LOCUS       NM_172162               2063 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus histone H4 transcription factor (Hinfp), transcript
            variant 1, mRNA.
ACCESSION   NM_172162 XM_909640
VERSION     NM_172162.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2063)
  AUTHORS   Kafer,G.R. and Cesare,A.J.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2063)
  AUTHORS   Ghule,P.N., Xie,R.L., Colby,J.L., Rivera-Perez,J.A., Jones,S.N.,
            Lian,J.B., Stein,J.L., van Wijnen,A.J. and Stein,G.S.
  TITLE     Maternal expression and early induction of histone gene
            transcription factor Hinfp sustains development in pre-implantation
            embryos
  JOURNAL   Dev Biol 419 (2), 311-320 (2016)
   PUBMED   27609454
  REMARK    GeneRIF: Induction of Hinfp begins at the 4-cell stage. Maternally
            encoded Hinfp sustains development of pre-implantation stage
            embryos. Hinfp loss delays growth of blastocyst stage embryos that
            later fail to implant. Hinfp ablation severely reduces histone H4
            mRNA and causes DNA damage. Transmission of maternal Hinfp
            transcripts and zygotic activation of the Hinfp gene together are
            neeeded to control early H4 gene expression.
REFERENCE   3  (bases 1 to 2063)
  AUTHORS   Ghule,P.N., Xie,R.L., Colby,J.L., Jones,S.N., Lian,J.B.,
            Wijnen,A.J., Stein,J.L. and Stein,G.S.
  TITLE     p53 checkpoint ablation exacerbates the phenotype of Hinfp
            dependent histone H4 deficiency
  JOURNAL   Cell Cycle 14 (15), 2501-2508 (2015)
   PUBMED   26030398
  REMARK    GeneRIF: simultaneous loss of both Hinfp and the p53 checkpoint is
            detrimental to normal cell growth and may predispose to cellular
            transformation.
REFERENCE   4  (bases 1 to 2063)
  AUTHORS   Ghule,P.N., Xie,R.L., Medina,R., Colby,J.L., Jones,S.N., Lian,J.B.,
            Stein,J.L., van Wijnen,A.J. and Stein,G.S.
  TITLE     Fidelity of histone gene regulation is obligatory for genome
            replication and stability
  JOURNAL   Mol Cell Biol 34 (14), 2650-2659 (2014)
   PUBMED   24797072
  REMARK    GeneRIF: Data show that conditional ablation of HINFP compromises
            cell proliferation, impairs DNA synthesis, alters nucleosome
            spacing and increases double-stranded DNA damage.
REFERENCE   5  (bases 1 to 2063)
  AUTHORS   Liu,L.J., Xie,R., Hussain,S., Lian,J.B., Rivera-Perez,J.,
            Jones,S.N., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Functional coupling of transcription factor HiNF-P and histone H4
            gene expression during pre- and post-natal mouse development
  JOURNAL   Gene 483 (1-2), 1-10 (2011)
   PUBMED   21605641
  REMARK    GeneRIF: The in vivo co-expression of Hinfp and histone H4 genes is
            consistent with the biological function of Hinfp as a principal
            transcriptional regulator of histone H4 gene expression during
            mouse development.
REFERENCE   6  (bases 1 to 2063)
  AUTHORS   Xie,R.L., Liu,L., Mitra,P., Stein,J.L., van Wijnen,A.J. and
            Stein,G.S.
  TITLE     Transcriptional activation of the histone nuclear factor P (HiNF-P)
            gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT
            defines a novel autoregulatory loop at the G1/S phase transition
  JOURNAL   Gene 402 (1-2), 94-102 (2007)
   PUBMED   17826007
  REMARK    GeneRIF: The dependence of HiNF-P gene transcription on cyclin
            E/CDK2/p220NPAT signaling defines a novel feed-forward loop that
            may sustain HiNF-P expression in proliferating cells to support the
            cell cycle regulated synthesis of histone H4 proteins.
REFERENCE   7  (bases 1 to 2063)
  AUTHORS   Zhou,W., Lin,L., Majumdar,A., Li,X., Zhang,X., Liu,W.,
            Etheridge,L., Shi,Y., Martin,J., Van de Ven,W., Kaartinen,V.,
            Wynshaw-Boris,A., McMahon,A.P., Rosenfeld,M.G. and Evans,S.M.
  TITLE     Modulation of morphogenesis by noncanonical Wnt signaling requires
            ATF/CREB family-mediated transcriptional activation of TGFbeta2
  JOURNAL   Nat Genet 39 (10), 1225-1234 (2007)
   PUBMED   17767158
REFERENCE   8  (bases 1 to 2063)
  AUTHORS   Sekimata,M. and Homma,Y.
  TITLE     Sequence-specific transcriptional repression by an MBD2-interacting
            zinc finger protein MIZF
  JOURNAL   Nucleic Acids Res 32 (2), 590-597 (2004)
   PUBMED   14752047
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2063)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   10 (bases 1 to 2063)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124577.5.
            
            On Apr 19, 2022 this sequence version replaced NM_172162.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029091.2, AK049348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC124577.5         195963-195981       c
            20-197              AC124577.5         192757-192934       c
            198-427             AC124577.5         189910-190139       c
            428-539             AC124577.5         189560-189671       c
            540-692             AC124577.5         189220-189372       c
            693-770             AC124577.5         188681-188758       c
            771-891             AC124577.5         188471-188591       c
            892-1030            AC124577.5         188246-188384       c
            1031-1155           AC124577.5         188040-188164       c
            1156-2063           AC124577.5         186020-186927       c
FEATURES             Location/Qualifiers
     source          1..2063
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2063
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /note="histone H4 transcription factor"
                     /db_xref="GeneID:102423"
                     /db_xref="MGI:MGI:2429620"
     exon            1..19
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            20..197
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1540
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /note="histone nuclear factor P; MBD2-interacting zinc
                     finger protein; methyl-CpG-binding protein 2-interacting
                     zinc finger protein; MBD2 (methyl-CpG-binding
                     protein)-interacting zinc finger protein"
                     /codon_start=1
                     /product="histone H4 transcription factor"
                     /protein_id="NP_751894.2"
                     /db_xref="CCDS:CCDS23102.1"
                     /db_xref="GeneID:102423"
                     /db_xref="MGI:MGI:2429620"
                     /translation="MSPPGKVPRKENLGLQCEWGSCSFVCSAMEEFFDHVTQHLQQHM
                     HGSKEEEEEDPLEEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQALQSQ
                     ADLSPCILDFQSRNVIPDTPDHFLCLWEHCESVFDNPEWFYRHVDAHSLCCEYQAVSK
                     DNHVVQCGWKGCTCTFKDRCKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQT
                     SLDQQRFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSE
                     DRPYKCDCCDYSCKNLIDLRKHLDTHSKESAYRCDFENCNFSARSLSSVKSHHRKVHE
                     GDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRY
                     ESVELTQQLLQQLQEGSDPGLALNESSLQGIVLETVLGGPGPEEETEEEGRVVEGTAL
                     SASQDNPSSAIHMVSQTDTQGQRDIVYCVLSEGPGEPPPVSETLKRDGKARGT"
     exon            198..427
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            428..539
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            540..692
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            693..770
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            771..891
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1030
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1155
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..2063
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /note="hexamer: AATAAA"
     polyA_site      2063
                     /gene="Hinfp"
                     /gene_synonym="HiNF-P; Mizf"
                     /note="major polyA site"
ORIGIN      
        1 aaaccagcgg cgctggcagg taaaggccat gtcgcctcct ggaaaagttc cccggaagga
       61 gaacctgggg ctccagtgtg agtgggggtc ctgctccttt gtgtgctcgg ccatggagga
      121 gttcttcgac catgtcactc agcacctgca gcagcacatg catggctcta aggaagaaga
      181 ggaagaggac ccacttgagg aagaattctc ctgcttgtgg caggaatgtg gcttttgctc
      241 tctggacagt tctgccgacc tcatccgcca tgtctacttc cactgctacc acaccaagct
      301 aaaacagtgg gggctgcaag ccttacaaag ccaggctgac ctcagcccct gcatcctgga
      361 ctttcagagc cggaacgtca tccctgacac ccctgaccat ttcctgtgcc tgtgggaaca
      421 ttgcgagagt gtcttcgaca atcctgagtg gttctatcgg catgtggatg cgcacagcct
      481 gtgctgtgaa taccaagctg tcagcaagga caaccatgtg gtgcagtgtg gctggaaagg
      541 ctgtacctgt accttcaagg accggtgtaa gcttcgagaa cacctccgca gccacaccca
      601 ggagaaggtg gtggcctgtc ccacctgtgg gggcatgttt gccaacaaca ccaagttctt
      661 agatcacatc cgtcgccaga cctcattgga tcagcagcga ttccagtgtt cccactgttc
      721 caagagattt gccacagaga ggctcttgcg tgaccacatg cggaaccatg tgaatcacta
      781 taaatgccct ttgtgtgaca tgacctgccc actgccttct tccctccgga atcacatgcg
      841 ctttcgacac agtgaggacc gaccctataa atgtgactgt tgtgactaca gctgtaagaa
      901 tttgattgac ctccggaagc acctagacac ccacagcaag gagtcagcct acaggtgtga
      961 ctttgagaac tgcaatttca gtgcgaggtc actcagctct gtcaagtccc atcaccgcaa
     1021 agtgcatgaa ggagactcag agccaaggta caaatgtcat gtctgtgaca aatgcttcac
     1081 acgtggcaac aacctcactg tgcaccttcg caagaagcac cagttcaagt ggccctcagg
     1141 acaccctcgc tttcggtaca aggaacatga agatggctac atgcgactgc agctagttcg
     1201 gtatgagagt gtggagctga cacagcagtt gctgcagcag ttacaagaag gatcagatcc
     1261 gggattggca ctgaatgaga gcagcctgca gggcattgtt ctggaaacag tgctaggggg
     1321 gccaggacct gaggaagaga cagaagagga aggtagggtt gttgagggaa cagctctctc
     1381 agcttctcag gacaacccca gctcagccat tcatatggtc agtcagacag acacccaagg
     1441 ccagcgagac attgtctact gtgtactgtc tgaaggccca ggagagcccc cgccagtctc
     1501 cgaaaccctc aagagagatg gaaaagctcg aggaacctga ggagccgggg tccaggtggg
     1561 ctgaggctgc agagtctggc cggtcctgct ccacatcttg aagtttgagc tgggcaggaa
     1621 gcggtgcccc aggggtcagc ctttgttctt ggatgccttt agaagtggtg ctgagaacag
     1681 tgtgttcccc tctgactcag aaggcatcat tctatagact ctggggagtt ggattcattg
     1741 aggaaatcct acatgtatgt tcttattaga ggagctgtta ccaggtttaa gtgtactccc
     1801 ttggcatgct agacagtaag tatttagtct acatccattc caatttccag ggatccatcg
     1861 atccattgac ccagggatga gggactgttc tttccaaggg ctgtttcctc actgttagtt
     1921 acgcattgag aaccaggtgc catttctctc aaggtttcct tttacattcc agggacactt
     1981 gttatcttca gggacacgat tatagatact gtgtatgtgt ggcagttgtc ttttggggaa
     2041 taaaagaaac acttgggctg tta
//
