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKL
                     LRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFP
                     GNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAG
                     QCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRS
                     SNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMD
                     MDASQQTLFDNKFDDVFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLD
                     NMKIESQRAMLQLKGRVSELEAELAEQQHLGRQAMDDCEFLRTELDELKRQREDTEKA
                     QRSLTEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLER
                     EKKELADSFARTQEQQDVLENLKHELATSRQELQVLHSNLETSAQSEAKWLTQIAELE
                     KEQGSLATVAAQREEELSALRDQLESTQIKLAGAQESMCQQVKDQRKTLLAGIRKAAE
                     REIQEALSQLEEPTLISCAGSTDHLLSKVSSVSSCLEQLEKNGSQYLACPEDISELLH
                     SITLLAHLTGDTIIQGSATSLRAPPEPADSLTEACRQYGRETLAYLSSLEEEGTMENA
                     DVTALRNCLSRVKTLGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATTRIEEILS
                     KSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVASKDLQKEIVESGRGTASPKEFYAK
                     NSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSREIAASTAQLVAASK
                     VKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQE
                     MDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGTEASPSTVQEAIPDKE"
     exon            187..250
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            251..393
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            394..450
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            451..531
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            532..608
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            609..670
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            671..811
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            812..869
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            870..945
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1086
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1184
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1257
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1441
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1530
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1623
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1725
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1869
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2005
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2092
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2200
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2337
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2448
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2507
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2601
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2702
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2808
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2932
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..2994
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3103
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..7855
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5175..5180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="hexamer: AATAAA"
     polyA_site      5199
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="major polyA site"
     regulatory      7761..7766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="hexamer: AATGAA"
     polyA_site      7787
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="major polyA site"
     regulatory      7814..7819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="hexamer: AATAAA"
     polyA_site      7842
                     /gene="Hip1"
                     /gene_synonym="2610109B09Rik; A930014B11Rik;
                     E130315I21Rik; mKIAA4113"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgggag gctccgcggg gatcccgggg cggccgaggg cccctgactc tgttcaccca
       61 gacaacatgg accgaatggc cagctccatg aagcaggtat ccaacccgct gcccaaagtg
      121 ttgagccgcc gcggagttgg tgctgggatg gaggctgcgg agcgcgagag cttcgagcgg
      181 actcagacgg tcagcgtcaa taaggccatt aatacgcagg aagtggccgt gaaagagaaa
      241 catgccagga cgtgtattct gggcacccac catgagaaag gagcgcagac cttttggtct
      301 gtggtcaacc gactgcctct ctccagcaac gccatgctgt gctggaagtt ttgtcacgtg
      361 ttccacaaac ttcttcgaga tggacatccg aacgtgctga aagactctct gagatacaaa
      421 aatgagttaa gcgacatgag caggatgtgg ggccacctga gcgaggggta tggacagctt
      481 tgcagcatct acctcaaact gctgagaaca aggatggagt accacaccaa aaatcccagg
      541 ttcccgggca acctccagat gagtgaccga cagctggatg aggccggaga aagtgacgtt
      601 aacaactttt ttcagctcac agtggagatg tttgattacc tggagtgtga actgaacctc
      661 ttccagactg tgttcaactc cttggacatg tcccgttcgg tgtccgtgac cacggctggc
      721 cagtgccgcc tcgcaccgct catccaggtc atcctggact gcagtcacct ctatgactac
      781 actgtcaagc tgctcttcaa gctccactcc tgtcttccag ctgacaccct gcagggccac
      841 cgagaccgct tcatggagca gttcacaaag ttgaaagatc tgtttcagcg ctccagcaac
      901 ctacagtact tcaagcggct cattcagatc ccccagctgc ccgagaatcc acccaacttc
      961 ctacgagcct cggccctgtc agagcacatc agtcctgtgg tggtgatccc ggcagaggtg
     1021 tcatccccag acagtgagcc tgtcctggag aaggatgacc tcatggacat ggacgcctcc
     1081 cagcagactt tgtttgacaa caagtttgat gacgtctttg gcagctcatt gagcagcgac
     1141 cctttcaatt tcaacaatca aaatggcgtg aacaaggacg agaaggacca cttgattgaa
     1201 cgcctgtaca gagagatcag tggactgaca gggcagctgg acaacatgaa gattgagagc
     1261 cagcgggcca tgctgcagct gaagggtcga gtgagtgagc tggaggcaga gctagcagag
     1321 cagcagcact tgggccggca ggctatggat gactgcgagt tcctgcgcac tgagctggat
     1381 gaactgaaga ggcagcgaga ggacacggag aaggcacagc gcagcctgac tgagatagaa
     1441 agaaaggccc aggctaatga acagaggtat agcaagttaa aagagaagta cagtgaactg
     1501 gtgcagaacc atgctgacct gctgcggaag aacgcagagg tgaccaaaca ggtgtccgtg
     1561 gcccggcaag cccaggtgga tttggaaaga gagaaaaaag agctagcaga ttcctttgca
     1621 cggactcaag agcaacagga tgttctagag aacctgaagc atgaactggc caccagcaga
     1681 caggagctgc aggtcctcca cagcaacctg gaaacctctg cccagtcaga agcgaaatgg
     1741 ctgacacaga tcgccgagtt ggagaaggaa caaggcagct tggcgactgt tgcagctcag
     1801 agagaggaag agttatcagc cctccgagac cagctggaaa gcacccagat caagctggct
     1861 ggggcccagg aatccatgtg ccagcaggtg aaggaccaga ggaaaaccct cttggcaggg
     1921 atcaggaagg ctgcggagcg tgagatacag gaggcgctga gccagcttga ggaacccacc
     1981 ctcatcagct gtgcaggatc cacagatcac cttctctcca aagtcagctc cgtttccagc
     2041 tgcctcgagc aactggaaaa gaacggcagc cagtatctgg cctgcccaga agatattagt
     2101 gagcttctgc actcgatcac cctgcttgcc cacttgaccg gtgacactat catccagggg
     2161 agtgccacca gcctccgggc cccaccggag ccagccgact cgctgacgga ggcctgtagg
     2221 cagtatggca gagaaaccct ggcctatctg tcctccctgg aggaagaggg aactatggag
     2281 aatgctgacg tcacagccct taggaactgc ctcagcaggg tcaagaccct tggcgaggag
     2341 ctgctgccca ggggcctgga catcaagcag gaagagctgg gtgacctggt ggacaaggag
     2401 atggcagcca cttcagctgc cattgaagct gccaccaccc ggatagagga aattctcagt
     2461 aagtcccgag caggagacac gggagtcaag ctggaggtga atgagaggat cctgggttcc
     2521 tgtaccagcc tgatgcaggc catcaaggtg ctcgttgtgg cctccaagga cctccagaag
     2581 gagatagtgg agagtggcag gggtactgca tcccctaaag aattttacgc caagaactct
     2641 cggtggacgg aagggctgat atccgcctcc aaagctgttg gttggggagc taccatcatg
     2701 gtggatgctg ctgatcttgt ggtccaaggc aaagggaagt tcgaggagct gatggtgtgt
     2761 tcacgcgaga ttgctgccag tactgcccag ctcgtggctg catccaaggt gaaagcgaac
     2821 aagggcagcc tcaatctgac ccagctgcag caggcctctc gaggagtgaa ccaggccaca
     2881 gccgctgtgg tggcctcaac catttctggc aaatctcaga ttgaggaaac agacagtatg
     2941 gacttctcaa gcatgacact gacccagatc aagcgccagg agatggattc ccaggttagg
     3001 gtgctggagc tggaaaatga cctgcagaag gagcgtcaga aactaggaga gctacggaag
     3061 aaacactacg agctggcggg cgtggctgag ggctgggagg aagggacaga agcatcaccg
     3121 tctactgtcc aagaagcaat accggacaaa gagtagagcc aagccgacac cccacacatc
     3181 agaatgtaaa tccttgttac ccttctgtga cactcgctcc ccactgtggc acatcaggtc
     3241 cttgtaggcc tctccagtga caaaagctga aggccatcgg gtctccccat gacaccacct
     3301 ccgtttgcat gcatgatggg ctcttcccct atatccctgg cacacaggca gaccagggtc
     3361 agccacgagc aagctcaggt ccacagaaaa acagcaacat ggccacttcc tcacaggcca
     3421 tgtccggctt agaggggctt cttgtcactg ggagcttgga gaggggacag cttacgtctt
     3481 ttctttttcc ccctcctcag tcctttgcat tttgtccttt gcacaaactt gtgagcatcc
     3541 aaactccgct ggattccaac ccagactgat gtccgactcc actgttggaa agaacacgaa
     3601 gggacagctg gcctccacac tacacttttt ggcagttcga tgggtcctct aactgcatct
     3661 taataggtgg tcgtttgggt cttttggttt cccgttttta aagtttcaca caaccaactt
     3721 tcccaaaaag gattcctccc ccacccagcc tgaccctgag ctctgagcct tctgagagga
     3781 agccccccca cagcgccagc acaccccggt gcggctcagg ctacgctttg gtgctccagc
     3841 tcggcagttc cgtcagccaa ggctactccc caggatgaca gctctccttg gaaggctgag
     3901 gctgagctag tgcctttact ttctgacctg gatgccagcc caaggcctct gtccaccatc
     3961 acaagccggg gagcaccaga gttgaagaca aagcagatgg tgccagggac ccagctgttc
     4021 aggggacgtt ttcttaggag ctcctgtcac caggctcaac ccaccacctg caagaatgga
     4081 gccggtgtgg aacagcaaca ctacatcccc agagcgaact tcctgtgcca tgtcatttgg
     4141 gtcacctcct gtcaaaccta gacaaggccc caagagggac aaatataaag gaaccggaag
     4201 tggttccttc tccgtctgcc tgcttctgca tcctactgaa ccagaaagca atggttccgt
     4261 gtgctactta cccaataggc ccactggatc aggaaacgag cttggctcgg tttaagactc
     4321 tttatattta ttactaacaa tctttatgca gcacatgccc cagagatgct tggagcaatc
     4381 aggaccaagg gtaactaaac aggcgtgccc tccgctatca atctccacag atcatcatag
     4441 agctaacgtg ccatccctgg gcatttccag gcttggattc caaagcaggc aggttcctta
     4501 aagcactgag gagcagggca gaggagaaag gggaccactg gctctagcac agtccccatc
     4561 accacccacc cactctggct cccatgcaga caggatgggg acagggggca ccacgcctag
     4621 ccacaagcag ggacagcact ttgcaactcc ctaatggacc cctgatctaa gtgaccttgt
     4681 gggccagggg ggtggtggct tctttatctg tagtaacaca taggtggcag ccagcaagca
     4741 cttctttgag cctgtcccca tggggcagag ctcagcttcg ctgggtgatg ggttgtgaga
     4801 ctagtgcttg atcactgtga atcaacctcc tccttcctgc cccactcacc cccactctgt
     4861 ccccggtggg cactccaaaa cctcccagag acccagatga tggctgtgac atgtgacctc
     4921 cacactgggc tgaaggagtt ttctgcagta gaaacgggcc cattctggtg ccagaacaat
     4981 gttttttggg tccaaggacc agaacactcg atggatgagt ggcattgttg gctcatttgt
     5041 gccaatgcag ctggtccatg tgttcactgc cagtcagctt ttcctacggt ggccatagag
     5101 tccttgtctc tagagtcact ctcatatgtc ccattgagat gacatcaaac acagcaatag
     5161 atgggggttt tctgaataaa tgacgaaccc atatgaaaag ccactatcat ttttaaaaaa
     5221 ccaataaaat ctgcctgggg agtgaaacag tgaaaagccc cagctcgagg taaggcagca
     5281 gcacagaagg gtccctacct gcttcatgtc acatcgggac tttgtaatag ctcgagtcgg
     5341 aagctgtcct tctacagcca ggctggctag cgcacacctg taaccttggc actcagcaga
     5401 ccgaggcagg aagatcctga atttacatac cttatctcaa aaaacaaaca aacaaaaaaa
     5461 ttaaaacagg ttatatatgt ttgtgtatag agatttatat aactggcttt tagagacagg
     5521 gtcttactgc atagtcctgg ctggcctcca actagctttg tccaccttat tgtcctgagg
     5581 tcacaggggt tccccttcct ctgtctccta aatgctggga tcaaaggtgt aagctatctc
     5641 acccagttga gaccataatt tttttggctc tgctactacc taaacgtgag tctttaaact
     5701 ggtggctggt caaaccaagc tggaaattct tttgtttttt cctctcacca aagcagtttt
     5761 tatttgaggc aaggagaagt ctgacccata tgattacagt tctaagcact cttaagtgtt
     5821 agtggcatga cttgggctat aaaacttgct tctgtttggt tggaaagggt attcgtgata
     5881 aagtcctcca ggtgggtaag aagaaagacc tcagctagtg gtactgccct ccagatccta
     5941 catcaaacta actaactctc accatctggt ttgcaaggtg ccacccagtg cagagggaca
     6001 tgggacactt gcaagggcag atgaggcaga aagaacaggt gcaagtcact tgaggagcag
     6061 ctcaaaagga acttcacagc cttcctcccc acacccccag gctgcttaga ctgaaggctg
     6121 ctgccttggg tgtagctaga tcctcaaggg agctgagggg ctggagaggt agctcagcag
     6181 ttagtactcc ccgctcttac agaggacccc caaatcagct cccagcaccc acatgtgacc
     6241 acgaccgcct tcaactccag cctcaaggga tccaatggca tctgctgcat gcgttcatgc
     6301 agaagtgccc acatactttt agagaaaata actcctgaaa aaaaaaataa ctttaaaggc
     6361 agaaaattga caaaataatg acttagggtg gggtgaggaa gaaactcaaa tccagctgtg
     6421 acttatattt agataatgca gtttcctggt gcctccaagg ctaagcataa gtgtgtgcat
     6481 aggagatcta cttctgtggg gttaggtcat agctcaaaaa ggaatttaaa tagttatgcc
     6541 aggtttgtca atgcacaact ataatcccag catttgggaa tccgaggcag gaggaatgtg
     6601 agttcaggtc tagcctgggc tatatactaa gaccttgtct caaaaacaaa gatcaggctc
     6661 taatttaact ggcttattgc agtactgtcc ccagcactat cctcagattc ctgttttgcc
     6721 ctgggagaat caaacacatg cagggcaccc tgtctcagaa ctggtgtggt aagtcagggt
     6781 cacaagtgtt tatcattctg gtcacattag ggtgctatgg cctctcatca tcggaggtat
     6841 tggtcctcat cctgtgtctg ggggagtttt tacttcttgg tcagtgactt agttgtagaa
     6901 gggtccctgg cactgtttga ccctgaattt taatgctgac caatgtgtta ctcccggttg
     6961 cctttccata tctctggaga ccttgctaga aaagcaagtc tatgggcgca acattaacct
     7021 gccaataaga gtggccctgc cctctgccgt cttggatcat ctgtagtagc cttccaacca
     7081 gagtgggctt tgctttctct ctcccatctt tgatcatctt ccaagttggc ttccaacaag
     7141 gatgagctct gctcggtcga tcttcatctt ggatccccta cattggcctt ccaaagagag
     7201 gggctttgcc ctctttccac ctttcaggtt ctcagagacc acactgtaac attggaaact
     7261 accatgacag cacttgccag gcattcacag tgacgcagaa gagctatttg actcccaggt
     7321 ccagcccaaa cccacgacca gcaaagcagt aatggagtgc ttcccctccc aggagccaga
     7381 gccaggaatg gtgggttaga cgtgactgga tccagttgtg aggatagaac cttccagaca
     7441 tgtgtttcag gtgaccctca actacctcag gtttgaagac cctaagttaa acttgattac
     7501 cactctaggg acaaaccgag gaatctggtt aaatcttggt gataacctaa atgtctcaag
     7561 cttataacaa actctcaaac cgtgcaggga tggggctgat ttttgtttgt ttatgcccgc
     7621 ccccttctgt ttctaacctt ttccactgtt ttccattaga gtagtcccta taagtgaatt
     7681 tcacttctca caaggtgcct accttcccag agcaggtagc cactggctct tgtttcctcc
     7741 tcacaggact tttattatgg aatgaagatc tttctttgta taatgcattg catctgtggt
     7801 ttcaattttt tccaataaat atgtcagcct ggctgtggag aactctggtg ataaaaaaaa
     7861 aaaaaaaaaa aaaaaaaaaa aaa
//
