LOCUS       NM_008248                655 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus histidine triad nucleotide binding protein 1 (Hint1),
            mRNA.
ACCESSION   NM_008248
VERSION     NM_008248.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 655)
  AUTHORS   Sato,M., Kadomatsu,T., Morinaga,J., Kinoshita,Y., Torigoe,D.,
            Horiguchi,H., Ohtsuki,S., Yamamura,S., Kusaba,R., Yamaguchi,T.,
            Yoshioka,G., Araki,K., Wakayama,T., Miyata,K., Node,K. and Oike,Y.
  TITLE     HINT1 suppression protects against age-related cardiac dysfunction
            by enhancing mitochondrial biogenesis
  JOURNAL   Mol Metab 93, 102107 (2025)
   PUBMED   39909188
REFERENCE   2  (bases 1 to 655)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 655)
  AUTHORS   Takahashi,S., Fukuhara,D., Kimura,T., Fukutomi,T., Tanaka,E.,
            Mikami,N., Hada,I., Takematsu,H., Nishibori,Y., Akimoto,Y.,
            Kiyonari,H., Abe,T., Huber,O. and Yan,K.
  TITLE     USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage
  JOURNAL   Biochem Biophys Res Commun 614, 198-206 (2022)
   PUBMED   35605301
  REMARK    GeneRIF: USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte
            damage.
REFERENCE   4  (bases 1 to 655)
  AUTHORS   Zhou,Y., Li,S.F., Deng,L.S., Ma,Y.K., Lei,G. and Dang,Y.H.
  TITLE     HINT1 deficiency in aged mice reduces anxiety-like and
            depression-like behaviours and enhances cognitive performances
  JOURNAL   Exp Gerontol 159, 111683 (2022)
   PUBMED   34995725
  REMARK    GeneRIF: HINT1 deficiency in aged mice reduces anxiety-like and
            depression-like behaviours and enhances cognitive performances.
REFERENCE   5  (bases 1 to 655)
  AUTHORS   Zhang,Y., Da,Q., Cao,S., Yan,K., Shi,Z., Miao,Q., Li,C., Hu,L.,
            Sun,S., Wu,W., Wu,L., Chen,F., Wang,L., Gao,Y., Huang,Z., Shao,Y.,
            Chen,H., Wei,Y., Chen,F., Han,Y., Xie,L. and Ji,Y.
  TITLE     HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates
            Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression
  JOURNAL   Circulation 144 (8), 638-654 (2021)
   PUBMED   34098726
  REMARK    GeneRIF: HINT1 (Histidine Triad Nucleotide-Binding Protein 1)
            Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5)
            Expression.
REFERENCE   6  (bases 1 to 655)
  AUTHORS   Lemaire,R., Prasad,J., Kashima,T., Gustafson,J., Manley,J.L. and
            Lafyatis,R.
  TITLE     Stability of a PKCI-1-related mRNA is controlled by the splicing
            factor ASF/SF2: a novel function for SR proteins
  JOURNAL   Genes Dev 16 (5), 594-607 (2002)
   PUBMED   11877379
REFERENCE   7  (bases 1 to 655)
  AUTHORS   Date,H., Onodera,O., Tanaka,H., Iwabuchi,K., Uekawa,K.,
            Igarashi,S., Koike,R., Hiroi,T., Yuasa,T., Awaya,Y., Sakai,T.,
            Takahashi,T., Nagatomo,H., Sekijima,Y., Kawachi,I., Takiyama,Y.,
            Nishizawa,M., Fukuhara,N., Saito,K., Sugano,S. and Tsuji,S.
  TITLE     Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is
            caused by mutations in a new HIT superfamily gene
  JOURNAL   Nat Genet 29 (2), 184-188 (2001)
   PUBMED   11586299
REFERENCE   8  (bases 1 to 655)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   9  (bases 1 to 655)
  AUTHORS   Hori,T., Asakawa,S., Itoh,Y., Shimizu,N. and Mizuno,S.
  TITLE     Wpkci, encoding an altered form of PKCI, is conserved widely on the
            avian W chromosome and expressed in early female embryos:
            implication of its role in female sex determination
  JOURNAL   Mol Biol Cell 11 (10), 3645-3660 (2000)
   PUBMED   11029061
REFERENCE   10 (bases 1 to 655)
  AUTHORS   Klein,M.G., Yao,Y., Slosberg,E.D., Lima,C.D., Doki,Y. and
            Weinstein,I.B.
  TITLE     Characterization of PKCI and comparative studies with FHIT, related
            members of the HIT protein family
  JOURNAL   Exp Cell Res 244 (1), 26-32 (1998)
   PUBMED   9770345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY261801.1, BC070415.1 and BE995722.1.
            
            On Feb 16, 2018 this sequence version replaced NM_008248.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE995722.1, BC070415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY261801.1         2-11
            11-627              BC070415.1         1-617
            628-655             BE995722.1         503-530
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..655
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /note="histidine triad nucleotide binding protein 1"
                     /db_xref="GeneID:15254"
                     /db_xref="MGI:MGI:1321133"
     exon            1..218
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..488
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /EC_number="3.-.-.-"
                     /note="adenosine 5'-monophosphoramidase; protein kinase
                     C-interacting protein 1; protein kinase C inhibitor 1; PKC
                     inhibitor/ interacting protein; desumoylating isopeptidase
                     HINT1"
                     /codon_start=1
                     /product="adenosine 5'-monophosphoramidase HINT1"
                     /protein_id="NP_032274.1"
                     /db_xref="CCDS:CCDS24702.1"
                     /db_xref="GeneID:15254"
                     /db_xref="MGI:MGI:1321133"
                     /translation="MADEIAKAQVAQPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDI
                     SPQAPTHFLVIPKKHISQISVADDDDESLLGHLMIVGKKCAADLGLKRGYRMVVNEGA
                     DGGQSVYHIHLHVLGGRQMNWPPG"
     exon            219..323
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..641
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      609..614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /note="hexamer: AATAAA"
     polyA_site      627
                     /gene="Hint1"
                     /gene_synonym="Hint; Ipk1; PKCI-1; PRKCNH1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcacg cgcaggccca ccgggcgcga gccggcagtc tccgcgcgct cccgcggttc
       61 ctctccccac tgtggccgcg gcgcgggaag gacagtgagc ggccgcgatg gctgacgaga
      121 ttgccaaggc tcaagtggcc cagcccggcg gcgacacgat cttcggcaag atcatccgca
      181 aagaaatccc cgccaagatc atcttcgagg acgaccggtg tcttgctttt catgacattt
      241 cccctcaagc accaacacac tttctggtga tacccaagaa gcatatatcc cagatttctg
      301 tagcagatga tgatgatgaa agtcttctag gacatttaat gattgttggc aagaaatgtg
      361 ctgcagatct gggcctgaag cgcgggtacc ggatggtggt gaatgaaggt gcagacgggg
      421 gacagtctgt ctatcacatt cacctccatg tccttggggg tcggcagatg aactggcctc
      481 ctggttaaag caggttgggg ataaagtgtc cttctctaga tagttggcaa gctccagtaa
      541 gataaatggc acacgtagtt ttgcctgtat atggagaaat tgaagagatc atttaaaatt
      601 ctgtgcctaa taaaagacat tgttgcacgt ctatgagtgg aaaaaaaaaa aaaaa
//
