LOCUS       NM_025933                613 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus HIG1 domain family, member 2A (Higd2a), mRNA.
ACCESSION   NM_025933
VERSION     NM_025933.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 613)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 613)
  AUTHORS   Huang,K., Liu,Z., Xie,Z., Li,X., Zhang,H., Chen,Y., Wang,Y.,
            Lin,Z., Li,C., Liu,H. and Zhang,X.
  TITLE     HIGD2A silencing impairs hepatocellular carcinoma growth via
            inhibiting mitochondrial function and the MAPK/ERK pathway
  JOURNAL   J Transl Med 21 (1), 253 (2023)
   PUBMED   37041638
  REMARK    GeneRIF: HIGD2A silencing impairs hepatocellular carcinoma growth
            via inhibiting mitochondrial function and the MAPK/ERK pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 613)
  AUTHORS   Salazar,C., Barros,M., Elorza,A.A. and Ruiz,L.M.
  TITLE     Dynamic Distribution of HIG2A between the Mitochondria and the
            Nucleus in Response to Hypoxia and Oxidative Stress
  JOURNAL   Int J Mol Sci 23 (1), 389 (2021)
   PUBMED   35008815
  REMARK    GeneRIF: Dynamic Distribution of HIG2A between the Mitochondria and
            the Nucleus in Response to Hypoxia and Oxidative Stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 613)
  AUTHORS   Salazar,C., Yanez,O., Elorza,A.A., Cortes,N., Garcia-Beltran,O.,
            Tiznado,W. and Ruiz,L.M.
  TITLE     Biosystem Analysis of the Hypoxia Inducible Domain Family Member
            2A: Implications in Cancer Biology
  JOURNAL   Genes (Basel) 11 (2), 206 (2020)
   PUBMED   32085461
  REMARK    GeneRIF: Biosystem Analysis of the Hypoxia Inducible Domain Family
            Member 2A: Implications in Cancer Biology.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 613)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 613)
  AUTHORS   Chen,Y.C., Taylor,E.B., Dephoure,N., Heo,J.M., Tonhato,A.,
            Papandreou,I., Nath,N., Denko,N.C., Gygi,S.P. and Rutter,J.
  TITLE     Identification of a protein mediating respiratory supercomplex
            stability
  JOURNAL   Cell Metab 15 (3), 348-360 (2012)
   PUBMED   22405070
REFERENCE   7  (bases 1 to 613)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC155262.2.
            
            On Apr 29, 2007 this sequence version replaced NM_025933.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005269.1, BM569807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC155262.2         119850-120038
            190-613             AC155262.2         120343-120766
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 28.84 cM"
     gene            1..613
                     /gene="Higd2a"
                     /gene_synonym="2010110M21Rik"
                     /note="HIG1 domain family, member 2A"
                     /db_xref="GeneID:67044"
                     /db_xref="MGI:MGI:1914294"
     exon            1..189
                     /gene="Higd2a"
                     /gene_synonym="2010110M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..356
                     /gene="Higd2a"
                     /gene_synonym="2010110M21Rik"
                     /codon_start=1
                     /product="HIG1 domain family member 2A"
                     /protein_id="NP_080209.1"
                     /db_xref="CCDS:CCDS26532.1"
                     /db_xref="GeneID:67044"
                     /db_xref="MGI:MGI:1914294"
                     /translation="MAAPGPVSPEAPFDPSKPPVIEGFSPTVYSNPEGFKEKFIRKTR
                     ENPMVPIGCLGTAAALTYGLYCFHRGQSHRSQLMMRTRIAAQGFTVVAILLGLAASAM
                     KSQA"
     exon            190..613
                     /gene="Higd2a"
                     /gene_synonym="2010110M21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatttgtgt cctacctatt tctgtgctgg tgggtatggc ggctcccggt cctgtgagtc
       61 cagaggcgcc ttttgatccg tccaagcccc cagttatcga gggcttcagc cccacggtct
      121 actccaaccc agagggcttt aaggaaaagt ttattcgcaa gacccgtgag aacccaatgg
      181 tgcctatagg ctgtctgggg acggcggctg ccctcaccta tggcctttac tgcttccacc
      241 gcggccagag ccaccgatcc caactcatga tgcgcacccg gatcgctgca cagggtttca
      301 cggtcgtagc catcttgttg gggttagcgg catctgctat gaagtctcaa gcctgagtat
      361 agccgggtct taaagcgcca tggaaaccat tacaaaaccc aggaacaaca gacatccctg
      421 tcagacttgc tccctccgtt tcagaccgga ccttattgtc atttgggtga ggaagtggcc
      481 gattttgtaa ctgatttgcg cttccaccgc tgccccctcc cgctcccaaa atcccaggtt
      541 catttcagtt gggttgcatg cttctatttg tgatgcgtcc ccttaattac ttaataaaag
      601 cttattacac ttg
//
