LOCUS       NM_026871                636 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus histidine triad nucleotide binding protein 2 (Hint2),
            mRNA.
ACCESSION   NM_026871 XM_143732 XM_904588 XM_973428
VERSION     NM_026871.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 636)
  AUTHORS   Zhang,N., Zhou,Z.Y., Meng,Y.Y., Liao,H.H., Mou,S.Q., Lin,Z.,
            Yan,H., Chen,S. and Tang,Q.Z.
  TITLE     HINT2 protects against pressure overload-induced cardiac
            remodelling through mitochondrial pathways
  JOURNAL   J Cell Mol Med 28 (8), e18276 (2024)
   PUBMED   38546629
  REMARK    GeneRIF: HINT2 protects against pressure overload-induced cardiac
            remodelling through mitochondrial pathways.
REFERENCE   2  (bases 1 to 636)
  AUTHORS   Li,F., Li,J., Hao,J., Liu,J., Zu,X., Li,S. and Wang,B.
  TITLE     HINT2 deficiency deteriorates oxidative stress in a mouse model of
            myocardial infarction
  JOURNAL   ESC Heart Fail 10 (2), 1305-1313 (2023)
   PUBMED   36722640
  REMARK    GeneRIF: HINT2 deficiency deteriorates oxidative stress in a mouse
            model of myocardial infarction.
REFERENCE   3  (bases 1 to 636)
  AUTHORS   Li,S., Chen,J., Liu,M., Chen,Y., Wu,Y., Li,Q., Ma,T., Gao,J.,
            Xia,Y., Fan,M., Chen,A., Lu,D., Su,E., Xu,F., Chen,Z., Qian,J. and
            Ge,J.
  TITLE     Protective effect of HINT2 on mitochondrial function via repressing
            MCU complex activation attenuates cardiac microvascular
            ischemia-reperfusion injury
  JOURNAL   Basic Res Cardiol 116 (1), 65 (2021)
   PUBMED   34914018
  REMARK    GeneRIF: Protective effect of HINT2 on mitochondrial function via
            repressing MCU complex activation attenuates cardiac microvascular
            ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 636)
  AUTHORS   Fan,M., Chen,Z., Huang,Y., Xia,Y., Chen,A., Lu,D., Wu,Y., Zhang,N.,
            Zhang,P., Li,S., Chen,J., Zhang,Y., Sun,A., Zou,Y., Hu,K., Qian,J.
            and Ge,J.
  TITLE     Overexpression of the histidine triad nucleotide-binding protein 2
            protects cardiac function in the adult mice after acute myocardial
            infarction
  JOURNAL   Acta Physiol (Oxf) 228 (4), e13439 (2020)
   PUBMED   31900976
  REMARK    GeneRIF: Overexpression of the histidine triad nucleotide-binding
            protein 2 protects cardiac function in the adult mice after acute
            myocardial infarction.
REFERENCE   5  (bases 1 to 636)
  AUTHORS   Rajasekaran,R., Felser,A., Nuoffer,J.M., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     The histidine triad nucleotide-binding protein 2 (HINT-2)
            positively regulates hepatocellular energy metabolism
  JOURNAL   FASEB J 32 (9), 5143-5161 (2018)
   PUBMED   29913563
REFERENCE   6  (bases 1 to 636)
  AUTHORS   Ndiaye,D., Collado-Hilly,M., Martin,J., Prigent,S., Dufour,J.F.,
            Combettes,L. and Dupont,G.
  TITLE     Characterization of the effect of the mitochondrial protein Hint2
            on intracellular Ca(2+) dynamics
  JOURNAL   Biophys J 105 (5), 1268-1275 (2013)
   PUBMED   24010670
  REMARK    GeneRIF: the effect of the mitochondrial protein Hint2 on
            intracellular Ca(2+) dynamics
REFERENCE   7  (bases 1 to 636)
  AUTHORS   Martin,J., Maurhofer,O., Bellance,N., Benard,G., Graber,F.,
            Hahn,D., Galinier,A., Hora,C., Gupta,A., Ferrand,G., Hoppeler,H.,
            Rossignol,R., Dufour,J.F. and St-Pierre,M.V.
  TITLE     Disruption of the histidine triad nucleotide-binding hint2 gene in
            mice affects glycemic control and mitochondrial function
  JOURNAL   Hepatology 57 (5), 2037-2048 (2013)
   PUBMED   22961760
  REMARK    GeneRIF: Hint2/HINT2 positively regulates mitochondrial lipid
            metabolism and respiration and glucose homeostasis.
REFERENCE   8  (bases 1 to 636)
  AUTHORS   Lenglet,S., Antigny,F., Vetterli,L., Dufour,J.F. and Rossier,M.F.
  TITLE     Hint2 is expressed in the mitochondria of H295R cells and is
            involved in steroidogenesis
  JOURNAL   Endocrinology 149 (11), 5461-5469 (2008)
   PUBMED   18653718
REFERENCE   9  (bases 1 to 636)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 636)
  AUTHORS   Korsisaari,N., Rossi,D.J., Luukko,K., Huebner,K., Henkemeyer,M. and
            Makela,T.P.
  TITLE     The histidine triad protein Hint is not required for murine
            development or Cdk7 function
  JOURNAL   Mol Cell Biol 23 (11), 3929-3935 (2003)
   PUBMED   12748294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086940.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_143732.5, XM_904588.2, XM_973428.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086940.1, CB204856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..636
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /note="histidine triad nucleotide binding protein 2"
                     /db_xref="GeneID:68917"
                     /db_xref="MGI:MGI:1916167"
     exon            1..87
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..498
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /note="histidine triad nucleotide-binding protein 2,
                     mitochondrial; HINT-2; HINT-3; adenosine
                     5'-monophosphoramidase HINT2"
                     /codon_start=1
                     /product="adenosine 5'-monophosphoramidase HINT2
                     precursor"
                     /protein_id="NP_081147.1"
                     /db_xref="CCDS:CCDS18106.1"
                     /db_xref="GeneID:68917"
                     /db_xref="MGI:MGI:1916167"
                     /translation="MAAAVLLAVGLRAARRTLAAAGARGAQVRGNAGVSDGSEVAKAQ
                     KAAPGGASPTIFSRILDRSLPADILYEDQQCLVFRDVAPQAPVHFLVIPRKPIPRISQ
                     AEEDDQQLLGHLLLVAKKIAQAQGLKDGYRLVVNDGKMGAQSVYHLHIHVLGGRQLQW
                     PPG"
     exon            88..228
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            229..333
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            334..406
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..591
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      571..576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      591
                     /gene="Hint2"
                     /gene_synonym="1190005L05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggaagatgg ctgctgctgt gctgctggcc gtgggcttgc gcgctgcgcg cagaaccctg
       61 gctgccgcgg gggcccgggg ggcgcaggtc cgaggaaacg caggggtgtc cgacgggagt
      121 gaagtggcca aggcccagaa agcagctcct ggaggagcat cgccaaccat cttctcccgg
      181 attttggacc ggagtctccc agctgacatt ctatatgaag atcagcagtg ccttgtgttc
      241 cgtgacgtag ctcctcaggc tcctgtgcac tttctggtca ttcctaggaa gcccattcct
      301 cgaattagcc aggctgaaga ggacgaccag cagcttctag gacacttact ccttgtggcc
      361 aagaagatag cacaggccca gggtctgaaa gatgggtatc gacttgtggt taatgatggc
      421 aagatgggcg cacagtctgt gtatcacctg cacattcacg tacttggagg ccgacagctg
      481 cagtggccac ctggctaaac ctgccagctg gccaaggacc acaggcctgg atgcttggac
      541 ggagaatggg aaaaggaacc ttgtggtgtt aataaactta ttctccctca aaaaaaaaaa
      601 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
