LOCUS       NM_023516                985 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus hypoxia inducible lipid droplet associated (Hilpda),
            transcript variant 2, mRNA.
ACCESSION   NM_023516
VERSION     NM_023516.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 985)
  AUTHORS   Rao,Z., Liu,S., Li,Z., Wang,Q., Gao,F., Peng,H., Ren,D., Zang,Y.,
            Li,H., Li,Y., Hu,Q., He,D. and Xu,H.
  TITLE     Alarmin-loaded extracellular lipid droplets induce airway
            neutrophil infiltration during type 2 inflammation
  JOURNAL   Immunity 57 (11), 2514-2529 (2024)
   PUBMED   39366382
REFERENCE   2  (bases 1 to 985)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 985)
  AUTHORS   Deng,L., Wu,S.A., Qi,L. and Kersten,S.
  TITLE     HILPDA is a lipotoxic marker in adipocytes that mediates the
            autocrine negative feedback regulation of triglyceride hydrolysis
            by fatty acids and alleviates cellular lipotoxic stress
  JOURNAL   Mol Metab 75, 101773 (2023)
   PUBMED   37422000
REFERENCE   4  (bases 1 to 985)
  AUTHORS   Povero,D., Chen,Y., Johnson,S.M., McMahon,C.E., Pan,M., Bao,H.,
            Petterson,X.T., Blake,E., Lauer,K.P., O'Brien,D.R., Yu,Y.,
            Graham,R.P., Taner,T., Han,X., Razidlo,G.L. and Liu,J.
  TITLE     HILPDA promotes NASH-driven HCC development by restraining
            intracellular fatty acid flux in hypoxia
  JOURNAL   J Hepatol 79 (2), 378-393 (2023)
   PUBMED   37061197
  REMARK    GeneRIF: HILPDA promotes NASH-driven HCC development by restraining
            intracellular fatty acid flux in hypoxia.
REFERENCE   5  (bases 1 to 985)
  AUTHORS   Liu,L., Liu,T., Jia,R., Zhang,L., Lv,Z., He,Z., Qu,Y., Sun,S. and
            Tai,F.
  TITLE     Downregulation of fatty acid oxidation led by Hilpda increases G2/M
            arrest/delay-induced kidney fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166701 (2023)
   PUBMED   36990128
  REMARK    GeneRIF: Downregulation of fatty acid oxidation led by Hilpda
            increases G2/M arrest/delay-induced kidney fibrosis.
REFERENCE   6  (bases 1 to 985)
  AUTHORS   DiStefano,M.T., Roth Flach,R.J., Senol-Cosar,O., Danai,L.V.,
            Virbasius,J.V., Nicoloro,S.M., Straubhaar,J., Dagdeviren,S.,
            Wabitsch,M., Gupta,O.T., Kim,J.K. and Czech,M.P.
  TITLE     Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition
            and diet-induced insulin resistance
  JOURNAL   Mol Metab 5 (12), 1149-1161 (2016)
   PUBMED   27900258
  REMARK    GeneRIF: Authors conclude that Hig2 localizes to LDs in adipocytes,
            promoting adipose tissue lipid deposition and that its selective
            deficiency in active brown/beige adipose tissue mediates improved
            glucose tolerance at 23 degrees C.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 985)
  AUTHORS   DiStefano,M.T., Danai,L.V., Roth Flach,R.J., Chawla,A.,
            Pedersen,D.J., Guilherme,A. and Czech,M.P.
  TITLE     The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic
            Triglyceride Deposition by Inhibiting Lipolysis
  JOURNAL   J Biol Chem 290 (24), 15175-15184 (2015)
   PUBMED   25922078
REFERENCE   8  (bases 1 to 985)
  AUTHORS   Mattijssen,F., Georgiadi,A., Andasarie,T., Szalowska,E., Zota,A.,
            Krones-Herzig,A., Heier,C., Ratman,D., De Bosscher,K., Qi,L.,
            Zechner,R., Herzig,S. and Kersten,S.
  TITLE     Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel
            peroxisome proliferator-activated receptor (PPAR) target involved
            in hepatic triglyceride secretion
  JOURNAL   J Biol Chem 289 (28), 19279-19293 (2014)
   PUBMED   24876382
  REMARK    GeneRIF: data uncover HILPDA as a novel PPAR target that raises
            hepatic triglyceride storage via regulation of triglyceride
            secretion.
REFERENCE   9  (bases 1 to 985)
  AUTHORS   Gimm,T., Wiese,M., Teschemacher,B., Deggerich,A., Schodel,J.,
            Knaup,K.X., Hackenbeck,T., Hellerbrand,C., Amann,K., Wiesener,M.S.,
            Honing,S., Eckardt,K.U. and Warnecke,C.
  TITLE     Hypoxia-inducible protein 2 is a novel lipid droplet protein and a
            specific target gene of hypoxia-inducible factor-1
  JOURNAL   FASEB J 24 (11), 4443-4458 (2010)
   PUBMED   20624928
  REMARK    GeneRIF: HIG2 was up-regulated by hypoxia and HIF inducers in all
            cell types and mouse organs investigated and abundantly expressed
            in renal clear-cell carcinomas
REFERENCE   10 (bases 1 to 985)
  AUTHORS   Wallgard,E., Larsson,E., He,L., Hellstrom,M., Armulik,A.,
            Nisancioglu,M.H., Genove,G., Lindahl,P. and Betsholtz,C.
  TITLE     Identification of a core set of 58 gene transcripts with broad and
            specific expression in the microvasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1469-1476 (2008)
   PUBMED   18483404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY113188.1, AK009377.1 and AW538932.1.
            
            On Jun 26, 2010 this sequence version replaced NM_023516.4.
            
            Transcript Variant: This variant (2) contains an alternate 5' exon
            and uses a downstream start codon, compared to variant 1. Isoform 2
            has a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144676.1, BY709134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BY113188.1         2-47
            47-978              AK009377.1         3-934
            979-985             AW538932.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..985
                     /gene="Hilpda"
                     /gene_synonym="2310016C08Rik; Hig2"
                     /note="hypoxia inducible lipid droplet associated"
                     /db_xref="GeneID:69573"
                     /db_xref="MGI:MGI:1916823"
     exon            1..185
                     /gene="Hilpda"
                     /gene_synonym="2310016C08Rik; Hig2"
                     /inference="alignment:Splign:2.1.0"
     exon            186..985
                     /gene="Hilpda"
                     /gene_synonym="2310016C08Rik; Hig2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..436
                     /gene="Hilpda"
                     /gene_synonym="2310016C08Rik; Hig2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hypoxia-inducible gene 2 protein; hypoxia-inducible lipid
                     droplet-associated protein"
                     /codon_start=1
                     /product="hypoxia-inducible lipid droplet-associated
                     protein isoform 2"
                     /protein_id="NP_076005.1"
                     /db_xref="CCDS:CCDS39450.1"
                     /db_xref="GeneID:69573"
                     /db_xref="MGI:MGI:1916823"
                     /translation="MKFMLNLYVLGIMLTLLSIFVRVMESLGGLLESPLPGSSWITRG
                     QLANTQPPKGLPDHPSRGVQ"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hilpda"
                     /gene_synonym="2310016C08Rik; Hig2"
                     /note="hexamer: AATAAA"
     polyA_site      982
                     /gene="Hilpda"
                     /gene_synonym="2310016C08Rik; Hig2"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgag gagcctcgcc cagaaggggc ggggctttgg gaggtccgtt tgtctttggg
       61 gcttatttct atccagagca gtgcctgcgt ggagcttcca cgttgcgact cagccgacct
      121 tcttccttac tcctgcacga cctggtgtga ctgtgagcag ccgtctctca acttttcctt
      181 ctgaggatct agcagcagaa agcagctcta cttccctgca aaggagctgg gcaccgtcgc
      241 catgaagttc atgctgaacc tctatgtgct gggcatcatg ttgaccctgc tttccatctt
      301 tgttagagtg atggagtctc tgggaggctt actggagagc ccactgcccg ggagctcctg
      361 gatcacgagg ggtcagctag ccaacacaca gcctcctaag ggcctgccag accatccatc
      421 ccgaggagtg cagtgaacct ccctccctgc aggcatcaca gcttcagcat gtccaaccac
      481 acgttccatt tctcgggagg cagcatcaag tgtctccaaa ggactcttac taggcctgga
      541 agggctgttc ccttaccctg gaaaagagcc tatttcccct agagctgtga gtgggctgtc
      601 tgtggctctg ggatggaggt gtaccagttc cagctgttgg gagaatggat tttggtttcg
      661 tttgtttcag acctctgtcc taaaggactc ttttggacct aagtatcttc tgttggttta
      721 ccattgagtc tcttccctga gagttgtttg gatggcatca aaggggttgt ggtttgactg
      781 tgaagacaga gggtggacta tccagtgtcc aggtcaagtt gtacatttaa gttctttctc
      841 cagtgtaatg cacatgtgtt tgtatataat gtctaaaggg ctatgggatg atcaggcctg
      901 cttagggtat gggagttcca gccactgtgt ggcttaaaca tgaatttttc taatgcaata
      961 aatgtgaata tatatgtttc cactg
//
