LOCUS       NM_026304               1012 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus heat shock protein nuclear import factor (Hikeshi),
            transcript variant 1, mRNA.
ACCESSION   NM_026304
VERSION     NM_026304.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1012)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1012)
  AUTHORS   Li,L., Li,D., Sun,D., Zhang,X., Lei,W., Wu,M., Huang,Q., Nian,X.,
            Dai,W., Lu,X., Zhou,Z., Zhu,Y., Xiao,Y., Zhang,L., Mo,W., Liu,Z.
            and Zhang,L.
  TITLE     Nuclear import carrier Hikeshi cooperates with HSP70 to promote
            murine oligodendrocyte differentiation and CNS myelination
  JOURNAL   Dev Cell 58 (21), 2275-2291 (2023)
   PUBMED   37865085
  REMARK    GeneRIF: Nuclear import carrier Hikeshi cooperates with HSP70 to
            promote murine oligodendrocyte differentiation and CNS myelination.
REFERENCE   3  (bases 1 to 1012)
  AUTHORS   Shen,G., Wu,R., Liu,B., Dong,W., Tu,Z., Yang,J., Xu,Z. and Pan,T.
  TITLE     Upstream and downstream mechanisms for the promoting effects of
            IGF-1 on differentiation of spermatogonia to primary spermatocytes
  JOURNAL   Life Sci 101 (1-2), 49-55 (2014)
   PUBMED   24582811
  REMARK    GeneRIF: study identified downregulation of let-7 as an upstream
            mechanism for IGF1/IGF1R upregulation and activation of ERK1/2 and
            PI3K as a downstream mechanism mediating the IGF1 signaling cascade
            promoting spermatogenesis.
REFERENCE   4  (bases 1 to 1012)
  AUTHORS   Fernandez-Valdivia,R., Zhang,Y., Pai,S., Metzker,M.L. and
            Schumacher,A.
  TITLE     l7Rn6 encodes a novel protein required for clara cell function in
            mouse lung development
  JOURNAL   Genetics 172 (1), 389-399 (2006)
   PUBMED   16157679
REFERENCE   5  (bases 1 to 1012)
  AUTHORS   Rinchik,E.M. and Carpenter,D.A.
  TITLE     N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the
            Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557
            gametes and deletion mapping and complementation analysis of 31
            mutations
  JOURNAL   Genetics 152 (1), 373-383 (1999)
   PUBMED   10224267
REFERENCE   6  (bases 1 to 1012)
  AUTHORS   Holdener,B.C., Thomas,J.W., Schumacher,A., Potter,M.D.,
            Rinchik,E.M., Sharan,S.K. and Magnuson,T.
  TITLE     Physical localization of eed: a region of mouse chromosome 7
            required for gastrulation
  JOURNAL   Genomics 27 (3), 447-456 (1995)
   PUBMED   7558026
REFERENCE   7  (bases 1 to 1012)
  AUTHORS   Rinchik,E.M. and Carpenter,D.A.
  TITLE     N-ethyl-N-nitrosourea-induced prenatally lethal mutations define at
            least two complementation groups within the embryonic ectoderm
            development (eed) locus in mouse chromosome 7
  JOURNAL   Mamm Genome 4 (7), 349-353 (1993)
   PUBMED   8358168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161229.10 and AC165077.3.
            
            On Dec 22, 2021 this sequence version replaced NM_026304.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002306.1, DQ196315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC161229.10        87139-87321         c
            184-421             AC161229.10        81897-82134         c
            422-573             AC161229.10        69734-69885         c
            574-692             AC165077.3         177111-177229       c
            693-1012            AC165077.3         175726-176045       c
FEATURES             Location/Qualifiers
     source          1..1012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.4 cM"
     gene            1..1012
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /note="heat shock protein nuclear import factor"
                     /db_xref="GeneID:67669"
                     /db_xref="MGI:MGI:96738"
     exon            1..183
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..747
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /note="isoform a is encoded by transcript variant 1;
                     lethal gene on chromosome 7 Rinchik 6 protein; protein
                     Hikeshi"
                     /codon_start=1
                     /product="protein Hikeshi isoform a"
                     /protein_id="NP_080580.1"
                     /db_xref="CCDS:CCDS21445.1"
                     /db_xref="GeneID:67669"
                     /db_xref="MGI:MGI:96738"
                     /translation="MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTI
                     PFPEGMGGSVYFSYPDSNGVPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNI
                     VRTPSVAQIGISVELLDSLAQQTPVGSAAVSSVDSFTQFTQKMLDNFYNFASSFALSQ
                     AQMTPNPSEMFIPANVVLKWYENFQRRLAQNPLFWKT"
     exon            184..421
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /inference="alignment:Splign:2.1.0"
     exon            422..573
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /inference="alignment:Splign:2.1.0"
     exon            574..692
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1012
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /note="hexamer: AATAAA"
     polyA_site      1012
                     /gene="Hikeshi"
                     /gene_synonym="0610007P06Rik; 1110002N09Rik; l(7)6Rn;
                     l7Rn6"
                     /note="major polyA site"
ORIGIN      
        1 agatgcgttc ctgtgttgtt atgtagtgga gggtcacgtt ccttcctgca aattctggaa
       61 ggttcttgag ttcaattagg acagtggctg cggaattcct ggtgtccggc ctgaggtgcc
      121 cgctggccta gcagaggcgc cgagggcgct gccatgtttg gctgcctggt ggcggggagg
      181 ctggtgcaaa cagctgcaca gcaagtggca gaggataaat ttgtttttga cttgcctgat
      241 tatgaaaata tcaaccatgt tgtggttttt atgctgggaa caatcccatt tcctgagggc
      301 atgggaggat ctgtctactt ttcctatcct gattcaaatg gggtgccagt gtggcagctc
      361 ctaggatttg tcacgaatgg aaagccaagt gccatcttca aaatatcagg tcttaaatct
      421 ggggaaggaa gccagcaccc atttggagcc atgaatattg tgcgaacccc atctgttgcc
      481 cagattggca tctcggtgga attgttggac agtctggctc agcagactcc tgtaggcagt
      541 gctgccgtgt cctccgttga ctcctttacg cagttcacac agaagatgtt ggacaacttc
      601 tacaattttg cttcatcatt tgctctctct caggcccaga tgacaccaaa tccatcagaa
      661 atgttcatcc cagcaaatgt ggttctgaaa tggtatgaaa actttcaaag acgactagca
      721 cagaaccccc tcttttggaa aacataattt gaataaaata acttgtcatg tgatgtaaaa
      781 gcatgaagtc aaaagggtca tgaaacctac ctttcaaaaa aaacctgctt agtgactatg
      841 agacttataa aacccttata aaaattagaa ctattgaatg aggaaaatgt tcaatattaa
      901 ttattttctc ccttataagt gtgacatact tcttggaggc aaacattttg tataaactgt
      961 cattcatttc ttaaaataaa ccctactctc attagtagta tttgaaatac ca
//
